Manuela Jorg

Research Fellow, Medicinal Chemistry

EmailManuela.Jorg@monash.edu

Research activity per year

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Personal profile

Biography

Research Fellow Faculty of Pharmacy and Pharmaceutical Sciences Medicinal Chemistry Monash Institute of Pharmaceutical Sciences

Research area keywords

Adenosine A2A Receptor
Dopamine D2 Receptor
Muscarenic M1 Receptor
Drug Design
Dual Acting Ligands
Homobivalent Ligands
Allosteric Ligands
Medicinal Chemistry

Network

Recent external collaboration on country level. Dive into details by clicking on the dots or

1 Finished

The Synthesis and Pharmacological Evaluation of Novel Bivalent Dopamine D2 and Adenosine A2A Ligands for the Treatment of Parkinson s Disease
Capuano, B., Jorg, M. & Scammells, P.
Australian Research Council (ARC), GlaxoSmithKline (GSK) Singapore
1/07/10 → 31/12/13
Project: Research

19 Article
2 Review Article

Development of Novel 4-Arylpyridin-2-one and 6-Arylpyrimidin-4-one Positive Allosteric Modulators of the M₁ Muscarinic Acetylcholine Receptor
Jörg, M., Khajehali, E., van der Westhuizen, E. T., C. Choy, K. H., Shackleford, D. M., Tobin, A. B., Sexton, P. M., Valant, C., Capuano, B., Christopoulos, A. & Scammells, P. J., 8 Jan 2021, In: ChemMedChem. 16, 1, p. 216-233 18 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

1 Citation (Scopus)
New small molecule fluorescent probes for G protein-coupled receptors: valuable tools for drug discovery
Conner, J., Poole, D. P., Jorg, M. & Veldhuis, N. A., Jan 2021, In: Future Medicinal Chemistry. 13, 1, p. 63-90 28 p.
Research output: Contribution to journal › Review Article › Other › peer-review
The effect of two selective A₁-receptor agonists and the bitopic ligand VCP746 on heart rate and regional vascular conductance in conscious rats
Cooper, S. L., March, J., Sabbatini, A. R., Hill, S. J., Jörg, M., Scammells, P. J. & Woolard, J., Jan 2020, In: British Journal of Pharmacology. 177, 2, p. 346-359 14 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access
File
6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M₁ mAChR: The Determinants of Allosteric Activity
Jorg, M. T., van der Westhuizen, E. T., Khajehali, E., Burger, W. A. C., White, J., Choy, K. H. C., Tobin, A. B., Sexton, P. M., Valant, C., Capuano, B., Christopoulos, A. & Scammells, P. J., 20 Mar 2019, In: ACS Chemical Neuroscience. 10, 3, p. 1099-1114 16 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access
File

3 Citations (Scopus)
Probe dependence of allosteric enhancers on the binding affinity of adenosine A ₁ -receptor agonists at rat and human A ₁ -receptors measured using NanoBRET
Cooper, S. L., Soave, M., Jörg, M., Scammells, P. J., Woolard, J. & Hill, S. J., Apr 2019, In: British Journal of Pharmacology. 176, 7, p. 864-878 15 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access
File

8 Citations (Scopus)

CASS Foundation Travel Award
Jorg, Manuela (Recipient), 2018
Prize: Prize (including medals and awards)
CTx Post-Graduate Student Travel Award
Jorg, Manuela (Recipient), 2012
Prize: Prize (including medals and awards)
Honourable Geoffrey Connard AM Early Career Research Travelling Award
Jorg, Manuela (Recipient), 2017
Prize: Prize (including medals and awards)
Merck Innovation Cup Award
Jorg, Manuela (Recipient), 2016
Prize: Prize (including medals and awards)
Monash University Post-Graduate Publication Award
Jorg, Manuela (Recipient), 2014
Prize: Prize (including medals and awards)