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Research Output 1983 2019

2019

Activin A target genes are differentially expressed between normal and neoplastic adult human testes: clues to gonocyte fate choice

Szarek, M., Bergmann, M., Konrad, L., Schuppe, H. C., Kliesch, S., Hedger, M. P. & Loveland, K. A. L., 1 Jan 2019, In : Andrology. 7, 1, p. 31-41 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Cumulin and FSH cooperate to regulate inhibin B and activin B production by human granulosa-lutein cells in vitro

Richani, D., Constance, K., Lien, S., Agapiou, D., Stocker, W. A., Hedger, M. P., Ledger, W., Thompson, J. G., Robertson, D. M., Mottershead, D. G., Walton, K. L., Harrison, C. A. & Gilchrist, R., 1 Apr 2019, In : Endocrinology. 160, 4, p. 853-862 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

Comparative analysis of activins A and B in the adult mouse epididymis and vas deferens

Wijayarathna, R., de Kretser, D. M., Sreenivasan, R., Ludlow, H., Middendorff, R., Meinhardt, A., Loveland, K. L. & Hedger, M. P., 1 Jan 2018, In : Reproduction. 155, 1, p. 15-23 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Infectious, inflammatory and 'autoimmune' male factor infertility: How do rodent models inform clinical practice?

Fijak, M., Pilatz, A., Hedger, M. P., Nicolas, N., Bhushan, S., Michel, V., Tung, K. S. K., Schuppe, H. C. & Meinhardt, A., 1 Jul 2018, In : Human Reproduction Update. 24, 4, p. 416-441 26 p.

Research output: Contribution to journalArticleResearchpeer-review

Inflammation in reproduction, pregnancy and development

Hedger, M., Hodyl, N. A. & Moss, T. J., 1 Nov 2018, In : Journal of Reproductive Immunology. 130, p. 23-24 2 p.

Research output: Contribution to journalEditorialOtherpeer-review

Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy

Marini, K., Croucher, D. R., McCloy, R. A., Vaghjiani, V., Gonzalez-Rajal, A., Hastings, J. F., Chin, V. T., Szczepny, A., Kostyrko, K., Marquez, C., Jayasekara, W. S. N., Alamgeer, M., Boolell, V., Han, J. Z. R., Waugh, T., Lee, H. C., Oakes, S. R., Kumar, B., Harrison, C. A., Hedger, M. P. & 13 othersLorensuhewa, N., Kita, B., arrow, R. B., Robinson, B. W. S., de Kretser, D. M., Wu, J., Ganju, V., Sweet-Cordero, E. A., Burgess, A., Martelotto, L. G., Rossello, F. J., Cain, J. & Watkins, D. N., 25 Jul 2018, In : Science Translational Medicine. 10, 451, 13 p., eaat3504.

Research output: Contribution to journalArticleResearchpeer-review

Weighting of orthostatic intolerance time measurements with standing difficulty score stratifies ME/CFS symptom severity and analyte detection

Richardson, A. M., Lewis, D. P., Kita, B., Ludlow, H., Groome, N. P., Hedger, M. P., de Kretser, D. M. & Lidbury, B. A., 12 Apr 2018, In : Journal of Translational Medicine. 16, 1, 11 p., 97.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017

Activin and follistatin interactions in the male reproductive tract: Activin expression and morphological abnormalities in mice lacking follistatin 288

Wijayarathna, R., Sarraj, M. A., Genovese, R., Girling, J. E., Michel, V., Ludlow, H., Loveland, K. L., Meinhardt, A., de Kretser, D. M. & Hedger, M. P., May 2017, In : Andrology. 5, 3, p. 578-588 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Activin Biology After Lung Transplantation

Westall, G. P., Snell, G. I., Loskot, M., Levvey, B., O'Hehir, R. E., Hedger, M. P. & de Kretser, D. M., May 2017, In : Transplantation Direct. 3, 6, 6 p., e159.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Activin B is a novel biomarker for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) diagnosis: A cross sectional study

Lidbury, B. A., Kita, B., Lewis, D. P., Hayward, S., Ludlow, H., Hedger, M. P. & de Kretser, D. M., 16 Mar 2017, In : Journal of Translational Medicine. 15, 1, 10 p., 60.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Activin over-expression in the testis of mice lacking the inhibin α-subunit gene is associated with androgen deficiency and regression of the male reproductive tract

Wijayarathna, R., de Kretser, D. M., Meinhardt, A., Middendorff, R., Ludlow, H., Groome, N. P., Loveland, K. A. & Hedger, M. P., 15 Jul 2017, In : Molecular and Cellular Endocrinology. 470, p. 188-198 11 p.

