Mark Febbraio

Professor

1993 …2022
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Research Output 1993 2019

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2019

Mouse Model of Mutated in Colorectal Cancer Gene Deletion Reveals Novel Pathways in Inflammation and Cancer

Currey, N., Jahan, Z., Caldon, C. E., Tran, P. N., Benthani, F., De Lacavalerie, P., Roden, D. L., Gloss, B. S., Campos, C., Bean, E. G., Bullman, A., Reibe-Pal, S., Dinger, M. E., Febbraio, M. A., Clarke, S. J., Dahlstrom, J. E. & Kohonen-Corish, M. R. J., 1 Jan 2019, In : CMGH. 7, 4, p. 819-839 21 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Protein Kinase C Epsilon Deletion in Adipose Tissue, but Not in Liver, Improves Glucose Tolerance

Brandon, A. E., Liao, B. M., Diakanastasis, B., Parker, B. L., Raddatz, K., McManus, S. A., O'Reilly, L., Kimber, E., van der Kraan, A. G., Hancock, D., Henstridge, D. C., Meikle, P. J., Cooney, G. J., James, D. E., Reibe, S., Febbraio, M. A., Biden, T. J. & Schmitz-Peiffer, C., 8 Jan 2019, In : Cell Metabolism. 29, 1, p. 183-191 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Redefining Tissue Crosstalk via Shotgun Proteomic Analyses of Plasma Extracellular Vesicles

Whitham, M. & Febbraio, M. A., 1 Jan 2019, In : Proteomics. 19, 1-2, 5 p., 1800154.

Research output: Contribution to journalArticleResearchpeer-review

2018

Activation of mitochondrial fusion provides a new treatment for mitochondria-related diseases

Szabo, A., Sumegi, K., Fekete, K., Hocsak, E., Debreceni, B., Setalo, G., Kovacs, K., Deres, L., Kengyel, A., Kovacs, D., Mandl, J., Nyitrai, M., Febbraio, M. A., Gallyas, F. & Sumegi, B., 1 Apr 2018, In : Biochemical Pharmacology. 150, p. 86-96 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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APP deficiency results in resistance to obesity but impairs glucose tolerance upon high fat feeding

Czeczor, J. K., Genders, A. J., Aston-Mourney, K., Connor, T., Hall, L. G., Hasebe, K., Ellis, M., De Jong, K. A., Henstridge, D. C., Meikle, P. J., Febbraio, M. A., Walder, K. & McGee, S. L., 1 Jun 2018, In : Journal of Endocrinology. 237, 3, p. 311-322 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Defective cholesterol metabolism in haematopoietic stem cells promotes monocyte-driven atherosclerosis in rheumatoid arthritis

Dragoljevic, D., Kraakman, M. J., Nagareddy, P. R., Ngo, D., Shihata, W., Kammoun, H. L., Whillas, A., Lee, M. K. S., Al-Sharea, A., Pernes, G., Flynn, M. C., Lancaster, G. I., Febbraio, M. A., Chin-Dusting, J., Hanaoka, B. Y., Wicks, I. P. & Murphy, A. J., 14 Jun 2018, In : European Heart Journal. 39, 23, p. 2158-2167 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Evidence against a role for NLRP3-driven islet inflammation in db/db mice

Kammoun, H. L., Allen, T. L., Henstridge, D. C., Barre, S., Coll, R. C., Lancaster, G. I., Cron, L., Reibe, S., Chan, J. Y., Bensellam, M., Laybutt, D. R., Butler, M. S., Robertson, A. A. B., O'Neill, L. A., Cooper, M. A. & Febbraio, M. A., 1 Apr 2018, In : Molecular Metabolism. 10, p. 66-73 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism

Lancaster, G. I., Langley, K. G., Berglund, N. A., Kammoun, H. L., Reibe, S., Estevez, E., Weir, J., Mellett, N. A., Pernes, G., Conway, J. R. W., Lee, M. K. S., Timpson, P., Murphy, A. J., Masters, S. L., Gerondakis, S., Bartonicek, N., Kaczorowski, D. C., Dinger, M. E., Meikle, P. J., Bond, P. J. & 1 others, Febbraio, M. A., 1 May 2018, In : Cell Metabolism. 27, 5, p. 1096-1110 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise

