Projects per year
Personal profile
Biography
Dr Lucy Vivash is a Research Fellow in the Department of Neuroscience, Monash University.
My research focuses on the application of neuroimaging (particularly PET imaging) to better understanding neurological and neurodegenerative diseases. I have several ongoing preclinical and clinical projects aim at the development and application of novel PET radiotracers for a range of neurodegenerative and neurologiical conditions.
I have a significant interest in the role of tau in neurodegenerative diseases. This has lead to numerous clinical trials in neurodegenerative diseases investigating the use of sodium selenate as an anti-tau therapy. I am also interested in the development of biomarkers to better identify tauopathies.
Projects
All projects are available research students
Tau-PET imaging in progressive supranuclear palsy
This project (in collaboration with industry partners) seeks to investigate the utility of a novel PET radiotracer to image tau in the living brain in patients with Progressive Supranuclear Palsy
Tau-PET imaging in animal models of neurological diseases
This project seeks to investigate whether tau is present in the pathogenesis of a number of neurological conditions including stroke and epilepsy
Development of radiotracers to target MerTK
This project aims to develop new radiotracers that specifically target MerTK, a protein expressed on neurprotective microglia, which is implicated in the pathogenesis of multiple sclerosis.
Monash Cognition Imaging Study (MCIS): Characterising Mild Cognitive Impairment using multimodal biomarkers
This project aims to utilise imaging (MRI, FDG-PET and amyloid-PET), cognitive and biofluid biomarkers to better understand the differing presentations of mild cognitive impairment
Sodium selenate as a disease-modifying treatment for tauopathies
These projects evaluate the safety and efficacy of sodium selenate as a disease-modifying treatment for tauopathies. A phase 1b study in behavioural variant frontotemporal dementia is due to complete in Dec 2020. Two phase 2 studies are due to begin in early 2021, in progressive supranuclear palsy and behavioural variant frontotemporal dementia.
Research area keywords
- Neurodegenerative Diseases/Disorders
- Neuropharmacology
- Progressive Supranuclear Palsy
- Neuroimaging
- Position Emission Tomography (PET)
Network
Recent external collaboration on country level. Dive into details by clicking on the dots or
Projects
- 5 Active
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Novel radioligands for PET imaging of multiple sclerosis diagnosis
Baell, J., Kilpatrick, T. J., Scott, A., Parker, M., Binder, M., Vivash, L., Ackermann, U. & Mudududdla, R.
1/01/21 → 31/12/23
Project: Research
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Testing of the effect of E2730 treatment on multimodality in-vivo biomarkers of GABAergic function in healthy rats and preclinical chronic epilepsy models
O'Brien, T., Kwan, P., Ali, I., Casillas-Espinosa, P., Jones, N., Jupp, B., Vivash, L., Wright, D., Mychasiuk, R. & Major, B.
22/10/20 → 21/10/21
Project: Research
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MCIS: Characterising Mild Cognitive Impairment using multimodal biomarkers.
17/08/20 → 31/12/21
Project: Research
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Sodium Selenate as a Disease Modifying Treatment for Progressive Supranuclear Palsy (Sodium Selenate for PSP)
O'Brien, T., Bertram, K., Vivash, L., Evans, A. H., Kimber, T. E., O'Sullivan, J. D., Malpas, C., Fielding, J., Velakoulis, D. & Law, M.
1/06/20 → 31/05/25
Project: Research
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Novel Radioligands for PET imaging and phenotyping of multiple sclerosis diagnosis
Baell, J., Kilpatrick, T. J., Binder, M. D., Vivash, L. & Ackermann, U.
1/01/18 → 31/12/21
Project: Research
Research output
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Cognitive profiles in patients with epileptic and nonepileptic seizures evaluated using a brief cognitive assessment tool
Dilcher, R., Malpas, C. B., Walterfang, M., Kwan, P., O'Brien, T. J., Velakoulis, D. & Vivash, L., 2021, In: Epilepsy & Behavior. 115, 7 p., 107643.Research output: Contribution to journal › Article › Research › peer-review
2 Citations (Scopus) -
The effect of injection time on rates of epileptogenic zone localization using SISCOM and STATISCOM
Hlauschek, G., Sinclair, B., Brinkmann, B., Fuge, J., Kwan, P., O'Brien, T. J. & Vivash, L., May 2021, In: Epilepsy & Behavior. 118, 7 p., 107945.Research output: Contribution to journal › Article › Research › peer-review
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The ENIGMA-Epilepsy working group: Mapping disease from large data sets
Sisodiya, S. M., Whelan, C. D., Hatton, S. N., Huynh, K., Altmann, A., Ryten, M., Vezzani, A., Caligiuri, M. E., Labate, A., Gambardella, A., Ives-Deliperi, V., Meletti, S., Munsell, B. C., Bonilha, L., Tondelli, M., Rebsamen, M., Rummel, C., Vaudano, A. E., Wiest, R., Balachandra, A. R. & 52 others, , 1 May 2020, (Accepted/In press) In: Human Brain Mapping. 16 p.Research output: Contribution to journal › Review Article › Other › peer-review
Open AccessFile5 Citations (Scopus) -
White matter abnormalities across different epilepsy syndromes in adults: an ENIGMA-Epilepsy study
Hatton, S. N., Huynh, K. H., Bonilha, L., Abela, E., Alhusaini, S., Altmann, A., Alvim, M. K. M., Balachandra, A. R., Bartolini, E., Bender, B., Bernasconi, N., Bernasconi, A., Bernhardt, B., Bargallo, N., Caldairou, B., Caligiuri, M. E., Carr, S. J. A., Cavalleri, G. L., Cendes, F., Concha, L. & 56 others, , Aug 2020, In: Brain. 143, 8, p. 2454-2473 20 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus) -
Ictal cerebral blood flow in psychogenic non-epileptic seizures: A preliminary SPECT study
Olver, J., Castro-de-Araujo, L. F., Mullen, S. A., O'Brien, T., Berlangieri, S. U., Vivash, L., Velakoulis, D., Lichtenstein, M. & Kanaan, R., Dec 2019, In: Journal of Neurology, Neurosurgery and Psychiatry. 90, 12, p. 1378-1380 3 p.Research output: Contribution to journal › Letter › Other › peer-review
1 Citation (Scopus)