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Personal profile

Biography

Dr Maliha Alikhan is a Research Fellow in the Centre for Inflammatory Diseases at Monash University. Maliha completed her PhD at Monash University in 2012 under the supervision of Professor Sharon Ricardo, investigating the role of reparative macrophages in acute kidney injury (AKI). Maliha joined the Autoimmune Kidney Disease and Vasculitis Research Group under the supervision of Professor Richard Kitching in 2013. Her main research area is investigating the immune responses in experimental models of autoimmune anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis, particularly focusing on adaptive immunity in acute and chronic myeloperoxidase (MPO) autoimmunity in ANCA-associated glomerulonephritis. She has established critical techniques to examine MPO antigen specific responses, T cell mediated injury and CD8 T cell memory phenotype and function using multi-colour flow cytometry analysis and gene sequencing to better understand the pathogenesis of T cell mediated kidney disease and identify potential therapeutics.

Maliha also works in developing mouse models of AKI that examine the AKI to chronic kidney disease progression in ischemia-reperfusion injury and cisplatin nephrotoxicity. Her studies investigate how the innate immune system drives injury particularly focusing on the role of the inflammasome and Toll-like receptors.  

Research area keywords

  • Renal disease
  • ANCA Vasculitis
  • T cells
  • Immunity and inflammation
  • Acute kidney injury

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Research Output 2011 2018

C5a receptor 1 promotes autoimmunity, neutrophil dysfunction and injury in experimental anti-myeloperoxidase glomerulonephritis

Dick, J., Gan, P. Y., Ford, S. L., Odobasic, D., Alikhan, M. A., Loosen, S. H., Hall, P., Westhorpe, C. L., Li, A., Ooi, J. D., Woodruff, T. M., Mackay, C. R., Kitching, A. R., Hickey, M. J. & Holdsworth, S. R., 1 Mar 2018, In : Kidney International. 93, 3, p. 615-625 11 p.

Research output: Contribution to journalArticleResearchpeer-review

CD8+ cells and glomerular crescent formation: Outside-in as well as inside-out

Kitching, A. R. & Alikhan, M. A., 1 Aug 2018, In : Journal of Clinical Investigation. 128, 8, p. 3231-3233 3 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Inflammasomes in the Kidney

Hutton, H., Alikhan, M. & Kitching, R., 1 Jan 2018, Inflammasomes: Clinical and Therapeutic Implications. Cordero, M. & Alcocer-Gomez, E. (eds.). Cham, Switzerland: Springer, p. 177-210 34 p. (Experientia Supplementum; vol. 108).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Regulatory T cells in renal disease

Alikhan, M. A., Huynh, M., Kitching, A. R. & Ooi, J. D., 1 Jan 2018, In : Clinical and Translational Immunology. 7, 1, 14 p., e1004.

Research output: Contribution to journalReview ArticleOtherpeer-review

Open Access
File

Activated renal dendritic cells cross present intrarenal antigens after ischemia reperfusion injury

Snelgrove, S. L. L., Lo, C., Hall, P., Lo, C. Y. Y., Alikhan, M. A. A., Coates, T. T., Holdsworth, S. R. R., Hickey, M. J. J. & Kitching, R. R., May 2017, In : Transplantation. 101, 5, p. 1013-1024 12 p.

Research output: Contribution to journalArticleResearchpeer-review