Whitham, M., Parker, B. L., Friedrichsen, M., Hingst, J. R., Hjorth, M., Hughes, W. E., Egan, C. L., Cron, L., Watt, K. I., Kuchel, R. P., Jayasooriah, N., Estevez, E., Petzold, T., Suter, C. M., Gregorevic, P., Kiens, B., Richter, E. A., James, D. E., Wojtaszewski, J. F. P. & Febbraio, M. A., 9 Jan 2018, In : Cell Metabolism. 27, 1, p. 237-251 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Female sex hormones are necessary for the metabolic effects mediated by loss of Interleukin 18 signaling

Lindegaard, B., Abildgaard, J., Heywood, S. E., Pedersen, B. K. & Febbraio, M. A., 1 Jun 2018, In : Molecular Metabolism. 12, p. 89-97 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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GeneXX: an online tool for the exploration of transcript changes in skeletal muscle associated with exercise

Reibe, S., Hjorth, M., Febbraio, M. A. & Whitham, M., 1 May 2018, In : Physiological Genomics. 50, 5, p. 376-384 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Skeletal muscle-specific overexpression of heat shock protein 72 improves skeletal muscle insulin-stimulated glucose uptake but does not alter whole body metabolism

Marshall, J. P. S., Estevez, E., Kammoun, H. L., King, E. J., Bruce, C. R., Drew, B. G., Qian, H., Iliades, P., Gregorevic, P., Febbraio, M. A. & Henstridge, D. C., 1 Aug 2018, In : Diabetes, Obesity and Metabolism. 20, 8, p. 1928-1936 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

Exercise metabolism in 2016: Health benefits of exercise — more than meets the eye!

Febbraio, M. A., 4 Jan 2017, In : Nature Reviews Endocrinology. 13, p. 72-74 2 p.

Research output: Contribution to journalArticleOtherpeer-review

High-density lipoprotein delivered after myocardial infarction increases cardiac glucose uptake and function in mice

Heywood, S. E., Richart, A. L., Henstridge, D. C., Alt, K., Kiriazis, H., Zammit, C., Carey, A. L., Kammoun, H. L., Delbridge, L. M., Reddy, M., Chen, Y. C., Du, X. J., Hagemeyer, C. E., Febbraio, M. A., Siebel, A. L. & Kingwell, B. A., 11 Oct 2017, In : Science Translational Medicine. 9, 411, 10 p., eaam6084.

Research output: Contribution to journalArticleResearchpeer-review

Increased liver AGEs induce hepatic injury mediated through an OST48 pathway

Zhuang, A., Yap, F. Y., Bruce, C., Leung, C., Plan, M. R., Sullivan, M. A., Herath, C. B., McCarthy, D., Sourris, K. C., Kantharidis, P., Coughlan, M. T., Febbraio, M. A., Hodson, M. P., Watt, M. J., Angus, P., Schulz, B. L. & Forbes, J. M., 1 Dec 2017, In : Scientific Reports. 7, 1, 12292.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Inflammation, but not recruitment, of adipose tissue macrophages requires signalling through Mac-1 (CD11B/CD18) in diet-induced obesity (DIO)

Wolf, D., Bukosza, N., Engel, D., Poggi, M., Jehle, F., Michel, N. A., Chen, Y. C., Colberg, C., Hoppe, N., Dufner, B., Boon, L., Blankenbach, H., Hilgendorf, I., Muhlen, C. V. Z., Reinöhl, J., Sommer, B., Marchini, T., Febbraio, M. A., Weber, C., Bode, C. & 3 others, Peter, K., Lutgens, E. & Zirlik, A., 2017, In : Thrombosis and Haemostasis. 117, 2, p. 325-338 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Muscle-specific overexpression of AdipoR1 or AdipoR2 gives rise to common and discrete local effects whilst AdipoR2 promotes additional systemic effects

Keshvari, S., Henstridge, D. C., Ng, C., Febbraio, M. A. & Whitehead, J. P., 1 Feb 2017, In : Scientific Reports. 7, 13 p., 41792.

