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Research Output 1999 2019

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2019

IL-37 increases in patients after ischemic stroke and protects from inflammatory brain injury, motor impairment and lung infection in mice

Zhang, S. R., Nold, M. F., Tang, S. C., Bui, C. B., Nold, C. A., Arumugam, T. V., Drummond, G. R., Sobey, C. G. & Kim, H. A., 1 Dec 2019, In : Scientific Reports. 9, 1, 12 p., 6922.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Interleukin-1 receptor antagonist protects newborn mice against pulmonary hypertension

Bui, C. B., Kolodziej, M., Lamanna, E., Elgass, K., Sehgal, A., Rudloff, I., Schwenke, D. O., Tsuchimochi, H., Kroon, M. A. G. M., Cho, S. X., Maksimenko, A., Cholewa, M., Berger, P. J., Young, M. J., Bourke, J. E., Pearson, J. T., Nold, M. F. & Nold-Petry, C. A., 11 Jul 2019, In : Frontiers in Immunology. 10, JULY, 15 p., 1480.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017

Gp96 peptide antagonist gp96-II confers therapeutic effects in murine intestinal inflammation

Nold-Petry, C. A., Nold, M. F., Levy, O., Kliger, Y., Oren, A., Borukhov, I., Becker, C., Wirtz, S., Sandhu, M. K., Neurath, M. & Dinarello, C. A., 11 Dec 2017, In : Frontiers in Immunology. 8, DEC, 13 p., 1531.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Homodimerization attenuates the anti-inflammatory activity of interleukin-37

Ellisdon, A. M., Nold-Petry, C. A., D'Andrea, L., Cho, S. X., Lao, J. C., Rudloff, I., Ngo, D., Lo, C. Y., Soares da Costa, T. P., Perugini, M. A., Conroy, P. J., Whisstock, J. C. & Nold, M. F., 10 Feb 2017, In : Science Immunology. 2, 8, 12 p., eaaj1548.

Research output: Contribution to journalArticleResearchpeer-review

IL-37 Causes Excessive Inflammation and Tissue Damage in Murine Pneumococcal Pneumonia

Schauer, A. E., Klassert, T. E., von Lachner, C., Riebold, D., Schneeweiss, A., Stock, M., Muller, M. M., Hammerschmidt, S., Bufler, P., Seifert, U., Dietert, K., Dinarello, C. A., Nold, M. F., Gruber, A. D., Nold-Petry, C. A. & Slevogt, H., 1 Jul 2017, In : Journal of Innate Immunity. 9, 4, p. 403-418 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Monocytes and dendritic cells are the primary sources of interleukin 37 in human immune cells

Rudloff, I., Cho, S. X., Lao, J. C., Ngo, D., McKenzie, M., Nold-Petry, C. A. & Nold, M. F., 1 Apr 2017, In : Journal of leukocyte biology. 101, 4, p. 901-911 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Refining anti-inflammatory therapy strategies for bronchopulmonary dysplasia

Rudloff, I., Cho, S. X., Bui, C. B., Mclean, C., Veldman, A., Berger, P. J., Nold, M. F. & Nold-Petry, C. A., Jun 2017, In : Journal of Cellular and Molecular Medicine. 21, 6, p. 1128-1138 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2016

Airway remodeling and hyperreactivity in a model of bronchopulmonary dysplasia and their modulation by IL-1Ra

Royce, S. G., Nold, M. F., Bui, C. B-Q., Donovan, C., Lam, M., Lamanna, E., Rudloff, I., Bourke, J. E. & Nold-Petry, C. A., 1 Dec 2016, In : American Journal of Respiratory Cell and Molecular Biology. 55, 6, p. 858-868 11 p.

Research output: Contribution to journalArticleResearchpeer-review

A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage

Koay, H-F., Gherardin, N. A., Enders, A., Loh, L., Mackay, L. K., Almeida, C. F., Russ, B. E., Nold-Petry, C. A., Nold, M. F., Bedoui, S., Chen, Z., Corbett, A. J., Eckle, S. B. G., Meehan, B., d'Udekem, Y., Konstantinov, I. E., Lappas, M., Liu, L., Goodnow, C. C., Fairlie, D. P. & 9 others, Rossjohn, J., Chong, M. M., Kedzierska, K., Berzins, S. P., Belz, G. T., McCluskey, J., Uldrich, A. P., Godfrey, D. I. & Pellicci, D. G., Nov 2016, In : Nature Immunology. 17, 11, p. 1300-1311 12 p.

