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Associate Professor Margaret Hibbs
Department of Immunology - Leukocyte Signalling Laboratory
Margaret Hibbs is an Associate Professor in the Department of Immunology, within the Central Clinical School, and Group leader of the Leukocyte Signalling Laboratory.
The Leukocyte Signaling Laboratory is studying signaling pathways that play a role in immune system development and function. We are primarily interested in what regulates the development of immunity and we are trying to understand the processes that are perturbed when autoimmunity and inflammatory diseases develop. We are also interested in understanding what regulates haematopoiesis or blood cell development, and believe that this will give us a greater understanding of the signals that go awry in the development of blood cell cancers. The lab also has a major interest in understanding the mechanisms underlying chronic inflammatory lung disease and we aim to identifying key pathways or targets for therapeutic intervention.
Keywords
- Autoimmunity
- Haematopoiesis
- Chronic inflammatory lung disease
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Projects 2010 2021
Designing superior killers in cancer immunotherapy
Borger, J., Hibbs, M. & Beavis, P.
1/01/19 → 31/12/19
Project: Research
G-CSF = granulocyte colony-stimulating factor: G-CSF: a pathogenic effector in chronic obstructive pulmonary disease and its comorbidities
Hibbs, M., Anderson, G. P. & Tsantikos, E.
National Health & Medical Research Council (NHMRC)
1/01/18 → 31/12/21
Project: Research
Dissecting the contribution of IL-17-producing γδ T cells to the pathogenesis of airway diseases
Hibbs, M. & Anderson, G. P.
National Health & Medical Research Council (NHMRC)
1/01/18 → 31/12/20
Project: Research
Characterisation of emerging new signaling networks that underlie COPD phenotypes
Hibbs, M. & Fouras, A. C.
National Health & Medical Research Council (NHMRC)
1/01/16 → 31/12/19
Project: Research
A strategy to treat the common deadly lung disease chronic obstructive pulmonary disease
1/01/17 → 31/12/17
Project: Research
Research Output 1984 2019
IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization
Eissmann, M. F., Dijkstra, C., Jarnicki, A., Phesse, T., Brunnberg, J., Poh, A. R., Etemadi, N., Tsantikos, E., Thiem, S., Huntington, N. D., Hibbs, M. L., Boussioutas, A., Grimbaldeston, M. A., Buchert, M., O’Donoghue, R. J. J., Masson, F. & Ernst, M., 1 Dec 2019, In : Nature Communications. 10, 1, 16 p., 2735.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Infections after a traumatic brain injury: The complex interplay between the immune and neurological systems
Sharma, R., Shultz, S. R., Robinson, M. J., Belli, A., Hibbs, M. L., O'Brien, T. J. & Semple, B. D., Jul 2019, In : Brain, Behavior, and Immunity. 79, p. 63-74 12 p.Research output: Contribution to journal › Review Article › Research › peer-review
Granulocyte-CSF links destructive inflammation and comorbidities in obstructive lung disease
Tsantikos, E., Lau, M., Castelino, C. M. N., Maxwell, M. J., Passey, S. L., Hansen, M. J., McGregor, N. E., Sims, N. A., Steinfort, D. P., Irving, L. B., Anderson, G. P. & Hibbs, M. L., 1 Jun 2018, In : Journal of Clinical Investigation. 128, 6, p. 2406-2418 13 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
LMP2 immunoproteasome promotes lymphocyte survival by degrading apoptotic BH3-only proteins
Zanker, D., Pang, K., Oveissi, S., Lu, C., Faou, P., Nowell, C., Mbogo, G. W., Carotta, S., Quillici, C., Karupiah, G., Hibbs, M. L., Nutt, S. L., Neeson, P., Puthalakath, H. & Chen, W., 1 Oct 2018, In : Immunology and Cell Biology. 96, 9, p. 981-993 13 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Regulation of hematopoietic cell signaling by SHIP-1 inositol phosphatase: growth factors and beyond
Hibbs, M. L., Raftery, A. L. & Tsantikos, E., 2 Nov 2018, In : Growth Factors. 36, 5-6, p. 213-231 19 p.Research output: Contribution to journal › Review Article › Research › peer-review