20042020
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Personal profile

Biography

Associate Professor Marcel Nold is a clinician-scientist, paediatrician and neonatologist, alumnus Larkins Fellow of Monash University and current Star Recruitment Fellow of MIMR-PHI Institute of Medical Research and the Department of Paediatrics, School of Clinical Sciences at Monash Health. After his graduation from medical school in 2000, he trained in paediatrics and basic immunology in Frankfurt, Germany. In 2006, he was awarded a competitive fellowship by the DFG, the German NHMRC-equivalent, to undertake a postdoctoral tenure at the laboratory of Charles Dinarello, one of the founding fathers of cytokine biology, in Denver, CO, USA. Some of his achievements of this productive time included the description of anti-viral and angiogenic properties of interleukin (IL-)32, and the important paper on the functional differences between monocytes and macrophages (200+ citations).

In 2009, Marcel and his wife Claudia were invited to lead the Inflammation in Neonatal Diseases Research Group at the Ritchie Centre/MIMR-PHI in Melbourne, and to continue his medical training at Monash Newborn. On the clinical side, he received his board certifications in paediatrics in 2010 and in neonatology in 2012.

In science, Claudia, Marcel and their team continued to publish at a very high level, with two accomplishments standing out: they revealed the powerful anti-inflammatory properties of IL-37, a landmark discovery whose impact is illustrated by 80+ citations, the consecutive renaming of the IL-1 family of cytokines the German Society of Immunologys prestigious Georges Kohler Prize, enthusiastic praise by the Faculty of 1000 and national and international TV and radio coverage. The second achievement exemplifies the translational trajectory that is paramount at their laboratory: the Nolds have almost completed the bedside-to-bench-and-back circuit with their work on interleukin 1 receptor antagonist (IL-1Ra) in bronchopulmonary dysplasia (BPD). As Marcel had experienced the urgent medical need to find the first safe and effective treatment for BPD in the neonatal intensive care unit, the Nolds showed in a mouse model that IL-1Ra prevents the disease.

They are now planning a clinical trial to prove the concept in babies. Because of these innovative programs, Claudia and Marcel have been awarded substantial grant funding and an international patent, and are collaborating with partners in the pharmaceutical industry.

Keywords

  • clinician-scientist
  • paediatrician
  • neonatologist
  • inflammation
  • newborn
  • babies
  • baby

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Projects 2004 2020

Research Output 2006 2017

Defining T helper cell immunity in bronchopulmonary dysplasia

Lao, J. C., Pang, M. A., Malhotra, A., Tan, K., Beker, F., Konig, K., Collins, C., Theda, C., Kamlin, C. O., Yeomans, E., Elsayed, K., Noble, E., Walsh, G., Argus, B., Twitchell, E., Berger, P., Veldman, A., Nold-Petry, C. A. & Nold, M. F. 1 May 2017 p. 125-126 1 p.

Research output: Contribution to conferenceAbstract

Homodimerization attenuates the anti-inflammatory activity of interleukin-37

Ellisdon, A. M., Nold-Petry, C. A., D'Andrea, L., Cho, S. X., Lao, J. C., Rudloff, I., Ngo, D., Lo, C. Y., Soares da Costa, T. P., Perugini, M. A., Conroy, P. J., Whisstock, J. C. & Nold, M. F. 10 Feb 2017 In : Science Immunology. 2, 8, 12 p., eaaj1548

Research output: Contribution to journalArticle

IL-37 Causes Excessive Inflammation and Tissue Damage in Murine Pneumococcal Pneumonia

Schauer, A. E., Klassert, T. E., von Lachner, C., Riebold, D., Schneeweiss, A., Stock, M., Muller, M. M., Hammerschmidt, S., Bufler, P., Seifert, U., Dietert, K., Dinarello, C. A., Nold, M. F., Gruber, A. D., Nold-Petry, C. A. & Slevogt, H. 1 Jul 2017 In : Journal of Innate Immunity. 9, 4, p. 403-418 16 p.

Research output: Contribution to journalArticle

Monocytes and dendritic cells are the primary sources of interleukin 37 in human immune cells

Rudloff, I., Cho, S. X., Lao, J. C., Ngo, D., McKenzie, M., Nold-Petry, C. A. & Nold, M. F. 1 Apr 2017 In : Journal of Leukocyte Biology. 101, 4, p. 901-911 11 p.

Research output: Contribution to journalArticle

Refining anti-inflammatory therapy strategies for bronchopulmonary dysplasia

Rudloff, I., Cho, S. X., Bui, C. B., Mclean, C., Veldman, A., Berger, P. J., Nold, M. F. & Nold-Petry, C. A. Jun 2017 In : Journal of Cellular and Molecular Medicine. 21, 6, p. 1128-1138 11 p.

Research output: Contribution to journalArticle

Open Access
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