Research output per year
Research output per year
Personal profile
Biography
Dr. Madeleine Fletcher is a research fellow within the Metabolic G Protein-Coupled Receptor Biology laboratory. She completed a PhD in Pharmacology and Pharmaceutical Sciences (2014-2018) at Monash Institute of Pharmaceutical Sciences examining the role of the internalisation and trafficking of the Glucagon-like peptide-1 receptor, a key target of diabetes and obesity therapeutics. She has a keen interest in drug and therapeutics and their translation to clinical use and her research involves investigating the pharmacology of treatments for a range of conditions including migraine, diabetes, obesity and vascular disorders.
Research area keywords
- Class B GPCR
- GLP-1R
- Calcitonin Receptor
- Amylin Receptors
- Calcitonin-Like Receptor
- Molecular Pharmacology
- Signal Transduction
- Receptor Trafficking
Network
Recent external collaboration on country level. Dive into details by clicking on the dots or
Research output
- 6 Article
-
Activation of the GLP-1 receptor by a non-peptidic agonist
Zhao, P., Liang, Y. L., Belousoff, M. J., Deganutti, G., Fletcher, M. M., Willard, F. S., Bell, M. G., Christe, M. E., Sloop, K. W., Inoue, A., Truong, T. T., Clydesdale, L., Furness, S. G. B., Christopoulos, A., Wang, M. W., Miller, L. J., Reynolds, C. A., Danev, R., Sexton, P. M. & Wootten, D., 8 Jan 2020, In : Nature. 577, 7790, p. 432-436 5 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile27 Citations (Scopus) -
Structure and Dynamics of Adrenomedullin Receptors AM1 and AM2 Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins
Liang, Y. L., Belousoff, M. J., Fletcher, M. M., Zhang, X., Khoshouei, M., Deganutti, G., Koole, C., Furness, S. G. B., Miller, L. J., Hay, D. L., Christopoulos, A., Reynolds, C. A., Danev, R., Wootten, D. & Sexton, P. M., 10 Apr 2020, In : ACS Pharmacology & Translational Science. 3, 2, p. 263-284 22 p.Research output: Contribution to journal › Article › Research › peer-review
15 Citations (Scopus) -
Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation
Liang, Y. L., Belousoff, M. J., Zhao, P., Koole, C., Fletcher, M. M., Truong, T. T., Julita, V., Christopoulos, G., Xu, H. E., Zhang, Y., Khoshouei, M., Christopoulos, A., Danev, R., Sexton, P. M. & Wootten, D., 6 Feb 2020, In : Molecular Cell. 77, 3, p. 656-668.e5 18 p.Research output: Contribution to journal › Article › Research › peer-review
20 Citations (Scopus) -
Glucagon-like peptide-1 receptor internalisation controls spatiotemporal signalling mediated by biased agonists
Fletcher, M. M., Halls, M. L., Zhao, P., Clydesdale, L., Christopoulos, A., Sexton, P. M. & Wootten, D., 1 Oct 2018, In : Biochemical Pharmacology. 156, p. 406-419 14 p.Research output: Contribution to journal › Article › Research › peer-review
15 Citations (Scopus) -
Glucagon-like peptide-1 and its class B G protein-coupled receptors: a long march to therapeutic successes
de Graaf, C., Donnelly, D., Wootten, D., Lau, J., Sexton, P. M., Miller, L. J., Ahn, J-M., Liao, J., Fletcher, M. M., Yang, D., Brown, A. J. H., Zhou, C., Deng, J. & Wang, M-W., 1 Oct 2016, In : Pharmacological Reviews. 68, 4, p. 954-1013 60 p.Research output: Contribution to journal › Article › Research › peer-review
104 Citations (Scopus)