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Manuela Jorg

Dr

20102020

Research output per year

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Personal profile

Biography

Research Fellow Faculty of Pharmacy and Pharmaceutical Sciences Medicinal Chemistry Monash Institute of Pharmaceutical Sciences

Research area keywords

  • Adenosine A2A Receptor
  • Dopamine D2 Receptor
  • Muscarenic M1 Receptor
  • Drug Design
  • Dual Acting Ligands
  • Homobivalent Ligands
  • Allosteric Ligands
  • Medicinal Chemistry

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Projects

The Synthesis and Pharmacological Evaluation of Novel Bivalent Dopamine D2 and Adenosine A2A Ligands for the Treatment of Parkinson s Disease

Capuano, B., Jorg, M. & Scammells, P.

Australian Research Council (ARC), GlaxoSmithKline (GSK) SG

1/07/10 → 31/12/13

Project: Research

Research Output

The effect of two selective A1-receptor agonists and the bitopic ligand VCP746 on heart rate and regional vascular conductance in conscious rats

Cooper, S. L., March, J., Sabbatini, A. R., Hill, S. J., Jörg, M., Scammells, P. J. & Woolard, J., Jan 2020, In : British Journal of Pharmacology. 177, 2, p. 346-359 14 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access
File

6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M1 mAChR: The Determinants of Allosteric Activity

Jorg, M. T., van der Westhuizen, E. T., Khajehali, E., Burger, W. A. C., White, J., Choy, K. H. C., Tobin, A. B., Sexton, P. M., Valant, C., Capuano, B., Christopoulos, A. & Scammells, P. J., 20 Mar 2019, In : ACS Chemical Neuroscience. 10, 3, p. 1099-1114 16 p.

Research output: Contribution to journal › Article › Research › peer-review

Probe dependence of allosteric enhancers on the binding affinity of adenosine A 1 -receptor agonists at rat and human A 1 -receptors measured using NanoBRET

Cooper, S. L., Soave, M., Jörg, M., Scammells, P. J., Woolard, J. & Hill, S. J., Apr 2019, In : British Journal of Pharmacology. 176, 7, p. 864-878 15 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access
File
5 Citations (Scopus)

Assessment of the molecular mechanisms of action of novel 4-phenylpyridine-2-one and 6-phenylpyrimidin-4-one allosteric modulators at the M1 muscarinic acetylcholine receptors

Van Der Westhuizen, E. T., Spathis, A., Khajehali, E., Jorg, M., Mistry, S. N., Capuano, B., Tobin, A. B., Sexton, P. M., Scammells, P. J., Valant, C. & Christopoulos, A., 1 May 2018, In : Molecular Pharmacology. 94, 1, p. 770-783 14 p.

Research output: Contribution to journal › Article › Research › peer-review

4 Citations (Scopus)

A Structure-Activity Relationship Study of Bitopic N 6-Substituted Adenosine Derivatives as Biased Adenosine A1 Receptor Agonists

Aurelio, L., Baltos, J. A., Ford, L., Nguyen, A. T. N., Jörg, M., Devine, S. M., Valant, C., White, P. J., Christopoulos, A., May, L. T. & Scammells, P. J., 8 Mar 2018, In : Journal of Medicinal Chemistry. 61, 5, p. 2087-2103 17 p.

Research output: Contribution to journal › Article › Research › peer-review

10 Citations (Scopus)

Prizes

CASS Foundation Travel Award

Jorg, Manuela (Recipient), 2018

Prize: Prize (including medals and awards)

CTx Post-Graduate Student Travel Award

Jorg, Manuela (Recipient), 2012

Prize: Prize (including medals and awards)

Honourable Geoffrey Connard AM Early Career Research Travelling Award

Jorg, Manuela (Recipient), 2017

Prize: Prize (including medals and awards)

Merck Innovation Cup Award

Jorg, Manuela (Recipient), 2016

Prize: Prize (including medals and awards)

Monash University Post-Graduate Publication Award

Jorg, Manuela (Recipient), 2014

Prize: Prize (including medals and awards)