Mark Febbraio

Professor

20002022
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Research Output 2000 2018

2018

Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism

Lancaster, G. I., Langley, K. G., Berglund, N. A., Kammoun, H. L., Reibe, S., Estevez, E., Weir, J., Mellett, N. A., Pernes, G., Conway, J. R. W., Lee, M. K. S., Timpson, P., Murphy, A. J., Masters, S. L., Gerondakis, S., Bartonicek, N., Kaczorowski, D. C., Dinger, M. E., Meikle, P. J., Bond, P. J. & 1 othersFebbraio, M. A., 1 May 2018, In : Cell Metabolism. 27, 5, p. 1096-1110 16 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

Adiponectin serenades ceramidase to improve metabolism

Reibe-Pal, S. & Febbraio, M. A., 1 Mar 2017, In : Molecular Metabolism. 6, 3, p. 233-235 3 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Exercise metabolism in 2016: Health benefits of exercise — more than meets the eye!

Febbraio, M. A., 4 Jan 2017, In : Nature Reviews Endocrinology. 13, p. 72-74 2 p.

Research output: Contribution to journalArticleOtherpeer-review

High-density lipoprotein delivered after myocardial infarction increases cardiac glucose uptake and function in mice

Heywood, S. E., Richart, A. L., Henstridge, D. C., Alt, K., Kiriazis, H., Zammit, C., Carey, A. L., Kammoun, H. L., Delbridge, L. M., Reddy, M., Chen, Y. C., Du, X. J., Hagemeyer, C. E., Febbraio, M. A., Siebel, A. L. & Kingwell, B. A., 11 Oct 2017, In : Science Translational Medicine. 9, 411, 10 p., eaam6084.

Research output: Contribution to journalArticleResearchpeer-review

IL-1β delivers a sweet deal

Hjorth, M. & Febbraio, M. A., 15 Feb 2017, In : Nature Immunology. 18, 3, p. 247-248 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Increased liver AGEs induce hepatic injury mediated through an OST48 pathway

Zhuang, A., Yap, F. Y., Bruce, C., Leung, C., Plan, M. R., Sullivan, M. A., Herath, C. B., McCarthy, D., Sourris, K. C., Kantharidis, P., Coughlan, M. T., Febbraio, M. A., Hodson, M. P., Watt, M. J., Angus, P., Schulz, B. L. & Forbes, J. M., 1 Dec 2017, In : Scientific Reports. 7, 1, 12292.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Inflammation, but not recruitment, of adipose tissue macrophages requires signalling through Mac-1 (CD11B/CD18) in diet-induced obesity (DIO)

Wolf, D., Bukosza, N., Engel, D., Poggi, M., Jehle, F., Michel, N. A., Chen, Y. C., Colberg, C., Hoppe, N., Dufner, B., Boon, L., Blankenbach, H., Hilgendorf, I., Muhlen, C. V. Z., Reinöhl, J., Sommer, B., Marchini, T., Febbraio, M. A., Weber, C., Bode, C. & 3 othersPeter, K., Lutgens, E. & Zirlik, A., 2017, In : Thrombosis and Haemostasis. 117, 2, p. 325-338 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Muscle-specific overexpression of AdipoR1 or AdipoR2 gives rise to common and discrete local effects whilst AdipoR2 promotes additional systemic effects

Keshvari, S., Henstridge, D. C., Ng, C., Febbraio, M. A. & Whitehead, J. P., 1 Feb 2017, In : Scientific Reports. 7, 41792.

Research output: Contribution to journalArticleResearchpeer-review

Neutrophil-derived S100 calcium-binding proteins A8/A9 promote reticulated thrombocytosis and atherogenesis in diabetes

Kraakman, M. J., Lee, M. K. S., Al-Sharea, A., Dragoljevic, D., Barrett, T. J., Montenont, E., Basu, D., Heywood, S. E., Kammoun, H. L., Flynn, M., Whillas, A., Hanssen, N. M. J., Febbraio, M. A., Westein, E., Fisher, E. A., Chin-Dusting, J., Cooper, M. E., Berger, J. S., Goldberg, I. J., Nagareddy, P. R. & 1 othersMurphy, A. J., 1 Jun 2017, In : Journal of Clinical Investigation. 127, 6, p. 2133-2147 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Over-expressing the soluble gp130-Fc does not ameliorate methionine and choline deficient diet-induced non alcoholic steatohepatitis in mice

