Accepting PhD Students

PhD projects

Targeting CD39 to improve outcome in models of small vessel thrombosis

20102019

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2019

Activated CD8+ T Cells Cause Long-Term Neurological Impairment after Traumatic Brain Injury in Mice

Daglas, M., Draxler, D. F., Ho, H., McCutcheon, F., Galle, A., Au, A. E., Larsson, P., Gregory, J., Alderuccio, F., Sashindranath, M. & Medcalf, R. L., 29 Oct 2019, In : Cell Reports. 29, 5, p. 1178-1191.e6 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)

The mode of anesthesia influences outcome in mouse models of arterial thrombosis

Sashindranath, M., Sturgeon, S., French, S. L., Craenmehr, D. D. D., Selan, C., Freddi, S., Johnson, C., Cody, S., Nesbitt, W., Hamilton, J., Cody, S. H., Nesbitt, W., Hamilton, J. & Nandurkar, H., Apr 2019, In : Thrombosis and Haemostasis. 3, 2, p. 197-206 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Tranexamic Acid Influences the Immune Response, but not Bacterial Clearance in a Model of Post-Traumatic Brain Injury Pneumonia

Draxler, D. F., Awad, M. M., Hanafi, G., Daglas, M., Ho, H., Keragala, C., Galle, A., Roquilly, A., Lyras, D., Sashindranath, M. & Medcalf, R. L., 1 Dec 2019, In : Journal of Neurotrauma. 36, 23, p. 3297-3308 12 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Tranexamic acid modulates the cellular immune profile after traumatic brain injury in mice without hyperfibrinolysis

Draxler, D. F., Daglas, M., Fernando, A., Hanafi, G., McCutcheon, F., Ho, H., Galle, A., Gregory, J., Larsson, P., Keragala, C., Wright, D. K., Tavancheh, E., Au, A. E., Niego, B., Wilson, K., Plebanski, M., Sashindranath, M. & Medcalf, R. L., Dec 2019, In : Journal of Thrombosis and Haemostasis. 17, 12, p. 2174-2187 14 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Tranexamic acid modulates the immune response and reduces postsurgical infection rates

Draxler, D. F., Yep, K., Hanafi, G., Winton, A., Daglas, M., Ho, H., Sashindranath, M., Wutzlhofer, L. M., Forbes, A., Goncalves, I., Tran, H. A., Wallace, S., Plebanski, M., Myles, P. S. & Medcalf, R. L., 28 May 2019, In : Blood Advances. 3, 10, p. 1598-1609 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
10 Citations (Scopus)

Transactive Response DNA-Binding Protein 43 Abnormalities after Traumatic Brain Injury

Tan, X. L., Sun, M., Brady, R. D., Liu, S., Llanos, R. M., Cheung, S., Wright, D. K., Casillas-Espinosa, P. M., Sashindranath, M., O'Brien, T. J., McDonald, S. J., Turner, B. J. & Shultz, S., 1 Jan 2019, In : Journal of Neurotrauma. 36, 1, p. 87-99 13 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)
2018

CD39 and CD73 activity are protective in a mouse model of antiphospholipid antibody-induced miscarriages

Samudra, A. N., Dwyer, K. M., Selan, C., Freddi, S., Murray-Segal, L., Nikpour, M., Hickey, M. J., Peter, K., Robson, S. C., Sashindranath, M., Cowan, P. J. & Nandurkar, H. H., Mar 2018, In : Journal of Autoimmunity. 88, p. 131-138 8 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)
2017

Development of a novel strategy to target CD39 antithrombotic activity to the endothelial-platelet microenvironment in kidney ischemia–reperfusion injury

Sashindranath, M., Dwyer, K. M., Dezfouli, S., Selan, C., Crikis, S., Lu, B., Yuan, Y., Hickey, M. J., Peter, K., Robson, S. C., Cowan, P. J. & Nandurkar, H. H., Jun 2017, In : Purinergic Signalling. 13, 2, p. 259-265 7 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Plasmin: A Modulator of Immune Function

Draxler, D. F., Sashindranath, M. & Medcalf, R. L., 1 Mar 2017, In : Seminars in Thrombosis and Hemostasis. 43, 2, p. 143-153 11 p., 02353.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)
2016

Ablation of Type-1 IFN Signaling in Hematopoietic Cells Confers Protection Following Traumatic Brain Injury

Karve, I. P., Zhang, M., Habgood, M., Frugier, T., Brody, K. M., Sashindranath, M., Ek, C. J., Chappaz, S., Kile, B. T., Wright, D., Wang, H., Johnston, L., Daglas, M., Ates, R. C., Medcalf, R. L., Taylor, J. M. & Crack, P. J., 1 Jan 2016, In : eNeuro. 3, 1, 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
18 Citations (Scopus)

Valproic acid selectively increases vascular endothelial tissue-type plasminogen activator production and reduces thrombus formation in the mouse

Larsson, P., Alwis, I., Niego, B., Sashindranath, M., Fogelstrand, P., Wu, M. C. L., Glise, L., Magnusson, M., Daglas, M., Bergh, N., Jackson, S. P., Medcalf, R. L. & Jern, S., 23 Nov 2016, In : Journal of Thrombosis and Haemostasis. 14, 12, p. 2496-2508 13 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)
2015

