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Associate Professor Margaret Hibbs 

Department of Immunology - Leukocyte Signalling Laboratory

Margaret Hibbs is an Associate Professor in the Department of Immunology, within the Central Clinical School, and Group leader of the Leukocyte Signalling Laboratory.

The Leukocyte Signaling Laboratory is studying signaling pathways that play a role in immune system development and function. We are primarily interested in what regulates the development of immunity and we are trying to understand the processes that are perturbed when autoimmunity and inflammatory diseases develop. We are also interested in understanding what regulates haematopoiesis or blood cell development, and believe that this will give us a greater understanding of the signals that go awry in the development of blood cell cancers. The lab also has a major interest in understanding the mechanisms underlying chronic inflammatory lung disease and we aim to identifying key pathways or targets for therapeutic intervention.


Education/Academic qualification

Medicine, PhD, University of Melbourne

Apr 1984Feb 1988

Pathology, BSc(Hons), University of Melbourne


Biochemistry and Pathology, BSc, University of Melbourne


Research area keywords

  • Autoimmunity
  • Haematopoiesis
  • Chronic inflammatory lung disease

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Projects 2010 2021

Research Output 1984 2019

4 Citations (Scopus)

IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization

Eissmann, M. F., Dijkstra, C., Jarnicki, A., Phesse, T., Brunnberg, J., Poh, A. R., Etemadi, N., Tsantikos, E., Thiem, S., Huntington, N. D., Hibbs, M. L., Boussioutas, A., Grimbaldeston, M. A., Buchert, M., O’Donoghue, R. J. J., Masson, F. & Ernst, M., 1 Dec 2019, In : Nature Communications. 10, 1, 16 p., 2735.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
1 Citation (Scopus)

Infections after a traumatic brain injury: The complex interplay between the immune and neurological systems

Sharma, R., Shultz, S. R., Robinson, M. J., Belli, A., Hibbs, M. L., O'Brien, T. J. & Semple, B. D., Jul 2019, In : Brain, Behavior, and Immunity. 79, p. 63-74 12 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

The influence of innate lymphoid cells and unconventional T cells in chronic inflammatory lung disease

Borger, J. G., Lau, M. & Hibbs, M. L., 11 Jul 2019, In : Frontiers in Immunology. 10, JULY, 16 p., 1597.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
6 Citations (Scopus)

Granulocyte-CSF links destructive inflammation and comorbidities in obstructive lung disease

Tsantikos, E., Lau, M., Castelino, C. M. N., Maxwell, M. J., Passey, S. L., Hansen, M. J., McGregor, N. E., Sims, N. A., Steinfort, D. P., Irving, L. B., Anderson, G. P. & Hibbs, M. L., 1 Jun 2018, In : Journal of Clinical Investigation. 128, 6, p. 2406-2418 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2 Citations (Scopus)

LMP2 immunoproteasome promotes lymphocyte survival by degrading apoptotic BH3-only proteins

Zanker, D., Pang, K., Oveissi, S., Lu, C., Faou, P., Nowell, C., Mbogo, G. W., Carotta, S., Quillici, C., Karupiah, G., Hibbs, M. L., Nutt, S. L., Neeson, P., Puthalakath, H. & Chen, W., 1 Oct 2018, In : Immunology and Cell Biology. 96, 9, p. 981-993 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access