Kammoun, H. L., Allen, T. L., Henstridge, D. C., Kraakman, M. J., Peijs, L., Rose-John, S. & Febbraio, M. A., 20 Jun 2017, In : PLoS ONE. 12, 6, 13 p., e0179099.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Scriptaid enhances skeletal muscle insulin action and cardiac function in obese mice

Gaur, V., Connor, T., Venardos, K., Henstridge, D. C., Martin, S. D., Swinton, C., Morrison, S., Aston-Mourney, K., Gehrig, S. M., van Ewijk, R., Lynch, G. S., Febbraio, M. A., Steinberg, G. R., Hargreaves, M., Walder, K. R. & McGee, S. L., 1 Jul 2017, In : Diabetes, Obesity and Metabolism. 19, 7, p. 936-943 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

BGP-15 Improves Aspects of the Dystrophic Pathology in mdx and dko Mice with Differing Efficacies in Heart and Skeletal Muscle

Kennedy, T. L., Swiderski, K., Murphy, K. T., Gehrig, S. M., Curl, C. L., Chandramouli, C., Febbraio, M. A., Delbridge, L. M. D., Koopman, R. & Lynch, G. S., 1 Dec 2016, In : American Journal of Pathology. 186, 12, p. 3246-3260 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Disruption of the Class IIa HDAC Corepressor Complex Increases Energy Expenditure and Lipid Oxidation

Gaur, V., Connor, T., Sanigorski, A., Martin, S. D., Bruce, C. R., Henstridge, D. C., Bond, S. T., McEwen, K. A., Kerr-Bayles, L., Ashton, T. D., Fleming, C. L., Wu, M., Pike Winer, L. S., Chen, D., Hudson, G. M., Schwabe, J. W. R., Baar, K., Febbraio, M. A., Gregorevic, P., Pfeffer, F. M. & 3 othersWalder, K. R., Hargreaves, M. & McGee, S. L., 13 Sep 2016, In : Cell Reports. 16, 11, p. 2802-2810 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Exercise and the immune system: Implications for elite athletes and the general population

Lancaster, G. I. & Febbraio, M. A., 1 Feb 2016, In : Immunology and Cell Biology. 94, 2, p. 115-116 2 p.

Research output: Contribution to journalEditorialOtherpeer-review

Heat shock proteins and exercise adaptations. Our knowledge thus far and the road still ahead

Henstridge, D. C., Febbraio, M. A. & Hargreaves, M., 15 Mar 2016, In : Journal of Applied Physiology. 120, 6, p. 683-691 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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High fat diet inhibits dendritic cell and T cell response to allergens but does not impair inhalational respiratory tolerance

Pizzolla, A., Oh, D. Y., Luong, S., Prickett, S. R., Henstridge, D. C., Febbraio, M. A., O'Hehir, R. E., Rolland, J. M. & Hardy, C. L., 1 Aug 2016, In : PLoS ONE. 11, 8, 18 p., e0160407.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Male-lineage transmission of an acquired metabolic phenotype induced by grand-paternal obesity

Cropley, J. E., Eaton, S. A., Aiken, A., Young, P. E., Giannoulatou, E., Ho, J. W. K., Buckland, M. E., Keam, S. P., Hutvagner, G., Humphreys, D. T., Langley, K. G., Henstridge, D. C., Martin, D. I. K., Febbraio, M. A. & Suter, C. M., 1 Aug 2016, In : Molecular Metabolism. 5, 8, p. 699-708 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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NFκB1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells

de Valle, E., Grigoriadis, G., O'Rielly, L. A., Willis, S. N., Maxwell, M. J., Corcoran, L. M., Tsantikos, E., Cornish, J. K. S., Fairfax, K. A., Vasanthakumar, A., Febbraio, M. A., Hibbs, M. L., Pellegrini, M., Banerjee, A., Hodgkin, P. D., Kallies, A., Mackay, F., Strasser, A., Gerondakis, S. & Gugasyan, R., 4 Apr 2016, In : Journal of Experimental Medicine. 213, 4, p. 621-641 21 p., PMC4821646.