Research output: Contribution to journalArticleResearchpeer-review

Neutrophil-derived S100 calcium-binding proteins A8/A9 promote reticulated thrombocytosis and atherogenesis in diabetes

Kraakman, M. J., Lee, M. K. S., Al-Sharea, A., Dragoljevic, D., Barrett, T. J., Montenont, E., Basu, D., Heywood, S. E., Kammoun, H. L., Flynn, M., Whillas, A., Hanssen, N. M. J., Febbraio, M. A., Westein, E., Fisher, E. A., Chin-Dusting, J., Cooper, M. E., Berger, J. S., Goldberg, I. J., Nagareddy, P. R. & 1 others, Murphy, A. J., 1 Jun 2017, In : Journal of Clinical Investigation. 127, 6, p. 2133-2147 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Over-expressing the soluble gp130-Fc does not ameliorate methionine and choline deficient diet-induced non alcoholic steatohepatitis in mice

Kammoun, H. L., Allen, T. L., Henstridge, D. C., Kraakman, M. J., Peijs, L., Rose-John, S. & Febbraio, M. A., 20 Jun 2017, In : PLoS ONE. 12, 6, 13 p., e0179099.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Scriptaid enhances skeletal muscle insulin action and cardiac function in obese mice

Gaur, V., Connor, T., Venardos, K., Henstridge, D. C., Martin, S. D., Swinton, C., Morrison, S., Aston-Mourney, K., Gehrig, S. M., van Ewijk, R., Lynch, G. S., Febbraio, M. A., Steinberg, G. R., Hargreaves, M., Walder, K. R. & McGee, S. L., 1 Jul 2017, In : Diabetes, Obesity and Metabolism. 19, 7, p. 936-943 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Transcription Factor IRF4 Promotes CD8+ T Cell Exhaustion and Limits the Development of Memory-like T Cells during Chronic Infection

Man, K., Gabriel, S. S., Liao, Y., Gloury, R., Preston, S., Henstridge, D. C., Pellegrini, M., Zehn, D., Berberich-Siebelt, F., Febbraio, M. A., Shi, W. & Kallies, A., 19 Dec 2017, In : Immunity. 47, 6, p. 1129-1141 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2016

BGP-15 Improves Aspects of the Dystrophic Pathology in mdx and dko Mice with Differing Efficacies in Heart and Skeletal Muscle

Kennedy, T. L., Swiderski, K., Murphy, K. T., Gehrig, S. M., Curl, C. L., Chandramouli, C., Febbraio, M. A., Delbridge, L. M. D., Koopman, R. & Lynch, G. S., 1 Dec 2016, In : American Journal of Pathology. 186, 12, p. 3246-3260 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Disruption of the Class IIa HDAC Corepressor Complex Increases Energy Expenditure and Lipid Oxidation

Gaur, V., Connor, T., Sanigorski, A., Martin, S. D., Bruce, C. R., Henstridge, D. C., Bond, S. T., McEwen, K. A., Kerr-Bayles, L., Ashton, T. D., Fleming, C. L., Wu, M., Pike Winer, L. S., Chen, D., Hudson, G. M., Schwabe, J. W. R., Baar, K., Febbraio, M. A., Gregorevic, P., Pfeffer, F. M. & 3 others, Walder, K. R., Hargreaves, M. & McGee, S. L., 13 Sep 2016, In : Cell Reports. 16, 11, p. 2802-2810 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Glucose-6-phosphate dehydrogenase contributes to the regulation of glucose uptake in skeletal muscle

Lee-Young, R. S., Hoffman, N. J., Murphy, K. T., Henstridge, D. C., Samocha-Bonet, D., Siebel, A. L., Iliades, P., Zivanovic, B., Hong, Y. H., Colgan, T. D., Kraakman, M. J., Bruce, C. R., Gregorevic, P., McConell, G. K., Lynch, G. S., Drummond, G. R., Kingwell, B. A., Greenfield, J. R. & Febbraio, M. A., 1 Nov 2016, In : Molecular Metabolism. 5, 11, p. 1083-1091 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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High fat diet inhibits dendritic cell and T cell response to allergens but does not impair inhalational respiratory tolerance

