Projects per year
Personal profile
Biography
Matthew Belousoff began his career as a structural biologist in 2008 as a post-doctoral fellow in the lab of Prof. Ada Yonath, doing X-ray crystallography on the bacterial ribosome. Since returning to Australia in 2011, he has been using single particle cryoEM as a tool for the development of new ribosomal interfering antibiotics. Since the beginning of 2019 he has joined the lab of Prof. Patrick Sexton where he is using cryoEM as a tool to explore the structure and function of G-coupled protein receptors.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Development of approaches for inactive, antagonist bound GPCR structures determination
Wootten, D., Sexton, P., Belousoff, M., Johnson, R. & Han, S.
22/02/22 → 21/02/26
Project: Research
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Cryo‐EM structure determination of G protein‐coupled receptors
Sexton, P., Wootten, D., Belousoff, M., Nar, H., Weichert, D., Ebenhoch, R., Ou, Q. & Lee, D.
21/09/21 → 21/09/25
Project: Research
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Development of approaches for orphan GPCR structure determination
Sexton, P., Wootten, D., Belousoff, M., Zhang, C., Russell, I. C. & Flocco, M.
7/04/21 → 6/04/25
Project: Research
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Optimisation of GPCR expression, purification and structure determination
Sexton, P., Wootten, D., Belousoff, M., Tovey, J. C., Williams, P. & Apelbaum, A.
7/04/21 → 6/04/25
Project: Research
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Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation
Liang, Y. L., Belousoff, M. J., Zhao, P., Koole, C., Fletcher, M. M., Truong, T. T., Julita, V., Christopoulos, G., Xu, H. E., Zhang, Y., Khoshouei, M., Christopoulos, A., Danev, R., Sexton, P. M. & Wootten, D., 6 Feb 2020, In: Molecular Cell. 77, 3, p. 656-668.e5 18 p.Research output: Contribution to journal › Article › Research › peer-review
68 Citations (Scopus) -
Activation of the GLP-1 receptor by a non-peptidic agonist
Zhao, P., Liang, Y. L., Belousoff, M. J., Deganutti, G., Fletcher, M. M., Willard, F. S., Bell, M. G., Christe, M. E., Sloop, K. W., Inoue, A., Truong, T. T., Clydesdale, L., Furness, S. G. B., Christopoulos, A., Wang, M. W., Miller, L. J., Reynolds, C. A., Danev, R., Sexton, P. M. & Wootten, D., 8 Jan 2020, In: Nature. 577, 7790, p. 432-436 5 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile92 Citations (Scopus) -
A structural basis for amylin receptor phenotype
Cao, J., Belousoff, M. J., Liang, Y. L., Johnson, R. M., Josephs, T. M., Fletcher, M. M., Christopoulos, A., Hay, D. L., Danev, R., Wootten, D. & Sexton, P. M., 25 Mar 2022, In: Science. 375, 6587, 14 p., eabm9609.Research output: Contribution to journal › Article › Research › peer-review
14 Citations (Scopus) -
A Structurally Characterized Staphylococcus aureus Evolutionary Escape Route from Treatment with the Antibiotic Linezolid
Perlaza-Jiménez, L., Tan, K. S., Piper, S. J., Johnson, R. M., Bamert, R. S., Stubenrauch, C. J., Wright, A., Lupton, D., Lithgow, T. & Belousoff, M. J., Jul 2022, In: Microbiology Spectrum. 10, 4, 11 p., e0058322.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile2 Citations (Scopus) -
Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation
Deganutti, G., Liang, Y. L., Zhang, X., Khoshouei, M., Clydesdale, L., Belousoff, M. J., Venugopal, H., Truong, T. T., Glukhova, A., Keller, A. N., Gregory, K. J., Leach, K., Christopoulos, A., Danev, R., Reynolds, C. A., Zhao, P., Sexton, P. M. & Wootten, D., 2022, In: Nature Communications. 13, 18 p., 92.Research output: Contribution to journal › Article › Research › peer-review
Open Access12 Citations (Scopus)
Activities
- 1 Membership of industry collaboration/ network
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Monash Antimicrobial Resistance Group (Event)
Trevor Lithgow (Chair/Co-Chair), Max Cryle (Member), Kellie Tuck (Member), Ana Traven (Member), Thomas Naderer (Member), Julian Rood (Member), Dena Lyras (Member), Anton Peleg (Member), Mibel Aguilar (Member), Fasseli Coulibaly (Member), Sheena McGowan (Member), Meredith Anne Okeeffe (Member), Matthew Belousoff (Member) & Philip Heraud (Member)
1 Mar 2017 → 1 Jan 2019Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of industry collaboration/ network
Press/Media
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Key to ‘superbug’ antibiotic resistance discovered
Matthew James Belousoff & Trevor Lithgow
10/05/17 → 19/05/18
12 items of Media coverage, 6 Media contributions
Press/Media: Research