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Research Output 1991 2019

2019

A ligand-induced structural change in fatty acid-binding protein 1 is associated with potentiation of peroxisome proliferator-activated receptor α agonists

Patil, R., Mohanty, B., Liu, B., Chandrashekaran, I. R., Headey, S. J., Williams, M. L., Clements, C. S., Ilyichova, O., Doak, B. C., Genissel, P., Weaver, R., Vuillard, L., Halls, M. L., Porter, C. J. H. & Scanlon, M. J., 8 Mar 2019, In : Journal of Biological Chemistry. 294, 10, p. 3720-3734 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Controlled Construction of Cyclic d / l Peptide Nanorods

Silk, M. R., Mohanty, B., Sampson, J. B., Scanlon, M. J., Thompson, P. E. & Chalmers, D. K., 8 Jan 2019, In : Angewandte Chemie - International Edition. 58, 2, p. 596-601 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Engaging Students with Multiple Pathways for Solving Complex Authentic Problems

Yuriev, E., Burton, J., Maher, S., Thompson, C. & Scanlon, M., 2019. 1 p.

Research output: Contribution to conferenceAbstractOther

Engaging students with multiple problem-solving pathways for complex problems

Yuriev, E., Burton, J., Devine, S., Vo, K., Maher, S., Thompson, C. & Scanlon, M., 2019.

Research output: Contribution to conferenceAbstractOther

Identification of the Binding Site of Apical Membrane Antigen 1 (AMA1) Inhibitors Using a Paramagnetic Probe

Akter, M., Drinkwater, N., Devine, S. M., Drew, S. C., Krishnarjuna, B., Debono, C. O., Wang, G., Scanlon, M. J., Scammells, P. J., McGowan, S., MacRaild, C. A. & Norton, R. S., 5 Mar 2019, In : ChemMedChem. 14, 5, p. 603-612 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

Applications of NMR spectroscopy in FBDD

Bentley, M., Doak, B. C., Mohanty, B. & Scanlon, M. J., 13 Jun 2018, Modern Magnetic Resonance. Webb, G. A. (ed.). 2 ed. Cham Switzerland: Springer, p. 2211-2231 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Cyclic Hexapeptide Mimics of the LEDGF Integrase Recognition Loop in Complex with HIV-1 Integrase

Northfield, S. E., Wielens, J., Headey, S. J., Williams-Noonan, B. J., Mulcair, M., Scanlon, M., Parker, M. W., Thompson, P. E. & Chalmers, D. K., 10 Aug 2018, In : ChemMedChem. 13, 15, p. 1555-1565 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Design of a Fragment-Screening Library

Taylor, A., Doak, B. C. & Scanlon, M. J., 1 Jan 2018, Methods in Enzymology. Pyle, A. M. & Christianson, D. W. (eds.). Cambridge MA USA: Elsevier, Vol. 610. p. 97-115 19 p. (Methods in Enzymology).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Fatty Acid-Binding Protein 5 Mediates the Uptake of Fatty Acids, but not Drugs, Into Human Brain Endothelial Cells

Lee, G. S., Pan, Y., Scanlon, M. J., Porter, C. J. H. & Nicolazzo, J. A., Apr 2018, In : Journal of Pharmaceutical Sciences. 107, 4, p. 1185-1193 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Fragment-based discovery of inhibitors of the bacterial DnaG-SSB interaction

Chilingaryan, Z., Headey, S. J., Lo, A. T. Y., Xu, Z. Q., Otting, G., Dixon, N. E., Scanlon, M. J. & Oakley, A. J., 1 Mar 2018, In : Antibiotics. 7, 1, p. 1-12 12 p., 14.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Inhibition of Diverse DsbA Enzymes in Multi-DsbA Encoding Pathogens

Totsika, M., Vagenas, D., Paxman, J. J., Wang, G., Dhouib, R., Sharma, P., Martin, J. L., Scanlon, M. J. & Heras, B., 1 Sep 2018, In : Antioxidants and Redox Signaling. 29, 7, p. 653-666 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Production, biophysical characterization and initial crystallization studies of the N- and C-terminal domains of DsbD, an essential enzyme in Neisseria meningitidis

Smith, R. P., Whitten, A. E., Paxman, J. J., Kahler, C. M., Scanlon, M. J. & Heras, B., 1 Jan 2018, In : Acta Crystallographica. Section F: Structural Biology Communications. 74, 1, p. 31-38 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Structural and biochemical insights into the disulfide reductase mechanism of DsbD, an essential enzyme for neisserial pathogens

