Personal profile
Biography
Alisa (Lisa) Higgins leads the Health Economics Program and is a Senior Research Fellow at the Australian and New Zealand Intensive Care Research Centre, Monash University. She is an NHMRC Emerging Leader Fellow, co-Chair of the Australian Clinical Trials Alliance (ACTA) Health Economics Alongside Trials (HEAT) Group, and an honorary Senior Research Fellow at the George Institute for Global Health. She is also a member of the Research Australia Health Economics Working group, the Australian Health Economics Society, and the Health Services Research Association of Australian and New Zealand. Lisa completed her PhD in 2019 titled ‘An economic evaluation of resuscitation in sepsis’, and also has an MPH majoring in epidemiology and biostatistics, a Graduate Diploma in Biostatistics and a Bachelor of Physiotherapy (Honours).
Lisa has been conducting clinical trials and health economics research for more than 15 years. Her research focuses on evaluating long-term outcomes following ICU, the costs of care in critical illness, and conducting economic evaluations alongside clinical trials in critical care. She has extensive experience in clinical trial methodology, long-term outcomes and health economics. Lisa also has extensive experience in adaptive platform trials, having being involved in the REMAP-CAP trial since its inception, leading its data coordination team throughout the pandemic and leading both the health economics and long-term outcomes globally. She also leads the health economics for the RECOMMEND, STRAP and PROMPT adaptive platform trials.
Lisa is a leader in the field and has authored more than 140 publications with over 14,000 citations and has multiple clinical trial publications in high impact journals including the New England Journal of Medicine and the Journal of the American Medical Association. Notable publications include “Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial” in The Journal of the American Medical Association (JAMA); and “Economic evaluations for intensive care unit randomised clinical trials in Australia and New Zealand: Practical recommendations for researchers” in Australian Critical Care.
Lisa has received over $60 million in competitive grant funding and has served as a member of the management committees of 23 large-scale international randomised controlled NHMRC/MRFF trials.
Education/Academic qualification
Critical Care/Economic Evaluations, PhD, An economic evaluation of resuscitation in sepsis
Award Date: 12 May 2020
Physiotherapy, BPhysio(Hons)
Biostatistics, GradDipBiostat
Public Health, MPH
External positions
Honorary Senior Research Fellow, George Institute for Global Health (Australia)
Research area keywords
- Critical care
- Health economics
- Clinical trials
- Intensive Care
- Cost-effectiveness
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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SDG 7 Affordable and Clean Energy
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SDG 12 Responsible Consumption and Production
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SDG 13 Climate Action
Collaborations and top research areas from the last five years
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Precision medicine Adaptive Network Platform Trial in Hypoxemic acute respiratory failure PANTHER
Burrell, A. (Primary Chief Investigator (PCI)), Hodgson, C. (Chief Investigator (CI)), Nichol, A. (Chief Investigator (CI)), Higgins, L. (Chief Investigator (CI)), Webb, S. (Chief Investigator (CI)), Serpa Neto, A. (Chief Investigator (CI)), Ridley, E. (Chief Investigator (CI)), Fraser, J. (Chief Investigator (CI)), Ryan, L. (Chief Investigator (CI)), Charles-Nelson, A. (Chief Investigator (CI)), Milford, E. (Chief Investigator (CI)), Andersen, C. R. (Chief Investigator (CI)), McAuley, D. F. (Chief Investigator (CI)), Bartlett, S. (Associate Investigator (AI)), White, K. C. (Associate Investigator (AI)) & Wood, A. (Associate Investigator (AI))
1/03/26 → 7/03/31
Project: Research
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PROTECTION economic evaluation
Higgins, L. (Primary Chief Investigator (PCI)), Fagery, M. (Chief Investigator (CI)) & Bellomo, R. (Chief Investigator (CI))
8/12/25 → 7/12/26
Project: Research
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Healthcare Environmental Sustainability: Creating the evidence to drive adoption of high value initiatives in Australian Hospitals
McGain, F. (Primary Chief Investigator (PCI)), Best, S. (Chief Investigator (CI)), Buising, K. (Chief Investigator (CI)), Higgins, L. (Chief Investigator (CI)), Monty, J. (Chief Investigator (CI)), McAlister, S. (Chief Investigator (CI)), Kainer, M. (Chief Investigator (CI)), Patrick, R. (Chief Investigator (CI)), Sinnott, R. (Chief Investigator (CI)), Walshe, C. (Chief Investigator (CI)), Davies, J. E. (Associate Investigator (AI)), Dunne, B. (Associate Investigator (AI)), Kayak, E. (Associate Investigator (AI)), Kevin, K. (Associate Investigator (AI)), Jamriska, M. (Associate Investigator (AI)), Aye, L. (Associate Investigator (AI)), Charlesworth, K. E. (Associate Investigator (AI)), McGushin, A. (Associate Investigator (AI)), Nguyen, M. (Associate Investigator (AI)) & Johnson, D. F. (Associate Investigator (AI))
1/05/25 → 1/05/27
Project: Research
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(PReVENT-NEURO) : PRophylaxis against VENTilator-associated infections in NEUROlogically injured ICU patients trial
