Projects per year
Personal profile
Biography
Dr Marina Harper works in the Faculty of Medicine, Nursing and Health Sciences at Monash University as a Research Fellow. Marina has extensive research experience microbial genetics and molecular biology. The focus of her research is on pathogenic Gram-negative bacteria and their virulence factors, and how the expression of these factors is regulated. This work utilizes a wide range of molecular techniques, including mutagenesis, combined with a range of cutting edge techniques including next generation genomic and transcriptomic analyses. Dr Harper is a world expert on the biology of the Pasteurella multocida, together with collaborators her work has shown the importance of lipopolysaccharide (LPS) and capsule in virulence, elucidated the structure of the LPS and revealed that LPS is a critical protective antigen in killed whole-cell vaccines but is not a protective antigen in live attenuated vaccines.
Research area keywords
- Bacterial Pathogenesis
- Pasteurella Multocida
- Acinetobacter Baumannii
- lipopolysaccharide
- Molecular Biology
- transcriptomics
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Projects 2017 2022
- 3 Active
Overcoming multidrug-resistant hypermutable Pseudomonas aeruginosa via antibiotic combinations
Landersdorfer, C., Oliver, A., Harper, M. & Nation, R.
National Health & Medical Research Council (NHMRC)
1/01/19 → 31/12/22
Project: Research
Co-opting bacterial weaponry: Manipulation of the Acinetobacter type VI secretion system for targeted killing of bacteria
Boyce, J., Harper, M. & Drinkwater, N.
1/01/19 → 31/12/21
Project: Research
Research Output 1990 2019
Mechanisms of Polymyxin Resistance
Moffatt, J. H., Harper, M. & Boyce, J. D., Jul 2019, Polymyxin Antibiotics: From Laboratory Bench to Bedside. Li, J., Nation, R. L. & Kaye, K. S. (eds.). Switzerland: Springer, p. 55-71 17 p. (Advances in Experimental Medicine and Biology; vol. 1145).Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review
Determination of the small RNA GcvB regulon in the Gram-negative bacterial pathogen Pasteurella multocida and identification of the GcvB seed binding region
Gulliver, E. L., Wright, A., Deveson, D., Megroz, M., Kleifeld, O., Schittenhelm, R. B., Powell, D. R., Seemann, T., Bulitta, J. B., Harper, M. & Boyce, J. D., 1 May 2018, In : Rna-A Publication of the Rna Society. 24, 5, p. 704-720 17 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Emergence of high-level colistin resistance in an acinetobacter baumannii clinical isolate mediated by inactivation of the global regulator H-NS
Lucas, D. D., Crane, B., Wright, A., Han, M-L., Moffatt, J., Bulach, D., Gladman, S. L., Powell, D., Aranda, J., Seemann, T., Machado, D., Pacheco, T., Marques, T., Viveiros, M., Nation, R., Li, J., Harper, M. & Boyce, J. D., 1 Jul 2018, In : Antimicrobial Agents and Chemotherapy. 62, 7, 17 p., e02442-17.Research output: Contribution to journal › Article › Research › peer-review
Identification of novel Acinetobacter baumannii type VI secretion system antibacterial effector and immunity pairs
Fitzsimons, T. C., Lewis, J. M., Wright, A., Kleifeld, O., Schittenhelm, R. B., Powell, D., Harper, M. & Boyce, J. D., 1 Aug 2018, In : Infection and Immunity. 86, 8, 23 p., e00297-18.Research output: Contribution to journal › Article › Research › peer-review
Characterization of two novel lipopolysaccharide phosphoethanolamine transferases in Pasteurella multocida and their role in resistance to cathelicidin-2
Harper, M., Wright, A., Michael, F. S., Li, J., Lucas, D. D., Ford, M., Adler, B., Cox, A. D. & Boyce, J. D., Nov 2017, In : Infection and Immunity. 85, 11, 16 p., e00557-17.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File