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Mark Shackleton

Professor

 https://orcid.org/0000-0002-7673-4655
20032021
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Personal profile

Biography

Professor Mark Shackleton is Director of Oncology at Alfred Health and Professor of Oncology in the Department of Medicine, Monash Univerisity.

Department of Medicine (Alfred) Research Laboratories - Shackleton Group

After training in medical oncology and at the Ludwig Institute in Melbourne, Prof Shackleton undertook PhD studies at the Walter and Eliza Hall Institute of Medical Research and post-doctoral work at the University of Michigan, USA, with resultant publications in Nature, Cell, Cancer Cell and the New England Journal of Medicine. He was awarded the 2006 Victorian Premier’s Award for Medical Research, a 2010 NHMRC Achievement Award, a 2011 Pfizer Australia Fellowship, and in 2012 received the Australian Science Minister’s Prize for Life Scientist of the Year. 

Most recently a Medical Oncologist and Head of the Cancer Development and Treatment Laboratory at the Peter MacCallum Cancer Centre, Prof Shackleton’s main clinical interests are centred on patients diagnosed with skin cancer, including melanoma. His research interests include cancer biology, developmental biology, oncogenic signaling pathways and clinical trials.

Keywords

  • Melanoma
  • Cancer Therapeutics

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Projects 2017 2021

The Hippo Pathway And Melanoma Growth

Harvey, K. F. & Shackleton, M.

National Health & Medical Research Council (NHMRC)

1/01/18 → 31/12/21

Project: Research

The PRECISE assay: Personalised medicine for cancer patients using next-generation sequencing

To, S. Q. G., Azad, A., Shortt, J., Wei, A., Shackleton, M. & Kenealy, M.

1/12/17 → 1/12/20

Project: Research

Deciphering mechanisms of disease evolution in melanoma

Shackleton, M.

1/10/17 → 31/12/19

Project: Research

Dissecting the significance of pigment heterogeneity in cutaneous melanoma

Shackleton, M.

1/10/17 → 30/09/19

Project: Research

Translating melanoma discoveries from the laboratory to the clinic

Shackleton, M.

1/08/17 → 23/09/21

Project: Research

Research Output 2003 2019

Incidence, features and management of radionecrosis in melanoma patients treated with cerebral radiotherapy and anti-PD-1 antibodies

Pires da Silva, I., Glitza, I. C., Haydu, L. E., Johnpulle, R., Banks, P. D., Grass, G. D., Goldinger, S. M. A., Smith, J. L., Everett, A. S., Koelblinger, P., Roberts-Thomson, R., Millward, M., Atkinson, V. G., Guminski, A., Kapoor, R., Conry, R. M., Carlino, M. S., Wang, W., Shackleton, M. J., Eroglu, Z. & 5 othersLo, S., Hong, A. M., Long, G. V., Johnson, D. B. & Menzies, A. M., 1 Jul 2019, In : Pigment Cell and Melanoma Research. 32, p. 553-563 11 p.

Research output: Contribution to journal › Article › Research › peer-review

Personalised surveillance after treatment for high-risk cancer

Guo, C., Lewin, J. & Shackleton, M., 1 Jan 2019, In : Oncotarget. 10, 7, p. 694-695 2 p.

Research output: Contribution to journal › Editorial › Other › peer-review

Open Access

Prediction and monitoring of relapse in stage III melanoma using circulating tumor DNA

Tan, L., Sandhu, S., Lee, R. J., Li, J., Callahan, J., Ftouni, S., Dhomen, N., Middlehurst, P., Wallace, A., Raleigh, J., Hatzimihalis, A., Henderson, M. A., Shackleton, M., Haydon, A., Mar, V., Gyorki, D. E., Oudit, D., Dawson, M. A., Hicks, R. J., Lorigan, P. & 4 othersMcArthur, G. A., Marais, R., Wong, S. Q. & Dawson, S. J., 1 May 2019, In : Annals of Oncology. 30, 5, p. 804-814 11 p.

Research output: Contribution to journal › Article › Research › peer-review

Somatic hypermutation of the YAP oncogene in a human cutaneous melanoma

Zhang, X., Tang, J. Z., Vergara, I. A., Zhang, Y., Szeto, P., Yang, L., Mintoff, C., Colebatch, A., McIntosh, L., Mitchell, K. A., Shaw, E., Rizos, H., Long, G. V., Hayward, N., McArthur, G. A., Papenfuss, A. T., Harvey, K. F. & Shackleton, M., 1 Jul 2019, In : Molecular Cancer Research. 17, 7, p. 1435-1449 15 p.

Research output: Contribution to journal › Article › Research › peer-review

Rheumatic immune-related adverse events secondary to anti–programmed death-1 antibodies and preliminary analysis on the impact of corticosteroids on anti-tumour response: A case series

Mitchell, E. L., Lau, P. K. H., Khoo, C., Liew, D., Leung, J., Liu, B., Rischin, A., Frauman, A. G., Kee, D., Smith, K., Brady, B., Rischin, D., Gibson, A., Mileshkin, L., Klein, O., Weickhardt, A., Arulananda, S., Shackleton, M., McArthur, G., Östör, A. & 7 othersCebon, J., Solomon, B., Buchanan, R. RC., Wicks, I. P., Lo, S., Hicks, R. J. & Sandhu, S., 1 Dec 2018, In : European Journal of Cancer. 105, p. 88-102 15 p.

Research output: Contribution to journal › Article › Research › peer-review