Smith, R. P., Mohanty, B., Mowlaboccus, S., Paxman, J. J., Williams, M. L., Headey, S. J., Wang, G., Subedi, P., Doak, B. C., Kahler, C. M., Scanlon, M. J. & Heras, B., 1 Jan 2018, In : Journal of Biological Chemistry. 293, 43, p. 16559-16571 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Structural basis for the inhibition of poxvirus assembly by the antibiotic rifampicin

Garriga, D., Headey, S., Accurso, C., Gunzburg, M., Scanlon, M. & Coulibaly, F., 14 Aug 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 33, p. 8424-8429 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

Fragment library screening identifies hits that bind to the non-catalytic surface of Pseudomonas aeruginosa DsbA1

Mohanty, B., Rimmer, K., McMahon, R. M., Headey, S. J., Vazirani, M., Shouldice, S. R., Coinçon, M., Tay, S., Morton, C. J., Simpson, J. S., Martin, J. L. & Scanlon, M. J., 1 Mar 2017, In : PLoS ONE. 12, 3, 20 p., e0173436.

Research output: Contribution to journalArticleResearchpeer-review

File

HN, N, Cα and Cβ assignments of the two periplasmic domains of Neisseria meningitidis DsbD

Smith, R. P., Mohanty, B., Williams, M. L., Scanlon, M. J. & Heras, B., 1 Oct 2017, In : Biomolecular NMR Assignments. 11, 2, p. 181–186 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular insights into the interaction between the SPRY domain-containing SOCS box protein SPSB2 and peptides based on the binding motif from iNOS

Leung, E., Mulcair, M., Yap, S., Nicholson, S. E., Scanlon, M. & Norton, R., 2017, In : Australian Journal of Chemistry. 70, 2, p. 191-200 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

Jensen, D. D., Lieu, T., Halls, M. L., Veldhuis, N. A., Imlach, W. L., Mai, Q. N., Poole, D. P., Quach, T., Aurelio, L., Conner, J., Klein Herenbrink, C., Barlow, N., Simpson, J. S., Scanlon, M. J., Graham, B., McCluskey, A., Robinson, P. J., Escriou, V., Nassini, R., Materazzi, S. & 6 others, Geppetti, P., Hicks, G. A., Christie, M. J., Porter, C. J. H., Canals, M. & Bunnett, N. W., 31 May 2017, In : Science Translational Medicine. 9, 392, 15 p., aal3447.

Research output: Contribution to journalArticleResearchpeer-review

The first total synthesis and solution structure of a polypeptin, PE2, a cyclic lipopeptide with broad spectrum antibiotic activity

Mountford, S. J., Mohanty, B., Roberts, K. D., Yu, H. H., Scanlon, M. J., Nation, R. L., Velkov, T., Li, J. & Thompson, P. E., 2017, In : Organic and Biomolecular Chemistry. 15, 34, p. 7173-7180 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Δ-Myrtoxin-Mp1a is a Helical Heterodimer from the Venom of the Jack Jumper Ant that has Antimicrobial, Membrane-Disrupting, and Nociceptive Activities

Dekan, Z., Headey, S. J., Scanlon, M., Baldo, B. A., Lee, T-H., Aguilar, M-I., Deuis, J. R., Vetter, I., Elliott, A. G., Amado, M., Cooper, M. A., Alewood, D. & Alewood, P. F., 2017, In : Angewandte Chemie - International Edition. 56, 29, p. 8495-8499 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

Binding of CFA/I pili of enterotoxigenic Escherichia coli to asialo-GM1 is mediated by the minor pilin CfaE

Madhavan, T. P. V., Riches, J. D., Scanlon, M. J., Ulett, G. C. & Sakellaris, H., 1 May 2016, In : Infection and Immunity. 84, 5, p. 1642-1649 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Determination of ligand binding modes in weak protein–ligand complexes using sparse NMR data

Mohanty, B., Williams, M., Doak, B. C., Vazirani, M., Ilyichova, O., Wang, G., Bermel, W., Simpson, J. S., Chalmers, D. K., King, G. F., Mobli, M. & Scanlon, M. J., Nov 2016, In : Journal of Biomolecular NMR. 66, 3, p. 195-208 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Fatty acid-binding protein 5 at the blood–brain barrier regulates endogenous brain docosahexaenoic acid levels and cognitive function

