Projects per year
Personal profile
Biography
Mastura Monif (BBiomed Sci, B Sci Hons, MBBS, PhD, FRACP) is an Associate Professor in the Van Cleef Centre for Nervous Diseases, Department of Neuroscience, within the School of Translational Medicine. She leads the Neuroimmunology, Neuroinflammation and Neuro Oncology Lab at Monash University Department of Neuroscience. Her research interests are to understand how neuroinflammation can induce neurological disease. The main areas of research focus in her lab are: Autoimmune Encephalitis, Glioblastoma (brain cancer), Autoimmune Epilepsy, Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorder (NMOSD) and Chimeric Antigen Receptor (CAR) T cell therapy related neurotoxicity.
Research interests
To understand how neuroinflammation and innate immune responses can lead to neurological diseases.
To decipher biomarkers of neuroinflammatory disease that can assist with disease diagnosis, prognostication and aid in improved therapeutics.
Clinical activities
She is also a Consultant Neurologist at Alfred Health. She leads the Neuroimmunology Service at Alfred Health. Her clinical interest and expertise are neuroimmunological diseases such as Multiple Sclerosis, Autoimmune Encephalitis, and other central nervous system inflammatory and autoimmune disorders. She is also leads the neurology division of CAR-T (Chimeric Antigen Receptor T cell) Therapy for haematological malignancies and autoimmune CNS diseases at Alfred Health focusing on diagnosis and management of neurological complications of CAR-T Therapy.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Neuroimmunology, Fellowship, Royal Melbourne Hospital
Award Date: 30 Dec 2017
Neurology, Neurology Specialist Qualification - FRACP, Royal Australasian College of Physicians (RACP)
Award Date: 20 Oct 2017
Physician Training, Fellow of the Australian College of Physicians, Royal Australasian College of Physicians (RACP)
Award Date: 29 Jul 2014
Bachelor of Medicine, Bachelor of Surgery, Bachelor of Medicine, Bachelor of Surgery, University of Melbourne
Award Date: 4 Dec 2010
Neuroscience, Neuroimmunology, PhD, P2X7 Receptor and its contribution to the activation and proliferation of microglia. , University of Melbourne
Award Date: 4 Dec 2010
Neuroscience, Bachelor of Science Honours, Development of a presynaptic calcium biosensor to study neuronal calcium dynamics. , University of Melbourne
Award Date: 4 Dec 2004
External positions
Head of Neuroimmunology Service , Alfred Hospital
20 Jun 2021 → …
Research area keywords
- neurology
- neuroimmunology
- neuroinflammation
- Multiple Sclerosis (MS)
- Autoimmune Encephalitis
- Gliomas
- Microglia / monocytes
- Purinergic receptors
- P2X7R
Collaborations and top research areas from the last five years
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The ACRF Centre for Dynamic Immuno-Oncology (CDIO)
Shackleton, M. (Primary Chief Investigator (PCI)), Cherk, M. (Chief Investigator (CI)), Naranbhai, V. (Chief Investigator (CI)), McLean, C. (Chief Investigator (CI)), Monif, M. (Chief Investigator (CI)), Si Lun Tam, C. (Chief Investigator (CI)), Kalff, A. (Chief Investigator (CI)), Fleming, S. (Chief Investigator (CI)), Mar, V. (Chief Investigator (CI)), Ge, Z. (Chief Investigator (CI)) & Cheung, J. (Project Manager)
7/04/25 → 7/01/30
Project: Research
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Electroencephalogram (EEG) in autoimmune encephalitis diagnosis and prognosis.
Tan, T., Monif, M., Wesselingh, R., Seery, N., Kwan, P. & O'Brien, T.
