Marina Harper

Dr

1990 …2022

Research output per year

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Research Output

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Article
2019

Polymyxin resistance in Klebsiella pneumoniae: multifaceted mechanisms utilized in the presence and absence of the plasmid-encoded phosphoethanolamine transferase gene mcr-1

Nang, S. C., Han, M-L., Yu, H. H., Wang, J., Torres, V. V. L., Dai, C., Velkov, T., Harper, M. & Li, J., 1 Nov 2019, In : Journal of Antimicrobial Chemotherapy. 74, 11, p. 3190-3198 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Systematic identification and analysis of Acinetobacter baumannii type vi secretion system effector and immunity components

Lewis, J. M., Deveson Lucas, D., Harper, M. & Boyce, J. D., 30 Oct 2019, In : Frontiers in Microbiology. 10, 23 p., 2440.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2018

Determination of the small RNA GcvB regulon in the Gram-negative bacterial pathogen Pasteurella multocida and identification of the GcvB seed binding region

Gulliver, E. L., Wright, A., Deveson, D., Megroz, M., Kleifeld, O., Schittenhelm, R. B., Powell, D. R., Seemann, T., Bulitta, J. B., Harper, M. & Boyce, J. D., 1 May 2018, In : RNA. 24, 5, p. 704-720 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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7 Citations (Scopus)

Emergence of high-level colistin resistance in an acinetobacter baumannii clinical isolate mediated by inactivation of the global regulator H-NS

Lucas, D. D., Crane, B., Wright, A., Han, M-L., Moffatt, J., Bulach, D., Gladman, S. L., Powell, D., Aranda, J., Seemann, T., Machado, D., Pacheco, T., Marques, T., Viveiros, M., Nation, R., Li, J., Harper, M. & Boyce, J. D., 1 Jul 2018, In : Antimicrobial Agents and Chemotherapy. 62, 7, 17 p., e02442-17.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Identification of novel Acinetobacter baumannii type VI secretion system antibacterial effector and immunity pairs

Fitzsimons, T. C., Lewis, J. M., Wright, A., Kleifeld, O., Schittenhelm, R. B., Powell, D., Harper, M. & Boyce, J. D., 1 Aug 2018, In : Infection and Immunity. 86, 8, 23 p., e00297-18.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)
2017

Characterization of two novel lipopolysaccharide phosphoethanolamine transferases in Pasteurella multocida and their role in resistance to cathelicidin-2

Harper, M., Wright, A., Michael, F. S., Li, J., Lucas, D. D., Ford, M., Adler, B., Cox, A. D. & Boyce, J. D., Nov 2017, In : Infection and Immunity. 85, 11, 16 p., e00557-17.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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6 Citations (Scopus)
2016

Perturbation of the two-component signal transduction system, BprRS, results in attenuated virulence and motility defects in Burkholderia pseudomallei

Lazar Adler, N. R., Allwood, E. M., Deveson Lucas, D., Harrison, P., Watts, S., Dimitropoulos, A., Treerat, P., Alwis, P., Devenish, R. J., Prescott, M., Govan, B., Adler, B., Harper, M. & Boyce, J. D., 4 May 2016, In : BMC Genomics. 17, 17 p., 331.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
7 Citations (Scopus)

Protective efficacy afforded by live Pasteurella multocida vaccines in chickens is independent of lipopolysaccharide outer core structure

Harper, M., John, M., Edmunds, M., Wright, A. A., Ford, M. E., Turni, C., Blackall, P. J., Cox, A. D., Adler, B. & Boyce, J. D., 2016, In : Vaccine. 34, 14, p. 1696 - 1703 8 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)
2015

Characterization of the lipopolysaccharide produced by Pasteurella multocida serovars 6, 7 and 16: identification of lipopolysaccharide genotypes L4 and L8

Harper, M., St Michael, F., Steen, J. A., John, M., Wright, A. L., van Dorsten, L., Vinogradov, E., Adler, B., Cox, A. D. & Boyce, J. D., 2015, In : Glycobiology. 25, 3, p. 294 - 302 9 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Comparative genomic analysis of asian haemorrhagic septicaemia-associated strains of pasteurella multocida identifies more than 90 haemorrhagic septicaemia-specific genes

Moustafa, A. M., Seemann, T., Gladman, S. L., Adler, B., Harper, M., Boyce, J. D. & Bennett, M. D., 2015, In : PLoS ONE. 10, 7, 16 p., e0130296.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
21 Citations (Scopus)

Development of a rapid multiplex PCR assay to genotype pasteurella multocida strains by use of the lipopolysaccharide outer core biosynthesis locus

Harper, M., John, M., Turni, C., Edmunds, M. L., St Michael, F., Adler, B., Blackall, P. J., Cox, A. D. & Boyce, J. D., 2015, In : Journal of Clinical Microbiology. 53, 2, p. 477 - 485 9 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

The transcriptomic response of Acinetobacter baumannii to colistin and doripenem alone and in combination in an in vitro pharmacokinetics/pharmacodynamics model

