Projects per year
Personal profile
Biography
Senior Principal Research Fellow
Research Group Head, Endocrinology and Immunophysiology Laboratory
Co-Deputy Head, Centre for Reproductive Health
Professor Mark Hedger has worked in men’s reproductive health since completing his PhD at Monash University in 1984. Subsequently, he received an NIH Visiting Fellowship to work in the Gamete Biology Section, Laboratory of Reproductive and Developmental Toxicology at the National Institute of Environmental Health Sciences in North Carolina, USA. In 1987, he returned to Melbourne to take up an Australian Postdoctoral Research Fellowship with the Department of Anatomy at Monash University.
From 1991 until 1994 Professor Hedger was an inaugural NHMRC Wright Fellow at the Institute of Reproduction and Development (now the Hudson Institute of Medical Research). In 1993 he was appointed an Institute Senior Scientist/Laboratory Head, and in 1996, Deputy-Director of the Centre for Reproduction and Development. In 2001 he was awarded an NHMRC Senior Research Fellowship, a position he continued to hold until 2016. He received an Associate Professorial Fellowship through Monash University’s Department of Physiology in 2003, and is currently a Senior Principal Research Fellow at the Hudson Institute of Medical Research and Professor in the Department of Molecular and Translational Sciences at Monash University. He has published more than 150 scholarly reports and scientific papers, principally in the fields of male reproductive tract biology, activin biology and inflammatory disease in various tissues. His research was recognized as one of the NHMRC’s “10 of the Best” Research Projects in 2008. He also serves on the editorial board of the Andrologia, and is a Section Editor for the Journal of Reproductive Immunology.
Professor Hedger is a member of several Australian and international scientific societies and was President of the Society for Reproductive Biology (2009 -2012). He is a Fellow of the Society for Reproductive Biology and a Fellow of the Society for the Study of Reproduction (USA).
Keywords
- activin
- follistatin
- fertility
- inflammation
- immunity
- testis
- epididymis
- macrophages
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Projects 2000 2022
IRTG: International Research Training Grant (IRTG)_Renewal of Molecular pathogenesis of male reproductive disorders project
Meinhardt, A., Loveland, K., Bhushan, S., Ellem, S., Hedger, M., O'Bryan, M., O'Donnell, L., Stanton, P., Risbridger, G., Baker, M. A., Hobbs, R., Loveland, B., Exintaris, B., Western, P., McLachlan, R., Whittaker, M., Wagenlehner, F. M. E., Bergmann, M., Diemer, T., Fietz, D., Fijak, M., Konrad, L., Linn, T., Middendorff, R., Pilatz, A., Schagdarsurengin, U., Schuppe, H. C., Steger, K. & Scheiner-Bobis, G.
1/10/17 → 31/03/22
Project: Research
The importance of the blood-testis barrier in human infertility
Stanton, P., Harrison, C., Hedger, M. & McLachlan, R.
National Health & Medical Research Council (NHMRC)
1/01/17 → 31/12/19
Project: Research
Activin and its binding protein, follistatin regulate functions of the epididymis and vas deferens
Hedger, M., Loveland, K., Meinhardt, A. & de Kretser, D.
National Health & Medical Research Council (NHMRC)
1/01/14 → 31/12/16
Project: Research
Activin A and follistatin are potential key regulators of organ transplant dysfunction and graft survival.
de Kretser, D., Dwyer, K., Hedger, M., Kotsimbos, A. T. & Snell, G.
National Health & Medical Research Council (NHMRC)
1/01/13 → 31/12/15
Project: Research
Research Output 1985 2019
Activin A target genes are differentially expressed between normal and neoplastic adult human testes: clues to gonocyte fate choice
Szarek, M., Bergmann, M., Konrad, L., Schuppe, H. C., Kliesch, S., Hedger, M. P. & Loveland, K. A. L., 1 Jan 2019, In : Andrology. 7, 1, p. 31-41 11 p.Research output: Contribution to journal › Article › Research › peer-review
Cumulin and FSH cooperate to regulate inhibin B and activin B production by human granulosa-lutein cells in vitro
Richani, D., Constance, K., Lien, S., Agapiou, D., Stocker, W. A., Hedger, M. P., Ledger, W., Thompson, J. G., Robertson, D. M., Mottershead, D. G., Walton, K. L., Harrison, C. A. & Gilchrist, R., 1 Apr 2019, In : Endocrinology. 160, 4, p. 853-862 10 p.Research output: Contribution to journal › Article › Research › peer-review
Comparative analysis of activins A and B in the adult mouse epididymis and vas deferens
Wijayarathna, R., de Kretser, D. M., Sreenivasan, R., Ludlow, H., Middendorff, R., Meinhardt, A., Loveland, K. L. & Hedger, M. P., 1 Jan 2018, In : Reproduction. 155, 1, p. 15-23 9 p.Research output: Contribution to journal › Article › Research › peer-review
Epididymal cysteine-rich secretory proteins are required for epididymal sperm maturation and optimal sperm function
Hu, J., Merriner, D. J., O'Connor, A. E., Houston, B. J., Furic, L., Hedger, M. P. & O'Bryan, M. K., 1 Mar 2018, In : Molecular Human Reproduction. 24, 3, p. 111-122 12 p.Research output: Contribution to journal › Article › Research › peer-review
Infectious, inflammatory and ‘autoimmune’ male factor infertility: how do rodent models inform clinical practice?
Fijak, M., Pilatz, A., Hedger, M. P., Nicolas, N., Bhushan, S., Michel, V., Tung, K. S. K., Schuppe, H. C. & Meinhardt, A., Jul 2018, In : Human Reproduction Update. 24, 4, p. 24 4 p.Research output: Contribution to journal › Article › Research › peer-review