20052020

Research output per year

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Personal profile

Biography

Matthew Belousoff began his career as a structural biologist in 2008 as a post-doctoral fellow in the lab of Prof. Ada Yonath, doing X-ray crystallography on the bacterial ribosome. Since returning to Australia in 2011, he has been using single particle cryoEM as a tool for the development of new ribosomal interfering antibiotics. Since the beginning of 2019 he has joined the lab of Prof. Patrick Sexton where he is using cryoEM as a tool to explore the structure and function of G-coupled protein receptors.

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Projects

Research Output

  • 49 Article
  • 2 Comment / Debate
  • 2 Review Article
  • 1 Chapter (Book)

Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation

Liang, Y. L., Belousoff, M. J., Zhao, P., Koole, C., Fletcher, M. M., Truong, T. T., Julita, V., Christopoulos, G., Xu, H. E., Zhang, Y., Khoshouei, M., Christopoulos, A., Danev, R., Sexton, P. M. & Wootten, D., 6 Feb 2020, In : Molecular Cell. 77, 3, p. 656-668.e5 18 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Activation of the GLP-1 receptor by a non-peptidic agonist

Zhao, P., Liang, Y. L., Belousoff, M. J., Deganutti, G., Fletcher, M. M., Willard, F. S., Bell, M. G., Christe, M. E., Sloop, K. W., Inoue, A., Truong, T. T., Clydesdale, L., Furness, S. G. B., Christopoulos, A., Wang, M. W., Miller, L. J., Reynolds, C. A., Danev, R., Sexton, P. M. & Wootten, D., 8 Jan 2020, In : Nature. 577, 7790, p. 432-436 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
5 Citations (Scopus)

Characterization of the Core Ribosomal Binding Region for the Oxazolidone Family of Antibiotics Using Cryo-EM

Wright, A., Deane-Alder, K., Marschall, E., Bamert, R., Venugopal, H., Lithgow, T., Lupton, D. W. & Belousoff, M. J., 12 Jun 2020, In : ACS Pharmacology & Translational Science. 3, 3, p. 425-432 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Global Trends in Proteome Remodeling of the Outer Membrane Modulate Antimicrobial Permeability in Klebsiella pneumoniae

Rocker, A., Lacey, J. A., Belousoff, M. J., Wilksch, J. J., Strugnell, R. A., Davies, M. R. & Lithgow, T., 14 Apr 2020, In : mBio. 11, 2, 16 p., e00603-20.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

cryoEM-Guided Development of Antibiotics for Drug-Resistant Bacteria

Belousoff, M. J., Venugopal, H., Wright, A., Seoner, S., Stuart, I., Stubenrauch, C., Bamert, R. S., Lupton, D. W. & Lithgow, T., 5 Mar 2019, In : ChemMedChem. 14, 5, p. 527-231 5 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Activities

  • 1 Membership of industry collaboration/ network

Monash Antimicrobial Resistance Group (Event)

Trevor Lithgow (Chair/Co-Chair), , Max Cryle (Member), , Kellie Tuck (Member), , Ana Traven (Member), , Thomas Naderer (Member), , Julian Rood (Member), , Dena Lyras (Member), , Anton Peleg (Member), , Mibel Aguilar (Member), , Fasseli Coulibaly (Member), , Sheena McGowan (Member), , Meredith Anne Okeeffe (Member), , Matthew Belousoff (Member), & Philip Heraud (Member)

1 Mar 20171 Jan 2019

Activity: Industry, Government and Philanthropy Engagement and PartnershipsMembership of industry collaboration/ network

Press / Media

Key to ‘superbug’ antibiotic resistance discovered

Matthew James Belousoff & Trevor Lithgow

10/05/1719/05/18

12 items of Media coverage, 6 Media contributions

Press/Media: Research