Research output: Contribution to journalArticleResearchpeer-review

An in vitro model demonstrates the potential of neoplastic human germ cells to influence the tumour microenvironment

Klein, B., Schuppe, H. -C., Bergmann, M., Hedger, M. P., Loveland, B. E. & Loveland, K. L., Jul 2017, In : Andrology. 5, 4, p. 763-770 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Cytokines in male fertility and reproductive pathologies: Immunoregulation and beyond

Loveland, K. L., Klein, B., Pueschl, D., Indumathy, S., Bergmann, M., Loveland, B. E., Hedger, M. P. & Schuppe, H-C., 20 Nov 2017, In : Frontiers in Endocrinology. 8, NOV, 16 p., 307.

Research output: Contribution to journalReview ArticleOtherpeer-review

Open Access
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Hyperglycemia is associated with reduced testicular function and activin dysregulation in the Ins2Akita+/- mouse model of type 1 diabetes

Maresch, C. C., Stute, D. C., Ludlow, H., Hammes, H. P., de Kretser, D. M., Hedger, M. P. & Linn, T., 5 May 2017, In : Molecular and Cellular Endocrinology. 446, p. 91-101 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Induction of EAO in mice: responses to 2 elevated circulating levels of the activin-binding protein, follistatin

Nicholas, N., Muir, J. A., Hayward, S., Chen, J. L., Stanton, P. G., Gregorevic, P., de Kretser, D. M., Loveland, K. L., Bhushan, S., Meinhardt, A., Fijak, M. & Hedger, M. P., 1 Sep 2017, In : Reproduction. 154, 3, p. 293-305 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Testicular activin and follistatin levels are elevated during the course of experimental autoimmune epididymo-orchitis in mice

Nicolas, N., Michel, V., Bhushan, S., Wahle, E., Hayward, S., Ludlow, H., De Kretser, D. M., Loveland, K., Schuppe, H. C., Meinhardt, A., Hedger, M. P. & Fijak, M., 13 Feb 2017, In : Scientific Reports. 7, 42391.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The testicular transcriptome associated with spermatogonia differentiation initiated by gonadotrophin stimulation in the juvenile rhesus monkey (Macaca mulatta)

Ramaswamy, S., Walker, W. H., Aliberti, P., Sethi, R., Marshall, G. R., Smith, A., Nourashrafeddin, S., Belgorosky, A., Chandran, U. R., Hedger, M. P. & Plant, T. M., 1 Oct 2017, In : Human Reproduction. 32, 10, p. 2088-2100 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

Gonadal peptides: Inhibins, activins, follistatin, and Müllerian-inhibiting substance (Antimüllerian hormone)

de Kretser, D. M., Hedger, M. P. & Burger, H. G., 2016, Endocrinology: Adult & Pediatric. Jameson, J. L., De Groot, L. J., de Kretser, D. M., Giudice, L. C., Grossman, A. B., Melmed, S., Potts Jr, J. T. & Weir, G. C. (eds.). 7th ed. Philadelphia PA USA: Elsevier, Vol. 1 and 2. p. 2037 - 2050 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Prepubertal Di-n-Butyl phthalate exposure alters Sertoli and Leydig cell function and lowers bone density in adult male mice

Bielanowicz, A., Johnson, R. W., Goh, H., Moody, S. C., Poulton, I. J., Croce, N., Loveland, K. L., Hedger, M. P., Sims, N. A. & Itman, C., Jul 2016, In : Endocrinology. 157, 7, p. 2595-2603 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Specific immune cell and cytokine characteristics of human testicular germ cell neoplasia

