Projects per year
Personal profile
Biography
Professor Marcel Nold is a consultant neonatologist in Monash Newborn, and Professor for Pediatric Immunology with the Department of Paediatrics, Monash University and also works as a clinician-scientist at the Hudson Institute of Medical Research. Prof Nold did his studies of Medicine at the JW Goethe-University at Frankfurt am Main, Germany, including final year rotations in Zürich (Switzerland), Montréal (Canada) and Capetown (South Africa). For his biomedical research training he spend six years at the Pharmazentrum at Frankfurt am Main and three years as a research Fellow at the laboratory of Prof CA Dinarello, University of Colorado Denver, USA. In 2009 he was recruited to The Ritchie Centre in Melbourne and finished his specialist training at Monash Newborn.
Prof Nold’s standing in cytokine research is evidenced by his key publications in Nature Immunology, Science Immunology and Proceedings of the National Academy of Sciences USA.
The discovery of the anti-inflammatory function of IL-37, which Prof Nold published in 2010, had a major impact on the interleukin field and necessitated a reorganisation of the IL-1 family nomenclature. Five years later, the discovery of the IL-37 receptor complex and the identification of the critical regions in the IL-37 structure lead to a modified IL-37 biologic with enhanced anti-inflammatory properties, which is now developed as an immunotherapeutic in collaboration with a pharmaceutical industry partner.
Prof Nold is a co-founder and Clinical Scientific Officer of a start-up company backed by a life science specialist venture capital investor that supports his research into cytokines and inflammatory diseases.
His academic Inflammation in Neonatal Diseases Research Group and his industry programs aim to characterise underlying pathways of inflammation in early life diseases, with an focus on interventional immunology in cardiopulmonary and intestinal diseases of the preterm.
Research area keywords
- clinician-scientist
- paediatrician
- neonatologist
- inflammation
- newborn
- babies
- baby
Network
Projects
- 18 Finished
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NHMRC Equipment Grant - Olympus FVMPE-RS multiphoton microscope
Hickey, M., Wong, C., Kitching, R., Nold, M., Voelcker, N. & Holdsworth, S.
Monash University – Internal University Contribution, Monash University – Internal School Contribution, Monash University – Internal Department Contribution
1/01/18 → 31/12/18
Project: Research
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Interleukin 37 – a novel cytokine therapy for Necrotizing Enterocolitis in the preterm.
Nold, C., King, S. K., Theda, C. & Nold, M.
1/01/18 → 31/12/20
Project: Research
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3D Light Sheet Fluorescent Microscopy system
Jenkin, G., Harper, I., Hooper, S., Nold, M., Hickey, M., Kitching, R., Loveland, K., Gargett, C., Ferrero, R. & Lim, R.
Monash University – Internal Department Contribution
1/01/18 → 31/12/18
Project: Research
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Modulating inflammation as a therapy for Harlequin Ichthyosis
Smyth, I., Cottle, D., Nold, M. & Nold, C.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/17 → 31/12/20
Project: Research
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Acquisition of a state-of-the-art confocal microscope for imaging of live and fixed samples
Nold, M., Elgass, K., Hickey, M., Kitching, R., Wallace, E., Nikolic-Paterson, D., Wong, C., Loveland, K., Gargett, C., Hooper, S., Ferrero, R., Lim, R., Mansell, A. & Harper, I.
1/12/16 → 31/12/17
Project: Research
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Protein engineering of a stable and potent anti-inflammatory IL-37-Fc fusion with enhanced therapeutic potential
Bujotzek, A., Tiefenthaler, G., Lariviere, L., D'Andrea, L., Marquez, E. A., Rudloff, I., Cho, S., Deen, N., Richter, W., Regenass-Lechner, F., Poehler, A., Whisstock, J., Sydow-Anderson, J., Reiser, X., Schuster, S., Neubauer, J., Hoepfl, S., Richter, K., Nold, M., Nold-Petry, C. & 2 others, , 17 Mar 2022, In: Cell Chemical Biology. 29, p. 1-11.e1–e4 15 p.Research output: Contribution to journal › Article › Research › peer-review
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Safety of in utero exposure to maternal IBD pharmacotherapies
Prentice, R. E., Bell, S. J., Nold-Petry, C. A., Nold, M. F. & Goldberg, R., Jan 2022, (Accepted/In press) In: Nature Reviews Gastroenterology and Hepatology. 2 p.Research output: Contribution to journal › Comment / Debate › Other › peer-review
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Circulating Interleukin-37 Levels in Healthy Adult Humans – Establishing a Reference Range
Santarelli, D. M., Vincent, F. B., Rudloff, I., Nold, C. A., Nold, M. F. & Russo, M., 23 Jul 2021, In: Frontiers in Immunology. 12, 11 p., 708425.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile1 Citation (Scopus) -
Interleukin-1 blockade attenuates white matter inflammation and oligodendrocyte loss after progressive systemic lipopolysaccharide exposure in near-term fetal sheep
Kelly, S. B., Stojanovska, V., Zahra, V. A., Moxham, A., Miller, S. L., Moss, T. J. M., Hooper, S. B., Nold, M. F., Nold-Petry, C. A., Dean, J. M., Bennet, L., Polglase, G. R., Gunn, A. J. & Galinsky, R., Dec 2021, In: Journal of Neuroinflammation. 18, 1, 18 p., 189.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus) -
Animal and translational models of SARS-CoV-2 infection and COVID-19
Johansen, M. D., Irving, A., Montagutelli, X., Tate, M. D., Rudloff, I., Nold, M. F., Hansbro, N. G., Kim, R. Y., Donovan, C., Liu, G., Faiz, A., Short, K. R., Lyons, J. G., McCaughan, G. W., Gorrell, M. D., Cole, A., Moreno, C., Couteur, D., Hesselson, D., Triccas, J. & 9 others, , 13 Nov 2020, In: Mucosal Immunology. 13, 6, p. 877-891 15 p.Research output: Contribution to journal › Review Article › Research › peer-review
87 Citations (Scopus)
Activities
- 5 Patents
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MONASH UNIVERSITY (Organisational unit)
Marcel Nold (Inventor) & Claudia Nold (Inventor)
31 May 2019Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
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MONASH UNIVERSITY (Organisational unit)
Claudia Nold (Inventor), Marcel Nold (Inventor), James Whisstock (Inventor) & Andrew Ellisdon (Inventor)
23 Mar 2018Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
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MONASH UNIVERSITY (Organisational unit)
Andrew Ellisdon (Inventor), James Whisstock (Inventor), Claudia Nold (Inventor) & Marcel Nold (Inventor)
28 Jun 2018Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
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MONASH UNIVERSITY (Organisational unit)
Claudia Nold (Inventor), Marcel Nold (Inventor), James Whisstock (Inventor) & Andrew Ellisdon (Inventor)
12 Apr 2018Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
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MONASH UNIVERSITY (Organisational unit)
Marcel Nold (Inventor), Claudia Nold (Inventor), Andrew Ellisdon (Inventor) & James Whisstock (Inventor)
22 Dec 2016Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent