Projects per year
Personal profile
Biography
Luke is an NHMRC Emerging Leader Fellow at the Monash Biomedical Discovery Institute. He completed his PhD in 2016 and conducted postdoctoral research in the lab of Prof. Mike Ryan where he primarily focused on studying proteins involved in the assembly of the electron transport chain in mitochondria. His research aims to uncover the mechanisms underlying mitochondrial diseases caused by defects in this process. Luke’s research has identified new proteins related to electron transport chain function, re-evaluated the roles of known mitochondrial proteins, and characterised genetic factors contributing to mitochondrial disease. In 2023, Luke became a Group Leader at the BDI, where he continues to pursue his research interests in understanding how changes in mitochondrial function affect mitochondrial metabolism. Specifically, he is passionate about identifying novel components involved in electron transport chain function and exploring the rewiring of mitochondrial metabolism in response to altered mitochondrial function.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Mitochondria
- Mitochondrial Disease
- Proteomics
- Gene Editing
- Metabolism
- complex I
- CRISPR Cas9
- complex IV
- heme
- membrane complexes
- complex assembly
Collaborations and top research areas from the last five years
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Understanding complex I assembly for better diagnosis and future treatment
Formosa, L. (Primary Chief Investigator (PCI))
1/01/22 → 31/12/26
Project: Research
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Mitochondrial COA7 is a heme-binding protein with disulfide reductase activity, which acts in the early stages of complex IV assembly
Formosa, L. E., Maghool, S., Sharpe, A. J., Reljic, B., Muellner-Wong, L., Stroud, D. A., Ryan, M. T. & Maher, M. J., 24 Feb 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 9, 10 p., e2110357119.Research output: Contribution to journal › Article › Research › peer-review
Open Access17 Citations (Scopus) -
Optic atrophy–associated TMEM126A is an assembly factor for the ND4-module of mitochondrial complex I
Formosa, L. E., Reljic, B., Sharpe, A. J., Hock, D. H., Muellner-Wong, L., Stroud, D. A. & Ryan, M. T., 27 Apr 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 17, 9 p., e2019665118.Research output: Contribution to journal › Article › Research › peer-review
19 Citations (Scopus) -
Two independent respiratory chains adapt OXPHOS performance to glycolytic switch
Fernández-Vizarra, E., López-Calcerrada, S., Sierra-Magro, A., Pérez-Pérez, R., Formosa, L. E., Hock, D. H., Illescas, M., Peñas, A., Brischigliaro, M., Ding, S., Fearnley, I. M., Tzoulis, C., Pitceathly, R. D. S., Arenas, J., Martín, M. A., Stroud, D. A., Zeviani, M., Ryan, M. T. & Ugalde, C., 1 Nov 2022, In: Cell Metabolism. 34, 11, p. 1792-1808.e6 24 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access38 Citations (Scopus) -
Dissecting the Roles of Mitochondrial Complex I Intermediate Assembly Complex Factors in the Biogenesis of Complex I
Formosa, L. E., Muellner-Wong, L., Reljic, B., Sharpe, A. J., Jackson, T. D., Beilharz, T. H., Stojanovski, D., Lazarou, M., Stroud, D. A. & Ryan, M. T., 21 Apr 2020, In: Cell Reports. 31, 3, 14 p., 107541.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile77 Citations (Scopus) -
Loss of endogenous estrogen alters mitochondrial metabolism and muscle clock-related protein Rbm20 in female mdx mice
Timpani, C. A., Debrincat, D., Kourakis, S., Boyer, R., Formosa, L. E., Steele, J. R., Zhang, H., Schittenhelm, R. B., Russell, A. P., Rybalka, E. & Lindsay, A., 15 Jun 2024, In: The FASEB Journal. 38, 11, 19 p., e23718.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus)
Activities
- 1 Contribution to workshop, seminar, course
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AussieMit 2024
Kate McArthur (Organiser) & Luke Formosa (Organiser)
26 Nov 2024 → 1 Dec 2024Activity: Participating in or organising an event types › Contribution to workshop, seminar, course