Henry, R. M., Crane, B. A., Powell, D. R., Deveson-Lucas, D. S., Li, Z., Aranda, J., Harrison, P. F., Nation, R. L., Adler, B., Harper, M., Boyce, J. D. & Li, J., 2015, In : Journal of Antimicrobial Chemotherapy. 70, 5, p. 1303 - 1313 11 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)
2014

Biological cost of different mechanisms of colistin resistance and their impact on virulence in Acinetobacter baumannii

Beceiro, A., Moreno, A., Fernandez, N., Vallejo, J. A., Aranda, J., Adler, B., Harper, M., Boyce, J. D. & Bou, G., 2014, In : Antimicrobial Agents and Chemotherapy. 58, 1, p. 518 - 526 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
113 Citations (Scopus)

Structural analysis of lipopolysaccharide produced by Heddleston serovars 10, 11, 12 and 15 and the identification of a new Pasteurella multocida lipopolysaccharide outer core biosynthesis locus, L6

Harper, M., St Michael, F., John, M., Steen, J. A., van Dorsten, L., Parnas, H., Vinogradov, E., Adler, B., Cox, A. D. & Boyce, J. D., 2014, In : Glycobiology. 24, 7, p. 649 - 659 11 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)
2013
37 Citations (Scopus)

Pasteurella multocida Heddleston serovar 3 and 4 strains share a common lipopolysaccharide biosynthesis locus but display both inter- and intrastrain lipopolysaccharide heterogeneity

Harper, M., St Michael, F., John, M., Vinogradov, E., Steen, J. A., van Dorsten, L., Steen, J. A., Turni, C., Blackall, P. J., Adler, B., Cox, A. D. & Boyce, J. D., 2013, In : Journal of Bacteriology. 195, 21, p. 4854 - 4864 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
21 Citations (Scopus)

Structure and biosynthetic locus of the lipopolysaccharide outer core produced by Pasteurella multocida serovars 8 and 13 and the identification of a novel phospho-glycero moiety

Harper, M., St Michael, F., Vinogradov, E., John, M., Steen, J. A., van Dorsten, L., Boyce, J. D., Adler, B. & Cox, A. D., 2013, In : Glycobiology. 23, 3, p. 286 - 294 9 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)
2012
6 Citations (Scopus)

Characterization of the lipopolysaccharide from Pasteurella multocida Heddleston serovar 9: identification of a proposed bi-functional dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis enzyme

Harper, M., St Michael, F., Vinogradov, E., John, M., Boyce, J. D., Adler, B. & Cox, A. D., 2012, In : Glycobiology. 22, 3, p. 332 - 344 13 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Pasteurella multocida: diseases and pathogenesis

Wilkie, I. W., Harper, M., Boyce, J. D. & Adler, B., 2012, In : Current topics in microbiology and immunology. 361, p. 1 - 22 22 p.

Research output: Contribution to journalArticleResearchpeer-review

98 Citations (Scopus)

Pathogenomics of pasteurella multocida

Boyce, J. D., Seemann, T., Adler, B. & Harper, M., 2012, In : Current topics in microbiology and immunology. 361, p. 23 - 38 16 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

The key surface components of pasteurella multocida: capsule and lipopolysaccharide

Harper, M., Boyce, J. D. & Adler, B., 2012, In : Current topics in microbiology and immunology. 361, p. 39 - 51 13 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)
2011
51 Citations (Scopus)
24 Citations (Scopus)
92 Citations (Scopus)

Pasteurella multocida Heddleston serovars 1 and 14 express different lipopolysaccharide structures but share the same lipopolysaccharide biosynthesis outer core locus

Harper, M., St Michael, F., John, M., Vinogradov, E., Adler, B., Boyce, J. D. & Cox, A. D., 2011, In : Veterinary Microbiology. 150, 3-4, p. 289 - 296 8 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Pasteurella multocida lipopolysaccharide: The long and the short of it

Harper, M., Cox, A., Adler, B. & Boyce, J., 2011, In : Veterinary Microbiology. 153, 1-2, p. 109 - 115 7 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)
2010

Colistin resistance in Acinetobacter baumannii is mediated by complete loss of lipopolysaccharide production

Moffatt, J. H., Harper, M., Harrison, P. F., Hale, J. DF., Vinogradov, E., Seemann, T., Henry, R. M., Crane, B. A., St Michael, F., Cox, A. D., Adler, B., Nation, R. L., Li, J. & Boyce, J. D., 2010, In : Antimicrobial Agents and Chemotherapy. 54, 12, p. 4971 - 4977 7 p.

