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2020

CRISP3 expression drives prostate cancer invasion and progression

Volpert, M., Furic, L., Hu, J., O'Connor, A. E., Rebello, R. J., Keerthikumar, S., Evans, J., Merriner, D. J., Pedersen, J., Risbridger, G. P., McIntyre, P. & O'Bryan, M. K., 1 May 2020, (Accepted/In press) In : Endocrine-Related Cancer.

Research output: Contribution to journalArticleResearchpeer-review

2019

Generally applicable transcriptome-wide analysis of translation using anota2seq

Oertlin, C., Lorent, J., Murie, C., Furic, L., Topisirovic, I. & Larsson, O., 9 Jul 2019, In : Nucleic Acids Research. 47, 12, 15 p., e70.

Research output: Contribution to journalArticleResearchpeer-review

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8 Citations (Scopus)

MTOR-mediated podocyte hypertrophy regulates glomerular integrity in mice and humans

Puelles, V. G., van der Wolde, J. W., Wanner, N., Scheppach, M. W., Cullen-McEwen, L. A., Bork, T., Lindenmeyer, M. T., Gernhold, L., Wong, M. N., Braun, F., Cohen, C. D., Kett, M. M., Kuppe, C., Kramann, R., Saritas, T., Van Roeyen, C. R., Moeller, M. J., Tribolet, L., Rebello, R., Sun, Y. B. Y. & 13 others, Li, J., Müller-Newen, G., Hughson, M. D., Hoy, W. E., Person, F., Wiech, T., Ricardo, S. D., Kerr, P. G., Denton, K. M., Furic, L., Huber, T. B., Nikolic-Paterson, D. J. & Bertram, J. F., 19 Sep 2019, In : JCI Insight. 4, 18, 18 p., e99271.

Research output: Contribution to journalArticleResearchpeer-review

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1 Citation (Scopus)

Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer

Watt, M. J., Clark, A. K., Selth, L. A., Haynes, V. R., Lister, N., Rebello, R., Porter, L. H., Niranjan, B., Whitby, S. T., Lo, J., Huang, C., Schittenhelm, R. B., Anderson, K. E., Furic, L., Wijayaratne, P. R., Matzaris, M., Montgomery, M. K., Papargiris, M., Norden, S., Febbraio, M. & 4 others, Risbridger, G. P., Frydenberg, M., Nomura, D. K. & Taylor, R. A., 6 Feb 2019, In : Science Translational Medicine. 11, 478, 12 p., eaau5758.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Translational offsetting as a mode of estrogen receptor α-dependent regulation of gene expression

Lorent, J., Kusnadi, E. P., van Hoef, V., Rebello, R. J., Leibovitch, M., Ristau, J., Chen, S., Lawrence, M. G., Szkop, K. J., Samreen, B., Balanathan, P., Rapino, F., Close, P., Bukczynska, P., Scharmann, K., Takizawa, I., Risbridger, G. P., Selth, L. A., Leidel, S. A., Lin, Q. & 3 others, Topisirovic, I., Larsson, O. & Furic, L., 2 Dec 2019, In : The EMBO Journal. 38, 23, 19 p., e101323.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

V-ATPase-associated prorenin receptor is upregulated in prostate cancer after PTEN loss

Mohammad, A. H., Assadian, S., Couture, F., Lefebvre, K. J., El-Assaad, W., Barrs, V., Ouellet, V., Boulay, P. L., Yang, J., Latour, M., Furic, L., Muller, W., Sonenberg, N., Mes-Masson, A. M., Saad, F., Day, R. & Teodoro, J. G., 13 Aug 2019, In : Oncotarget. 10, 48, p. 4923-4936 14 p.

