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Personal profile

Biography

Dr Luise Cullen-McEwen is a Research Fellow with the Department of Anatomy and Developmental Biology. Luise obtained her Bachelor of Biomedical Science at the University of Wollongong (1998), Honours degree at Melbourne University (1999) and her PhD at Monash University (2002). In 2002 she was appointed as a Postdoctoral Research Fellow in the Department of Anatomy and Developmental Biology in the School of Biomedical Sciences at Monash University. Luise's research focuses on kidney development, particularly the regulation of branching morphogenesis and thereby nephron number during embryogenesis. Luise's PhD studied the role of Glial Cell Line-Derived Neurotrophic Factor (GDNF) in regulating ureteric branching morphogenesis. GDNF is a key regulator of early branching in the developing kidney. Luise has extensive experience in animal handling, embryo dissection, embryonic kidney culture, whole mount immunofluorescence, histology and unbiased stereology.



Luise Cullen-McEwen obtained her Bachelor of Biomedical Science at the University of Wollongong (1998), Honours degree at Melbourne University (1999) and her PhD at Monash University (2002). In 2002 she was appointed as a Postdoctoral Research Fellow in the Department of Anatomy and Developmental Biology in the School of Biomedical Sciences at Monash University. Luise's research focuses on kidney development, particularly the regulation of branching morphogenesis and thereby nephron number during embryogenesis. Luise's PhD studied the role of Glial Cell Line-Derived Neurotrophic Factor (GDNF) in regulating ureteric branching morphogenesis. GDNF is a key regulator of early branching in the developing kidney. Luise has extensive experience in animal handling, embryo dissection, embryonic kidney culture, whole mount immunofluorescence, histology and unbiased stereology. Luise has applied for NHMRC funding in 2010 for a research project to investigate the effect of maternal hyperglycemia (maternal diabetes) on kidney development.

blue kidney tree

Above Image: Histological section of embryonic day 15 rat kidney stained for ureteric tree (Dolichos Biflorus Agglutinin staining)

green fluoresence image tag

Above Image: Immunofluorescence photomicrographs of the ureteric tree in metanephroi cultured for 3 days in control media (i), or media supplemented with rhGDNF (ii), FCS (iii), or rhGDNF plus 10% FCS (iv).

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Projects 2000 2017

Research Output 2000 2019

Impaired SIRT1 activity leads to diminution in glomerular endowment without accelerating age-associated GFR decline

Bellin, A. R., Zhang, Y., Thai, K., Rosenblum, N. D., Cullen-McEwen, L. A., Bertram, J. F. & Gilbert, R. E., 1 May 2019, In : Physiological Reports. 7, 9, 11 p., e14044.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Maternal low-protein diet programmes low ovarian reserve in offspring

Winship, A. L., Gazzard, S. E., Cullen-McEwen, L. A., Bertram, J. F. & Hutt, K., 10 Jul 2018, In : Reproduction. 156, 4, p. 299-311 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Wnt11 directs nephron progenitor polarity and motile behavior ultimately determining nephron endowment

O’brien, L. L., Combes, A. N., Short, K. M., Lindström, N. O., Whitney, P. H., Cullen-McEwen, L. A., Ju, A., Abdelhalim, A., Michos, O., Bertram, J. F., Smyth, I. M., Little, M. H. & McMahon, A. P., 5 Dec 2018, In : eLife. 7, 25 p., e40392.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Combining new tools to assess renal function and morphology: A holistic approach to study the effects of aging and a congenital nephron deficit

Geraci, S., Chacon-Caldera, J., Cullen-McEwen, L., Schad, L. R., Sticht, C., Puelles, V. G., Bertram, J. F. & Gretz, N., 1 Sep 2017, In : American Journal of Physiology - Renal Physiology. 313, 3, p. F576-F584 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Development of the kidney: Morphology and mechanisms

Smyth, I. M., Cullen-McEwen, L. A., Caruana, G., Black, M. J. & Bertram, J. F., 2017, Fetal and Neonatal Physiology. Polin, R. A., Abman, S. H., Rowitch, D. H., Benitz, W. E. & Fox, W. W. (eds.). 5th ed. Philadelphia, PA: Elsevier, Vol. 2. p. 953-964.e4 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review