Projects per year
Personal profile
Biography
Industry experience promotes collaborative approach
Professor Mark Sleeman brings a unique wealth of experience to Monash. Mark arrived in July 2011 after 18 years in the United States, including 13 at the US biotechnology company, Regeneron Pharmaceuticals Inc. As Head of Metabolic Research, Mark oversaw discovery research and therapeutic development for a variety of metabolic diseases. One of his former team's lead therapeutics is now in Phase-III clinical trials, and Mark says it could be a breakthrough for the treatment of high cholesterol in humans. Having returned to where he did his PhD, and is currently assembling the Physiological Genomics Group to research metabolic disease.
Mark says his work at Regeneron gave him the opportunity to generate clinically relevant models, do discovery research and quickly make therapeutics to treat associated human diseases. He hopes to bring this approach to his new team.
'The goal is to bring my expertise in the translation of basic science to therapeutic development and put it into the clinic,' Mark says. 'We're starting to initiate some work on the regulation of food intake, body weight, obesity and lipid disorders, but it's still in very early stages.
'One of the biggest issues facing the pharmaceutical industry and biotechnology is that they don't have enough validated targets. Academics have a greater understanding of the specific disease mechanisms, but few pathways for development of therapeutics and commercialisation. There is a big disconnect. I hope that we can speed the development process up.
'I want to bridge that gap and bring technology from the US to Australia. One example would be to integrate the existing monoclonal antibodies facilities at Monash, with new mouse models for producing fully human antibodies. Mark applies two common ideas in his studies. He first aligns his work with clinical groups that are doing relevant research into disease areas of interest, and then uses genetics and genomics to help understand the molecular basis of a disease. One of Mark's main interests is type 2 diabetes.
'The development of insulin resistance is one of the biggest problems facing type 2 diabetes, and the therapeutic options for combating that problem are limited. We've done a lot on the discovery side of things, looking at proteins within the insulin receptor signalling pathways that potentially mediate insulin resistance. We've identified intra-cellular proteins that may be targets for therapeutics, but developing therapies and specific molecules to those targets has been very difficult. So it's still basic research, but it fits nicely with what a lot of other people are doing at Monash,' Mark says.
Mark's obesity research has also led him to examine non-alcoholic steatohepatitis (NASH), an inflammatory disease of the liver.
'I am very interested in NASH. It ranges from simple fatty liver... to more severe fibrosis and cirrhosis. It's associated with obesity, as increased adipose mass leads to inappropriate lipid stores in the liver. We're looking at the inflammation side of this because it appears to be a significant problem. It's developing as the population becomes more obese.'
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Adjunct Professor, Murdoch University
2012 → …
Adjunct Professor, Yale University
2008 → …
Research area keywords
- Diabetes
- Obesity
- Lipid Disorders
- Therapeutic Antibodies
- Thrombosis
- Biotechnology
- immuno-oncology
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JDRF Strategic Research Agreement - Novel Adjunctive Therapeutic For T1D; a-MSH/MC5R agonist axis
Cowley, M., Sleeman, M., Thompson, P., Wentworth, J. & Kelly, L.
1/07/19 → 28/02/25
Project: Research
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Novel Treatment of Type 1 Diabetes via Melanocortin 5 Agoinsm
Cowley, M., Sleeman, M., Thompson, P., Wentworth, J., Wilks, A. F., Le Roux, C. W. & Kelly, L.
Department of Health (DH) (Victoria), Synthesis Pty Ltd, Monash University – Internal School Contribution
6/02/19 → 31/08/23
Project: Research
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Proof-of-concept studies for a novel anti-thrombotic agent
Hamilton, J., Sleeman, M. & Nandurkar, H.
1/01/18 → 31/12/20
Project: Research
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Generation and proof-of-concept testing of novel therapies for improved heart attack and stroke prevention
1/01/17 → 31/12/17
Project: Research
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Chemoselective Methionine Labelling of Recombinant Trastuzumab Shows High In Vitro and In Vivo Tumour Targeting
Hashad, R., Jap, E., Casey, J. L., Ho, Y. T. C., Wright, A., Thalmann, C., Sleeman, M., Lupton, D. W., Hagemeyer, C. E., Cryle, M. J., Robert, R. & Alt, K., 21 Feb 2023, In: Chemistry - A European Journal. 29, 11, 7 p., e202202491.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus) -
Food hypersensitivity-induced chronic gastrointestinal inflammation in a non-human primate model of diet-induced obesity
Mustafa, T., Li, Q., Kelly, L. E., Gibbon, A., Ryan, I., Roffey, K., Simonds, S., Cowley, M. A. & Sleeman, M. W., 4 Apr 2019, In: PLoS ONE. 14, 4, 18 p., e0214621.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile3 Citations (Scopus) -
Proteomics and the microbiome: pitfalls and potential
Lin, H., He, Q-Y., Shi, L., Sleeman, M., Baker, M. S. & Nice, E. C., 1 Jun 2019, In: Expert Review of Proteomics. 16, 6, p. 501-511 11 p.Research output: Contribution to journal › Review Article › Research › peer-review
29 Citations (Scopus) -
Reelin is modulated by diet-induced obesity and has direct actions on arcuate proopiomelanocortin neurons
Roberts, B. L., Bennett, B. J., Bennett, C. M., Carroll, J. M., Dalbøge, L. S., Hall, C., Hassouneh, W., Heppner, K. M., Kirigiti, M. A., Lindsley, S. R., Tennant, K. G., True, C. A., Whittle, A., Wolf, A. C., Roberts, C. T., Tang-Christensen, M., Sleeman, M. W., Cowley, M. A., Grove, K. L. & Kievit, P., Aug 2019, In: Molecular Metabolism. 26, p. 18-29 12 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile8 Citations (Scopus) -
A function-blocking PAR4 antibody is markedly antithrombotic in the face of a hyperreactive PAR4 variant
French, S. L., Thalmann, C., Bray, P. F., Macdonald, L. E., Murphy, A. J., Sleeman, M. W. & Hamilton, J. R., 12 Jun 2018, In: Blood Advances. 2, 11, p. 1283-1293 11 p.Research output: Contribution to journal › Article › Research › peer-review
24 Citations (Scopus)