Research output: Contribution to journalArticleResearchpeer-review

BNP, troponin I, and YKL-40 as screening markers in extremely preterm infants at risk for pulmonary hypertension associated with bronchopulmonary dysplasia

König, K., Guy, K. J., Nold-Petry, C. A., Barfield, C. P., Walsh, G., Drew, S. M., Veldman, A., Nold, M. F. & Casalaz, D. M., 2016, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 311, 6, p. L1076-L1081 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Clinical associations of IL-10 and IL-37 in systemic lupus erythematosus

Godsell, J., Rudloff, I., Kandane-Rathnayake, R., Hoi, A., Nold, M. F., Morand, E. F. & Harris, J., 6 Oct 2016, In : Scientific Reports. 6, 34604.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Suppression of innate inflammation and immunity by interleukin-37

Dinarello, C. A., Nold-Petry, C., Nold, M., Fujita, M., Li, S., Kim, S. & Bufler, P., 1 May 2016, In : European Journal of Immunology. 46, 5, p. 1067-1081 15 p.

Research output: Contribution to journalArticleResearchpeer-review

The immunological landscape in necrotising enterocolitis

Cho, S. X., Berger, P. J., Nold-Petry, C. A. & Nold, M. F., 24 Jun 2016, In : Expert Reviews in Molecular Medicine. 18, 17 p., e12.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2015

Fetal inhibition of inflammation improves disease phenotypes in harlequin ichthyosis

Cottle, D. L., Ursino, G. M. A., Ip, S. C. L., Jones, L. K., Ditommaso, T. M., Hacking, D. F., Mangan, N. E., Mellett, N. A., Henley, K. J., Sviridov, D., Nold-Petry, C. A., Nold, M. F., Meikle, P. J., Kile, B. T. & Smyth, I. M., 2015, In : Human Molecular Genetics. 24, 2, p. 436-449 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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IL-37 requires the receptors IL-18Ralpha and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction

Nold-Petry, C. A., Lo, C. Y-W., Rudloff, I., Elgass, K., Li, S., Gantier, M. P. M., Lotz-Havla, A. S., Gersting, S. W., Cho, S., Lao, C. W. J., Ellisdon, A. M., Rotterd, B., Azam, T., Mangan, N., Rossello, F. J., Whisstock, J., Bufler, P., Garlanda, C., Mantovani, A. A., Dinarello, C. A. & 1 others, Nold, M. F., 2015, In : Nature Immunology. 16, 4, p. 354 - 365 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Interleukin-38 exerts antiinflammatory functions and is associated with disease activity in systemic lupus erythematosus

Rudloff, I., Godsell, J., Nold-Petry, C. A., Harris, J., Hoi, A., Morand, E. F. & Nold, M. F., 2015, In : Arthritis and Rheumatology. 67, 12, p. 3219 - 3225 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

IL-32 promotes angiogenesis

Nold, C. A., Rudloff, I., Baumer, Y., Ruvo, M., Marasco, D., Botti, P., Farkas, L., Cho, S., Zepp, J. A., Azam, T., Dinkel, H., Palmer, B. E., Boisvert, W. A., Cool, C. D., Taraseviciene-Stewart, L., Heinhuis, B., Joosten, L. A. B., Dinarello, C. A., Voelkel, N. F. & Nold, M. F., 2014, In : Journal of Immunology. 192, 2, p. 589 - 602 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses

Bulau, A-M., Nold, M. F., Li, S., Nold, C. A., Fink, M., Mansell, A. S., Schwerd, T., Hong, J-W., Rubartelli, A., Dinarello, C. A. & Bufler, P., 2014, In : Proceedings of the National Academy of Sciences. 111, 7, p. 2650 - 2655 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Suppression of antigen-specific adaptive immunity by IL-37 via induction of tolerogenic dendritic cells

Luo, Y., Cai, X., Liu, S., Wang, S., Nold, C. A., Nold, M. F., Bufler, P., Norris, D., Dinarello, C. A. & Fujita, M., 2014, In : Proceedings of the National Academy of Sciences. 111, 42, p. 15178 - 15183 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2013

Interleukin-1 receptor antagonist prevents murine bronchopulmonary dysplasia induced by perinatal inflammation and hyperoxia

Nold, M. F., Mangan, N., Rudloff, I., Cho, S., Shariatian, N., Samarasinghe, T. D., Skuza, E. M., Pedersen, J. S., Veldman, A., Berger, P. J. & Nold-Petry, C. A., 2013, In : Proceedings of the National Academy of Sciences. 110, 35, p. 14384-14389 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Remifentanil ameliorates intestinal ischemia-reperfusion injury

