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Personal profile

Biography

Dr Lucy Vivash is a Research Fellow in the Department of Neuroscience, Monash University.

My research focuses on the application of neuroimaging (particularly PET imaging) to better understanding neurological and neurodegenerative diseases. I have several ongoing preclinical and clinical projects aim at the development and application of novel PET radiotracers for a range of neurodegenerative and neurologiical conditions.
I have a significant interest in the role of tau in neurodegenerative diseases. This has lead to numerous clinical trials in neurodegenerative diseases investigating the use of sodium selenate as an anti-tau therapy. I am also interested in the development of biomarkers to better identify tauopathies.

 

 

Projects

All projects are available research students


Tau-PET imaging in progressive supranuclear palsy
This project (in collaboration with industry partners) seeks to investigate the utility of a novel PET radiotracer to image tau in the living brain in patients with Progressive Supranuclear Palsy

Tau-PET imaging in animal models of neurological diseases
This project seeks to investigate whether tau is present in the pathogenesis of a number of neurological conditions including stroke and epilepsy

Development of radiotracers to target MerTK
This project aims to develop new radiotracers that specifically target MerTK, a protein expressed on neurprotective microglia, which is implicated in the pathogenesis of multiple sclerosis.

Monash Cognition Imaging Study (MCIS): Characterising Mild Cognitive Impairment using multimodal biomarkers
This project aims to utilise imaging (MRI, FDG-PET and amyloid-PET), cognitive and biofluid biomarkers to better understand the differing presentations of mild cognitive impairment

Sodium selenate as a disease-modifying treatment for tauopathies
These projects evaluate the safety and efficacy of sodium selenate as a disease-modifying treatment for tauopathies. A phase 1b study in behavioural variant frontotemporal dementia is due to complete in Dec 2020. Two phase 2 studies are due to begin in early 2021, in progressive supranuclear palsy and behavioural variant frontotemporal dementia.

 

 

Research area keywords

  • Neurodegenerative Diseases/Disorders
  • Neuropharmacology
  • Progressive Supranuclear Palsy
  • Neuroimaging
  • Position Emission Tomography (PET)

Network

Recent external collaboration on country level. Dive into details by clicking on the dots or
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