Pan, Y., Short, J. L., Choy, K. H. C., Zeng, A. X., Marriott, P. J., Owada, Y., Scanlon, M. J., Porter, C. J. H. & Nicolazzo, J. A., 16 Nov 2016, In : Journal of Neuroscience. 36, 46, p. 11755-11767 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Protein unfolding is essential for cleavage within the α-helix of a model protein substrate by the serine protease, thrombin

Robertson, A. L., Headey, S. J., Ng, N. M., Wijeyewickrema, L. C., Scanlon, M. J., Pike, R. N. & Bottomley, S. P., Mar 2016, In : Biochimie. 122, p. 227-234 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Redox-stable cyclic peptide inhibitors of the SPSB2-iNOS interaction

Yap, B. K., Harjani, J. R., Leung, E. W. W., Nicholson, S. E., Scanlon, M. J., Chalmers, D. K., Thompson, P. E., Baell, J. B. & Norton, R. S., 1 Mar 2016, In : FEBS Letters. 590, 6, p. 696-704 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Solution NMR characterization of apical membrane antigen 1 and small molecule interactions as a basis for designing new antimalarials

Krishnarjuna, B., Lim, S. S., Devine, S. M., Debono, C. O., Lam, R., Chandrashekaran, I. R., Jaipuria, G., Yagi, H., Atreya, H. S., Scanlon, M. J., MacRaild, C. A., Scammells, P. J. & Norton, R. S., 1 Jun 2016, In : Journal of Molecular Recognition. 29, 6, p. 281-291 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure–activity studies of β-hairpin peptide inhibitors of the Plasmodium falciparum AMA1–RON2 interaction

Wang, G., Drinkwater, N., Drew, D. R., MacRaild, C. A., Chalmers, D. K., Mohanty, B., Lim, S. S., Anders, R. F., Beeson, J. G., Thompson, P. E., McGowan, S., Simpson, J. S., Norton, R. S. & Scanlon, M. J., 9 Oct 2016, In : Journal of Molecular Biology. 428, 20, p. 3986-3998 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeting bacterial Dsb proteins for the development of anti-virulence agents

Smith, R. P., Paxman, J. J., Scanlon, M. J. & Heras, B., 1 Jul 2016, In : Molecules. 21, 7, 15 p., 811.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File

The ways and means of fragment-based drug design

Doak, B. C., Norton, R. S. & Scanlon, M. J., 1 Nov 2016, In : Pharmacology and Therapeutics. 167, p. 28-37 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

Application of fragment-based screening to the design of inhibitors of Escherichia coli DsbA

Adams, L. A., Sharma, P., Mohanty, B., Ilyichova, O., Mulcair, M., Williams, M., Gleeson, E., Torsika, M., Doak, B. C., Dias de Gouveia Caria, S. M., Rimmer, K., Horne, H. J., Shouldice, S. R., Vazirani, M., Headey, S. J., Plumb, B. R., Martin, J., Heras, B., Simpson, J. S. & Scanlon, M., 2015, In : Angewandte Chemie - International Edition. 54, 7, p. 2179-2184 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Conserved features in TamA enable interaction with TamB to drive the activity of the translocation and assembly module

Selkrig, J. P., Belousoff, M. J., Headey, S. J., Heinz, E., Shiota, T., Shen, H-H., Beckham, S. A., Bamert, R. S., Phan, M-D., Schembri, M. A., Wilce, M. C., Scanlon, M. J., Strugnell, R. A. & Lithgow, T. J., 2015, In : Scientific Reports. 5, 12 p., 12905.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Determinants of proteolysis and cell-binding for the shigella flexneri cytotoxin, SigA

Chua, E. G., Al-Hasani, K., Scanlon, M. J., Adler, B. & Sakellaris, H. H., 2015, In : Current Microbiology. 71, 5, p. 613 - 617 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Fatty acid-binding protein 5 facilitates the blood-brain barrier transport of docosahexaenoic acid

Pan, Y., Scanlon, M., Owada, Y., Yamamoto, Y., Porter, C. J. & Nicolazzo, J., 2015, In : Molecular Pharmaceutics. 12, 12, p. 4375 - 4385 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Fatty acid-binding proteins 1 and 2 differentially modulate the activation of peroxisome proliferator-activated receptor alpha in a ligand-selective manner

Hughes, M. L. R., Liu, B., Halls, M. L., Wagstaff, K. M., Patil, R., Velkov, T., Jans, D. A., Bunnett, N. W., Scanlon, M. & Porter, C. J., 2015, In : Journal of Biological Chemistry. 290, 22, p. 13895 - 13906 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Fatty acid binding proteins expressed at the human blood-brain barrier bind drugs in an isoform-specific manner

