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Personal profile

Education/Academic qualification

Biochemistry, PhD

… → 2015

Biochemistry, BSc Hons (1st Class), University of Otago

… → 2009

External positions

Research Fellow, Boston Children's Hospital

Jan 2017Mar 2019

Research Fellow, Harvard Medical School

Jan 2017Mar 2019

Postdoctoral Scientist, Malaghan Institute of Medical Research

Aug 2015Dec 2016

Research area keywords

  • Cell Death
  • Inflammation
  • Host-Pathogen Interactions
  • Innate Immunity

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output

Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation

Speir, M., Nowell, C. J., Chen, A. A., O’Donnell, J. A., Shamie, I. S., Lakin, P. R., D’Cruz, A. A., Braun, R. O., Babon, J. J., Lewis, R. S., Bliss-Moreau, M., Shlomovitz, I., Wang, S., Cengia, L. H., Stoica, A. I., Hakem, R., Kelliher, M. A., O’Reilly, L. A., Patsiouras, H., Lawlor, K. E. & 5 others, Weller, E., Lewis, N. E., Roberts, A. W., Gerlic, M. & Croker, B. A., 1 Jan 2020, In : Nature Immunology. 21, 1, p. 54-64 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils

D'Cruz, A. A., Speir, M., Bliss-Moreau, M., Dietrich, S., Wang, S., Chen, A. A., Gavillet, M., Al-Obeidi, A., Lawlor, K. E., Vince, J. E., Kelliher, M. A., Hakem, R., Pasparakis, M., Williams, D. A., Ericsson, M. & Croker, B. A., 4 Sep 2018, In : Science Signaling. 11, 546, 11 p., aao1716.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Legionella pneumophila strain 130b evades macrophage cell death independent of the effector SidF in the absence of flagellin

Speir, M., Vogrin, A., Seidi, A., Abraham, G., Hunot, S., Han, Q., Dorn 11, G. W., Masters, S. L., Flavell, R. A., Vince, J. E. & Naderer, T., 16 Feb 2017, In : Frontiers in Cellular and Infection Microbiology. 7, 12 p., 35.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
7 Citations (Scopus)

Eliminating Legionella by inhibiting BCL-XL to induce macrophage apoptosis

Speir, M., Lawlor, K. E., Glaser, S. P., Abraham, G., Chow, S., Vogrin, A., Schulze, K. E., Schuelein, R., O'Reilly, L. A., Mason, K., Hartland, E. L., Lithgow, T., Strasser, A., Lessene, G., Huang, D. C. S., Vince, J. E. & Naderer, T., 24 Feb 2016, In : Nature Microbiology. 1, 3, 9 p., 15034.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Antibiotic regimen based on population analysis of residing persister cells eradicates Staphylococcus epidermidis biofilms

Yang, S., Hay, I. D., Cameron, D. R., Speir, M., Cui, B., Su, F., Peleg, A. Y., Lithgow, T. J., Deighton, M. A. & Qu, Y., 2015, In : Scientific Reports. 5, 11 p., 18578.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
21 Citations (Scopus)