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Personal profile

Biography

I am a Research Fellow in the Department of Neuroscience, Monash University and an emerging leader in the field of Positron Emission Topography (PET) radiotracer development, application and translation for rare neurodegenerative and neurological diseases known as tauopathies. I have a major interest in the role of the protein tau in neurodegenerative diseases, and the development of biomarkers to better identify tauopathies.

I use neuroimaging techniques (particularly PET imaging) to study the underlying pathogenic mechanisms of neurodegenerative diseases in order to change the current diagnosis and treatment of rare neurodegenerative diseases.

I have a strong translational research focus with capability in proof of concept in vitro studies (preclinical development and commercialisation), through to diagnostic validity in clinical application. My work in developing PET radiotracers has received substantial funding through the NIH (CI $1.4M USD, 2022-2025), the Department of Science the Environment and Resources (CI $1M, 2022-24), Multiple Sclerosis Research Australia (CI $235,000, 2021-22) and the NHMRC (CID $870,000, 2018-21).

My research program has focussed on early phase “first in human” and “first in disease” clinical trials of sodium selenate, a potentially disease-modifying treatment for tauopathies. Long term (<23 months) treatment with sodium selenate showed reduced cognitive decline than expected with natural history.

I lead a research group in which I supervise two PhD students, one MSc student, and three Honours students. I also co-supervise one post-doc and one PhD student. I am part of the iBRAIN research group leadership team.

I am one of the chief investigators of the Monash Cognition and Imaging Study (MCIS), a study that aims to better characterise different neurodegenerative diseases and find new biomarkers for earlier diagnosis. This is funded by the pharmaceutical company Biogen (USD$169,000) and philanthropic donations ($50,000).

I am an active collaborator in the ENIGMA epilepsy and MELD consortia.

Research area keywords

  • Neurodegenerative Diseases/Disorders
  • Neuropharmacology
  • Progressive Supranuclear Palsy
  • Neuroimaging
  • Position Emission Tomography (PET)

Network

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
  • A systems-level analysis highlights microglial activation as a modifying factor in common epilepsies

    Altmann, A., Ryten, M., Di Nunzio, M., Ravizza, T., Tolomeo, D., Reynolds, R. H., Somani, A., Bacigaluppi, M., Iori, V., Micotti, E., Di Sapia, R., Cerovic, M., Palma, E., Ruffolo, G., Botía, J. A., Absil, J., Alhusaini, S., Alvim, M. K. M., Auvinen, P., Bargallo, N. & 82 others, Bartolini, E., Bender, B., Bergo, F. P. G., Bernardes, T., Bernasconi, A., Bernasconi, N., Bernhardt, B. C., Blackmon, K., Braga, B., Caligiuri, M. E., Calvo, A., Carlson, C., Carr, S. J. A., Cavalleri, G. L., Cendes, F., Chen, J., Chen, S., Cherubini, A., Concha, L., David, P., Delanty, N., Depondt, C., Devinsky, O., Doherty, C. P., Domin, M., Focke, N. K., Foley, S., Franca, W., Gambardella, A., Guerrini, R., Hamandi, K., Hibar, D. P., Isaev, D., Jackson, G. D., Jahanshad, N., Kälviäinen, R., Keller, S. S., Kochunov, P., Kotikalapudi, R., Kowalczyk, M. A., Kuzniecky, R., Kwan, P., Labate, A., Langner, S., Lenge, M., Liu, M., Martin, P., Mascalchi, M., Meletti, S., Morita-Sherman, M. E., O'Brien, T. J., Pariente, J. C., Richardson, M. P., Rodriguez-Cruces, R., Rummel, C., Saavalainen, T., Semmelroch, M. K., Severino, M., Striano, P., Thesen, T., Thomas, R. H., Tondelli, M., Tortora, D., Vaudano, A. E., Vivash, L., von Podewils, F., Wagner, J., Weber, B., Wiest, R., Yasuda, C. L., Zhang, G., Zhang, J., ENIGMA-Epilepsy Working Group, Leu, C., Avbersek, A., EpiPGX Consortium, Thom, M., Whelan, C. D., Thompson, P., McDonald, C. R., Vezzani, A. & Sisodiya, S. M., Feb 2022, In: Neuropathology and Applied Neurobiology. 48, 1, 15 p., e12758.

    Research output: Contribution to journalArticleResearchpeer-review

    Open Access
    4 Citations (Scopus)
  • Atlas of lesion locations and postsurgical seizure freedom in focal cortical dysplasia: A MELD study

    Wagstyl, K., Whitaker, K., Raznahan, A., Seidlitz, J., Vértes, P. E., Foldes, S., Humphreys, Z., Hu, W., Mo, J., Likeman, M., Davies, S., Lenge, M., Cohen, N. T., Tang, Y., Wang, S., Ripart, M., Chari, A., Tisdall, M., Bargallo, N., Conde-Blanco, E. & 47 others, Pariente, J. C., Pascual-Diaz, S., Delgado-Martínez, I., Pérez-Enríquez, C., Lagorio, I., Abela, E., Mullatti, N., O'Muircheartaigh, J., Vecchiato, K., Liu, Y., Caligiuri, M., Sinclair, B., Vivash, L., Willard, A., Kandasamy, J., McLellan, A., Sokol, D., Semmelroch, M., Kloster, A., Opheim, G., Yasuda, C., Zhang, K., Hamandi, K., Barba, C., Guerrini, R., Gaillard, W. D., You, X., Wang, I., González-Ortiz, S., Severino, M., Striano, P., Tortora, D., Kalviainen, R., Gambardella, A., Labate, A., Desmond, P., Lui, E., O'Brien, T., Shetty, J., Jackson, G., Duncan, J. S., Winston, G. P., Pinborg, L., Cendes, F., Cross, J. H., Baldeweg, T. & Adler, S., Jan 2022, In: Epilepsia. 63, 1, p. 61-74 14 p.

