Projects per year
Personal profile
Biography
Mark A Febbraio
Professor Mark Febbraio is a Senior Principal Research Fellow of the NHMRC, and the Head of the Cellular and Molecular Metabolism Laboratory within the Drug Discovery Program at Monash Institute of Pharmaceutical Sciences, Monash University Australia. He is also the CSO of N-Gene Research Laboratories Inc., a USA based Biotechnology Company and the Founder and CSO of the recently incorporated company Kinomedica. His research is focussed on understanding mechanisms associated with exercise, obesity, type 2 diabetes and cancer and his aim is to develop novel drugs to treat lifestyle related diseases. He has authored over 260 peer reviewed papers in leading journals, has over 35,000 career citations and an H factor of 105. He has won prizes at international, national and institutional levels including the A K McIntyre Prize for significant contributions to Australian Physiological Science (1999), the ESA/ADS Joint Plenary Lecture (2009), the Sandford Skinner Oration from the University of Melbourne (2011), Eureka Scientific Prize Finalist (2013) and the Kellion Award for the Australian Diabetes Society (2017).
Research area keywords
- Cell Metabolism
- Diabetes
- Cancer Biology
- Exercise physiology
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 15 Finished
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Targeting gut ceramides - a new way to improve systemic insulin sensitivity
Turpin-Nolan, S. (Primary Chief Investigator (PCI)) & Febbraio, M. (Chief Investigator (CI))
15/01/24 → 14/01/25
Project: Research
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Advancing Preclinical Development of Novel GPCR-targeted Therapeutics for Heart Failure
Ritchie, R. (Primary Chief Investigator (PCI)), Figtree, G. A. (Chief Investigator (CI)), Qin, C. H. (Chief Investigator (CI)), May, L. (Chief Investigator (CI)), Nicholls, S. (Chief Investigator (CI)), Taylor, A. (Chief Investigator (CI)), Yang, J. Y. H. (Chief Investigator (CI)), Shackleford, D. (Chief Investigator (CI)), Schiattarella, G. (Chief Investigator (CI)), Pinto, A. (Chief Investigator (CI)), Drummond, G. (Chief Investigator (CI)), Horowitz, J. D. (Chief Investigator (CI)), Bubb, K. (Chief Investigator (CI)), Vecchio, L. (Associate Investigator (AI)), Nelson, A. (Associate Investigator (AI)), Kirkpatrick, C. (Associate Investigator (AI)), McDonald, C. (Associate Investigator (AI)), Febbraio, M. (Associate Investigator (AI)), Vinh, A. (Associate Investigator (AI)), Odiba, J. (Associate Investigator (AI)), Brown, H. (Associate Investigator (AI)) & Stupple, P. (Chief Investigator (CI))
1/02/23 → 31/07/26
Project: Research
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Mapping and defining inter-organ cross talk during exercise
Febbraio, M. (Primary Chief Investigator (PCI)) & Ramm, G. (Partner Investigator (PI))
29/06/22 → 31/12/24
Project: Research
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Role of extracellular vesicles in exercise-induced protection of liver steatosis and insulin resistance
Febbraio, M. (Primary Chief Investigator (PCI)), Karin, M. (Chief Investigator (CI)) & Whitham, M. (Chief Investigator (CI))
Diabetes Australia, Monash University – Internal School Contribution
1/01/22 → 31/12/22
Project: Research
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Targeting Immune Checkpoints In Obesity-Driven HCC
Wiede, F. (Primary Chief Investigator (PCI)), Tiganis, T. (Associate Investigator (AI)), Darcy, P. (Associate Investigator (AI)), Johnstone, R. W. (Associate Investigator (AI)), McLean, C. (Associate Investigator (AI)) & Febbraio, M. (Associate Investigator (AI))
1/07/21 → 30/06/23
Project: Research
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Convergence on CaMK4: A Key Modulator of Autism-Associated Signaling Pathways in Neurons
Kaiser, J., Risteska, A., Muller, A. G., Sun, H., Lei, B., Nay, K., Means, A. R., Cousin, M. A., Drewry, D. H., Oakhill, J. S., Kemp, B. E., Hannan, A. J., Berk, M., Febbraio, M. A., Gundlach, A. L., Hill-Yardin, E. L. & Scott, J. W., 1 Mar 2025, In: Biological Psychiatry. 97, 5, p. 439-449 11 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access11 Link opens in a new tab Citations (Scopus) -
Decorin, an exercise-induced secretory protein, is associated with improved prognosis in breast cancer patients but does not mediate anti-tumorigenic tissue crosstalk in mice
Hjorth, M., Egan, C. L., Telles, G. D., Pal, M., Gallego-Ortega, D., Fuller, O. K., McLennan, E. D., Gillis, R. D., Oh, T. G., Muscat, G. E. O., Tegegne, S., Mah, M. S. M., Skhinas, J., Estevez, E., Adams, T. E., McKay, M. J., Molloy, M., Watt, K. I., Qian, H. & Gregorevic, P. & 11 others, , Dec 2025, In: Journal of Sport and Health Science. 14, 18 p., 100991.Research output: Contribution to journal › Article › Research › peer-review
Open Access13 Link opens in a new tab Citations (Scopus) -
Exercising through cancer: Physical activity as medicine for cancer care
Nash, D. M., Terry, L. V. & Febbraio, M. A., 8 Dec 2025, In: Cancer Cell. 43, 12, p. 2175-2180 6 p.Research output: Contribution to journal › Comment / Debate › Other › peer-review
3 Link opens in a new tab Citations (Scopus) -
Extracellular vesicles contribute to the beneficial effects of exercise training in APP/PS1 mice
Fuller, O. K., McLennan, E. D., Egan, C. L., Perera, N., Terry, L. V., Pyun, J., de Mendonca, M., Telles, G. D., Smeuninx, B., Burrows, E. L., Siddiqui, G., Creek, D. J., Scott, J. W., Pearen, M. A., Fonseka, P., Nicolazzo, J. A., Mathivanan, S., Hannan, A. J., Ramm, G. A. & Whitham, M. & 1 others, , 21 Feb 2025, In: iScience. 28, 2, 23 p., 111752.Research output: Contribution to journal › Article › Research › peer-review
Open Access16 Link opens in a new tab Citations (Scopus) -
Harnessing the therapeutic potential of exercise in extracellular vesicle-based therapy in metabolic disease associated cardiovascular complications
Perera, N., De Blasio, M. J. & Febbraio, M. A., Jan 2025, In: Free Radical Biology and Medicine. 226, p. 230-236 7 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access8 Link opens in a new tab Citations (Scopus)