Pizzolla, A., Oh, D. Y., Luong, S., Prickett, S. R., Henstridge, D. C., Febbraio, M. A., O'Hehir, R. E., Rolland, J. M. & Hardy, C. L., 1 Aug 2016, In : PLoS ONE. 11, 8, 18 p., e0160407.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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IL-18 production from the NLRP1 inflammasome prevents obesity and metabolic syndrome

Murphy, A. J., Kraakman, M. J., Kammoun, H. L., Dragoljevic, D., Lee, M. K. S., Lawlor, K. E., Wentworth, J. M., Vasanthakumar, A., Gerlic, M., Whitehead, L. W., DiRago, L., Cengia, L., Lane, R. M., Metcalf, D., Vince, J. E., Harrison, L. C., Kallies, A., Kile, B. T., Croker, B. A., Febbraio, M. A. & 1 others, Masters, S. L., 12 Jan 2016, In : Cell Metabolism. 23, 1, p. 155-164 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Male-lineage transmission of an acquired metabolic phenotype induced by grand-paternal obesity

Cropley, J. E., Eaton, S. A., Aiken, A., Young, P. E., Giannoulatou, E., Ho, J. W. K., Buckland, M. E., Keam, S. P., Hutvagner, G., Humphreys, D. T., Langley, K. G., Henstridge, D. C., Martin, D. I. K., Febbraio, M. A. & Suter, C. M., 1 Aug 2016, In : Molecular Metabolism. 5, 8, p. 699-708 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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NFκB1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells

de Valle, E., Grigoriadis, G., O'Rielly, L. A., Willis, S. N., Maxwell, M. J., Corcoran, L. M., Tsantikos, E., Cornish, J. K. S., Fairfax, K. A., Vasanthakumar, A., Febbraio, M. A., Hibbs, M. L., Pellegrini, M., Banerjee, A., Hodgkin, P. D., Kallies, A., Mackay, F., Strasser, A., Gerondakis, S. & Gugasyan, R., 4 Apr 2016, In : Journal of Experimental Medicine. 213, 4, p. 621-641 21 p., PMC4821646.

Research output: Contribution to journalArticleResearchpeer-review

PKR is not obligatory for high-fat diet-induced obesity and its associated metabolic and inflammatory complications

Lancaster, G. I., Kammoun, H. L., Kraakman, M. J., Kowalski, G. M., Bruce, C. R. & Febbraio, M. A., 3 Feb 2016, In : Nature Communications. 7, 10 p., 10626.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The roles of c-Jun NH2-terminal kinases (JNKs) in obesity and insulin resistance

Pal, M., Febbraio, M. A. & Lancaster, G. I., 15 Jan 2016, In : The Journal of Physiology. 594, 2, p. 267-279 13 p.

Research output: Contribution to journalArticleOtherpeer-review

2015

Analysis of the liver lipidome reveals insights into the protective effect of exercise on high-fat diet-induced hepatosteatosis in mice

Jordy, A. B., Kraakman, M. J., Gardner, T., Estevez, E., Kammoun, H. L., Weir, J. M., Kiens, B., Meikle, P. J., Febbraio, M. A. & Henstridge, D. C., May 2015, In : American Journal of Physiology - Endocrinology and Metabolism. 308, 9, p. E778-E791 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation

Ramiscal, R. R., Parish, I. A., Lee-Young, R. S., Babon, J., Blagih, J., Pratama, A., Martin, J. L., Hawley, N., Cappello, J. Y., Nieto, P. F., Ellyard, J. I., Kershaw, N. J., Sweet, R. A., Goodnow, C. C., Jones, R. G., Febbraio, M. A., Vinuesa, C. G. & Athanasopoulos, V., 23 Oct 2015, In : eLife. 4, 22 p., e08698.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance

Kraakman, M. J., Kammoun, H. L., Allen, T. L., Deswaerte, V., Henstridge, D. C., Estevez, E., Matthews, V. B., Neill, B. A., White, D. A., Murphy, A. J., Peijs, L., Yang, C., Risis, S., Bruce, C. R., Du, X-J., Bobik, A., Lee-Young, R. S., Kingwell, B. A., Vasanthakumar, A., Shi, W. & 4 others, Kallies, A., Lancaster, G. I., Rose-John, S. & Febbraio, M. A., 3 Mar 2015, In : Cell Metabolism. 21, 3, p. 403-416 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Erratum to: Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase [for 2008010335]

