Projects per year
Personal profile
Biography
Position
Professor of Medicinal Chemistry
Director ARC Centre for Fragment-Based Design
Scientific Director Monash Fragment-Based Drug Design Platform
Medicinal Chemistry
Monash Institute of Pharmaceutical Sciences
Research interests
Fragment-based drug design
NMR Spectroscopy
Structure-based design of novel anti-microbial agents
Analysis of protein-ligand interactions
Protein structure determination and structural biology
Monash teaching commitment
- Spectrometric identification of small molecules
- Drug-protein interactions
Research area keywords
- Fragment-Based Drug Design
- NMR spectroscopy
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Developing and optimising compounds targeting the flaviviral protease enzymes from Zika and Dengue
Scanlon, M. & Murray, J.
28/01/22 → 21/07/24
Project: Research
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IC18.12 Cytiva SPR method development for Fragment-Based Design
Scanlon, M., Norton, R. & O'Meara, T.
16/09/21 → 16/09/25
Project: Research
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A structure-based design approach to maximising targeting interactions
Porter, C., Johnston, A., Scanlon, M. & Owen, D. J.
29/04/21 → 29/04/24
Project: Research
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IC18.13 VAST Fragment Based Discovery towards novel P2X4 inhibitors
Kassiou, M., Scanlon, M. & Mackay, J. P.
1/01/21 → 30/06/24
Project: Research
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IC18.5 Developing and optimising chemical elaboration (REFiL) of fragments into potent leads (Vernalis) for bacterial virulence enzyme DsbA
Scanlon, M. & Murray, J.
1/01/20 → 31/12/23
Project: Research
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Binding of a pyrimidine RNA base-mimic to SARS-CoV-2 nonstructural protein 9
Littler, D. R., Mohanty, B., Lowery, S. A., Colson, R. N., Gully, B. S., Perlman, S., Scanlon, M. J. & Rossjohn, J., Sep 2021, In: Journal of Biological Chemistry. 297, 3, 10 p., 101018.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus) -
NMR fragment screening reveals a novel small molecule binding site near the catalytic surface of the disulfide–dithiol oxidoreductase enzyme DsbA from Burkholderia pseudomallei
Nebl, S., Alwan, W. S., Williams, M. L., Sharma, G., Taylor, A., Doak, B. C., Wilde, K. L., McMahon, R. M., Halili, M. A., Martin, J. L., Capuano, B., Fenwick, R. B., Mohanty, B. & Scanlon, M. J., 6 Aug 2020, In: Journal of Biomolecular NMR. 74, p. 595-611 17 p.Research output: Contribution to journal › Article › Research › peer-review
3 Citations (Scopus) -
Rapid Elaboration of Fragments into Leads by X-ray Crystallographic Screening of Parallel Chemical Libraries (REFiLX)
Bentley, M. R., Ilyichova, O. V., Wang, G., Williams, M. L., Sharma, G., Alwan, W. S., Whitehouse, R. L., Mohanty, B., Scammells, P. J., Heras, B., Martin, J. L., Totsika, M., Capuano, B., Doak, B. C. & Scanlon, M. J., 9 Jul 2020, In: Journal of Medicinal Chemistry. 63, 13, p. 6863-6875 13 p.Research output: Contribution to journal › Article › Research › peer-review
9 Citations (Scopus) -
Substituted 1-methyl-4-phenylpyrrolidin-2-ones – Fragment-based design of N-methylpyrrolidone-derived bromodomain inhibitors
Hilton-Proctor, J. P., Ilyichova, O., Zheng, Z., Jennings, I. G., Johnstone, R. W., Shortt, J., Mountford, S. J., Scanlon, M. J. & Thompson, P. E., 1 Apr 2020, In: European Journal of Medicinal Chemistry. 191, 112120.Research output: Contribution to journal › Article › Research › peer-review
3 Citations (Scopus) -
A ligand-induced structural change in fatty acid-binding protein 1 is associated with potentiation of peroxisome proliferator-activated receptor α agonists
Patil, R., Mohanty, B., Liu, B., Chandrashekaran, I. R., Headey, S. J., Williams, M. L., Clements, C. S., Ilyichova, O., Doak, B. C., Genissel, P., Weaver, R., Vuillard, L., Halls, M. L., Porter, C. J. H. & Scanlon, M. J., 8 Mar 2019, In: Journal of Biological Chemistry. 294, 10, p. 3720-3734 15 p.Research output: Contribution to journal › Article › Research › peer-review
6 Citations (Scopus)
Activities
- 1 Submissions to industry or govt committees, commissions and inquiries
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Medicinal Chemistry
Martin Scanlon (Member)
2 Sep 2013Activity: External Academic Engagement › Submissions to industry or govt committees, commissions and inquiries
Equipment
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Monash Fragment Platform
Bradley Doak (Manager) & Martin Scanlon (Manager)
Faculty of Pharmacy and Pharmaceutical SciencesFacility/equipment: Facility