Research output: Contribution to journalArticleResearchpeer-review

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2018

AMP-activated protein kinase selectively inhibited by the type II inhibitor SBI-0206965

Dite, T. A., Langendorf, C. G., Hoque, A., Galic, S., Rebello, R. J., Ovens, A. J., Lindqvist, L. M., Ngoei, K. R. W., Ling, N. X. Y., Furic, L., Kemp, B. E., Scott, J. W. & Oakhill, J. S., 1 Jan 2018, In : The Journal of Biological Chemistry. 293, 23, p. 8874-8885 12 p.

Research output: Contribution to journalArticleResearchpeer-review

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23 Citations (Scopus)
11 Citations (Scopus)

Identification of Pik3ca mutation as a genetic driver of prostate cancer that cooperates with Pten loss to accelerate progression and castration-resistant growth

Pearson, H. B., Li, J., Meniel, V. S., Fennell, C. M., Waring, P., Montgomery, K. G., Rebello, R. J., Macpherson, A. A., Koushyar, S., Furic, L., Cullinane, C., Clarkson, R. W., Smalley, M. J., Simpson, K. J., Phesse, T. J., Shepherd, P. R., Humbert, P. O., Sansom, O. J. & Phillips, W. A., 1 Jun 2018, In : Cancer Discovery. 8, 6, p. 764-779 16 p.

Research output: Contribution to journalArticleResearchpeer-review

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20 Citations (Scopus)

Patient-derived Models of Abiraterone- and Enzalutamide-resistant Prostate Cancer Reveal Sensitivity to Ribosome-directed Therapy

Lawrence, M. G., Obinata, D., Sandhu, S., Selth, L. A., Wong, S. Q., Porter, L. H., Lister, N., Pook, D., Pezaro, C. J., Goode, D. L., Rebello, R. J., Clark, A. K., Papargiris, M., Van Gramberg, J., Hanson, A. R., Banks, P., Wang, H., Niranjan, B., Keerthikumar, S., Hedwards, S. & 32 others, Huglo, A., Yang, R., Henzler, C., Li, Y., Lopez-Campos, F., Castro, E., Toivanen, R., Azad, A., Bolton, D., Goad, J., Grummet, J., Harewood, L., Kourambas, J., Lawrentschuk, N., Moon, D., Murphy, D. G., Sengupta, S., Snow, R., Thorne, H., Mitchell, C., Pedersen, J., Clouston, D., Norden, S., Ryan, A., Dehm, S. M., Tilley, W. D., Pearson, R. B., Hannan, R. D., Frydenberg, M., Furic, L., Taylor, R. A. & Risbridger, G. P., 1 Nov 2018, In : European Urology. 74, 5, p. 562-572 11 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)
2016

From sphingosine kinase to dihydroceramide desaturase: a structure-activity relationship (SAR) study of the enzyme inhibitory and anticancer activity of 4-((4-(4-chlorophenyl)thiazol-2-yl)amino)phenol (SKI-II)

Aurelio, L., Scullino, C. V., Pitman, M. R., Sexton, A. E., Oliver, V., Davies, L., Rebello, R. J., Furic, L., Creek, D. J., Pitson, S. M. & Flynn, B. L., 11 Feb 2016, In : Journal of Medicinal Chemistry. 59, 3, p. 965-984 20 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

mTORC1 and CK2 coordinate ternary and eIF4F complex assembly

Gandin, V., Masvidal, L., Cargnello, M., Gyenis, L., McLaughlan, S., Cai, Y., Tenkerian, C., Morita, M., Balanathan, P., Jean-Jean, O., Stambolic, V., Trost, M., Furic, L., Larose, L., Koromilas, A. E., Asano, K., Litchfield, D. W., Larsson, O. & Topisirovic, I., 4 Apr 2016, In : Nature Communications. 7, 15 p., 11127.

Research output: Contribution to journalArticleResearchpeer-review

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34 Citations (Scopus)

nanoCAGE reveals 5' UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs

Gandin, V., Masvidal, L., Hulea, L., Gravel, S-P., Cargnello, M., McLaughlan, S., Cai, Y., Balanathan, P., Morita, M., Rajakumar, A., Furic, L., Pollak, M., Porco Jr, J. A., St-Pierre, J., Pelletier, J., Larsson, O. & Topisirovic, I., May 2016, In : Genome Research. 26, 5, p. 636-648 13 p.

