Manuela Jorg

Personal profile

Biography

Research Fellow Faculty of Pharmacy and Pharmaceutical Sciences Medicinal Chemistry Monash Institute of Pharmaceutical Sciences

Keywords

• Adenosine A2A Receptor
• Dopamine D2 Receptor
• Muscarenic M1 Receptor
• Drug Design
• Dual Acting Ligands
• Homobivalent Ligands
• Allosteric Ligands
• Medicinal Chemistry

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Projects 2010 2013

• 1 Finished

Projects per year

The Synthesis and Pharmacological Evaluation of Novel Bivalent Dopamine D2 and Adenosine A2A Ligands for the Treatment of Parkinson s Disease

Capuano, B., Jorg, M. & Scammells, P.

Australian Research Council (ARC), GlaxoSmithKline (GSK) SG

1/07/10 → 31/12/13

Project: Research

Research Output 2013 2019

• 17 Article
• 1 Review Article

Research Output per year

6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M₁ mAChR: The Determinants of Allosteric Activity

Jorg, M. T., van der Westhuizen, E. T., Khajehali, E., Burger, W. A. C., White, J., Choy, K. H. C., Tobin, A. B., Sexton, P. M., Valant, C., Capuano, B., Christopoulos, A. & Scammells, P. J., 20 Mar 2019, In : ACS Chemical Neuroscience. 10, 3, p. 1099-1114 16 p.

Research output: Contribution to journal › Article › Research › peer-review

Probe dependence of allosteric enhancers on the binding affinity of adenosine A ₁ -receptor agonists at rat and human A ₁ -receptors measured using NanoBRET

Cooper, S. L., Soave, M., Jörg, M., Scammells, P. J., Woolard, J. & Hill, S. J., Apr 2019, In : British Journal of Pharmacology. 176, 7, p. 864-878 15 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

File

Assessment of the molecular mechanisms of action of novel 4-phenylpyridine-2-one and 6-phenylpyrimidin-4-one allosteric modulators at the M1 muscarinic acetylcholine receptors

Van Der Westhuizen, E. T., Spathis, A., Khajehali, E., Jorg, M., Mistry, S. N., Capuano, B., Tobin, A. B., Sexton, P. M., Scammells, P. J., Valant, C. & Christopoulos, A., 1 May 2018, In : Molecular Pharmacology. 94, 1, p. 770-783 14 p.

Research output: Contribution to journal › Article › Research › peer-review

A Structure-Activity Relationship Study of Bitopic N ⁶-Substituted Adenosine Derivatives as Biased Adenosine A₁ Receptor Agonists

Aurelio, L., Baltos, J. A., Ford, L., Nguyen, A. T. N., Jörg, M., Devine, S. M., Valant, C., White, P. J., Christopoulos, A., May, L. T. & Scammells, P. J., 8 Mar 2018, In : Journal of Medicinal Chemistry. 61, 5, p. 2087-2103 17 p.

Research output: Contribution to journal › Article › Research › peer-review

Probing the binding site of novel selective positive allosteric modulators at the M₁ muscarinic acetylcholine receptor

Khajehali, E., Valant, C., Jörg, M., Tobin, A. B., Conn, P. J., Lindsley, C. W., Sexton, P. M., Scammells, P. J. & Christopoulos, A., 1 Aug 2018, In : Biochemical Pharmacology. 154, p. 243-254 12 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

File

Prizes

CASS Foundation Travel Award

Manuela Jorg (Recipient), 2018

Prize: Prize (including medals and awards)

CTx Post-Graduate Student Travel Award

Manuela Jorg (Recipient), 2012

Prize: Prize (including medals and awards)

Honourable Geoffrey Connard AM Early Career Research Travelling Award

Manuela Jorg (Recipient), 2017

Prize: Prize (including medals and awards)

Merck Innovation Cup Award

Manuela Jorg (Recipient), 2016

Prize: Prize (including medals and awards)

Monash University Post-Graduate Publication Award

Manuela Jorg (Recipient), 2014

Prize: Prize (including medals and awards)