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Personal profile


Senior Principal Research Fellow

Research Group Head, Endocrinology and Immunophysiology Laboratory

Co-Deputy Head, Centre for Reproductive Health

Professor Mark Hedger has worked in men’s reproductive health since completing his PhD at Monash University in 1984. Subsequently, he received an NIH Visiting Fellowship to work in the Gamete Biology Section, Laboratory of Reproductive and Developmental Toxicology at the National Institute of Environmental Health Sciences in North Carolina, USA. In 1987, he returned to Melbourne to take up an Australian Postdoctoral Research Fellowship with the Department of Anatomy at Monash University.

From 1991 until 1994 Professor Hedger was an inaugural NHMRC Wright Fellow at the Institute of Reproduction and Development (now the Hudson Institute of Medical Research). In 1993 he was appointed an Institute Senior Scientist/Laboratory Head, and in 1996, Deputy-Director of the Centre for Reproduction and Development. In 2001 he was awarded an NHMRC Senior Research Fellowship, a position he continued to hold until 2016. He received an Associate Professorial Fellowship through Monash University’s Department of Physiology in 2003, and is currently a Senior Principal Research Fellow at the Hudson Institute of Medical Research and Professor in the Department of Molecular and Translational Sciences at Monash University. He has published more than 150 scholarly reports and scientific papers, principally in the fields of male reproductive tract biology, activin biology and inflammatory disease in various tissues. His research was recognized as one of the NHMRC’s “10 of the Best” Research Projects in 2008. He also serves on the editorial board of the Andrologia, and is a Section Editor for the Journal of Reproductive Immunology.

Professor Hedger is a member of several Australian and international scientific societies and was President of the Society for Reproductive Biology (2009 -2012). He is a Fellow of the Society for Reproductive Biology and a Fellow of the Society for the Study of Reproduction (USA).

Research area keywords

  • activin
  • follistatin
  • fertility
  • inflammation
  • immunity
  • testis
  • epididymis
  • macrophages

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Research Output

Differential tissue-specific damage caused by bacterial epididymo-orchitis in the mouse

Klein, B., Bhushan, S., Gunther, S., Middendorff, R., Loveland, K. L., Hedger, M. P. & Meinhardt, A., 24 Apr 2020, In : Molecular Human Reproduction. 26, 4, p. 215-227 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Intravascular Follistatin gene delivery improves glycemic control in a mouse model of type 2 diabetes

Davey, J. R., Estevez, E., Thomson, R. E., Whitham, M., Watt, K. I., Hagg, A., Qian, H., Henstridge, D. C., Ludlow, H., Hedger, M. P., McGee, S. L., Coughlan, M. T., Febbraio, M. A. & Gregorevic, P., Apr 2020, In : The FASEB Journal. 34, 4, p. 5697-5714 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Activin A target genes are differentially expressed between normal and neoplastic adult human testes: clues to gonocyte fate choice

Szarek, M., Bergmann, M., Konrad, L., Schuppe, H. C., Kliesch, S., Hedger, M. P. & Loveland, K. A. L., 1 Jan 2019, In : Andrology. 7, 1, p. 31-41 11 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Activins, follistatin and immunoregulation in the epididymis

Wijayarathna, R. & Hedger, M. P., Sep 2019, In : Andrology. 7, 5, p. 703-711 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
2 Citations (Scopus)

Acute heat-treatment disrupts inhibin-related protein production and gene expression in the adult rat testis

Aldahhan, R. A., Stanton, P., Ludlow, H., de Kretser, D. & Hedger, M., 1 Dec 2019, In : Molecular and Cellular Endocrinology. 498, 12 p., 110546.

Research output: Contribution to journalArticleResearchpeer-review