Research output: Contribution to journalArticleResearchpeer-review

PKR is not obligatory for high-fat diet-induced obesity and its associated metabolic and inflammatory complications

Lancaster, G. I., Kammoun, H. L., Kraakman, M. J., Kowalski, G. M., Bruce, C. R. & Febbraio, M. A., 3 Feb 2016, In : Nature Communications. 7, 10 p., 10626.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Targeting Disease through Metabolism

Green, D., DeBerardinis, R. & Febbraio, M., 16 Jun 2016, In : Cell. 165, 7, p. 1561-1562 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

The ever-expanding myokinome: Discovery challenges and therapeutic implications

Whitham, M. & Febbraio, M. A., 12 Sep 2016, In : Nature Reviews Drug Discovery. 15, 10, p. 719-729 11 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

The role of gp130 receptor cytokines in the regulation of metabolic homeostasis

Cron, L., Allen, T. L. & Febbraio, M. A., 1 Jan 2016, In : Journal of Experimental Biology. 219, 2, p. 259-265 7 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

The roles of c-Jun NH2-terminal kinases (JNKs) in obesity and insulin resistance

Pal, M., Febbraio, M. A. & Lancaster, G. I., 15 Jan 2016, In : The Journal of Physiology. 594, 2, p. 267-279 13 p.

Research output: Contribution to journalArticleOtherpeer-review

2015

Analysis of the liver lipidome reveals insights into the protective effect of exercise on high-fat diet-induced hepatosteatosis in mice

Jordy, A. B., Kraakman, M. J., Gardner, T., Estevez, E., Kammoun, H. L., Weir, J. M., Kiens, B., Meikle, P. J., Febbraio, M. A. & Henstridge, D. C., May 2015, In : American Journal of Physiology - Endocrinology and Metabolism. 308, 9, p. E778-E791 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation

Ramiscal, R. R., Parish, I. A., Lee-Young, R. S., Babon, J., Blagih, J., Pratama, A., Martin, J. L., Hawley, N., Cappello, J. Y., Nieto, P. F., Ellyard, J. I., Kershaw, N. J., Sweet, R. A., Goodnow, C. C., Jones, R. G., Febbraio, M. A., Vinuesa, C. G. & Athanasopoulos, V., 23 Oct 2015, In : eLife. 4, 22 p., e08698.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance

Kraakman, M. J., Kammoun, H. L., Allen, T. L., Deswaerte, V., Henstridge, D. C., Estevez, E., Matthews, V. B., Neill, B. A., White, D. A., Murphy, A. J., Peijs, L., Yang, C., Risis, S., Bruce, C. R., Du, X. J., Bobik, A., Lee-Young, R. S., Kingwell, B. A., Vasanthakumar, A., Shi, W. & 4 othersKallies, A., Lancaster, G. I., Rose-John, S. & Febbraio, M. A., 3 Mar 2015, In : Cell Metabolism. 21, 3, p. 403-416 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Erratum to: Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase [for 2008010335]

Matthews, V. B., Astrom, M. B., Chan, M. H. S., Bruce, C. R., Krabbe, K. S., Prelovsek, O., Akerstrom, T. C. A., Yfanti, C., Broholm, C., Mortensen, O. H., Penkowa, M., Hojman, P., Zankari, A., Watt, M. J., Bruunsgaard, H., Pedersen, B. K. & Febbraio, M. A., 2015, In : Diabetologia. 58, 4, p. 854 - 855 2 p.

Research output: Contribution to journalArticleOther

Exercise improves adipose function and inflammation and ameliorates fatty liver disease in obese diabetic mice

Haczeyni, F., Barn, V., Mridha, A. R., Yeh, M. M., Estevez, E., Febbraio, M. A., Nolan, C. J., Bell-Anderson, K. S., Teoh, N. C. & Farrell, G. C., 1 Sep 2015, In : Obesity. 23, 9, p. 1845-1855 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Fetuin B Is a Secreted Hepatocyte Factor Linking Steatosis to Impaired Glucose Metabolism

Meex, R. C., Hoy, A. J., Morris, A., Brown, R. D., Lo, C. Y. J., Burke, M. L., Goode, R. J. A., Kingwell, B. A., Kraakman, M. J., Febbraio, M. A., Greve, J. W., Rensen, S. S., Molloy, M. P., Lancaster, G. I., Bruce, C. R. & Watt, M. J., 2015, In : Cell Metabolism. 22, 6, p. 1078 - 1089 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Genetic manipulation of cardiac Hsp72 levels does not alter substrate metabolism but reveals insights into high-fat feeding-induced cardiac insulin resistance

