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Personal profile

Biography

Homepage: http://bioeng-he.org

Dr Lizhong He is a Senior Lecturer at Department of Chemical Engineering, Monash University. Dr He completed Bachelor of Science in Applied Chemistry and Master of Engineering in Biochemical Engineering at Tianjin University, China. He then carried out his PhD research at GKSS Research Centre, Germany, working on self-assembly and affinity adsorption of glycoconjugates. Dr He spent two years as a postdoctoral researcher at the Max-Planck-Institute for Polymer Research, developing tethered lipid membranes as biosensors. Before joining Monash University, Dr He was an AINSE Research Fellow and Deputy Director at Center for Biomolecular Engineering, Australian Institute for Bioengineering and Nanotechnology at The University of Queensland, carrying out research on engineering bio-interfaces and development of therapeutic proteins.

Research interests

My research focuses on the interface between biomolecules and nanomaterials towards the building of new functional products. My group carries out multidisciplinary research in the field of bioengineering and nanotechnology to develop products that are simple, cost-efficient and environment friendly.

Our research is centered on protein engineering, particularly for bio-interfaces involving biomolecular interactions at various interfaces like solid-liquid, liquid-air and nanoparticle surfaces, which are of great importance in the area of medical, pharmaceutical, biotechnological and food industries. Our primary objective is to develop new and simple approaches to control assembly of biomolecule at interfaces to have desirable attributes such as controlled orientations for the application of biocatalysis, drug-delivery and stimuli-responsive foams. Protein engineering plays a central role to achieve this goal.
  
We integrate bioengineering and nanotechnology to engineer advanced products ranging from stimuli-responsive peptide-controlled foams and functional food such as these containing bioactive proteins or peptides, to nanoparticle-based enzyme biocatalysts and antibody-based biosensors. Biophysical methods including neutron and x-ray scattering and surface plasmon resonance (SPR) are utilized to reveal interfacial structure of proteins and peptides, guiding design and production of advanced products at interfaces. 

Supervision interests

Project 1: Dynamics of engineering enzymes at solid-liquid interfaces

This project will study dynamics of engineered enzymes using single molecule technique. It will understand that how properties of enzymes can be tuned to have desired properties such as higher selectivity to substrates and better activities. The work includes design of enzymes, making enzymes using genetic engineering methods, and study enzymes using surface-sensitive technology at a single molecule level. The student will have the opportunities to develop research skills in protein engineering, bioprocess and surface-sensitive biophysical methods.

 

Project 2: Integration of enzymes and catalysts for advanced one-pot reaction

The project aims to integrate biocatalysis and chemo-catalysis for production of highly valuable chemicals. The student will combine bioengineering with nanotechnology to develop new hybrid enzyme/chemo-catalytic nanoreactor. The work includes engineering enzymes with surface-specific binding ability, preparing nano-catalysts in collaboration with world-leading experts in the field, and developing new bio-chemo nanoreactors. The student will have the opportunities to develop research skills in enzyme engineering, nanoparticle technology, and reaction engineering.

 

 

Project 3: Engineering proteins towards biological optic fibres

 

This project aims to develop soft optic fibres which are entirely based on proteins. In contrast to conventional inorganic optic fibres, protein-based optic fibres are flexible and biocompatible, promising a new class of biomaterials for biomedical application. The student will design proteins that have the desired optic properties and can self-assemble into the required structure on-demand. Through the project, the student will develop skills including protein engineering, biomaterials and optics.

 

For more details of the projects, please email Dr Lizhong He (lizhong.he@monash.edu)

Consulting

I am interested in engaging with industry to solve practical problems such as:

 

1) Molecular design of proteins/peptides

2) Bioprocess developing for production of bio-products such as proteins/peptides

3) Immobilization of proteins on surfaces such as enzymes immobilization

4) Bio-separation including purification of proteins from natural sources or fermentation

5) Developing functional foods, particularly these containing bioactive proteins or peptides

Monash teaching commitment

CHE3171 Bioprocess Technology

CHE4171 Biochemical Engineering

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Research Output 1997 2019

Computational design of single-molybdenum catalysts for the nitrogen reduction reaction

Li, Q., Qiu, S., Liu, C., Liu, M., He, L., Zhang, X. & Sun, C., 31 Jan 2019, In : Journal of Physical Chemistry C. 123, 4, p. 2347-2352 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Enhanced production of high-value cyclopropane fatty acid in yeast engineered for increased lipid synthesis and accumulation

Peng, H., He, L. & Haritos, V. S., Apr 2019, In : Biotechnology Journal. 14, 4, 5 p., 1800487.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Impact of H-termination on the nitrogen reduction reaction of molybdenum carbide as an electrochemical catalyst

Li, Q., Qiu, S., He, L., Zhang, X. & Sun, C., 2018, In : Physical Chemistry Chemical Physics. 20, 36, p. 23338-23343 6 p.

Research output: Contribution to journalArticleResearchpeer-review