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Biography

Associate Professor Margaret Hibbs 

Department of Immunology - Leukocyte Signalling Laboratory

Margaret Hibbs is an Associate Professor in the Department of Immunology, within the Central Clinical School, and Group leader of the Leukocyte Signalling Laboratory.

The Leukocyte Signaling Laboratory is studying signaling pathways that play a role in immune system development and function. We are primarily interested in what regulates the development of immunity and we are trying to understand the processes that are perturbed when autoimmunity and inflammatory diseases develop. We are also interested in understanding what regulates haematopoiesis or blood cell development, and believe that this will give us a greater understanding of the signals that go awry in the development of blood cell cancers. The lab also has a major interest in understanding the mechanisms underlying chronic inflammatory lung disease and we aim to identifying key pathways or targets for therapeutic intervention.

 

Keywords

  • Autoimmunity
  • Haematopoiesis
  • Chronic inflammatory lung disease

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Projects 2010 2021

Research Output 1984 2019

IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization

Eissmann, M. F., Dijkstra, C., Jarnicki, A., Phesse, T., Brunnberg, J., Poh, A. R., Etemadi, N., Tsantikos, E., Thiem, S., Huntington, N. D., Hibbs, M. L., Boussioutas, A., Grimbaldeston, M. A., Buchert, M., O’Donoghue, R. J. J., Masson, F. & Ernst, M., 1 Dec 2019, In : Nature Communications. 10, 1, 16 p., 2735.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Infections after a traumatic brain injury: The complex interplay between the immune and neurological systems

Sharma, R., Shultz, S. R., Robinson, M. J., Belli, A., Hibbs, M. L., O'Brien, T. J. & Semple, B. D., Jul 2019, In : Brain, Behavior, and Immunity. 79, p. 63-74 12 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Granulocyte-CSF links destructive inflammation and comorbidities in obstructive lung disease

Tsantikos, E., Lau, M., Castelino, C. M. N., Maxwell, M. J., Passey, S. L., Hansen, M. J., McGregor, N. E., Sims, N. A., Steinfort, D. P., Irving, L. B., Anderson, G. P. & Hibbs, M. L., 1 Jun 2018, In : Journal of Clinical Investigation. 128, 6, p. 2406-2418 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

LMP2 immunoproteasome promotes lymphocyte survival by degrading apoptotic BH3-only proteins

Zanker, D., Pang, K., Oveissi, S., Lu, C., Faou, P., Nowell, C., Mbogo, G. W., Carotta, S., Quillici, C., Karupiah, G., Hibbs, M. L., Nutt, S. L., Neeson, P., Puthalakath, H. & Chen, W., 1 Oct 2018, In : Immunology and Cell Biology. 96, 9, p. 981-993 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Regulation of hematopoietic cell signaling by SHIP-1 inositol phosphatase: growth factors and beyond

Hibbs, M. L., Raftery, A. L. & Tsantikos, E., 2 Nov 2018, In : Growth Factors. 36, 5-6, p. 213-231 19 p.

Research output: Contribution to journalReview ArticleResearchpeer-review