• Innovation Walk, 19

    3168 Melbourne

    Australia

Accepting PhD Students

20102023

Research output per year

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Personal profile

Biography

www.monash.edu/discovery-institute/davey-lab 

Dr Martin Davey gained his PhD (2013) in the group of Prof. Bernhard Moser and Dr Matthias Eberl at Cardiff University, exploring the responses of human γδ T cells towards multi-drug resistant bacterial pathogens, in concert with monocytes and neutrophils. He then undertook postdoctoral research training in the group of Prof. Ben Willcox at the University of Birmingham, UK. There he employed T cell receptor (TCR) deep sequencing and single cell methodology to explore the underlying biology of this enigmatic T cell population, revealing an alternative immunobiology that governs a large population of human γδ T cells. He joined Monash University’s Biomedicine Discovery Institute in June 2018 and has established the immune surveillance laboratory to explore the role of γδ T cells in microbial infections and tissue immune surveillance.

Research interests

We investigate the role of an “unconventional” group of human immune cells in their ability to protect human body throughout life. The human immune system is a highly specialised network of cells, organs, receptors and soluble factors that protects the host from infection and cancer, while promoting normal function of the tissues in concert with the microbiome. The immune system uses lymphocytes to generate immunological memory responses to numerous challenges throughout life. Three lineages of lymphocytes have co-evolved over the last 550 million years: B cells, ɑβ T cells and γδ T cells. While conventional ɑβ T cells and B cells have been the subject of significant scientific research, leading to life changing breakthroughs in vaccination and cancer treatment, our group studies poorly understood subsets of unconventional T cells: γδ T cells and mucosal associated invariant T (MAIT) cells.

We use cutting-edge approaches, supported by Monash Platform Technologies, that includes the application of multi parameter flow cytometry and next generation sequencing (RNA-seq and TCR-seq) to human patient samples after exposure to pathogens of global importance (Malaria, tuberculosis and cytomegalovirus) and human tissue samples.

Research area keywords

  • T cell receptors
  • gamma delta T cells
  • Human Immunology
  • Viral immunity
  • Malaria

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Projects

Research Output

A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1

Le Nours, J., Gherardin, N. A., Ramarathinam, S. H., Awad, W., Wiede, F., Gully, B. S., Khandokar, Y., Praveena, T., Wubben, J. M., Sandow, J. J., Webb, A. I., von Borstel, A., Rice, M. T., Redmond, S. J., Seneviratna, R., Sandoval-Romero, M. L., Li, S., Souter, M. N. T., Eckle, S. B. G., Corbett, A. J. & 15 others, Reid, H. H., Liu, L., Fairlie, D. P., Giles, E. M., Westall, G. P., Tothill, R. W., Davey, M. S., Berry, R., Tiganis, T., McCluskey, J., Pellicci, D. G., Purcell, A. W., Uldrich, A. P., Godfrey, D. I. & Rossjohn, J., 20 Dec 2019, In : Science. 366, 6472, p. 1522-1527 6 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

Cossarizza, A., Chang, H. D., Radbruch, A., Acs, A., Adam, D., Adam-Klages, S., Agace, W. W., Aghaeepour, N., Akdis, M., Allez, M., Almeida, L. N., Alvisi, G., Anderson, G., Andrä, I., Annunziato, F., Anselmo, A., Bacher, P., Baldari, C. T., Bari, S., Barnaba, V. & 4 others, Borger, J. G., Davey, M. S., Quinn, K. & Von Borstel, A., 1 Oct 2019, In : European Journal of Immunology. 49, 10, p. 1457-1973 517 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
File
91 Citations (Scopus)

γδ T cells take the stage

Eriksson, E. M. & Davey, M. S., 2019, In : Clinical & Translational Immunology. 8, 11, 2 p., e01085.

Research output: Contribution to journalEditorialOtherpeer-review

Open Access
File

Development and selection of the human Vγ9Vδ2+ T-Cell Repertoire

Willcox, C. R., Davey, M. S. & Willcox, B. E., 2 Jul 2018, In : Frontiers in Immunology. 9, 7 p., 1501.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File
15 Citations (Scopus)

Human liver infiltrating γδ T cells are composed of clonally expanded circulating and tissue-resident populations

Hunter, S., Willcox, C. R., Davey, M. S., Kasatskaya, S. A., Jeffery, H. C., Chudakov, D. M., Oo, Y. H. & Willcox, B. E., 1 Sep 2018, In : Journal of Hepatology. 69, 3, p. 654-665 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
25 Citations (Scopus)

Prizes

Bright Sparks in European Immunology (3rd Prize)

Davey, Martin (Recipient), Sep 2012

Prize: Prize (including medals and awards)

Bright Sparks in Immunology (1st Prize)

Davey, Martin (Recipient), Dec 2011

Prize: Prize (including medals and awards)