    Research output: Contribution to journalArticleResearchpeer-review

    Open Access
    2 Citations (Scopus)
  • Neuroinflammation in the cerebellum and brainstem in Friedreich ataxia: an [18F]-FEMPA PET study

    Khan, W., Corben, L. A., Bilal, H., Vivash, L., Delatycki, M. B., Egan, G. F. & Harding, I. H., Jan 2022, In: Movement Disorders. 37, 1, p. 218-224 7 p.

    Research output: Contribution to journalArticleResearchpeer-review

  • The ENIGMA-Epilepsy working group: Mapping disease from large data sets

    Sisodiya, S. M., Whelan, C. D., Hatton, S. N., Huynh, K., Altmann, A., Ryten, M., Vezzani, A., Caligiuri, M. E., Labate, A., Gambardella, A., Ives-Deliperi, V., Meletti, S., Munsell, B. C., Bonilha, L., Tondelli, M., Rebsamen, M., Rummel, C., Vaudano, A. E., Wiest, R., Balachandra, A. R. & 53 others, Bargalló, N., Bartolini, E., Bernasconi, A., Bernasconi, N., Bernhardt, B., Caldairou, B., Carr, S. J. A., Cavalleri, G. L., Cendes, F., Concha, L., Desmond, P. M., Domin, M., Duncan, J. S., Focke, N. K., Guerrini, R., Hamandi, K., Jackson, G. D., Jahanshad, N., Kälviäinen, R., Keller, S. S., Kochunov, P., Kowalczyk, M. A., Kreilkamp, B. A. K., Kwan, P., Lariviere, S., Lenge, M., Lopez, S. M., Martin, P., Mascalchi, M., Moreira, J. C. V., Morita-Sherman, M. E., Pardoe, H. R., Pariente, J. C., Raviteja, K., Rocha, C. S., Rodríguez-Cruces, R., Seeck, M., Semmelroch, M. K. H. G., Sinclair, B., Soltanian-Zadeh, H., Stein, D. J., Striano, P., Taylor, P. N., Thomas, R. H., Thomopoulos, S. I., Velakoulis, D., Vivash, L., Weber, B., Yasuda, C. L., Zhang, J., Thompson, P. M., McDonald, C. R. & for the ENIGMA Consortium Epilepsy Working Group, Jan 2022, In: Human Brain Mapping. 43, 1, p. 113-128 16 p.

    Research output: Contribution to journalReview ArticleResearchpeer-review

    Open Access
    16 Citations (Scopus)
  • Topographic divergence of atypical cortical asymmetry and atrophy patterns in temporal lobe epilepsy

    Park, B., Lariviere, S., Rodríguez-Cruces, R., Royer, J., Tavakol, S., Wang, Y., Caciagli, L., Caligiuri, M. E., Gambardella, A., Concha, L., Keller, S. S., Cendes, F., Alvim, M. K. M., Yasuda, C. L., Bonilha, L., Gleichgerrcht, E., Focke, N. K., Kreilkamp, B. A. K., Domin, M., Von Podewils, F. & 67 others, Langner, S., Rummel, C., Rebsamen, M., Wiest, R., Martin, P., Kotikalapudi, R., Bender, B., O'Brien, T. J., Law, M., Sinclair, B., Vivash, L., Kwan, P., Desmond, P. M., Malpas, C. B., Lui, E. H., Alhusaini, S., Doherty, C. P., Cavalleri, G. L., Delanty, N., Kälviäinen, R., Jackson, G. D., Kowalczyk, M. A., Mascalchi, M., Semmelroch, M. K., Thomas, R., Soltanian-Zadeh, H., Davoodi-Bojd, E., Zhang, J., Lenge, M., Guerrini, R., Bartolini, E., Hamandi, K., Foley, S., Weber, B., Depondt, C., Absil, J., Carr, S. J. A., Abela, E., Richardson, M. P., Devinsky, O., Severino, M., Striano, P., Parodi, C., Tortora, D., Hatton, S. N., Vos, S. B., Duncan, J. S., Galovic, M., Whelan, C. D., Bargalló, N., Pariente, J. C., Conde-Blanco, E., Vaudano, A. E., Tondelli, M., Meletti, S., Kong, XZ., Francks, C., Fisher, S. E., Caldairou, B., Ryten, M., Labate, A., Sisodiya, S. M., Thompson, P. M., McDonald, C. R., Bernasconi, A., Bernasconi, N. & Bernhardt, B. C., Apr 2022, In: Brain. 145, 4, p. 1285–1298 14 p.

    Research output: Contribution to journalArticleResearchpeer-review

    Open Access