Cho, S., Rudloff, I., Berger, P. J., Irwin, M. G., Nold, M. F., Cheng, W. & Nold, C. A., 2013, In : BMC Gastroenterology. 13, 1, p. 1 - 9 9 p., 69.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2011

IL-37: a new anti-inflammatory cytokine of the IL-1 family

Boraschi, D., Lucchesi, D., Hainzl, S., Leitner, M., Maier, E., Mangelberger, D., Oostingh, G., Pfaller, T., Pixner, C., Posselt, G., Italiani, P., Nold, M., Nold, C., Bufler, P. & Dinarello, C., 2011, In : European Cytokine Network. 22, 3, p. 127 - 147 21 p.

Research output: Contribution to journalArticleResearchpeer-review

Interleukin 37 expression protects mice from colitis

McNamee, E., Masterson, J., Jedlicka, P., McManus, M., Grenz, A., Collins, C., Nold, M., Nold, C., Bufler, P., Dinarello, C. & Rivera-Nieves, J., 2011, In : Proceedings of the National Academy of Sciences. 108, 40, p. 16711 - 16716 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Protection from RNA and DNA viruses by IL-32

Zepp, J., Nold, C., Dinarello, C. & Nold, M., 2011, In : Journal of Immunology. 186, 7, p. 4110 - 4118 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

Disseminated intravascular coagulation in term and preterm neonates

Veldman, A., Fischer, D., Nold, M. & Wong, F., 2010, In : Seminars in Thrombosis and Hemostasis. 36, 4, p. 419 - 428 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Failure of interferon gamma to induce the anti-inflammatory interleukin 18 binding protein in familial hemophagocytosis.

Nold-Petry, C., Lehrnbecher, T., Jarisch, A., Schwabe, D., Pfeilschifter, J., Muhl, H. & Nold, M., 2010, In : PLoS ONE. 5, 1 (Art. No: e8663), p. 1 - 6 6 p.

Research output: Contribution to journalArticleResearchpeer-review

IL-37 is a fundamental inhibitor of innate immunity

Nold, M., Nold, C., Zepp, J., Palmer, B., Bufler, P. & Dinarello, C., 2010, In : Nature Immunology. 11, 11, p. 1014 - 1022 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The histone deacetylase inhibitor ITF2357 decreases surface CXCR4 and CCR5 expression on CD4+ T-cells and monocytes and is superior to valproic acid for latent HIV-1 expression in vitro

Matalon, S., Palmer, B., Nold, M., Furlan, A., Kassu, A., Fossati, G., Mascagni, P. & Dinarello, C., 2010, In : JAIDS. 54, 1, p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages

Netea, M. G., Nold-Petry, C. A., Nold, M. F., Joosten, L. A. B., Opitz, B., van der Meer, J. H. M., van de Veerdonk, F. L., Ferwerda, G., Heinhuis, B., Devesa, I., Funk, C. J. J., Mason, R. J., Kullberg, B. J., Rubartelli, A., van der Meer, J. W. M. & Dinarello, C. A., 2009, In : Blood. 113, 10, p. 2324 - 2335 12 p.

Research output: Contribution to journalArticleResearchpeer-review

IL-32-dependent effects of IL-1beta on endothelial cell functions

Nold-Petry, C. A., Nold, M. F., Zepp, J. A., Kim, S-H., Voelkel, N. F. & Dinarello, C. A., 2009, In : Proceedings of the National Academy of Sciences. 106, 10, p. 3883 - 3888 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Increased cytokine productionin interleukin-18 receptor alpha-deficient cells is associated with dysregulation of suppressors of cytokine signaling

Nold-Petry, C. A., Nold, M. F., Nielsen, J. W., Bustamante, A., Zepp, J. A., Storm, K. A., Hong, J-W., Kim, S-H. & Dinarello, C. A., 2009, In : Journal of Biological Chemistry. 284, 38, p. 25900 - 25911 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Protein C concentrate in preterm neonates with sepsis

Fischer, D., Schloesser, R., Nold-Petry, C. A., Nold, M. & Veldman, A., 2009, In : Acta Paediatrica. 98, 9, p. 1526 - 1529 4 p.