Lee, G. S. Y., Kappler, K., Porter, C. J., Scanlon, M. & Nicolazzo, J., 2015, In : Pharmaceutical Research. 32, 10, p. 3432 - 3446 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibitors of BCATm: a tough nut to crack

Scanlon, M., 24 Sep 2015, In : Journal of Medicinal Chemistry. 58, 18, p. 7138-7139 2 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Promiscuous 2-aminothiazoles (PrATs): a frequent hitting scaffold

Devine, S., Mulcair, M., Debono, C., Leung, E. W. W., Nissink, J. W. M., Lim, S. S., Chandrashekaran, I. R., Vazirani, M., Mohanty, B., Simpson, J. S., Baell, J. B., Scammells, P. J., Norton, R. S. & Scanlon, M., 2015, In : Journal of Medicinal Chemistry. 58, 3, p. 1205 - 1214 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Propargyloxyproline regio- and stereoisomers for click-conjugation of peptides: synthesis and application in linear and cyclic peptides

Northfield, S. E., Mountford, S. J., Wielens, J., Liu, M., Zhang, L., Herzog, H., Holliday, N. D., Scanlon, M., Parker, M. W., Chalmers, D. K. & Thompson, P., 2015, In : Australian Journal of Chemistry. 68, 9, p. 1365-1372 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Sent packing: protein engineering generates a new crystal form of Pseudomonas aeruginosa DsbA1 with increased catalytic surface accessibility

McMahon, R. M., Coincon, M., Tay, S., Heras, B., Morton, C. J., Scanlon, M. J. & Martin, J. L., 2015, In : Acta Crystallographica Section D: Biological Crystallography. 71, 12, p. 2386-2395 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Small molecule inhibitors of disulfide bond formation by the bacterial DsbA-DsbB dual enzyme system

Halili, M. A., Bachu, P., Lindahl, F., Bechara, C., Mohanty, B., Reid, R. C., Scanlon, M., Robinson, C. V., Fairlie, D. P. & Martin, J. L., 2015, In : ACS Chemical Biology. 10, 4, p. 957 - 964 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Solution structure and DNA binding of the catalytic domain of the large serine resolvase TnpX

Headey, S. J., Sivakumaran, A., Adams, V., Lyras, D., Rood, J. I., Scanlon, M. & Wilce, M. C. J., 2015, In : Journal of Molecular Recognition. 28, 5, p. 316-324 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeting virulence not viability in the search for future antibacterials

Heras, B., Scanlon, M. & Martin, J. L., 2015, In : British Journal of Clinical Pharmacology. 79, 2, p. 208 - 215 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

19F NMR as a probe of ligand interactions with the iNOS binding site of SPRY domain-containing SOCS box protein 2

Leung, E. W. W., Yagi, H., Harjani, J. R., Mulcair, M., Scanlon, M., Baell, J. B. & Norton, R. S., 2014, In : Chemical Biology & Drug Design. 84, 5, p. 616 - 625 10 p.

Research output: Contribution to journalArticleResearchpeer-review

A critical evaluation of pyrrolo[2,3-d]pyrimidine-4-amines as Plasmodium falciparum apical membrane antigen 1 (AMA1) inhibitors

Devine, S., Lim, S. S., Chandrashekaran, I. R., MacRaild, C. A., Drew, D. R., Debono, C., Lam, R., Anders, R. F., Beeson, J. G., Scanlon, M., Scammells, P. J. & Norton, R. S., 2014, In : MedChemComm. 5, 10, p. 1500 - 1506 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

Hildebrand, J. M., Tanzer, M. C., Lucet, I. S., Young, S. N., Spall, S. K., Sharma, P., Pierotti, C., Garnier, J-M., Dobson, R. C. J., Webb, A. I., Tripaydonis, A., Babon, J. J., Mulcair, M., Scanlon, M. J., Alexander, W. S., Wilks, A. F., Czabotar, P. E., Lessene, G., Murphy, J. M. & Silke, J., 2014, In : Proceedings of the National Academy of Sciences. 111, 42, p. 15072 - 15077 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Assignments of human integrin a1I domain in the apo and Mg2+ bound states

Chin, Y. K-Y., Headey, S. J., Mohanty, B., Emsley, J., Simpson, J. S. & Scanlon, M., 2014, In : Biomolecular NMR Assignments. 8, 1, p. 117 - 121 5 p.

Research output: Contribution to journalArticleResearchpeer-review