1/01/25 → 1/01/26
Project: Research
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An open-label, multi-center, phase I/II study to assess safety, disease progression, and cellular kinetics following YTB323 administration in participants with non-active Progressive Multiple Sclerosis (PMS)
Monif, M. (Primary Chief Investigator (PCI))
18/11/24 → 2/05/28
Project: Research
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An open-label, multi-center, phase 1/2 study to assess safety, efficacy, and cellular kinetics of YTB323 in participants with Relapsing Multiple Sclerosis with breakthrough disease activity during previous treatment with a highly efficacious therapy
Monif, M. (Primary Chief Investigator (PCI))
1/10/24 → 30/09/26
Project: Research
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CureMOG: A randomised double-blind placebo-controlled multicentre phase III clinical trial for the treatment of MOGAD
Ramanathan, S. (Primary Chief Investigator (PCI)), Butzkueven, H. (Chief Investigator (CI)), Brown, D. A. (Chief Investigator (CI)), Van Der Walt, A. (Chief Investigator (CI)), Kalincik, T. (Chief Investigator (CI)), Miteff, C. (Associate Investigator (AI)), Fraser, C. (Associate Investigator (AI)), Klistorner, A. (Associate Investigator (AI)), Hardy, T. A. (Associate Investigator (AI)), Barnett, M. H. (Chief Investigator (CI)), Broadley, S. (Chief Investigator (CI)), Spelman, T. D. (Chief Investigator (CI)), Lindley, R. I. (Chief Investigator (CI)), Brilot-Turville, F. (Chief Investigator (CI)), Dale, R. C. (Chief Investigator (CI)), Slee, M. (Chief Investigator (CI)), Lewfelar, J. (Chief Investigator (CI)), Reddel, S. W. (Chief Investigator (CI)), Lechner-Scott, J. (Chief Investigator (CI)), Monif, M. (Associate Investigator (AI)) & George, S. (Associate Investigator (AI))
1/06/24 → 31/05/29
Project: Research
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Characterizing cognitive function in patients with autoimmune encephalitis: an Australian prospective study
Griffith, S. P., Wesselingh, R., Seery, N., Rushen, T., Kyndt, C., Long, B., Seneviratne, U., Buzzard, K., Butzkueven, H., O’Brien, T. J., Alpitsis, R., Malpas, C. B. & Monif, M., 2024, In: Journal of Neurology. 27, p. 310–324 15 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus) -
Clinical outcomes among initial survivors of cryptogenic new-onset refractory status epilepsy (NORSE)
Costello, D. J., Matthews, E., Aurangzeb, S., Doran, E., Stack, J., Wesselingh, R., Dugan, P., Choi, H., Depondt, C., Devinsky, O., Doherty, C., Kwan, P., Monif, M., O'Brien, T. J., Sen, A. & Gaspard, N., Jun 2024, In: Epilepsia. 65, 6, p. 1581-1588 8 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access6 Citations (Scopus) -
Cognitive and psychopathological features of neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein antibody-associated disease: A narrative review
Kazzi, C., Alpitsis, R., O'Brien, T. J., Malpas, C. B. & Monif, M., May 2024, In: Multiple Sclerosis and Related Disorders. 85, 7 p., 105596.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access5 Citations (Scopus) -
Cognitive and psychopathological outcomes in acute disseminated encephalomyelitis
Kazzi, C., Alpitsis, R., O'Brien, T. J., Malpas, C. & Monif, M., 8 May 2024, In: BMJ Neurology Open. 6, 1, 7 p., e000640.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access2 Citations (Scopus) -
Comparing ocrelizumab to interferon/glatiramer acetate in people with multiple sclerosis over age 60
Foong, Y. C., Merlo, D., Gresle, M., Buzzard, K., Zhong, M., Yeh, W. Z., Jokubaitis, V., Monif, M., Skibina, O., Ozakbas, S., Patti, F., Grammond, P., Amato, M. P., Kalincik, T., Horakova, D., Havrdova, E. K., Weinstock-Guttman, B., Scott, J. L., Boz, C. & Sa, M. J. & 4 others, , Aug 2024, In: Journal of Neurology, Neurosurgery and Psychiatry. 95, 8, p. 767–774 8 p., 332883.Research output: Contribution to journal › Article › Research › peer-review
5 Citations (Scopus)
Prizes
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2019 Monash Graduate Supervisor of the year
Monif, M. (Recipient), 19 Dec 2019
Prize: Prize (including medals and awards)
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Brain Foundation Research Award
Monif, Mastura (Recipient), 2018
Prize: Prize (including medals and awards)
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Charles and Sylvia Viertel Clinical Investigator Award
Monif, M. (Recipient), 6 Nov 2019
Prize: Prize (including medals and awards)
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Neurosciences Foundation Haynes Fellowship
Monif, Mastura (Recipient), 2017
Prize: Competitive Fellowships
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Royal Australian College of Physicians Trainee Research Award in Victoria
Monif, Mastura (Recipient), 2017
Prize: Prize (including medals and awards)
Press/Media
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Neuroscience researchers support Brain Cancer Awareness month
27/05/22
1 Media contribution
Press/Media: Public Engagement Activities
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Zeroing in on improved brain cancer diagnosis and treatment: Rare Disease Day feature
28/02/22
1 Media contribution
Press/Media: Article/Feature
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News article story on Autoimmune Encephalitis
24/11/21
1 Media contribution
Press/Media: Profile/Interview