Research output: Contribution to journalArticleOther

Protein C preserves microcirculation in a model of neonatal septic shock

Fischer, D., Nold, M., Nold-Petry, C. A., Furlan, A. & Veldman, A., 2009, In : Vascular Health and Risk Management. 5, p. 755 - 781 26 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

Endogenous IL-32 controls cytokine and HIV-1 production

Nold, M., Nold-Petry, C., Pott, G., Zepp, J., Saavedra, M., Kim, S-H. & Dinarello, C., 2008, In : Journal of Immunology. 181, 1, p. 557 - 565 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The IL-1 family member 7b translocates to the nucleus and down-regulates proinflammatory cytokines

Sharma, S., Kulk, N., Nold, M., Graf, R., Kim, S-H., Reinhardt, D., Dinarello, C. & Bufler, P., 2008, In : Journal of Immunology. 180, 8, p. 5477 - 5482 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Thrombosis in the critically ill neonate: incidence, diagnosis, and management

Veldman, A., Nold, M. & Michel-Behnke, I., 2008, In : Vascular Health and Risk Management. 4, 6, p. 1337 - 1348 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2007

Activated protein C downregulates p38 mitogen-activated protein kinase and improves clinical parameters in an in-vivo model of septic shock

Nold, M., Nold-Petry, C., Fischer, D., Richter, B., Blaheta, R., Pfeilschifter, J., Muhl, H., Schranz, D. & Veldman, A., 2007, In : Thrombosis and Haemostasis. 98, 5, p. 1118 - 1126 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2006

Interleukin-18 secretion and Th1-like cytokine responses in human peripheral blood mononuclear cells under the influence of the toll-like receptor-5 ligand flagellin

Bachmann, M., Horn, K., Poleganov, M., Paulukat, J., Nold, M., Pfeilschifter, J. & Muhl, H., 2006, In : Cellular Microbiology. 8, 2, p. 289 - 300 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2004

262 interleukin 10 is up-regulated by human protein c-concentrate in the early phase of a neonatal piglet model of septic shock

Veldman, A., Nold, M., Petry, C., Richter, B. & Fischer, D., 1 Jan 2004, In : Pediatric Research. 56, 3, 1 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access

85 intestinal microcirculation in neonatal piglets with lps-induced septic shock: influence of human protein c concentrate (ceprotin®)

Fischer, D., Nold, M. & Veldman, A., 1 Jan 2004, In : Pediatric Research. 56, 3, 1 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
2003

IL-18BPa:Fc cooperates with immunosuppressive drugs in human whole blood

Nold, M., Hauser, I. A., Höfler, S., Goede, A., Eberhardt, W., Ditting, T., Geiger, H., Pfeilschifter, J. & Mühl, H., 1 Aug 2003, In : Biochemical Pharmacology. 66, 3, p. 505-510 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Interferon-γ induces expression of interleukin-18 binding protein in fibroblast-like synoviocytes

Möller, B., Paulukat, J., Nold, M., Behrens, M., Kukoc-Zivojnov, N., Kaltwasser, J. P., Pfeilschifter, J. & Mühl, H., 1 Mar 2003, In : Rheumatology. 42, 3, p. 442-445 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2002

Expression of interleukin-8, heme oxygenase-1 and vascular endothelial growth factor in DLD-1 colon carcinoma cells exposed to pyrrolidine dithiocarbamate

Hellmuth, M., Wetzler, C., Nold, M., Chang, J. H., Frank, S., Pfeilschifter, J. & Mühl, H., 1 Jan 2002, In : Carcinogenesis. 23, 8, p. 1273-1279 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2001

Expression and release of IL-18 binding protein in response to IFN-γ

Paulukat, J., Bosmann, M., Nold, M., Garkisch, S., Kämpfer, H., Frank, S., Raedle, J., Zeuzem, S., Pfeilschifter, J. & Mühl, H., 15 Dec 2001, In : Journal of Immunology. 167, 12, p. 7038-7043 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2000

Nitric oxide augments release of chemokines from monocytic U937 cells: Modulation by anti-inflammatory pathways

Mühl, H., Chang, J. H., Huwiler, A., Bosmann, M., Paulukat, J., Ninic, R., Nold, M., Hellmuth, M. & Pfeilschifter, J., 15 Nov 2000, In : Free Radical Biology and Medicine. 29, 10, p. 969-980 12 p.

Research output: Contribution to journalArticleResearchpeer-review

1999

Expression and release of chemokines associated with apoptotic cell death in human promonocytic U937 cells and peripheral blood mononuclear cells

Mühl, H., Nold, M., Chang, J. H., Frank, S., Eberhardt, W. & Pfeilschifter, J., 26 Oct 1999, In : European Journal of Immunology. 29, 10, p. 3225-3235 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access