Matthews, V. B., Astrom, M. B., Chan, M. H. S., Bruce, C. R., Krabbe, K. S., Prelovsek, O., Akerstrom, T. C. A., Yfanti, C., Broholm, C., Mortensen, O. H., Penkowa, M., Hojman, P., Zankari, A., Watt, M. J., Bruunsgaard, H., Pedersen, B. K. & Febbraio, M. A., 2015, In : Diabetologia. 58, 4, p. 854 - 855 2 p.

Research output: Contribution to journalArticleOther

Exercise improves adipose function and inflammation and ameliorates fatty liver disease in obese diabetic mice

Haczeyni, F., Barn, V., Mridha, A. R., Yeh, M. M., Estevez, E., Febbraio, M. A., Nolan, C. J., Bell-Anderson, K. S., Teoh, N. C. & Farrell, G. C., 1 Sep 2015, In : Obesity. 23, 9, p. 1845-1855 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Fetuin B Is a Secreted Hepatocyte Factor Linking Steatosis to Impaired Glucose Metabolism

Meex, R. C., Hoy, A. J., Morris, A., Brown, R. D., Lo, C. Y. J., Burke, M. L., Goode, R. J. A., Kingwell, B. A., Kraakman, M. J., Febbraio, M. A., Greve, J. W., Rensen, S. S., Molloy, M. P., Lancaster, G. I., Bruce, C. R. & Watt, M. J., 2015, In : Cell Metabolism. 22, 6, p. 1078 - 1089 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Genetic manipulation of cardiac Hsp72 levels does not alter substrate metabolism but reveals insights into high-fat feeding-induced cardiac insulin resistance

Henstridge, D. C., Estevez, E., Allen, T. L., Heywood, S. E., Gardner, T., Yang, C., Mellett, N. A., Kingwell, B. A., Meikle, P. J. & Febbraio, M. A., 1 May 2015, In : Cell Stress and Chaperones. 20, 3, p. 461-472 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Long-term overexpression of Hsp70 does not protect against cardiac dysfunction and adverse remodeling in a murc transgenic mouse model with chronic heart failure and atrial fibrillation

Bernardo, B. C., Sapra, G., Patterson, N. L., Cemerlang, N., Kiriazis, H., Ueyama, T., Febbraio, M. A. & McMullen, J. R., 14 Dec 2015, In : PLoS ONE. 10, 12, 17 p., 0145173.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Mitochondrial dysfunction in oocytes of obese mothers: Transmission to offspring and reversal by pharmacological endoplasmic reticulum stress inhibitors

Wu, L., Russell, D. L., Wong, S. L., Chen, M., Tsai, T-S., St John, J. C., Norman, R. J., Febbraio, M. A., Carroll, J. G. & Robker, R., 2015, In : Development. 142, 4, p. 681 - 691 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Nanoporous metal-phenolic particles as ultrasound imaging probes for hydrogen peroxide

Guo, J., Wang, X., Henstridge, D. C., Richardson, J. J., Cui, J., Sharma, A., Febbraio, M. A., Peter, K., De Haan-Klein, J. B., Hagemeyer, C. E. & Caruso, F., 2015, In : Advanced Healthcare Materials. 4, 14, p. 2170 - 2175 6 p.

Research output: Contribution to journalArticleResearchpeer-review

The CDP-ethanolamine pathway regulates skeletal muscle diacylglycerol content and mitochondrial biogenesis without altering insulin sensitivity

Selathurai, A., Kowalski, G. M., Burch, M. L., Sepulveda, P. V., Risis, S., Lee-Young, R. S., Lamon, S., Meikle, P. J., Genders, A. J., McGee, S. L., Watt, M. J., Russell, A. P., Frank, M., Jackowski, S., Febbraio, M. A. & Bruce, C. R., 2015, In : Cell Metabolism. 21, 5, p. 718 - 730 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance

