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Personal profile

Biography

Associate Professor Martin Stone is a researcher and teacher in the Monash University Department of Biochemistry and Molecular Biology and the Monash Biomedicine Discovery Institute. He received his BSc and MSc (Hons) degrees from the University of Auckland (New Zealand) and his PhD from the University of Cambridge (UK). He was a postdoctoral research fellow at the Scripps Research Institute in (San Diego, USA) and a faculty member at Indiana University (Bloomington, USA) before moving to Monash in 2007. From 2013-2016 he served as Director of the Graduate Program in Biomedical Science at Monash.

Martin’s research program focuses on the biochemistry and pharmacology of chemokines and their receptors, which play critical roles in directing the migration of leukocytes in inflammatory responses. Recently, his lab has made important contributions to understanding the influence of post-translational tyrosine sulfation on chemokine receptor recognition and function and the structural basis by which chemokines can differentially activate a shared receptor to elicit distinct cellular outcomes.

Research interests

Inflammation is the response of a tissue and its microvascular system to injury or infection. A hallmark of inflammation is the accumulation of leukocytes (white blood cells), which remove pathogens and necrotic tissue by phagocytosis and proteolytic degradation. However, excessive leukocyte recruitment or activity leads to the release of toxic substances and degradation of healthy tissue, i.e. inflammatory disease.
Leukocyte recruitment in inflammation is controlled by the expression and secretion of small proteins called chemokines at the site of inflammation and by the subsequent interaction of those chemokines with chemokine receptors located on the surfaces of circulating leukocytes. A detailed understanding of chemokine-receptor interactions is required in order to rationally develop novel therapeutic agents against inflammatory diseases. Our group is investigating several important aspects of chemokine and chemokine receptor biochemistry with the overall goals of better understanding and ultimately controlling their biological functions.

Keywords

  • chemokine
  • chemokine receptor
  • biochemistry
  • Structural Biology
  • signal transduction
  • evasin

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Projects 2009 2022

Research Output 1989 2018

Ticks from diverse genera encode chemokine-inhibitory evasin proteins

Hayward, J., Sanchez, J., Perry, A., Huang, C., Rodriguez Valle, M., Canals, M., Payne, R. J. & Stone, M. J., 22 Sep 2017, In : Journal of Biological Chemistry. 292, 38, p. 15670-15680 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Key determinants of selective binding and activation by the monocyte chemoattractant proteins at the chemokine receptor CCR2

Huma, Z. E., Sanchez, J., Lim, H. D., Bridgford, J. L., Huang, C., Parker, B. J., Pazhamalil, J. G., Porebski, B. T., Pfleger, K. D. G., Lane, J. R., Canals, M. & Stone, M. J., 23 May 2017, In : Science Signaling. 10, 480, 13 p., eaai8529.

Research output: Contribution to journalArticleResearchpeer-review

Homogeneous sulfopeptides and sulfoproteins: synthetic approaches and applications to characterize the effects of tyrosine sulfation on biochemical function

Stone, M. J. & Payne, R. J., 2015, In : Accounts of Chemical Research. 48, 8, p. 2251 - 2261 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Structural basis of receptor sulfotyrosine recognition by a CC chemokine: the N-terminal region of CCR3 bound to CCL11/eotaxin-1

Millard, C. J., Ludeman, J. P., Canals, M., Bridgford, J. L., Hinds, M. G., Clayton, D. J., Christopoulos, A., Payne, R. J. & Stone, M. J., 2014, In : Structure. 22, 11, p. 1571 - 1581 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Regulation of chemokine recognition by site-specific tyrosine sulfation of receptor peptides

Simpson, L. S., Zhu, J. Z., Widlanski, T. S. & Stone, M. J., 2009, In : Chemistry and Biology. 16, 2, p. 153 - 161 9 p.

Research output: Contribution to journalArticleResearchpeer-review