Delaney, A. (Primary Chief Investigator (PCI)), Myburgh, J. (Chief Investigator (CI)), Hammond, N. (Chief Investigator (CI)), Anderson, C. S. (Chief Investigator (CI)), Young, P. J. (Chief Investigator (CI)), Higgins, L. (Chief Investigator (CI)), Sherry, N. (Chief Investigator (CI)), Litton, E. (Chief Investigator (CI)), Haines, K. (Chief Investigator (CI)), Talbot, P. (Chief Investigator (CI)), Venkatesh, B. (Associate Investigator (AI)), Finfer, S. (Associate Investigator (AI)), Jenkins, C. (Associate Investigator (AI)), Udy, A. (Associate Investigator (AI)), Knowles, S. (Associate Investigator (AI)), Hadley-Brown, K. (Associate Investigator (AI)), Fitzgerald, E. (Associate Investigator (AI)), Andersen, C. R. (Associate Investigator (AI)), Li, Q. (Associate Investigator (AI)) & Saxena, M. K. (Associate Investigator (AI))
1/07/24 → 30/06/29
Project: Research
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Antithrombotic therapy to ameliorate clinical complications in community acquired pneumonia (ATTACC-CAP)
McQuilten, Z. (Primary Chief Investigator (PCI)), Tong, S. (Chief Investigator (CI)), Webb, S. (Chief Investigator (CI)), Higgins, L. (Chief Investigator (CI)), Ryan, L. (Chief Investigator (CI)), Venkatesh, B. (Chief Investigator (CI)), Roberts, J. A. (Chief Investigator (CI)), Tran, H. (Chief Investigator (CI)), Zarychanski, R. (Chief Investigator (CI)), McFadyen, J. (Chief Investigator (CI)), Aung, A. K. (Chief Investigator (CI)), Lawler, P. (Chief Investigator (CI)), Winearls, J. (Chief Investigator (CI)) & Burrell, A. (Chief Investigator (CI))
1/07/24 → 30/06/28
Project: Research
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Feasibility and pilot studies in critical care—Our top five lessons learnt as early- and mid-career researchers in Australia and New Zealand
Haines, K. J., Attokaran, A., Chapple, L. A., Coombes, J., Crichton, B., Higgins, A. M., Hodgson, C., Howe, B., Mackle, D., Poole, A., Ridley, E. J., Saxena, M. & Glassford, N., Feb 2026, In: Australian Critical Care. 39, 1, 5 p., 101464.Research output: Contribution to journal › Comment / Debate › Other › peer-review
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Adverse events during and after early mobilisation: A post hoc analysis of the TEAM trial
Broadley, T., Serpa Neto, A., Bailey, M., Bellomo, R., Brickell, K., Buhr, H., Gabbe, B. J., Gould, D. W., Harrold, M., Hurford, S., Iwashyna, T. J., Nichol, A. D., Presneill, J. J., Schaller, S. J., Sivasuthan, J., Tipping, C. J., Webb, S., Young, P. J., Higgins, A. M. & Hodgson, C. L., May 2025, In: Australian Critical Care. 38, 3, 7 p., 101156.Research output: Contribution to journal › Article › Research › peer-review
Open Access7 Link opens in a new tab Citations (Scopus) -
Australasian Resuscitation in Sepsis Evaluation: FLUid or vasopressors in emergency Department Sepsis (ARISE FLUIDS) trial: Study protocol
Howe, B. D. (Leading Author), MacDonald, S. P. J., Arendts, G., Bellomo, R., Burcham, J., Delaney, A., Egerton-Warburton, D., Fatovich, D., Fraser, J. F., Higgins, A., Jones, P., Keijzers, G., Milford, E., Udy, A. A., Williams, P., Young, P. & Peake, S. L. (Leading Author), Jul 2025, In: BMJ Open. 15, 7, 8 p., e101215.Research output: Contribution to journal › Article › Other › peer-review
Open Access1 Link opens in a new tab Citation (Scopus) -
Australian clinical practice guideline for physical rehabilitation and mobilisation in adult intensive care units
Hodgson, C. L. (Leading Author), Broadley, T. (Leading Author), Paton, M., Higgins, A. M., Anderson, S., Brennan, S., Granger, C. L., Hammond, N. E., Magana Cruz, S., Lang, J. K., Leditschke, I. A., Orford, N. R., Parry, S. M., Price, B., Taylor, P., Udy, A. A. & Green, S. E., Jul 2025, In: Australian Critical Care. 38, 4, 8 p., 101235.Research output: Contribution to journal › Article › Research › peer-review
Open Access7 Link opens in a new tab Citations (Scopus) -
Blood Transfusion Practices in Intensive Care: A Prospective Observational Binational Study
Flint, A. W. J., Poole, A., Raasveld, S. J., Bailey, M., Brady, K., Chen, P. Y., Chen, Y., Cooper, D. J., French, C., Higgins, A., Irving, A. H., McAllister, R. E., Neto, A. S., Trapani, T., Waters, N., Winearls, J., Reade, M. C., Wood, E. M., Vlaar, A. P. J. & McQuilten, Z. K., Mar 2025, In: Critical Care Explorations. 7, 3, 12 p., e1197.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Link opens in a new tab Citations (Scopus)
Prizes
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Alfred Research Week: Senior Medical Staff Prize for Clinical / Public Health Research for “ Disability And Poor Return To Work After Critical Illness: A Multicentre Cohort Study” (Hodgson et al)
Higgins, L. (Recipient), 2016
Prize: Prize (including medals and awards)
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American Thoracic Society Critical Care International Early Career Achievement Award
Higgins, L. (Recipient), 21 May 2024
Prize: Prize (including medals and awards)
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Australian Physiotherapy Association (APA) Victorian Branch Honours Research Prize
Higgins, L. (Recipient), 1998
Prize: Prize (including medals and awards)
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Best presentation: ANZICS Global ICU Datathon and Clinical Informatics Workshop
Higgins, L. (Recipient), Oct 2019
Prize: Prize (including medals and awards)