Klein, B., Haggeney, T., Fietz, D., Indumathy, S., Loveland, K. L., Hedger, M., Kliesch, S., Weidner, W., Bergmann, M. & Schuppe, H-C., 1 Oct 2016, In : Human Reproduction. 31, 10, p. 2192-2202 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Substantial Increases Occur in Serum Activins and Follistatin during Lung Transplantation

de Kretser, D. M., Bensley, J. G., Phillips, D. J., Levvey, B., Snell, G. I., Lin, E., Hedger, M. P. & O'Hehir, R. E., 2016, In : PLoS ONE. 11, 1, 16 p., e140948.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Uropathogenic Escherichia coli causes fibrotic remodelling of the epididymis

Michel, V., Duan, Y., Stoschek, E., Bhushan, S., Middendorff, R., Young, J. M., Loveland, K. L., Kretser, D. M. D., Hedger, M. P. & Meinhardt, A., 1 Sep 2016, In : Journal of Pathology. 240, 1, p. 15-24 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

Activins and inhibins in Sertoli cell biology: implications for testis development and function

Loveland, K. L. & Hedger, M. P., 2015, Sertoli Cell Biology. Griswold, M. D. (ed.). 2nd ed. Amsterdam The Netherlands: Elsevier, p. 201-232 32 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Epididymitis: revelations at the convergence of clinical and basic sciences

Michel, V., Pilatz, A., Hedger, M. P. & Meinhardt, A., 2015, In : Asian Journal of Andrology. 17, 5, p. 756 - 763 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Follistatin is essential for normal postnatal development and function of mouse oviduct and uterus

Holdsworth-Carson, S. J., Craythorn, R. G., Winnall, W. R., Dhaliwal, K., Genovese, R., Nowell, C. J., Rogers, P. A. W., de Kretser, D. M., Hedger, M. P. & Girling, J. E., 2015, In : Reproduction, Fertility and Development. 27, 7, p. 985 - 999 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Murine inhibin alpha-subunit haploinsufficiency causes transient abnormalities in prepubertal testis development followed by adult testicular decline

Itman, C. M., Bielanowicz, A., Goh, H., Lee, Q. C. Y., Fulcher, A. J., Moody, S. C., Doery, J. C. G., Martin, J., Eyre, S., Hedger, M. P. & Loveland, K. A. L., 2015, In : Endocrinology. 156, 6, p. 2254 - 2268 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Simian immunodeficiency virus infection and immune responses in the pig-tailed macaque testis

Winnall, W. R., Lloyd, S. B., De Rose, R., Alcantara, S., Amarasena, T. H., Hedger, M. P., Girling, J. E. & Kent, S. J., 2015, In : Journal of leukocyte biology. 97, 3, p. 599 - 609 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The activin A antagonist follistatin inhibits cystic fibrosis-like lung inflammation and pathology

Hardy, C. L., King, S. J., Mifsud, N. A., Hedger, M. P., Phillips, D. J., Mackay, F., de Kretser, D. M., Wilson, J. W., Rolland, J. M. & O'Hehir, R. E., Jul 2015, In : Immunology and Cell Biology. 93, 6, p. 567-574 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The Immunophysiology of Male Reproduction

Hedger, M. P., 2015, Knobil and Neill's Physiology of Reproduction. Plant, T. M. & Zeleznik, A. J. (eds.). 4th ed. USA: Elsevier, Vol. I . p. 805-892 88 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

2014

Regulation and actions of activin A and follistatin in myocardial ischaemia-reperfusion injury

Chen, Y., Rothnie, C., Spring, D., Verrier, E., Venardos, K., Kaye, D. M., Phillips, D. J., Hedger, M. P. & Smith, J. A., 2014, In : Cytokine. 69, 2, p. 255 - 262 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Relationships among body composition, circulating concentrations of leptin and follistatin, and the onset of puberty and fertility in young female sheep

Rosales Nieto, C. A., Thompson, A. N., Macleay, C. A., Briegel, J. R., Hedger, M. P., Ferguson, M. B. & Martin, G. B., 2014, In : Animal Reproduction Science. 151, 3-4, p. 148 - 156 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Serum activin A and B, and follistatin in critically ill patients with influenza A(H1N1) infection

Linko, R. T., Hedger, M. P., Pettila, V., Ruokonen, E. T., Ludlow, H. & de Kretser, D. M., 2014, In : BMC Infectious Diseases. 14, 1 (Art. ID: 253), p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2013

Characterisation of macaque testicular leucocyte populations and T-lymphocyte immunity

