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Personal profile


Professor Mark Shackleton is Director of Oncology at Alfred Health and Professor of Oncology in the Department of Medicine, Monash Univerisity.

Department of Medicine (Alfred) Research Laboratories - Shackleton Group

After training in medical oncology and at the Ludwig Institute in Melbourne, Prof Shackleton undertook PhD studies at the Walter and Eliza Hall Institute of Medical Research and post-doctoral work at the University of Michigan, USA, with resultant publications in Nature, Cell, Cancer Cell and the New England Journal of Medicine. He was awarded the 2006 Victorian Premier’s Award for Medical Research, a 2010 NHMRC Achievement Award, a 2011 Pfizer Australia Fellowship, and in 2012 received the Australian Science Minister’s Prize for Life Scientist of the Year

Most recently a Medical Oncologist and Head of the Cancer Development and Treatment Laboratory at the Peter MacCallum Cancer Centre, Prof Shackleton’s main clinical interests are centred on patients diagnosed with skin cancer, including melanoma. His research interests include cancer biology, developmental biology, oncogenic signaling pathways and clinical trials.


  • Melanoma
  • Cancer Therapeutics

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Projects 2017 2021

Research Output 2003 2016

  • 7 Article
  • 2 Comment / Debate

Restoration of tumor suppression in prostate cancer by targeting the E3 ligase E6AP

Paul, P. J., Raghu, D., Chan, A. L., Gulati, T., Lambeth, L. S., Takano, E., Herold, M. J., Hagekyriakou, J., Vessella, R. L., Fedele, C., Shackleton, M., Williams, E. D., Fox, S., Williams, S., Haupt, S., Gamell, C. & Haupt, Y., 1 Dec 2016, In : Oncogene. 35, 48, p. 6235-6245 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Corrigendum: Whole-genome characterization of chemoresistant ovarian cancer

Patch, A-M., Christie, E. L., Etemadmoghadam, D., Garsed, D. W., George, J., Fereday, S., Nones, K., Cowin, P., Alsop, K., Bailey, P. J., Kassahn, K. S., Newell, F., Quinn, M. C. J., Kazakoff, S., Quek, K., Wilhelm-Benartzi, C., Curry, E., Leong, H. S., Hamilton, A., Mileshkin, L. & 63 othersAu-Yeung, G. H., Kennedy, C., Hung, J., Chiew, Y. E., Harnett, P., Friedlander, M., Quinn, M. C. J., Pyman, J. M., Cordner, S., O'Brien, P., Leditschke, J., Young, G., Strachan, K., Waring, P., Azar, W. J., Mitchell, C., Traficante, N., Hendley, J., Thorne, H. J., Shackleton, M., Miller, D. K., Arnau, G. M., Tothill, R. W., Holloway, T. P., Semple, T., Harliwong, I., Nourse, C., Nourbakhsh, E., Manning, S., Idrisoglu, S., Bruxner, T. J. C., Christ, A. N., Poudel, B., Holmes, O., Anderson, M., Leonard, C., Lonie, A., Hall, N., Wood, S., Taylor, D. F., Xu, Q., Fink, J. L., Waddell, N., Drapkin, R., Stronach, E., Gabra, H., Brown, R., Jewell, A., Nagaraj, S. H., Markham, E., Wilson, P. J., Ellul, J., McNally, O. M., Doyle, M. A., Vedururu, R., Stewart, C., Lengyel, E., Pearson, J. V., Waddell, N., DeFazio, A., Grimmond, S., Bowtell, D. D. L. & The Australian Ovarian Cancer Study Group, 19 Nov 2015, In : Nature. 527, 7578, p. 398 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

The transcription cofactor c-JUN mediates phenotype switching and BRAF inhibitor resistance in melanoma

Ramsdale, R., Jorissen, R. N., Li, F. Z., Al-Obaidi, S., Ward, T., Sheppard, K. E., Bukczynska, P. E., Young, R. J., Boyle, S. E., Shackleton, M., Bollag, G., Long, G. V., Tulchinsky, E., Rizos, H., Pearson, R. B., McArthur, G. A., Dhillon, A. S. & Ferrao, P. T., 18 Aug 2015, In : Science Signaling. 8, 390, p. ra82

Research output: Contribution to journalArticleResearchpeer-review

Characterization of antigen-specific CD8+ T lymphocyte responses in skin and peripheral blood following intradermal peptide vaccination

Chen, Q., Jackson, H., Shackleton, M., Parente, P., Hopkins, W., Sturrock, S., MacGregor, D., Maraskovsky, E., Tai, T. Y., Dimopoulos, N., Masterman, K. A., Luke, T., Davis, I. D., Chen, W. & Cebon, J., 9 Mar 2005, In : Cancer Immunity. 5, 5.

Research output: Contribution to journalArticleResearchpeer-review

Erratum: Recombinant NY-ESO-1 protein with ISCOMATRIX adjuvant induces broad integrated antibody and CD4+ and CD8+ T cell responses in humans (Proceedings of the National Academy of Sciences of the United States of America (July 20, 2004) 101, 29 (10697-10702))

Davis, I. D., Chen, W., Jackson, H., Parente, P., Shackleton, M., Hopkins, W., Chen, Q., Dimopoulos, N., Luke, T., Murphy, R., Scott, A. M., Maraskovsky, E., McArthur, G., MacGregor, D., Sturrock, S., Tai, T. Y., Green, S., Cuthbertson, A., Maher, D., Miloradovic, L. & 8 othersMitchell, S. V., Ritter, G., Jungbluth, A. A., Chen, Y. T., Gnjatic, S., Hoffman, E. W., Old, L. J. & Cebon, J. S., 5 Jul 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 27, 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review