Manuela Jorg

Dr

20102019
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Research Output 2013 2019

2019

6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M1 mAChR: The Determinants of Allosteric Activity

Jorg, M. T., van der Westhuizen, E. T., Khajehali, E., Burger, W. A. C., White, J., Choy, K. H. C., Tobin, A. B., Sexton, P. M., Valant, C., Capuano, B., Christopoulos, A. & Scammells, P. J., 20 Mar 2019, In : ACS Chemical Neuroscience. 10, 3, p. 1099-1114 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Probe dependence of allosteric enhancers on the binding affinity of adenosine A 1 -receptor agonists at rat and human A 1 -receptors measured using NanoBRET

Cooper, S. L., Soave, M., Jörg, M., Scammells, P. J., Woolard, J. & Hill, S. J., Apr 2019, In : British Journal of Pharmacology. 176, 7, p. 864-878 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Probing the binding site of novel selective positive allosteric modulators at the M1 muscarinic acetylcholine receptor

Khajehali, E., Valant, C., Jörg, M., Tobin, A. B., Conn, P. J., Lindsley, C. W., Sexton, P. M., Scammells, P. J. & Christopoulos, A., 1 Aug 2018, In : Biochemical Pharmacology. 154, p. 243-254 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2017

Structure of the adenosine A1 receptor reveals the basis for subtype selectivity

Glukhova, A., Thal, D. M., Nguyen, A. T., Vecchio, L., Jorg, M., Scammells, P. J., May, L. T., Sexton, P. M. & Christopoulos, A., 23 Feb 2017, In : Cell. 168, 5, p. 867-877.e13

Research output: Contribution to journalArticleResearchpeer-review

2016

4-phenylpyridin-2-one derivatives: a novel class of positive allosteric modulator of the M1 muscarinic acetylcholine receptor

Mistry, S. N., Jorg, M., Lim, H., Vinh, N. B., Sexton, P. M., Capuano, B., Christopoulos, A., Lane, J. R. & Scammells, P. J., 14 Jan 2016, In : Journal of Medicinal Chemistry. 59, 1, p. 388-409 22 p.

Research output: Contribution to journalArticleResearchpeer-review

Guidelines for the Synthesis of Small-Molecule Irreversible Probes Targeting G Protein-Coupled Receptors

Jorg, M. & Scammells, P. J., 19 Jul 2016, In : ChemMedChem. 11, 14, p. 1488-1498 11 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Novel fused arylpyrimidinone based allosteric modulators of the M1 muscarinic acetylcholine receptor

Mistry, S. N., Lim, H., Jorg, M., Capuano, B., Christopoulos, A., Lane, J. R. & Scammells, P. J., 18 May 2016, In : ACS Chemical Neuroscience. 7, 5, p. 647-661 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Novel irreversible agonists acting at the A1 adenosine receptor

Jorg, M., Glukhova, A., Abdul Ridha, A., Vecchio, E. A., Nguyen, A., Sexton, P., White, P., May, L., Christopoulos, A. & Scammells, P., 22 Dec 2016, In : Journal of Medicinal Chemistry. 59, 24, p. 11182-11194 13 p.

Research output: Contribution to journalArticleResearchpeer-review

The dopamine D2 receptor dimer and its interaction with homobivalent antagonists: homology modeling, docking and molecular dynamics

Kaczor, A. A., Jorg, M. & Capuano, B., 1 Sep 2016, In : Journal of Molecular Modeling. 22, 9, 14 p., 203.

Research output: Contribution to journalArticleResearchpeer-review

2015

Synthesis and pharmacological evaluation of dual acting ligands targeting the adenosine A2A and dopamine D2 receptors for the potential treatment of Parkinson's disease

Jorg, M. T., May, L. T., Mak, F. S., Lee, K. C. K., Miller, N. D., Scammells, P. J. & Capuano, B., 2015, In : Journal of Medicinal Chemistry. 58, 2, p. 718 - 738 21 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Investigation of novel ropinirole analogues: Synthesis, pharmacological evaluation and computational analysis of dopamine D2 receptor functionalized congeners and homobivalent ligands

Jorg, M. T., Kaczor, A. A., Mak, F. S., Lee, K. C. K., Poso, A., Miller, N. D., Scammells, P. J. & Capuano, B., 2014, In : MedChemComm. 5, 7, p. 891 - 898 8 p.

Research output: Contribution to journalArticleResearchpeer-review

NMR case study of ropinirole: Concentration-dependent effects of nonexchangeable proton resonances

Jorg, M. T., Headey, S. J., Scammells, P. J. & Capuano, B., 2014, In : Magnetic Resonance in Chemistry. 52, 11, p. 715 - 718 4 p.

Research output: Contribution to journalArticleOtherpeer-review

The dopamine D2 and adenosine A2A receptors: Past, present and future trends for the treatment of parkinson's disease

Jorg, M. T., Scammells, P. J. & Capuano, B., 2014, In : Current Medicinal Chemistry. 21, 27, p. 3188 - 3210 23 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis, molecular structure, NMR spectroscopic and computational analysis of a selective adenosine A2A antagonist, ZM 241385

Jorg, M., Agostino, M. J., Yuriev, E., Mak, F. S., Miller, N. D., White, J., Scammells, P. J. & Capuano, B., 2013, In : Structural Chemistry. 24, 4, p. 1241 - 1251 11 p.

Research output: Contribution to journalArticleResearchpeer-review