Henstridge, D. C., Estevez, E., Allen, T. L., Heywood, S. E., Gardner, T., Yang, C., Mellett, N. A., Kingwell, B. A., Meikle, P. J. & Febbraio, M. A., 1 May 2015, In : Cell Stress and Chaperones. 20, 3, p. 461-472 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Long-term overexpression of Hsp70 does not protect against cardiac dysfunction and adverse remodeling in a murc transgenic mouse model with chronic heart failure and atrial fibrillation

Bernardo, B. C., Sapra, G., Patterson, N. L., Cemerlang, N., Kiriazis, H., Ueyama, T., Febbraio, M. A. & McMullen, J. R., 14 Dec 2015, In : PLoS ONE. 10, 12, 17 p., 0145173.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Mitochondrial dysfunction in oocytes of obese mothers: Transmission to offspring and reversal by pharmacological endoplasmic reticulum stress inhibitors

Wu, L., Russell, D. L., Wong, S. L., Chen, M., Tsai, T-S., St John, J. C., Norman, R. J., Febbraio, M. A., Carroll, J. G. & Robker, R., 2015, In : Development. 142, 4, p. 681 - 691 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Nanoporous metal-phenolic particles as ultrasound imaging probes for hydrogen peroxide

Guo, J., Wang, X., Henstridge, D. C., Richardson, J. J., Cui, J., Sharma, A., Febbraio, M. A., Peter, K., De Haan-Klein, J. B., Hagemeyer, C. E. & Caruso, F., 2015, In : Advanced Healthcare Materials. 4, 14, p. 2170 - 2175 6 p.

Research output: Contribution to journalArticleResearchpeer-review

The CDP-ethanolamine pathway regulates skeletal muscle diacylglycerol content and mitochondrial biogenesis without altering insulin sensitivity

Selathurai, A., Kowalski, G. M., Burch, M. L., Sepulveda, P. V., Risis, S., Lee-Young, R. S., Lamon, S., Meikle, P. J., Genders, A. J., McGee, S. L., Watt, M. J., Russell, A. P., Frank, M., Jackowski, S., Febbraio, M. A. & Bruce, C. R., 2015, In : Cell Metabolism. 21, 5, p. 718 - 730 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance

Henstridge, D. C., Bruce, C. R., Drew, B. G., Tory, K., Kolonics, A., Estevez, E., Chung, J., Watson, N., Gardner, T., Lee-Young, R. S., Connor, T., Watt, M. J., Carpenter, K., Hargreaves, M., McGee, S. L., Hevener, A. & Febbraio, M. A., 2014, In : Diabetes. 63, 6, p. 1881 - 1894 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Adipose tissue inflammation in glucose metabolism

Kammoun, H. L., Kraakman, M. J. & Febbraio, M. A., 2014, In : Reviews in Endocrine & Metabolic Disorders. 15, 1, p. 31 - 44 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Chaperoning to the metabolic party: The emerging therapeutic role of heat-shock proteins in obesity and type 2 diabetes

Henstridge, D. C., Whitham, M. & Febbraio, M. A., 1 Nov 2014, In : Molecular Metabolism. 3, 8, p. 781-793 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access

Coinhibitory suppression of t cell activation by CD40 protects against obesity and adipose tissue inflammation in mice

Wolf, D., Jehle, F., Michel, N. A., Bukosza, E. N., Rivera, J., Chen, Y. C., Hoppe, N., Dufner, B., Rodriguez, A. O., Colberg, C., Nieto, L., Rupprecht, B., Wiedemann, A., Schulte, L., Peikert, A., Bassler, N., Lozhkin, A., Hergeth, S. P., Stachon, P., Hilgendorf, I. & 11 othersWillecke, F., Von Zur Mühlen, C., von Elverfeldt, D., Binder, C. J., Aichele, P., Varo, N., Febbraio, M. A., Libby, P., Bode, C., Peter, K. & Zirlik, A., 10 Jun 2014, In : Circulation. 129, 23, p. 2414-2425 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Come on BAIBA light my fire

Kammoun, H. L. & Febbraio, M. A., 7 Jan 2014, In : Cell Metabolism. 19, 1, 2 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Erratum: The transcription factor IRF4 is essential for TCR affinity-mediated metabolic programming and clonal expansion of T cells (Nature Immunology (2013) 14 (1155-1165 ))

Man, K., Miasari, M., Shi, W., Xin, A., Henstridge, D. C., Preston, S. P., Pellegrini, M., Belz, G. T., Smyth, G. K., Febbraio, M. A., Nutt, S. L. & Kallies, A., 2014, In : Nature Immunology. 15, 9, p. 894 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

From cytokine to myokine: The emerging role of interleukin-6 in metabolic regulation

Pal, M., Febbraio, M. A. & Whitham, M., 2014, In : Immunology and Cell Biology. 92, 4, p. 331-339 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

HSP72 is a mitochondrial stress sensor critical for Parkin action, oxidative metabolism, and insulin sensitivity in skeletal muscle

Drew, B. G., Ribas, V., Le, J. A., Henstridge, D. C., Phun, J., Zhou, Z., Soleymani, T., Daraei, P., Sitz, D., Vergnes, L., Wanagat, J., Reue, K., Febbraio, M. A. & Hevener, A. L., 2014, In : Diabetes. 63, 5, p. 1488-1505 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors

Haeusler, R. A., Hartil, K., Vaitheesvaran, B., Arrieta-Cruz, I., Knight, C. M., Cook, J. R., Kammoun, H. L., Febbraio, M. A., Gutierrez-Juarez, R., Kurland, I. J. & Accili, D., 13 Oct 2014, In : Nature Communications. 5, 5190.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Role of IL-6 in exercise training- and cold-induced UCP1 expression in subcutaneous white adipose tissue

Knudsen, J. G., Murholm, M., Carey, A. L., Biensø, R. S., Basse, A. L., Allen, T. L., Hidalgo, J., Kingwell, B. A., Febbraio, M. A., Hansen, J. B. & Pilegaard, H., 8 Jan 2014, In : PLoS ONE. 9, 1, 8 p., e84910.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Role of interleukins in obesity: Implications for metabolic disease

Febbraio, M. A., 2014, In : Trends in Endocrinology and Metabolism. 25, 6, p. 312-319 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

Mauer, J., Chaurasia, B., Goldau, J., Vogt, M. C., Ruud, J., Nguyen, K. D., Theurich, S., Hausen, A. C., Schmitz, J., Brönneke, H. S., Estevez, E., Allen, T. L., Mesaros, A., Partridge, L., Febbraio, M. A., Chawla, A., Wunderlich, F. T. & Brüning, J. C., 2014, In : Nature Immunology. 15, 5, p. 423-430 8 p.

Research output: Contribution to journalArticleResearchpeer-review

The dual-specificity phosphatase 2 (DUSP2) does not regulate obesity-associated inflammation or insulin resistance in mice

Lancaster, G. I., Kraakman, M. J., Kammoun, H. L., Langley, K. G., Estevez, E., Banerjee, A., Grumont, R. J., Febbraio, M. A. & Gerondakis, S. D., 2014, In : PLoS ONE. 9, 11, 8 p., e111524.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The immunomodulating role of exercise in metabolic disease

Lancaster, G. I. & Febbraio, M. A., 2014, In : Trends in Immunology. 35, 6, p. 262-269 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice

Sapra, G., Tham, Y. K., Cemerlang, N., Matsumoto, A., Kiriazis, H., Bernardo, B. C., Henstridge, D. C., Ooi, J. Y. Y., Pretorius, L., Boey, E. J. H., Lim, L., Sadoshima, J., Meikle, P. J., Mellett, N. A., Woodcock, E. A., Marasco, S., Ueyama, T., Du, X-J., Febbraio, M. A. & McMullen, J. R., 2014, In : Nature Communications. 5, p. 1 - 16 16 p., 5705.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2013

Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding

Turner, N., Kowalski, G., Leslie, S. J., Risis, S., Yang, C., Lee-Young, R. S., Babb, J. R., Meikle, P. J., Lancaster, G. I., Henstridge, D. C., White, P. J., Kraegen, E. W., Marette, A., Cooney, G. J., Febbraio, M. A. & Bruce, C., 2013, In : Diabetologia. 56, 7, p. 1638 - 1648 11 p.

Research output: Contribution to journalArticleResearchpeer-review