De Rose, R., Fernandez, C. S., Hedger, M. P., Kent, S. J. & Winnall, W. R., 2013, In : Journal of Reproductive Immunology. 100, 2, p. 146 - 156 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Expression patterns of activin, inhibin and follistatin variants in the adult male mouse reproductive tract suggest important roles in the epididymis and vas deferens

Winnall, W. R., Wu, H., Sarraj, M., Rogers, P. A., de Kretser, D. M., Girling, J. E. & Hedger, M. P., 2013, In : Reproduction, Fertility and Development. 25, 3, p. 570 - 580 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Follistatin and activins in polycystic ovary syndrome: relationship to metabolic and hormonal markers

Teede, H. J., Ng, S. N. J., Hedger, M. P. & Moran, L. J., 2013, In : Metabolism: Clinical and Experimental. 62, 10, p. 1394 - 1400 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Phenotypic and functional heterogeneity of the testicular macrophage population: A new regulatory model

Winnall, W. R. & Hedger, M. P., 2013, In : Journal of Reproductive Immunology. 97, 2, p. 147 - 158 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Regulation of activin A release from murine bone marrow-derived neutrophil precursors by tumour necrosis factor-alpha and insulin

Wu, H., Chen, Y., Winnall, W. R., Phillips, D. J. & Hedger, M. P., 2013, In : Cytokine. 61, 1, p. 199 - 204 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Serum activin A and B levels predict outcome in patients with acute respiratory failure: a prospective cohort study

de Kretser, D. M., Bensley, J. G. A., Pettila, V., Hedger, M. P., Hayward, S., Allan, C. A., McLachlan, R. I., Ludlow, H. & Phillips, D. J., 2013, In : Critical Care. 17, 5 (Art # R263), p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2012

Acute regulation of activin A and its binding protein, follistatin, in serum and tissues following lipopolysaccharide treatment of adult male mice

Wu, H., Chen, Y., Winnall, W. R., Phillips, D. J. & Hedger, M. P., 2012, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 303, 6, p. R-665 - R-675 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Correlation between blood activin levels and clinical parameters of type 2 diabetes

Wu, H., Wu, M., Chen, Y., Allan, C. A., Phillips, D. J. & Hedger, M. P., 2012, In : Experimental diabetes research. 2012, Article 410579, p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Immune privilege of the testis: Meaning, mechanisms, and manifestations

Hedger, M. P., 1 Jan 2012, Infection, Immune Homeostasis and Immune Privilege. Stein-Streilein, J. (ed.). Basel, Switzerland: Springer, p. 31-52 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Progesterone stimulates expression of follistatin splice variants Fst288 and Fst315 in the mouse uterus

Craythorn, R., Winnall, W., Lederman, F., Gold, E., O'Connor, A., de Kretser, D., Hedger, M., Rogers, P. & Girling, J., 2012, In : Reproductive BioMedicine Online. 24, 3, p. 364 - 374 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Regulation of activin and inhibin in the adult testis and the evidence for functional roles in spermatogenesis and immunoregulation

Hedger, M. P. & Winnall, W. R., 2012, In : Molecular and Cellular Endocrinology. 359, 1-2, p. 30 - 42 13 p.

Research output: Contribution to journalArticleResearchpeer-review

The roles of activin A and its binding protein, follistatin, in inflammation and tissue repair

de Kretser, D., O'Hehir, R., Hardy, C. & Hedger, M., 2012, In : Molecular and Cellular Endocrinology. 359, 1-2, p. 101 - 106 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

Immunological, paracrine and endocrine aspects of testicular immune privilege

Meinhardt, A. & Hedger, M., 2011, In : Molecular and Cellular Endocrinology. 335, 1, p. 60 - 68 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Immunophysiology and pathology of inflammation in the testis and epididymis

Hedger, M., 2011, In : Journal of Andrology. 32, 6, p. 625 - 640 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Pattern of activin A and follistatin release in a sheep model of cardiopulmonary bypass

Chen, Y., Phillips, D. J., McMillan, J., Bedford, P., Goldstein, J., Wu, H., Hedger, M. & Smith, J., 2011, In : Cytokine. 54, 2, p. 154 - 160 7 p.

Research output: Contribution to journalArticleResearchpeer-review