Research output: Contribution to journalArticleResearchpeer-review

365 Citations (Scopus)

Fis is essential for capsule production in Pasteurella multocida and regulates expression of other important virulence factors

Steen, J. A., Steen, J. A., Harrison, P. F., Seemann, T., Wilkie, I. W., Harper, M., Adler, B. & Boyce, J. D., 2010, In : PLoS Pathogens. 6, 2, p. e1000750-1 - e1000750-14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

Natural selection in the chicken host identifies 3-deoxy-D-manno- octulosonic acid kinase residues essential for phosphorylation of Pasteurella multocida lipopolysaccharide

Harper, M., Cox, A. D., St Michael, F., Ford, M., Wilkie, I. W., Adler, B. & Boyce, J. D., 2010, In : Infection and Immunity. 78, 9, p. 3669 - 3677 9 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)
2009

Identification of novel glycosyltransferases required for assembly of the Pasteurella multocida A:1 lipopolysaccharide and their involvement in virulence

Boyce, J. D., Harper, M., St Michael, F., John, M., Aubry, A., Parnas, H., Logan, S. M., Wilkie, I. W., Ford, M. E., Cox, A. D. & Adler, B., 2009, In : Infection and Immunity. 77, 4, p. 1532 - 1542 11 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Structural and genetic basis for the serological differentiation of Pasteurella multocida Heddleston Serotypes 2 and 5

St Michael, F., Harper, M., Parnas, H., John, M., Stupak, J., Vinogradov, E., Adler, B., Boyce, J. D. & Cox, A. D., 2009, In : Journal of Bacteriology. 191, 22, p. 6950 - 6959 10 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

The molecular and cellular basis of pathogenesis in melioidosis: How does Burkholderia pseudomallei cause disease?

Lazar Adler, N. R., Govan, B., Cullinane, M., Harper, M., Adler, B. & Boyce, J. D., 2009, In : FEMS Microbiology Reviews. 33, 6, p. 1079 - 1099 21 p.

Research output: Contribution to journalArticleResearchpeer-review

103 Citations (Scopus)
2007

Decoration of pasteurella multocida lipopolysaccharide with phosphocholine is important for virulence

Harper, M., Cox, A. D., St Michael, F., Parnas, H., Wilkie, I. W., Blackall, P. J., Adler, B. & Boyce, J. D., 2007, In : Journal of Bacteriology. 189, 20, p. 7384 - 7391 8 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Pasteurella multocida expresses two lipopolysaccharide glycoforms simultaneously, but only a single form is required for virulence: Identification of two acceptor-specific heptosyl I transferases

Harper, M., Boyce, J. D., Cox, A. D., St Michael, F., Wilkie, I. W., Blackall, P. J. & Adler, B., 2007, In : Infection and Immunity. 75, 8, p. 3885 - 3893 9 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)
2006

Pasteurella multocida pathogenesis: 125 years after Pasteur

Harper, M., Boyce, J. D. & Adler, B., 2006, In : FEMS Microbiology Letters. 265, 1, p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

220 Citations (Scopus)
2005

Structural analysis of the lipopolysaccharide of Pasteurella multocida strain VP161: Identification of both Kdo-P and Kdo-Kdo species in the lipopolysaccharide

St. Michael, F., Li, J., Vinogradov, E., Larocque, S., Harper, M. & Cox, A. D., 2005, In : Carbohydrate Research. 340, 1, p. 59 - 68 10 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)
2004

A heptosyltransferase mutant of Pasteurella multocida produces a truncated lipopolysaccharide structure and Is attenuated in virulence

Harper, M., Cox, A. D., St Michael, F., Wilkie, I. W., Boyce, J. D. & Adler, B., 2004, In : Infection and Immunity. 72, 6, p. 3436 - 3443 8 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

Genomic-scale analysis of Pasteurella multocida gene expression during growth within liver tissue of chickens with fowl cholera

Boyce, J. D., Wilkie, I. W., Harper, M., Paustian, M. L., Kapur, V. & Adler, B., 2004, In : Microbes and Infection. 6, 3, p. 290 - 298 9 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)
2003

Signature-tagged mutagenesis of Pasteurella multocida identifies mutants displaying differential virulence characteristics in mice and chickens

Harper, M., Boyce, J. D., Wilkie, I. W. & Adler, B., 2003, In : Infection and Immunity. 71, 9, p. 5440 - 5446 7 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)
2002

Genomic Scale Analysis of Pasteurella multocida Gene Expression during Growth within the Natural Chicken Host

Boyce, J. D., Wilkie, I., Harper, M., Paustian, M. L., Kapur, V. & Adler, B., 2002, In : Infection and Immunity. 70, 12, p. 6871 - 6879 9 p.

Research output: Contribution to journalArticleResearchpeer-review

82 Citations (Scopus)
2000

Overexpression and immunogenicity of the Oma87 outer membrane protein of Pasteurella multocida

Harper (Mitchison), M., Wei, L., Kwang, J., Wilkie, I. & Adler, B., 2000, In : Veterinary Microbiology. 72, 1-2, p. 91 - 96 6 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)
1997
44 Citations (Scopus)
1991

Molecular analysis of a Leptospira borgpetersenii gene encoding an endoflagellar subunit protein

Harper (Mitchison), M., Rood, J. I., Faine, S. & Adler, B., 1991, In : Journal of General Microbiology. 137, 7, p. 1529-1536 8 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)
1990

Identification and genetic mapping of proteins encoded in the fimbrial subunit gene region of Bacteroides nodosus

Billington, S. J., Harper (Mitchison), M., Adler, B. & Rood, J. I., 1990, In : Veterinary Microbiology. 22, 1, p. 53-68 16 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)