Martin Scanlon

Professor

Professor, Medicinal Chemistry

https://orcid.org/0000-0002-9230-7506

EmailMartin.Scanlon@monash.edu

Accepting PhD Students

Research activity per year

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Personal profile

Biography

Position
Professor of Medicinal Chemistry
Director ARC Centre for Fragment-Based Design

Scientific Director Monash Fragment-Based Drug Design Platform

Medicinal Chemistry
Monash Institute of Pharmaceutical Sciences

Research interests

Fragment-based drug design

NMR Spectroscopy
Structure-based design of novel anti-microbial agents
Analysis of protein-ligand interactions
Protein structure determination and structural biology

Monash teaching commitment

Spectrometric identification of small molecules
Drug-protein interactions

Research area keywords

Fragment-Based Drug Design
NMR spectroscopy

Network

Recent external collaboration on country level. Dive into details by clicking on the dots or

14 Active
47 Finished

IC18.13 VAST Fragment Based Discovery towards novel P2X4 inhibitors
Kassiou, M., Scanlon, M. & Mackay, J. P.
1/01/21 → 30/06/24
Project: Research
Using fragment-based drug discovery to identify small molecule inhibitors of SARS-CoV-2 (COVID-19) RNA-dependent RNA polymerase (RdRp) and future starting points for other Coronaviruses
Scanlon, M. & Angell, R.
20/10/20 → 19/10/21
Project: Research
Developing new tools for chemical biology
Scanlon, M., Porter, C., Halls, M. & Doak, B.
1/01/20 → 31/12/22
Project: Research
IC18.5 Developing and optimising chemical elaboration (REFiL) of fragments into potent leads (Vernalis) for bacterial virulence enzyme DsbA
Scanlon, M. & Murray, J.
1/01/20 → 31/12/23
Project: Research
IC18.4 Enabling fragment-based lead discovery for challenging targets
Mackay, J. P., Kassiou, M., Scanlon, M. & Capuano, B.
19/12/19 → 21/07/24
Project: Research

123 Article
3 Chapter (Book)
2 Abstract
2 Poster
More

NMR fragment screening reveals a novel small molecule binding site near the catalytic surface of the disulfide–dithiol oxidoreductase enzyme DsbA from Burkholderia pseudomallei
Nebl, S., Alwan, W. S., Williams, M. L., Sharma, G., Taylor, A., Doak, B. C., Wilde, K. L., McMahon, R. M., Halili, M. A., Martin, J. L., Capuano, B., Fenwick, R. B., Mohanty, B. & Scanlon, M. J., 6 Aug 2020, In : Journal of Biomolecular NMR. 74, p. 595-611 17 p.
Research output: Contribution to journal › Article › Research › peer-review

1 Citation (Scopus)
Rapid Elaboration of Fragments into Leads by X-ray Crystallographic Screening of Parallel Chemical Libraries (REFiL_X)
Bentley, M. R., Ilyichova, O. V., Wang, G., Williams, M. L., Sharma, G., Alwan, W. S., Whitehouse, R. L., Mohanty, B., Scammells, P. J., Heras, B., Martin, J. L., Totsika, M., Capuano, B., Doak, B. C. & Scanlon, M. J., 9 Jul 2020, In : Journal of Medicinal Chemistry. 63, 13, p. 6863-6875 13 p.
Research output: Contribution to journal › Article › Research › peer-review

2 Citations (Scopus)
Substituted 1-methyl-4-phenylpyrrolidin-2-ones – Fragment-based design of N-methylpyrrolidone-derived bromodomain inhibitors
Hilton-Proctor, J. P., Ilyichova, O., Zheng, Z., Jennings, I. G., Johnstone, R. W., Shortt, J., Mountford, S. J., Scanlon, M. J. & Thompson, P. E., 1 Apr 2020, In : European Journal of Medicinal Chemistry. 191, 112120.
Research output: Contribution to journal › Article › Research › peer-review

1 Citation (Scopus)
A ligand-induced structural change in fatty acid-binding protein 1 is associated with potentiation of peroxisome proliferator-activated receptor α agonists
Patil, R., Mohanty, B., Liu, B., Chandrashekaran, I. R., Headey, S. J., Williams, M. L., Clements, C. S., Ilyichova, O., Doak, B. C., Genissel, P., Weaver, R., Vuillard, L., Halls, M. L., Porter, C. J. H. & Scanlon, M. J., 8 Mar 2019, In : Journal of Biological Chemistry. 294, 10, p. 3720-3734 15 p.
Research output: Contribution to journal › Article › Research › peer-review

5 Citations (Scopus)
Controlled Construction of Cyclic d / l Peptide Nanorods
Silk, M. R., Mohanty, B., Sampson, J. B., Scanlon, M. J., Thompson, P. E. & Chalmers, D. K., 8 Jan 2019, In : Angewandte Chemie - International Edition. 58, 2, p. 596-601 6 p.
Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)

1 Submissions to industry or govt committees, commissions and inquiries

Medicinal Chemistry
Martin Scanlon (Member)
2 Sep 2013
Activity: External Academic Engagement › Submissions to industry or govt committees, commissions and inquiries