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75 Citations (Scopus)

The dual inhibition of RNA Pol I transcription and PIM kinase as a new therapeutic approach to treat advanced prostate cancer

Rebello, R. J., Kusnadi, E., Cameron, D. P., Pearson, H. B., Lesmana, A., Devlin, J. R., Drygin, D., Clark, A. K., Porter, L., Pedersen, J., Sandhu, S., Risbridger, G. P., Pearson, R. B., Hannan, R. D. & Furic, L., 15 Nov 2016, In : Clinical Cancer Research. 22, 22, p. 5539-5552 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
26 Citations (Scopus)
2015

Estrogen receptor alpha drives proliferation in PTEN-deficient prostate carcinoma by stimulating survival signaling, MYC expression and altering glucose sensitivity

Takizawa, I., Lawrence, M. G., Balanathan, P., Rebello, R., Pearson, H. B., Garg, E., Pedersen, J. S., Pouliot, N., Nadon, R., Watt, M. J., Taylor, R. A., Humbert, P. O., Topisirovic, I., Larsson, O., Risbridger, G. P. & Furic, L., 2015, In : Oncotarget. 6, 2, p. 604 - 616 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
21 Citations (Scopus)

Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3

Robichaud, N., del Rincon, S. V., Huor, B., Alain, T., Petruccelli, L. A., Hearnden, J., Goncalves, C., Grotegut, S., Spruck, C. H. I., Furic, L., Larsson, O., Muller, W. J., Miller, W. H. & Sonenberg, N., 2015, In : Oncogene. 34, 16, p. 2032 - 2042 11 p.

Research output: Contribution to journalArticleResearchpeer-review

124 Citations (Scopus)
2014

A pro-tumourigenic loop at the human prostate tumour interface orchestrated by oestrogen, CXCL12 and mast cell recruitment

Ellem, S. J., Taylor, R. A., Furic, L., Larsson, O., Frydenberg, M., Pook, D. W., Pedersen, J. S., Cawsey, B., Trotta, A., Need, E. F., Buchanan, G. & Risbridger, G. P., 2014, In : Journal of Pathology. 234, 1, p. 86 - 98 13 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)
2013

Hedgehog signaling is active in human prostate cancer stroma and regulates proliferation and differentiation of adjacent epithelium

Wilkinson, S., Furic, L., Buchanan, G., Larsson, O., Pedersen, J. S., Frydenberg, M., Risbridger, G. P. & Taylor, R. A., 2013, In : Prostate. 73, 16, p. 1810 - 1823 14 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)
2012

Estrogen receptor beta activation impairs prostatic regeneration by Inducing apoptosis in murine and human stem/progenitor enriched cell populations

Hussain, S., Lawrence, M. G., Taylor, R. A., Lo, C. Y-W., Frydenberg, M., Ellem, S. J., Furic, L. & Risbridger, G. P., 2012, In : PLoS ONE. 7, 7, 9 p., e40732.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
27 Citations (Scopus)

Translational control of the activation of transcription factor NF-?B and production of type I interferon by phosphorylation of the translation factor eIF4E

Herdy, B., Jaramillo, M., Svitkin, Y. V., Rosenfeld, A. B., Kobayashi, M., Walsh, D., Alain, T., Sean, P., Robichaud, N., Topisirovic, I., Furic, L., Dowling, R. J. O., Sylvestre, A., Rong, L., Colina, R., Costa-Mattioli, M., Fritz, J. H., Olivier, M., Brown, E., Mohr, I. & 1 others, Sonenberg, N., 2012, In : Nature Immunology. 13, 6, p. 543 - 550 8 p.

