Projects per year
Personal profile
Biography
Professor Marcel Nold is a consultant neonatologist in Monash Newborn, and Professor for Pediatric Immunology with the Department of Paediatrics, Monash University and also works as a clinician-scientist at the Hudson Institute of Medical Research. Prof Nold did his studies of Medicine at the JW Goethe-University at Frankfurt am Main, Germany, including final year rotations in Zürich (Switzerland), Montréal (Canada) and Capetown (South Africa). For his biomedical research training he spend six years at the Pharmazentrum at Frankfurt am Main and three years as a research Fellow at the laboratory of Prof CA Dinarello, University of Colorado Denver, USA. In 2009 he was recruited to The Ritchie Centre in Melbourne and finished his specialist training at Monash Newborn.
Prof Nold’s standing in cytokine research is evidenced by his key publications in Nature Immunology, Science Immunology and Proceedings of the National Academy of Sciences USA.
The discovery of the anti-inflammatory function of IL-37, which Prof Nold published in 2010, had a major impact on the interleukin field and necessitated a reorganisation of the IL-1 family nomenclature. Five years later, the discovery of the IL-37 receptor complex and the identification of the critical regions in the IL-37 structure lead to a modified IL-37 biologic with enhanced anti-inflammatory properties, which is now developed as an immunotherapeutic in collaboration with a pharmaceutical industry partner.
Prof Nold is a co-founder and Clinical Scientific Officer of a start-up company backed by a life science specialist venture capital investor that supports his research into cytokines and inflammatory diseases.
His academic Inflammation in Neonatal Diseases Research Group and his industry programs aim to characterise underlying pathways of inflammation in early life diseases, with an focus on interventional immunology in cardiopulmonary and intestinal diseases of the preterm.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- clinician-scientist
- paediatrician
- neonatologist
- inflammation
- newborn
- babies
- baby
Network
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The Monash Partners Children’s Acute Care Data Project: Optimising the use of electronic medical records data to improve hospital care for children
Craig, S., Williams, K., Lovett, A., Taylor, D. A., Nixon, G., Coleman, J. M., Winderlich, J., Noorman, J., Parkhurst, K., Fahey, M., Nataraja, R., Hunt, R., Lamont, S., Nold, M., Polglase, G., Jones, A. & Pigott, C.
1/01/23 → …
Project: Research
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NHMRC Equipment Grant - Olympus FVMPE-RS multiphoton microscope
Hickey, M., Wong, C., Kitching, R., Nold, M., Voelcker, N. & Holdsworth, S.
Monash University – Internal University Contribution, Monash University – Internal School Contribution, Monash University – Internal Department Contribution
1/01/18 → 31/12/18
Project: Research
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3D Light Sheet Fluorescent Microscopy system
Jenkin, G., Harper, I., Hooper, S., Nold, M., Hickey, M., Kitching, R., Loveland, K., Gargett, C., Ferrero, R. & Lim, R.
Monash University – Internal Department Contribution
1/01/18 → 31/12/18
Project: Research
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Interleukin 37 – a novel cytokine therapy for Necrotizing Enterocolitis in the preterm.
Nold, C., King, S. K., Theda, C. & Nold, M.
1/01/18 → 31/12/20
Project: Research
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Modulating inflammation as a therapy for Harlequin Ichthyosis
Smyth, I., Cottle, D., Nold, M. & Nold, C.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/17 → 31/12/20
Project: Research
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Interleukin-1: an important target for perinatal neuroprotection?
Kelly, S. B., Green, E., Hunt, R. W., Nold-Petry, C. A., Gunn, A. J., Nold, M. F. & Galinsky, R., Jan 2023, In: Neural Regeneration Research. 18, 1, p. 47-50 4 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access3 Citations (Scopus) -
The role of interleukin-1 in perinatal inflammation and its impact on transitional circulation
Owen, J. C., Garrick, S. P., Peterson, B. M., Berger, P. J., Nold, M. F., Sehgal, A. & Nold-Petry, C. A., 2023, In: Frontiers in Pediatrics. 11, 11 p., 1130013.Research output: Contribution to journal › Review Article › Other › peer-review
Open Access -
The Role of the Interleukin-1 Family in Complications of Prematurity
Green, E. A., Garrick, S. P., Peterson, B., Berger, P. J., Galinsky, R., Hunt, R. W., Cho, S. X., Bourke, J. E., Nold, M. F. & Nold-Petry, C. A., Feb 2023, In: International Journal of Molecular Sciences. 24, 3, 29 p., 2795.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access1 Citation (Scopus) -
Understanding respiratory microbiome-immune system interactions in health and disease
Di Simone, S. K., Rudloff, I., Nold-Petry, C. A., Forster, S. C. & Nold, M. F., 11 Jan 2023, In: Science Translational Medicine. 15, 678, 15 p., eabq5126.Research output: Contribution to journal › Review Article › Research › peer-review
1 Citation (Scopus) -
Anakinra Pilot – a clinical trial to demonstrate safety, feasibility and pharmacokinetics of interleukin 1 receptor antagonist in preterm infants
Green, E. A., Metz, D., Galinsky, R., Atkinson, R., Skuza, E. M., Clark, M., Gunn, A. J., Kirkpatrick, C. M., Hunt, R. W., Berger, P. J., Nold-Petry, C. A. & Nold, M. F., 27 Oct 2022, In: Frontiers in Immunology. 13, 14 p., 1022104.Research output: Contribution to journal › Article › Other › peer-review
Open Access
Activities
- 5 Patents
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MONASH UNIVERSITY (Organisational unit)
Marcel Nold (Inventor) & Claudia Nold (Inventor)
31 May 2019Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
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MONASH UNIVERSITY (Organisational unit)
Claudia Nold (Inventor), Marcel Nold (Inventor), James Whisstock (Inventor) & Andrew Ellisdon (Inventor)
12 Apr 2018Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
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MONASH UNIVERSITY (Organisational unit)
Andrew Ellisdon (Inventor), James Whisstock (Inventor), Claudia Nold (Inventor) & Marcel Nold (Inventor)
28 Jun 2018Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
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MONASH UNIVERSITY (Organisational unit)
Claudia Nold (Inventor), Marcel Nold (Inventor), James Whisstock (Inventor) & Andrew Ellisdon (Inventor)
23 Mar 2018Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
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MONASH UNIVERSITY (Organisational unit)
Marcel Nold (Inventor), Claudia Nold (Inventor), Andrew Ellisdon (Inventor) & James Whisstock (Inventor)
22 Dec 2016Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent