Projects per year
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Biography
Associate Professor Margaret Hibbs
Department of Immunology - Leukocyte Signalling Laboratory
Margaret Hibbs is an Associate Professor in the Department of Immunology, within the School of Translational Medicine, and Group leader of the Leukocyte Signalling Laboratory.
The Leukocyte Signaling Laboratory is studying signaling pathways that play a role in immune system development and function. We are primarily interested in what regulates the development of immunity and we are trying to understand the processes that are perturbed when autoimmunity and inflammatory diseases develop. We are also interested in understanding what regulates haematopoiesis or blood cell development, and believe that this will give us a greater understanding of the signals that go awry in the development of blood cell cancers. The lab also has a major interest in understanding the mechanisms underlying chronic inflammatory lung disease and we aim to identifying key pathways or targets for therapeutic intervention.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Medicine, PhD, Biochemical and molecular biological analysis of mouse and human Fc receptors, University of Melbourne
Apr 1984 → Feb 1988
Pathology, BSc(Hons), The cell surface phenotype of mouse neutrophils, University of Melbourne
1983
Biochemistry and Pathology, BSc, University of Melbourne
1979 → 1982
Research area keywords
- Autoimmunity
- Haematopoiesis
- Chronic inflammatory lung disease
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Dysregulated lymphatic vasculature in the pathogenesis of bronchopulmonary dysplasia
Hibbs, M. (Primary Chief Investigator (PCI)), Tsantikos, E. (Chief Investigator (CI)), Stacker, S. (Associate Investigator (AI)), Anderson, G. P. (Associate Investigator (AI)), Malhotra, A. (Associate Investigator (AI)), Kumar, B. (Associate Investigator (AI)), Wong, N. (Associate Investigator (AI)) & Cho, E. H. J. (Associate Investigator (AI))
1/01/23 → 31/12/26
Project: Research
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MAGPIX
Monif, M. (Primary Chief Investigator (PCI)), Hibbs, M. (Chief Investigator (CI)), Tarlinton, D. (Chief Investigator (CI)) & O'Brien, T. (Chief Investigator (CI))
1/01/21 → 31/12/21
Project: Research
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Novel therapeutic approaches for SLE
Mackay, F. (Primary Chief Investigator (PCI)), Mackay, C. (Chief Investigator (CI)) & Hibbs, M. (Chief Investigator (CI))
1/12/19 → 31/05/25
Project: Research
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Designing superior killers in cancer immunotherapy
Borger, J. (Primary Chief Investigator (PCI)), Hibbs, M. (Chief Investigator (CI)) & Beavis, P. A. (Partner Investigator (PI))
1/01/19 → 31/12/19
Project: Research
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G-CSF = granulocyte colony-stimulating factor: G-CSF: a pathogenic effector in chronic obstructive pulmonary disease and its comorbidities
Hibbs, M. (Primary Chief Investigator (PCI)), Anderson, G. P. (Chief Investigator (CI)) & Tsantikos, E. (Chief Investigator (CI))
NHMRC - National Health and Medical Research Council (Australia)
1/01/18 → 31/12/21
Project: Research
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An unconventional T cell nexus drives HCK-mediated chronic obstructive pulmonary disease in mice
Hsu, A. T., O'Donoghue, R. J. J., Tsantikos, E., Gottschalk, T. A., Borger, J. G., Gherardin, N. A., Xu, C., Koay, H. F., Godfrey, D. I., Ernst, M., Anderson, G. P. & Hibbs, M. L., May 2025, In: EBioMedicine. 115, 24 p., 105707.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Lyn restrains lupus via kinase-independent mechanisms that limit Toll-like receptor activation and type I interferon responsiveness
L'Estrange-Stranieri, E., Gottschalk, T. A., Kong, A. M., Maxwell, M. J., Pang, E. S., Tsantikos, E., Tarlinton, D. M., O'Keeffe, M., Wright, M. D. & Hibbs, M. L., Oct 2025, In: Science Advances. 11, 42, 18 p., eadz1726.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Tetraspanin CD53 Promotes Inflammation but Restrains Mucus Production in a Mouse Model of Allergic Airway Inflammation
Hsu, A. T., Bugajev, V., Gottschalk, T. A., Demkova, L., Potuckova, L., Draberova, L., Bambouskova, M., Hagemann, P., O'Brien, C. A., Riecan, M., Kuda, O., Tsantikos, E., Draber, P., Wright, M. D., van Spriel, A. B., Hibbs, M. L. & Halova, I., Apr 2025, In: Allergy. 80, 4, p. 1127-1131 5 p.Research output: Contribution to journal › Letter › Research › peer-review
Open Access1 Citation (Scopus) -
VEGF-D Protects the Lung in Neonatal Hyperoxia-induced Lung Injury
Wickramasinghe Mudiyanselage, L. (Leading Author), L'Estrange-Stranieri, E. (Leading Author), Cardwell, B., O'Brien, C. A., Shad, A., Hsu, A. T., van Wijngaarden, P., Anderson, G. P., Stacker, S. A., Achen, M. G., Tsantikos, E. (Leading Author) & Hibbs, M. L. (Leading Author), Nov 2025, In: American Journal of Respiratory Cell and Molecular Biology. 73, 5, p. 790-804 15 p.Research output: Contribution to journal › Article › Research › peer-review
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Activated eosinophils in early life impair lung development and promote long-term lung damage
Raftery, A. L., O'Brien, C. A., Shad, A., L'Estrange-Stranieri, E., Hsu, A. T., Jacobsen, E. A., Harris, N. L., Tsantikos, E. & Hibbs, M. L., Oct 2024, In: Mucosal Immunology. 17, 5, p. 871-891 21 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus)