Projects per year
Personal profile
Biography
Dr Liza O’Donnell is a senior researcher in the Centre of Reproductive Health at the Hudson. She joined the Prince Henry’s Institute (now Hudson Institute of Medical Research) in 1991 after completing an undergraduate degree in Biotechnology at RMIT Melbourne, and completed her PhD in 1996.
Dr O’Donnell studies the biology of the testis, including how it produces both sperm and androgens. Her work has focussed on the regulation of sperm production (spermatogenesis) by androgens and estrogens, the development of hormone-based male contraceptives, the role of cell adhesion proteins in spermatogenesis, cytoskeletal proteins important for sperm production, transgenic models of infertility, the regulation of foetal testis development, the process of spermiation (sperm release), the identification of genes and proteins essential for spermatogenesis and the development of biomarkers to diagnose testis function.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Androgen regulation of spermiogenesis, MONASH UNIVERSITY
1 Jan 1993 → 1 Sept 1996
Award Date: 1 Dec 1996
Biotechnology, B App Sci, RMIT University
1988 → 1990
Award Date: 1 Dec 1990
Research area keywords
- male fertility
- Spermatogenesis
- sperm development
- Testis
- male reproduction
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Transformative rat models to study sex differences in disease
Arnold, A. (Primary Chief Investigator (PCI)), Eghbali, M. (Chief Investigator (CI)), Dwinell, M. R. (Chief Investigator (CI)), Geurts, A. (Chief Investigator (CI)), Harley, V. (Chief Investigator (CI)), Sandberg, K. (Chief Investigator (CI)), O'Donnell, L. (Chief Investigator (CI)) & Browne, J. (Chief Investigator (CI))
NIH - National Institutes of Health (United States of America)
15/06/21 → 31/08/26
Project: Research
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IRTG: International Research Training Grant (IRTG)_Renewal of Molecular pathogenesis of male reproductive disorders project
Meinhardt, A. (Primary Chief Investigator (PCI)), Loveland, K. (Chief Investigator (CI)), Bhushan, S. (Chief Investigator (CI)), Ellem, S. J. (Chief Investigator (CI)), Hedger, M. (Chief Investigator (CI)), O'Bryan, M. (Chief Investigator (CI)), O'Donnell, L. (Chief Investigator (CI)), Stanton, P. (Chief Investigator (CI)), Risbridger, G. (Chief Investigator (CI)), Baker, M. A. (Associate Investigator (AI)), Hobbs, R. (Associate Investigator (AI)), Loveland, B. E. (Associate Investigator (AI)), Exintaris, B. (Chief Investigator (CI)), Western, P. (Chief Investigator (CI)), McLachlan, R. (Chief Investigator (CI)), Whittaker, M. (Associate Investigator (AI)), Wagenlehner, F. M. E. (Associate Investigator (AI)), Bergmann, M. (Chief Investigator (CI)), Diemer, T. (Chief Investigator (CI)), Fietz, D. (Chief Investigator (CI)), Fijak, M. (Chief Investigator (CI)), Konrad, L. (Chief Investigator (CI)), Linn, T. (Chief Investigator (CI)), Middendorff, R. (Chief Investigator (CI)), Pilatz, A. M. E. (Chief Investigator (CI)), Schagdarsurengin, U. (Chief Investigator (CI)), Schuppe, H. C. (Chief Investigator (CI)), Steger, K. (Chief Investigator (CI)) & Scheiner-Bobis, G. (Chief Investigator (CI))
1/10/17 → 31/03/22
Project: Research
Research output
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Testis exposure to unopposed/elevated activin A in utero affects somatic and germ cells and alters steroid levels mimicking phthalate exposure
Whiley, P. A. F., Luu, M. C. M., O’Donnell, L., Handelsman, D. J. & Loveland, K. L., 2023, In: Frontiers in Endocrinology. 14, 19 p., 1234712.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Activin A and Sertoli Cells: Key to Fetal Testis Steroidogenesis
O’Donnell, L., Whiley, P. A. F. & Loveland, K. L., 24 May 2022, In: Frontiers in Endocrinology. 13, 7 p., 898876.Research output: Contribution to journal › Review Article › Other › peer-review
Open Access11 Citations (Scopus) -
Sperm proteins and cancer-testis antigens are released by the seminiferous tubules in mice and men
O'Donnell, L., Rebourcet, D., Dagley, L. F., Sgaier, R., Infusini, G., O'Shaughnessy, P. J., Chalmel, F., Fietz, D., Weidner, W., Legrand, J. M. D., Hobbs, R. M., McLachlan, R. I., Webb, A. I., Pilatz, A., Diemer, T., Smith, L. B. & Stanton, P. G., Mar 2021, In: The FASEB Journal. 35, 3, 18 p., e21397.Research output: Contribution to journal › Article › Research › peer-review
Open Access17 Citations (Scopus) -
Activin A Determines Steroid Levels and Composition in the Fetal Testis
Whiley, P. A. F., O'Donnell, L., Moody, S. C., Handelsman, D. J., Young, J. C., Richards, E. A., Almstrup, K., Western, P. S. & Loveland, K. L., Jul 2020, In: Endocrinology. 161, 7, 16 p., bqaa058.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile16 Citations (Scopus) -
The cytoskeleton in spermatogenesis
Dunleavy, J. E. M., O'Bryan, M. K., Stanton, P. G. & O'Donnell, L., 1 Jan 2019, In: Reproduction. 157, 2, p. R53-R72 20 p.Research output: Contribution to journal › Review Article › Research › peer-review
106 Citations (Scopus)