Manuela Jorg

Dr

20102019
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Personal profile

Biography

Research Fellow Faculty of Pharmacy and Pharmaceutical Sciences Medicinal Chemistry Monash Institute of Pharmaceutical Sciences

Keywords

  • Adenosine A2A Receptor
  • Dopamine D2 Receptor
  • Muscarenic M1 Receptor
  • Drug Design
  • Dual Acting Ligands
  • Homobivalent Ligands
  • Allosteric Ligands
  • Medicinal Chemistry

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Projects 2010 2013

Research Output 2013 2019

6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M1 mAChR: The Determinants of Allosteric Activity

Jorg, M. T., van der Westhuizen, E. T., Khajehali, E., Burger, W. A. C., White, J., Choy, K. H. C., Tobin, A. B., Sexton, P. M., Valant, C., Capuano, B., Christopoulos, A. & Scammells, P. J., 20 Mar 2019, In : ACS Chemical Neuroscience. 10, 3, p. 1099-1114 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Probe dependence of allosteric enhancers on the binding affinity of adenosine A 1 -receptor agonists at rat and human A 1 -receptors measured using NanoBRET

Cooper, S. L., Soave, M., Jörg, M., Scammells, P. J., Woolard, J. & Hill, S. J., Apr 2019, In : British Journal of Pharmacology. 176, 7, p. 864-878 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

A Structure-Activity Relationship Study of Bitopic N 6-Substituted Adenosine Derivatives as Biased Adenosine A1 Receptor Agonists

Aurelio, L., Baltos, J. A., Ford, L., Nguyen, A. T. N., Jörg, M., Devine, S. M., Valant, C., White, P. J., Christopoulos, A., May, L. T. & Scammells, P. J., 8 Mar 2018, In : Journal of Medicinal Chemistry. 61, 5, p. 2087-2103 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Probing the binding site of novel selective positive allosteric modulators at the M1 muscarinic acetylcholine receptor

Khajehali, E., Valant, C., Jörg, M., Tobin, A. B., Conn, P. J., Lindsley, C. W., Sexton, P. M., Scammells, P. J. & Christopoulos, A., 1 Aug 2018, In : Biochemical Pharmacology. 154, p. 243-254 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Prizes

CASS Foundation Travel Award

Manuela Jorg (Recipient), 2018

Prize: Prize (including medals and awards)

CTx Post-Graduate Student Travel Award

Manuela Jorg (Recipient), 2012

Prize: Prize (including medals and awards)

Honourable Geoffrey Connard AM Early Career Research Travelling Award

Manuela Jorg (Recipient), 2017

Prize: Prize (including medals and awards)

Merck Innovation Cup Award

Manuela Jorg (Recipient), 2016

Prize: Prize (including medals and awards)

Monash University Post-Graduate Publication Award

Manuela Jorg (Recipient), 2014

Prize: Prize (including medals and awards)