Projects per year
Personal profile
Biography
I am an academic medical oncologist with clinical (MBBS, FRACP) and research interests in neuro-oncology and early phase clinical trials. In addition to recently submitting my PhD, I currently hold a consultant oncologist position at the Alfred Hospital as the Head of Molecular Oncology and Rare Cancers. Despite being an early-career researcher, I have already made significant original contributions to my research field (27 peer reviewed papers, ten as first author and two as senior author) including publishing a large series on clinical correlates of PD-L1 immunohistochemistry in non-small cell lung cancer, a Cochrane meta-analysis on anti-angiogenic therapy in glioblastoma, a number of reports demonstrating novel therapeutic approaches in rarer brain tumours, as well as a range of research contributing in the field of early drug development including being first author of a first-in-human study of a novel BET inhibitor, the identification of a number of clinical relevant biomarkers in early phase trials and novel computational approaches to drug repurposing. I have established a number of international collaborations over the course of this research and have ongoing projects related to my PhD which I expect to come to fruition in the near future.
After finishing formal training in 2015, I have completed a two-year fellowship at the Institute of Cancer Research/Royal Marsden Hospital drug development unit under the supervision of Professor Johann de Bono. During this fellowship, in addition to being a sub-investigator on a large number of early phase and first-in-human trials, I was the senior clinical fellow, was primary fellow in charge of the molecular characterisation program and actively participated in the development of clinical trials including concept design, pitching investigator initiated trials, protocol writing and development of risk mitigation plans. Subsequent to completion of this fellowship, I have submitted my PhD in the Shackleton laboratory, having developed bench skills in tissue culture, cloning, lentiviral transduction, CRISPR, working with immunosuppressed mouse models, flow cytometry and other standard molecular biology techniques and statistical techniques. I believe that developing these foundational laboratory skills, in addition to my strong background in early-phase clinical trials, is a unique set of skills that provides a strong platform for developing as a clinician scientist in the translational space. Clinically, I have done a fellowship in neuro-oncology and continue to manage neuro-oncology patients in my clinical practice.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Head of Molecular Oncology and Rare Cancers, Alfred Hospital
2022 → …
Medical oncologist, Alfred Hospital
2018 → …
Medical oncologist, Cabrini Health Limited
2018 → …
Collaborations and top research areas from the last five years
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TRIUMPH: TRIUMPH – Tebentafusp and Roginolisib in Uveal Melanoma to Prolong T-cell Homeostasis
Ameratunga, M. (Primary Chief Investigator (PCI)) & Shackleton, M. (Supervisor)
1/08/25 → 31/07/27
Project: Research
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A Phase 1-1b Study to Evaluate the Safety, Efficacy and Dosimetry of [225Ac]Ac-A9-3408 in Subjects with Unresectable or Metastatic Melanoma Expressing MC1R
Ameratunga, M. (Primary Chief Investigator (PCI))
30/07/25 → 29/07/27
Project: Research
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A first-in-human, phase 1, multi-center, open-label, dose-escalation study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics and preliminary evidence of antitumor activity of IDOV-Immune in adult participants with advanced solid tumors
Ameratunga, M. (Primary Chief Investigator (PCI))
21/07/25 → 20/07/27
Project: Research
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SILVER TRIAL - Supplementing with IL-2 to Verifiably eRadicate Radiological Progression
Ameratunga, M. (Primary Chief Investigator (PCI))
25/06/25 → 24/06/27
Project: Research
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A Phase 1b/2, Safety Lead-in and Dose-Expansion, Open label, Multicenter Trial Investigating the Safety, Tolerability, and Preliminary Activity of Ivosidenib in Combination with Durvalumab and Gemcitabine/Cisplatin as First-line Therapy in Participants with Locally Advanced, Unresectable or Metastatic Cholangiocarcinoma with an IDH1 Mutation
Ameratunga, M. (Primary Chief Investigator (PCI))
28/05/25 → 27/05/27
Project: Research
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Dramatic clinical response in the treatment of small cell glioblastoma multiforme
Zaman, F. Y., McLean, C. & Ameratunga, M., Jun 2022, In: Journal of Clinical Pharmacy and Therapeutics. 47, 6, p. 832-834 3 p.Research output: Contribution to journal › Article › Other › peer-review
Open Access1 Citation (Scopus) -
The Immune Microenvironment, Genome-wide Copy Number Aberrations, and Survival in Mesothelioma
Thapa, B., Salcedo, A., Lin, X., Walkiewicz, M., Murone, C., Ameratunga, M., Asadi, K., Deb, S., Barnett, S. A., Knight, S., Mitchell, P., Watkins, D. N., Boutros, P. C. & John, T., May 2017, In: Journal of Thoracic Oncology. 12, 5, p. 850-859 10 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile88 Citations (Scopus) -
Fever in melanoma: New drugs or bugs?
Macesic, N., Ameratunga, M., Grayson, M. L. & Johnson, D. F., 1 Oct 2015, In: Clinical Microbiology and Infection. 21, 10, p. e77-e78 2 p.Research output: Contribution to journal › Letter › Other › peer-review
Open Access4 Citations (Scopus) -
A Delphi study of current practices and establishing consensus regarding assessment of fitness to drive among patients with brain tumours
Lapidus, A. H., Devitt, B., Herbison, H., Tran, S., Cheung, J., Gately, L., Neal, A. & Ameratunga, M., 2025, In: Journal of Neuro-Oncology. 173, 3, p. 645–653 9 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Prospective Isolation According to Melanin Pigment Content of Melanoma Cells With Heterogeneous Potentials for Disease Propagation
Fedele, C., Kuser-Abali, G., Rossi, R., Zhao, P., Li, J., Ameratunga, M., Szeto, P., Zhang, Y. F., Andrews, M. & Shackleton, M., Jul 2025, In: Pigment Cell and Melanoma Research. 38, 4, 18 p., e70011.Research output: Contribution to journal › Article › Research › peer-review
Open Access
Activities
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Medical Oncology Group of Australia
Ameratunga, M. (Organiser)
27 Aug 2025Activity: Participating in or organising an event types › Contribution to conference
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Caitlin Murphy
Ameratunga, M. (Host)
1 Jun 2025 → 30 Aug 2025Activity: Hosting a visitor types › Hosting an academic or industry visitor
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Oncologie (Journal)
Ameratunga, M. (Editor in chief)
2025 → …Activity: Publication peer-review and editorial work types › Editorial responsibility
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Cooperative Trials Group for Neruo-Oncology (COGNO) Annual Scientific Meeting 2025
Ameratunga, M. (Invited speaker)
15 Sept 2025Activity: Participating in or organising an event types › Contribution to conference
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Australian Precision Oncology Symposium 2025
Ameratunga, M. (Invited speaker)
7 Mar 2025Activity: Participating in or organising an event types › Contribution to conference
Press/Media
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First in the world melanoma trial to breakthrough barriers
24/02/23
1 Media contribution
Press/Media: Article/Feature