Henstridge, D. C., Bruce, C. R., Drew, B. G., Tory, K., Kolonics, A., Estevez, E., Chung, J., Watson, N., Gardner, T., Lee-Young, R. S., Connor, T., Watt, M. J., Carpenter, K., Hargreaves, M., McGee, S. L., Hevener, A. & Febbraio, M. A., 2014, In : Diabetes. 63, 6, p. 1881 - 1894 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Adipose tissue inflammation in glucose metabolism

Kammoun, H. L., Kraakman, M. J. & Febbraio, M. A., 2014, In : Reviews in Endocrine & Metabolic Disorders. 15, 1, p. 31 - 44 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Coinhibitory suppression of t cell activation by CD40 protects against obesity and adipose tissue inflammation in mice

Wolf, D., Jehle, F., Michel, N. A., Bukosza, E. N., Rivera, J., Chen, Y. C., Hoppe, N., Dufner, B., Rodriguez, A. O., Colberg, C., Nieto, L., Rupprecht, B., Wiedemann, A., Schulte, L., Peikert, A., Bassler, N., Lozhkin, A., Hergeth, S. P., Stachon, P., Hilgendorf, I. & 11 others, Willecke, F., Von Zur Mühlen, C., von Elverfeldt, D., Binder, C. J., Aichele, P., Varo, N., Febbraio, M. A., Libby, P., Bode, C., Peter, K. & Zirlik, A., 10 Jun 2014, In : Circulation. 129, 23, p. 2414-2425 12 p.

Research output: Contribution to journalArticleResearchpeer-review

HSP72 is a mitochondrial stress sensor critical for Parkin action, oxidative metabolism, and insulin sensitivity in skeletal muscle

Drew, B. G., Ribas, V., Le, J. A., Henstridge, D. C., Phun, J., Zhou, Z., Soleymani, T., Daraei, P., Sitz, D., Vergnes, L., Wanagat, J., Reue, K., Febbraio, M. A. & Hevener, A. L., May 2014, In : Diabetes. 63, 5, p. 1488-1505 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors

Haeusler, R. A., Hartil, K., Vaitheesvaran, B., Arrieta-Cruz, I., Knight, C. M., Cook, J. R., Kammoun, H. L., Febbraio, M. A., Gutierrez-Juarez, R., Kurland, I. J. & Accili, D., 13 Oct 2014, In : Nature Communications. 5, 8 p., 5190.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Role of IL-6 in exercise training- and cold-induced UCP1 expression in subcutaneous white adipose tissue

Knudsen, J. G., Murholm, M., Carey, A. L., Biensø, R. S., Basse, A. L., Allen, T. L., Hidalgo, J., Kingwell, B. A., Febbraio, M. A., Hansen, J. B. & Pilegaard, H., 8 Jan 2014, In : PLoS ONE. 9, 1, 8 p., e84910.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

Mauer, J., Chaurasia, B., Goldau, J., Vogt, M. C., Ruud, J., Nguyen, K. D., Theurich, S., Hausen, A. C., Schmitz, J., Brönneke, H. S., Estevez, E., Allen, T. L., Mesaros, A., Partridge, L., Febbraio, M. A., Chawla, A., Wunderlich, F. T. & Brüning, J. C., May 2014, In : Nature Immunology. 15, 5, p. 423-430 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The dual-specificity phosphatase 2 (DUSP2) does not regulate obesity-associated inflammation or insulin resistance in mice

Lancaster, G. I., Kraakman, M. J., Kammoun, H. L., Langley, K. G., Estevez, E., Banerjee, A., Grumont, R. J., Febbraio, M. A. & Gerondakis, S. D., 2014, In : PLoS ONE. 9, 11, 8 p., e111524.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice

Sapra, G., Tham, Y. K., Cemerlang, N., Matsumoto, A., Kiriazis, H., Bernardo, B. C., Henstridge, D. C., Ooi, J. Y. Y., Pretorius, L., Boey, E. J. H., Lim, L., Sadoshima, J., Meikle, P. J., Mellett, N. A., Woodcock, E. A., Marasco, S., Ueyama, T., Du, X-J., Febbraio, M. A. & McMullen, J. R., 2014, In : Nature Communications. 5, p. 1 - 16 16 p., 5705.

Research output: Contribution to journalArticleResearchpeer-review

Open Access