Marina Harper

Dr

1990 …2022
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Personal profile

Biography

Dr Marina Harper works in the Faculty of Medicine, Nursing and Health Sciences at Monash University as a Research Fellow. Marina has extensive research experience microbial genetics and molecular biology. The focus of her research is on pathogenic Gram-negative bacteria and their virulence factors, and how the expression of these factors is regulated. This work utilizes a wide range of molecular techniques, including mutagenesis, combined with a range of cutting edge techniques including next generation genomic and transcriptomic analyses. Dr Harper is a world expert on the biology of the Pasteurella multocida, together with collaborators her work has shown the importance of lipopolysaccharide (LPS) and capsule in virulence, elucidated the structure of the LPS and revealed that LPS is a critical protective antigen in killed whole-cell vaccines but is not a protective antigen in live attenuated vaccines. 

Keywords

  • Bacterial Pathogenesis
  • Pasteurella Multocida
  • Acinetobacter Baumannii
  • lipopolysaccharide
  • Molecular Biology
  • transcriptomics

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Projects 2017 2022

Research Output 1990 2018

Determination of the small RNA GcvB regulon in the Gram-negative bacterial pathogen Pasteurella multocida and identification of the GcvB seed binding region

Gulliver, E. L., Wright, A., Deveson, D., Megroz, M., Kleifeld, O., Schittenhelm, R. B., Powell, D. R., Seemann, T., Bulitta, J. B., Harper, M. & Boyce, J. D., 1 May 2018, In : Rna-A Publication of the Rna Society. 24, 5, p. 704-720 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Emergence of high-level colistin resistance in an acinetobacter baumannii clinical isolate mediated by inactivation of the global regulator H-NS

Lucas, D. D., Crane, B., Wright, A., Han, M-L., Moffatt, J., Bulach, D., Gladman, S. L., Powell, D., Aranda, J., Seemann, T., Machado, D., Pacheco, T., Marques, T., Viveiros, M., Nation, R., Li, J., Harper, M. & Boyce, J. D., 1 Jul 2018, In : Antimicrobial Agents and Chemotherapy. 62, 7, 17 p., e02442-17.

Research output: Contribution to journalArticleResearchpeer-review

Identification of novel Acinetobacter baumannii type VI secretion system antibacterial effector and immunity pairs

Fitzsimons, T. C., Lewis, J. M., Wright, A., Kleifeld, O., Schittenhelm, R. B., Powell, D., Harper, M. & Boyce, J. D., 1 Aug 2018, In : Infection and Immunity. 86, 8, 23 p., e00297-18.

Research output: Contribution to journalArticleResearchpeer-review

Characterization of two novel lipopolysaccharide phosphoethanolamine transferases in Pasteurella multocida and their role in resistance to cathelicidin-2

Harper, M., Wright, A., Michael, F. S., Li, J., Lucas, D. D., Ford, M., Adler, B., Cox, A. D. & Boyce, J. D., Nov 2017, In : Infection and Immunity. 85, 11, 16 p., e00557-17.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

The myriad properties of Pasteurella multocida lipopolysaccharide

Harper, M. & Boyce, J. D., 21 Aug 2017, In : Toxins. 9, 8, 21 p., 254.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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