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Personal profile

Biography

Web link: https://www.monash.edu/medicine/ccs/medicine-alfred/research/epidermal-development

Dr Carpinelli completed her PhD in 2006 at the Walter and Eliza Hall Institute of Medical Research in Melbourne. Here she studied the mechanisms that maintain a constant number of platelets in the blood. She then spent six years characterising the molecular pathways underlying hereditary deafness.  The latter part of this project was completed at the Murdoch Children's Research Institute in Melbourne.  In 2014 she moved to the Department of Medicine, Central Clinical School, Monash University.  Here she investigated the developmental mechanisms whereby the palate, or roof of the mouth, forms.  She is currently investigating the molecular pathways that control neural tube closure during fetal development.  The neural tube becomes the brain and spinal cord and failed closure leads to devastating birth defects.

Research interests

Dr Carpinelli is interested in the molecular pathways that control neural tube closure during early fetal development.  Failure of this developmental process leads to the serious birth defects spina bifida and anencephaly.

Community service

Dr Carpinelli has given honorary lectures in genetics at the University of Melbourne (2011-2013) and La Trobe University (2010-2012).

Research area keywords

  • genetics
  • epithelial morphogenesis
  • neural tube closure
  • transcription factors
  • epigenetics
  • Histone variants
  • Developmental Biology

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Research Output 2002 2018

2 Citations (Scopus)

An intronic mutation in Chd7 creates a cryptic splice site, causing aberrant splicing in a mouse model of CHARGE syndrome

Ogier, J. M., Arhatari, B. D., Carpinelli, M. R., McColl, B. K., Wilson, M. A. & Burt, R. A., 3 Apr 2018, In : Scientific Reports. 8, 1, 9 p., 5482.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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10 Citations (Scopus)

Stage-dependent therapeutic efficacy in PI3K/mTOR-driven squamous cell carcinoma of the skin

Darido, C., Georgy, S. R., Cullinane, C., Partridge, D. D., Walker, R., Srivastava, S., Roslan, S., Carpinelli, M. R., Dworkin, S., Pearson, R. B. & Jane, S. M., 1 Jun 2018, In : Cell Death and Differentiation. 25, 6, p. 1146-1159 14 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Grainyhead-like Transcription Factors in Craniofacial Development

Carpinelli, M. R., de Vries, M. E., Jane, S. M. & Dworkin, S., 1 Oct 2017, In : Journal of Dental Research. 96, 11, p. 1200-1209 10 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

7 Citations (Scopus)

Mice Haploinsufficient for Ets1 and Fli1 display middle ear abnormalities and model aspects of Jacobsen syndrome

Carpinelli, M. R., Kruse, E. A., Arhatari, B. D., Debrincat, M. A., Ogier, J. M., Bories, J-C., Kile, B. T. & Burt, R. A., Jul 2015, In : American Journal of Pathology. 185, 7, p. 1867-1876 10 p., 2047.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

A new mouse model of Canavan leukodystrophy displays hearing impairment due to central nervous system dysmyelination

Carpinelli, M. R., Voss, A. K., Manning, M. G., Perera, A. A., Cooray, A. A., Kile, B. T. & Burt, R. A., 2014, In : Disease Models and Mechanisms. 7, 6, p. 649-657 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Prizes

Colman Speed Medal

Marina Carpinelli (Recipient), 2000

Prize: Prize (including medals and awards)

Dwight's prize in Genetics

Marina Carpinelli (Recipient), 1999

Prize: Prize (including medals and awards)

Student Seminar Prize

Marina Carpinelli (Recipient), 2000

Prize: Prize (including medals and awards)