Evaluation of gait impairment in mice subjected to craniotomy and traumatic brain injury

Sashindranath, M., Daglas, M. & Medcalf, R. L., 2015, In : Behavioural Brain Research. 286, p. 33 - 38 6 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Imatinib treatment reduces brain injury in a murine model of traumatic brain injury

Su, E. J., Fredriksson, L. T., Kanzawa, M., Moore, S., Folestad, E., Stevenson, T. K., Nilsson, I., Sashindranath, M., Schielke, G. P., Warnock, M., Ragsdale, M., Mann, K. M., Lawrence, A-L. E., Medcalf, R. L., Eriksson, U., Murphy, G. G. & Lawrence, D. A., 2015, In : Frontiers in Cellular Neuroscience. 9, (Art. No: 385), p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
24 Citations (Scopus)

Sodium selenate reduces hyperphosphorylated tau and improves outcomes after traumatic brain injury

Schultz, S. R., Wright, D. K., Zheng, P., Stuchbery, R., Liu, S-J., Sashindranath, M., Medcalf, R. L., Johnston, L. A., Hovens, C. M., Jones, N. C. & O'Brien, T. J., 2015, In : Brain. 138, 5, p. 1297 - 1313 17 p.

Research output: Contribution to journalArticleResearchpeer-review

79 Citations (Scopus)
2014

Activated platelets rescue apoptotic cells via paracrine activation of EGFR and DNA-dependent protein kinase

Au, A. E-L., Sashindranath, M., Borg, R. J., Kleifeld, O., Andrews, R. K., Gardiner, E. E., Medcalf, R. L. & Samson, A. L., 2014, In : Cell Death and Disease. 5, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
16 Citations (Scopus)

Anti-lysophosphatidic acid antibodies improve traumatic brain injury outcomes

Crack, P. J., Zhang, M., Morganti-Kossmann, M. C., Morris, A., Wojciak, J. M., Fleming, J. K., Karve, I., Wright, D. K., Sashindranath, M., Goldshmit, Y., Conquest, A., Daglas, M., Johnston, L. A., Medcalf, R. L., Sabbadini, R. A. & Pebay, A., 2014, In : Journal of Neuroinflammation. 11, (Art. No: 37), p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
40 Citations (Scopus)

TNFalpha stimulation desensitises a human in vitro BBB model to t-PA-mediated permeabilisation.

Niego, B., Sashindranath, M., Galle, A., Freeman, R. & Medcalf, R., 11 Dec 2014.

Research output: Contribution to conferenceAbstract

2013

Tissue-type plasminogen activator is an extracellular mediator of Purkinje cell damage and altered gait

Cops, E., Sashindranath, M., Daglas, M., Short, K. M., Pereira, C. D. F., Pang, T., Lijnen, R., Smyth, I. M., Hannan, A. J., Samson, A. L. & Medcalf, R. L., 2013, In : Experimental Neurology. 249C, p. 8 - 19 12 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)
2012

Nucleocytoplasmic coagulation: an injury-induced aggregation event that disulfide crosslinks proteins and facilitates their removal by plasmin

Samson, A. L., Knaupp, A. S., Sashindranath, M., Borg, R. J., Au, A. E-L., Cops, E. J., Saunders, H. M., Cody, S. H., McLean, C. A., Nowell, C., Hughes, V. A., Bottomley, S. P. & Medcalf, R. L., 2012, In : Cell Reports. 2, 4, p. 889 - 901 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
23 Citations (Scopus)

The tissue-type plasminogen activator-plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: evidence from mice and humans

Sashindranath, M., Sales, E., Daglas, M., Freeman, R., Samson, A. L., Cops, E., Beckham, S. A., Galle, A. A., McLean, C. A., Morganti-Kossmann, M. C., Rosenfeld, J. V., Madani, R., Vassalli, J-D., Su, E. J., Lawrence, D. A. & Medcalf, R. L., 2012, In : Brain. 135, 11, p. 3251 - 3264 14 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Tissue plasminogen activator does not alter development of acquired epilepsy

Tan, M-L., Ng, A. Q. P., Pandher, P., Sashindranath, M., Hamilton, J. A., Davis, S. M., O'Brien, T. J., Medcalf, R. L., Yan, B. & Jones, N., 2012, In : Epilepsia. 53, 11, p. 1998 - 2004 7 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)
2011

Compartment- and context-specific changes in tissue-type plasminogen activator (tPA) activity following brain injury and pharmacological stimulation

Sashindranath, M., Samson, A., Downes, C. E., Crack, P., Lawrence, A. J., Li, Q-X., Ng, A. Q. P., Jones, N. C., Farrugia, J., Abdella, E., Vassalli, J-D., Madani, R. & Medcalf, R., 2011, In : Laboratory Investigation. 91, 7, p. 1079 - 1091 13 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)
2010

Early hippocampal oxidative stress is a direct consequence of seizures in the rapid electrical amygdala kindling model

Sashindranath, M., Mclean, K., Trounce, I. A., Cotton, R. & Cook, M., 2010, In : Epilepsy Research. 90, 3, p. 285 - 294 10 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)