Marina Harper

Dr

1990 …2022
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Personal profile

Biography

Dr Marina Harper works in the Faculty of Medicine, Nursing and Health Sciences at Monash University as a Research Fellow. Marina has extensive research experience microbial genetics and molecular biology. The focus of her research is on pathogenic Gram-negative bacteria and their virulence factors, and how the expression of these factors is regulated. This work utilizes a wide range of molecular techniques, including mutagenesis, combined with a range of cutting edge techniques including next generation genomic and transcriptomic analyses. Dr Harper is a world expert on the biology of the Pasteurella multocida, together with collaborators her work has shown the importance of lipopolysaccharide (LPS) and capsule in virulence, elucidated the structure of the LPS and revealed that LPS is a critical protective antigen in killed whole-cell vaccines but is not a protective antigen in live attenuated vaccines. 

Research area keywords

  • Bacterial Pathogenesis
  • Pasteurella Multocida
  • Acinetobacter Baumannii
  • lipopolysaccharide
  • Molecular Biology
  • transcriptomics

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Projects 2017 2022

Research Output 1990 2019

1 Citation (Scopus)

Mechanisms of Polymyxin Resistance

Moffatt, J. H., Harper, M. & Boyce, J. D., Jul 2019, Polymyxin Antibiotics: From Laboratory Bench to Bedside. Li, J., Nation, R. L. & Kaye, K. S. (eds.). Switzerland: Springer, p. 55-71 17 p. (Advances in Experimental Medicine and Biology; vol. 1145).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Polymyxin resistance in Klebsiella pneumoniae: multifaceted mechanisms utilized in the presence and absence of the plasmid-encoded phosphoethanolamine transferase gene mcr-1

Nang, S. C., Han, M-L., Yu, H. H., Wang, J., Torres, V. V. L., Dai, C., Velkov, T., Harper, M. & Li, J., 1 Nov 2019, In : Journal of Antimicrobial Chemotherapy. 74, 11, p. 3190-3198 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Systematic identification and analysis of acinetobacter baumannii type vi secretion system effector and immunity components

Lewis, J. M., Deveson Lucas, D., Harper, M. & Boyce, J. D., 30 Oct 2019, In : Frontiers in Microbiology. 10, 23 p., 2440.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
5 Citations (Scopus)

Determination of the small RNA GcvB regulon in the Gram-negative bacterial pathogen Pasteurella multocida and identification of the GcvB seed binding region

Gulliver, E. L., Wright, A., Deveson, D., Megroz, M., Kleifeld, O., Schittenhelm, R. B., Powell, D. R., Seemann, T., Bulitta, J. B., Harper, M. & Boyce, J. D., 1 May 2018, In : Rna-A Publication of the Rna Society. 24, 5, p. 704-720 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
7 Citations (Scopus)

Emergence of high-level colistin resistance in an acinetobacter baumannii clinical isolate mediated by inactivation of the global regulator H-NS

Lucas, D. D., Crane, B., Wright, A., Han, M-L., Moffatt, J., Bulach, D., Gladman, S. L., Powell, D., Aranda, J., Seemann, T., Machado, D., Pacheco, T., Marques, T., Viveiros, M., Nation, R., Li, J., Harper, M. & Boyce, J. D., 1 Jul 2018, In : Antimicrobial Agents and Chemotherapy. 62, 7, 17 p., e02442-17.

Research output: Contribution to journalArticleResearchpeer-review