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Personal profile

Biography

Dr. Mark Guthridge completed his Ph.D studies at Monash University after which he took up a postdoctoral position at New York University Medical Centre as a Darland Research Fellow. He returned to the Institute of Medical and Veterinary Science, Adelaide Australia in 1998 and was awarded a Peter Nelson Leukaemia Research Fellowship to examine molecular approaches for the therapeutic targeting of acute myeloid leukemic (AML) cells. In 2011 Dr. Guthridge moved his laboratory to the Division of Blood Cancers at the Australian Centre for Blood Diseases (ACBD) located on the Alfred Medical Research and Education Precinct (AMREP) in Melbourne.

Since 2000, Dr. Guthridge's lab has received continual funding from International (NIH, AICR), National (NHandMRC, LFA) and State agencies (Cancer Council of SA). His work has been published in top-tier journals including Cell, Molecular Cell, Cell Stem Cell and EMBO J as well as leading specialist cancer/hemopoietic journals such as Blood, Leukemia and Cancer Research. Dr. Guthridge regularly serves of NHandMRC GRPs and is co-convenor of the New Directions in Leukaemia Research (NDLR) conference held biennially on the Sunshine Coast, QLD.

Dr. Guthridge's research focuses on the mechanisms by which cancer cells co-opt and coerce intracellular signalling pathways to promote deregulated cell survival, proliferation and growth. Through the molecular analysis of intracellular signalling pathways, Dr. Guthridge's laboratory seeks to identify new therapeutic targets in diseases such as leukaemia.

Consulting

Dr. Guthridge consulted for the Commonwealth Serum Laboratories (CSL) between 2004-2009.

Keywords

  • Cytokine
  • Gene Transcription
  • Phosphatidyl Inositol 3-Kinase
  • Leukaemia
  • Apoptosis
  • Signalling
  • Kinase
  • Phosphorylation

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Projects 2010 2019

Research Output 1992 2018

  • 26 Article
  • 1 Encyclopaedia / Dictionary Entry
  • 1 Comment / Debate
  • 1 Review Article

Enhancing venetoclax activity in acute myeloid leukemia by co-targeting MCL1

Teh, T. C., Nguyen, N. Y., Moujalled, D. M., Segal, D., Pomilio, G., Rijal, S., Jabbour, A., Cummins, K., Lackovic, K., Blombery, P., Thompson, E., Ekert, P. G., Lessene, G., Glaser, S. P., Huang, D. C. S., Roberts, A. W., Guthridge, M. A. & Wei, A. H. 1 Feb 2018 In : Leukemia. 32, 2, p. 303-312 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

Hein, N. , Cameron, D. P. , Hannan, K. M. , Nguyen, N. Y. N. , Fong, C. Y. , Sornkom, J. , Wall, M. , Pavy, M. , Cullinane, C. M. , Diesch, J. , Devlin, J. R. , George, A. J. , Sanij, E. , Quin, J. E. , Poortinga, G. , Verbrugge, I. , Baker, A. , Drygin, D. J. , Harrison, S. J. , Rozario, J. D. & 10 others Powell, J. A., Pitson, S. M., Zuber, J., Johnstone, R. W., Dawson, M. A., Guthridge, M. A., Wei, A., McArthur, G. A., Pearson, R. B. & Hannan, R. D. 25 May 2017 In : Blood. 129, 21, p. 2882-2895 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Activation of protein phosphatase 2A in FLT3+ acute myeloid leukemia cells enhances the cytotoxicity of FLT3 tyrosine kinase inhibitors

Smith, A. M., Dun, M. D., Lee, E. M., Harrison, C., Kahl, R., Flanagan, H., Panicker, N., Mashkani, B., Don, A. S., Morris, J., Toop, H., Lock, R. B., Powell, J. A., Thomas, D., Guthridge, M. A., Moore, A., Ashman, L. K., Skelding, K. A., Enjeti, A. & Verrills, N. M. 2016 In : Oncotarget. 7, 30, p. 47465-47478 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Correction: Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics (Cancer Cell (2016) 30(3) (499–500) (S1535610816000350) (10.1016/j.ccell.2016.01.006))

Lalaoui, N. , Hänggi, K. , Brumatti, G. , Chau, D. , Nguyen, N. Y. N. , Vasilikos, L. , Spilgies, L. M. , Heckmann, D. A. , Ma, C. , Ghisi, M. , Salmon, J. M. , Matthews, G. M. , de Valle, E. , Moujalled, D. M. , Menon, M. B. , Spall, S. K. , Glaser, S. P. , Richmond, J. , Lock, R. B. , Condon, S. M. & 10 others Gugasyan, R., Gaestel, M., Guthridge, M., Johnstone, R. W., Munoz, L., Wei, A., Ekert, P. G., Vaux, D. L., Wong, W. W. L. & Silke, J. 12 Sep 2016 In : Cancer Cell. 30, 3, p. 499-500 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Cytokine Receptors and Their Ligands

Dhagat, U., Nero, T. L., Kan, W. L., Hercus, T. R., Broughton, S. E., De Weerd, N. A., Jenkins, B. J., Mansell, A., Guthridge, M. A., Hertzog, P. J., Lopez, A. F. & Parker, M. W. 2016 Encyclopedia of Cell Biology. Bradshaw, R. A. & Stahl, P. D. (eds.). MA USA: Elsevier, Vol. 3, p. 22-36 15 p.

Research output: Chapter in Book/Report/Conference proceedingEncyclopaedia / Dictionary EntryOtherpeer-review