Projects per year
Personal profile
Biography
Professor Mark Shackleton is the Group Leader, Cancer Development and Treatment Laboratory, in the School of Translational Medicine at Monash University, Professor of Oncology in the Department of Medicine, at Monash Univerisity, and the Director of Oncology at Alfred Health.
Department of Medicine (Alfred) Research Laboratories - Shackleton Group
After training in medical oncology and at the Ludwig Institute in Melbourne, Prof Shackleton undertook PhD studies at the Walter and Eliza Hall Institute of Medical Research and post-doctoral work at the University of Michigan, USA, with resultant publications in Nature, Cell, Cancer Cell and the New England Journal of Medicine. He was awarded the 2006 Victorian Premier’s Award for Medical Research, a 2010 NHMRC Achievement Award, a 2011 Pfizer Australia Fellowship, and in 2012 received the Australian Science Minister’s Prize for Life Scientist of the Year.
Most recently a Medical Oncologist and Head of the Cancer Development and Treatment Laboratory at the Peter MacCallum Cancer Centre, Prof Shackleton’s main clinical interests are centred on patients diagnosed with skin cancer, including melanoma. His research interests include cancer biology, developmental biology, oncogenic signaling pathways and clinical trials.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Walter and Eliza Hall Institute of Medical Research (WEHI)
2001 → 2006
External positions
Co-Director, Monash Partners Comprehensive Cancer Consortium (MPCCC)
2023 → …
Director of Oncology, Alfred Health
2017 → …
Research area keywords
- Melanoma
- Cancer Therapeutics
Collaborations and top research areas from the last five years
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A novel, therapeutically actionable, signalling axis in poor prognosis cancers
Daly, R., Ellisdon, A., Lucet, I., Stratton, M., Tiganis, T., Pajic, M., Abud, H., Shackleton, M., Jarde, T. & Swarbrick, A.
1/01/25 → 31/12/28
Project: Research
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A randomized, open-label Phase 3 study in patients with previously treated unresectable or metastatic NRAS mutant cutaneous melanoma comparing the combination of naporafenib + trametinib to physician’s choice of therapy (dacarbazine, temozolomide or trametinib monotherapy) with a dose optimization lead-in [SEACRAFT-2]
25/09/24 → 24/09/26
Project: Research
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Centre of Excellence for Cancer Immunotherapy.
Andrews, M., Shackleton, M., Bucknall, T., McKimm, A., Boussioutas, A., Moore, M., Kern, J. & McTier, L.
1/07/24 → 1/06/26
Project: Research
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Melanoma Research Victoria (MRV) Collaboration
Mar, V., McArthur, G., Kee, D., Underhill, C., Vico-Alonso, C., Ge, Z., Yu, Z., Button-Sloan, A. E., Shackleton, M., Trapani, J. A., Fox, S., Sandhu, S. K., Dobrovic, A., Neeson, P. J., Gyorki, D., Haydon, A., Papenfuss , T., Behren, A., Hicks, R. J., Parente, P., Sheppard, K. E., Underhill, C., Harvey, K. F., Speakman, D., Kok, D., Kelly, J., Cebon , J., Rao, A. & Da Gama Duarte, J.
28/03/24 → 28/03/29
Project: Research
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Globe Salvage and Vision Preservation by Neoadjuvant Darovasertib and Crizotinib in Uveal Melanoma
Hiong, A., O'Day, R., Fog, L. S., McKay, D., McKenzie, J., Ameratunga, M., Joshua, A. M. & Shackleton, M., Apr 2024, In: Ophthalmology Retina. 8, 4, p. 325-330 6 p.Research output: Contribution to journal › Article › Research › peer-review
5 Citations (Scopus) -
Malignancy risk and mortality after lung transplantation: A single-institution experience over 31 years
Yeoh, H-L., Shingles, H. V., Paul, E., Levvey, B. J., Schwarz, M., Voskoboynik, M., Haydon, A., Shackleton, M., Snell, G. I. & Andrews, M. C., May 2024, In: JHLT Open. 4, 13 p., 100094.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Predictive Impact of Tumor Mutational Burden on Real-World Outcomes of First-Line Immune Checkpoint Inhibition in Metastatic Melanoma
Andrews, M. C., Li, G., Graf, R. P., Fisher, V. A., Mitchell, J., Aboosaiedi, A., O’Rourke, H., Shackleton, M., Iddawela, M., Oxnard, G. R. & Huang, R. S. P., 1 Jun 2024, In: JCO Precision Oncology. 8, 13 p., e2300640.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
A capability framework to inform the fundamental requirements for clinical trial unit development, growth and long term success in outer metropolitan and rural areas
Woollett, A., Duncan, J., Voskoboynik, M., Shackleton, M., Dooley, M., Blum, R., McPhee, N., Wright, T., Wong, Z. W., Dixon, J. & Jane, S. M., Apr 2023, In: Contemporary Clinical Trials Communications. 32, 9 p., 101072.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus) -
Design, optimisation and standardisation of a high-dimensional spectral flow cytometry workflow assessing T-cell immunophenotype in patients with melanoma
Edwards, J. M., Andrews, M. C., Burridge, H., Smith, R., Owens, C., Edinger, M., Pilkington, K., Desfrancois, J., Shackleton, M., Senthi, S. & van Zelm, M. C., Sept 2023, In: Clinical & Translational Immunology. 12, 9, 16 p., e1466.Research output: Contribution to journal › Article › Research › peer-review
Open Access
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Member
Mark Shackleton (Member)
2023 → …Activity: External Academic Engagement › Committees and working groups
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Member
Mark Shackleton (Member)
2023 → …Activity: External Academic Engagement › Committees and working groups
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Member
Mark Shackleton (Member)
2023 → …Activity: External Academic Engagement › Committees and working groups
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Member
Mark Shackleton (Member)
2023 → …Activity: External Academic Engagement › Committees and working groups
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Member
Mark Shackleton (Member)
2023 → …Activity: External Academic Engagement › Committees and working groups
Press/Media
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TV recorded interview re: Paula Fox Melanoma and Cancer Centre, Channel 9
1/06/23
1 Media contribution
Press/Media: Profile/Interview
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TV recorded interview re: melanoma sequencing study, Channel 10
1/03/21
1 Media contribution
Press/Media: Profile/Interview
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The Herald Sun re: melanoma autopsy sequencing study
1/01/21
1 Media contribution
Press/Media: Article/Feature
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TV recorded interview re: melanoma research, Channel 9
1/08/15
1 Media contribution
Press/Media: Profile/Interview
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Radio live interview with Red Symons (ABC Breakfast) re: melanoma research
1/08/15
1 Media contribution
Press/Media: Profile/Interview