Research output: Contribution to journalArticleResearchpeer-review

64 Citations (Scopus)
2011

Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung metastases

Konicek, B., Stephens, J., McNulty, A., Robichaud, N., Peery, R., Dumstorf, C., Dowless, M., Iversen, P., Parsons, S., Ellis, K., McCann, D., Pelletier, J., Furic, L., Yingling, J., Stancato, L., Sonenberg, N. & Graff, J., 2011, In : Cancer Research. 71, 5, p. 1849 - 1857 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
134 Citations (Scopus)
2010

eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression

Furic, L., Rong, L., Larsson, O., Koumakpayi, I., Yoshida, K., Brueschke, A., Petroulakis, E., Robichaud, N., Pollak, M., Gaboury, L., Pandolfi, P., Saad, F. & Sonenberg, N., 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 32, p. 14134 - 14139 6 p.

Research output: Contribution to journalArticleResearchpeer-review

296 Citations (Scopus)

Modulation of 4E-BP1 function as a critical determinant of enzastaurin-induced apoptosis

Dumstorf, C., Konicek, B., McNulty, A., Parsons, S., Furic, L., Sonenberg, N. & Graff, J., 2010, In : Molecular Cancer Therapeutics. 9, 12, p. 3158 - 3163 6 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)
2009

p53-dependent translational control of senescence and transformation via 4E-BPs

Petroulakis, E., Parsyan, A., Dowling, R., LeBacquer, O., Martineau, Y., Bidinosti, M., Larsson, O., Alain, T., Rong, L., Mamane, Y., Paquet, M., Furic, L., Topisirovic, I., Shahbazian, D., Livingstone, M., Costa-Mattioli, M., Teodoro, J. & Sonenberg, N., 2009, In : Cancer Cell. 16, 5, p. 439 - 446 8 p.

Research output: Contribution to journalArticleResearchpeer-review

81 Citations (Scopus)
2008

A genome-wide approach identifies distinct but overlapping subsets of cellular mRNAs associated with Staufen1- and Staufen2-containing ribonucleoprotein complexes

Furic, L., Maher-Laporte, M. & DesGroseillers, L., 2008, In : Rna-A Publication of the Rna Society. 14, 2, p. 324 - 335 12 p.

Research output: Contribution to journalArticleResearchpeer-review

76 Citations (Scopus)
2007

Staufen1 regulates diverse classes of mammalian transcripts

Kim, Y. K., Furic, L., Parisien, M., Major, F., DesGroseillers, L. & Maquat, L. E., 2007, In : The EMBO Journal. 26, 11, p. 2670 - 2681 12 p.

Research output: Contribution to journalArticleResearchpeer-review

133 Citations (Scopus)
2006

Staufen1 is imported into the nucleolus via a bipartite nuclear localization signal and several modulatory determinants

Martel, C., Macchi, P., Furic, L., Kiebler, M. A. & DesGroseillers, L., 2006, In : Biochemical Journal. 393, Pt. 1, p. 245 - 254 10 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)
2005

Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay

Kim, Y. K., Furic, L., DesGroseillers, L. & Maquat, L. E., 2005, In : Cell. 120, 2, p. 195 - 208 14 p.

Research output: Contribution to journalArticleResearchpeer-review

329 Citations (Scopus)
2003

Localization of the RNA-binding proteins Staufenl and Staufen2 at the mammalian neuromuscular junction

Bélanger, G., Stocksley, M. A., Vandromme, M., Schaeffer, L., Furic, L., DesGroseillers, L. & Jasmin, B. J., Aug 2003, In : Journal of Neurochemistry. 86, 3, p. 669-677 9 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)
2002

Staufen2 isoforms localize to the somatodendritic domain of neurons and interact with different organelles

Duchaîne, T. F., Hemraj, I., Furic, L., Deitinghoff, A., Kiebler, M. A. & DesGroseillers, L., 15 Aug 2002, In : Journal of Cell Science. 115, 16, p. 3285-3295 11 p.

Research output: Contribution to journalArticleResearchpeer-review

90 Citations (Scopus)