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Associate Professor Margaret Hibbs
Department of Immunology - Leukocyte Signalling Laboratory
Margaret Hibbs is an Associate Professor in the Department of Immunology, within the Central Clinical School, and Group leader of the Leukocyte Signalling Laboratory.
The Leukocyte Signaling Laboratory is studying signaling pathways that play a role in immune system development and function. We are primarily interested in what regulates the development of immunity and we are trying to understand the processes that are perturbed when autoimmunity and inflammatory diseases develop. We are also interested in understanding what regulates haematopoiesis or blood cell development, and believe that this will give us a greater understanding of the signals that go awry in the development of blood cell cancers. The lab also has a major interest in understanding the mechanisms underlying chronic inflammatory lung disease and we aim to identifying key pathways or targets for therapeutic intervention.
Keywords
- Autoimmunity
- Haematopoiesis
- Chronic inflammatory lung disease
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Projects 2010 2021
Dissecting the contribution of IL-17-producing γδ T cells to the pathogenesis of airway diseases
Hibbs, M. & Anderson, G.
National Health & Medical Research Council (NHMRC)
1/01/18 → 31/12/20
Project: Research
Characterisation of emerging new signaling networks that underlie COPD phenotypes
Hibbs, M. & Fouras, A.
National Health & Medical Research Council (NHMRC)
1/01/16 → 31/12/18
Project: Research
A strategy to treat the common deadly lung disease chronic obstructive pulmonary disease
1/01/17 → 31/12/17
Project: Research
NHMRC equipment grant - BD LSR Fortessa X20 Flow Cytometry system
Tarlinton, D., O'Hehir, R. E., Cooper, M., Peleg, A. Y., Curtis, D. J., Dickins, R. A., van Zelm, M. C., Plebanski, M., Spencer, A., Hibbs, M., Wei, A., Guthridge, M. A. & Thomas, M.
1/12/16 → 31/12/16
Project: Research
Research Output 2004 2017
Csk-binding protein controls red blood cell development via regulation of Lyn tyrosine kinase activity
Plani-Lam, J. H. C., Slavova-Azmanova, N. S., Kucera, N., Louw, A., Satiaputra, J., Singer, P., Lam, K. P., Hibbs, M. L. & Ingley, E. 1 Feb 2017 In : Experimental Hematology. 46, p. 70-82 13 p.Research output: Contribution to journal › Article
Foxp3+ Tregs are recruited to the retina to repair pathological angiogenesis
Deliyanti, D., Talia, D. M., Zhu, T., Maxwell, M. J., Agrotis, A., Jerome, J. R., Hargreaves, E. M., Gerondakis, S., Hibbs, M. L., Mackay, F. & Wilkinson-Berka, J. L. 1 Dec 2017 In : Nature Communications. 8, 1, 12 p., 748Research output: Contribution to journal › Article
Open Access
File
SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages
Luo, L., Bokil, N. J., Wall, A. A., Kapetanovic, R., Lansdaal, N. M., Marceline, F., Burgess, B. J., Tong, S. J., Guo, Z., Alexandrov, K., Ross, I. L., Hibbs, M. L., Stow, J. L. & Sweet, M. J. 18 Jan 2017 In : Nature Communications. 8, 14 p., 14133Research output: Contribution to journal › Article
Open Access
File
The contributions of lung macrophage and monocyte heterogeneity to influenza pathogenesis
Duan, M., Hibbs, M. L. & Chen, W. 1 Mar 2017 In : Immunology and Cell Biology. 95, 3, p. 225-235 11 p.Research output: Contribution to journal › Review Article
CD11b immunophenotyping identifies inflammatory profiles in the mouse and human lungs
Duan, M., Steinfort, D. P., Smallwood, D., Hew, M., Chen, W., Ernst, M., Irving, L. B., Anderson, G. P. & Hibbs, M. L. 1 Mar 2016 In : Mucosal Immunology. 9, 2, p. 550-563 14 p.Research output: Contribution to journal › Article