Projects per year
Personal profile
Biography
Liam completed his PhD in Professor Norman Saunders' laboratory at the University of Melbourne, investigating the permeability of medicines across the blood-brain barrier at different stages of development. He then undertook a postdoctoral fellowship in Professor Barbara Stonestreet's laboratory at the Women and Infants Hospital of Rhode Island and Brown University, where he investigated the efficacy and mechanism of action of a novel treatment for neonatal hypoxic-ischemic brain injuries. In 2022 Liam Joined the Nicolazzo laboratory where he investigated changes to the blood-brain barrier in glioblastoma multiforme and disease pathophysiology and novel treatment efficacy for amyotrophic lateral sclerosis. In 2024 Dr. Koehn was awarded the FightMND Early Career Research Fellowship to investigate neuroinflammation in amyotrophic lateral sclerosis.
In the Nicolazzo laboratory, Liam will investigate changes to the blood-brain barrier in glioblastoma multiforme in order to determine novel means of improving delivery of chemotherapeutics to the brain in this disease.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
Projects
- 1 Active
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Targeting neuroinflammation in amyotrophic lateral sclerosis with inter-alpha inhibitor proteins
Koehn, L. (Primary Chief Investigator (PCI))
28/01/25 → 31/12/28
Project: Research
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Effects of paracetamol/acetaminophen on the expression of solute carriers (SLCs) in late-gestation fetal rat brain, choroid plexus and the placenta
Huang, Y., Qiu, F., Dziegielewska, K. M., Koehn, L. M., Habgood, M. D. & Saunders, N. R., 1 Mar 2024, In: Experimental Physiology. 109, 3, p. 427-444 18 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Iron Reduces the Trafficking of Fatty Acids from Human Immortalised Brain Microvascular Endothelial Cells Through Modulation of Fatty Acid Transport Protein 1 (FATP1/SLC27A1)
Supti, S. T., Koehn, L. M., Newman, S. A., Pan, Y. & Nicolazzo, J. A., Aug 2024, In: Pharmaceutical Research. 41, 8, p. 1631–1648 18 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Plasma, brain and spinal cord concentrations of caffeine are reduced in the SOD1G93A mouse model of amyotrophic lateral sclerosis following oral administration
Koehn, L. M., Jalaldeen, R., Pelle, J. & Nicolazzo, J. A., Oct 2024, In: European Journal of Pharmaceutics and Biopharmaceutics. 203, 10 p., 114434.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Sex-Dependent Changes to the Intestinal and Hepatic Abundance of Drug Transporters and Metabolizing Enzymes in the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis
Koehn, L. M., Steele, J. R., Schittenhelm, R. B., Turner, B. J. & Nicolazzo, J. A., Apr 2024, In: Molecular Pharmaceutics. 21, 4, p. 1756-1767 12 p.Research output: Contribution to journal › Article › Research › peer-review
2 Citations (Scopus) -
Effects of Three Different Doses of Inter-Alpha Inhibitor Proteins on Severe Hypoxia–Ischemia-Related Brain Injury in Neonatal Rats
Koehn, L. M., Nguyen, K., Chen, X., Santoso, A., Tucker, R., Lim, Y. P. & Stonestreet, B. S., Nov 2022, In: International Journal of Molecular Sciences. 23, 21, 18 p., 13473.Research output: Contribution to journal › Article › Research › peer-review
Open Access7 Citations (Scopus)
Prizes
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AINSE International Travel Scholarship
Koehn, L. (Recipient), 2019
Prize: Prize (including medals and awards)
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ASCEPT Conference Integrative Pharmacology and Toxicology Conference Award
Koehn, L. (Recipient), 2016
Prize: Prize (including medals and awards)
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Charles Medgett Postgraduate Student Award
Koehn, L. (Recipient), 2017
Prize: Prize (including medals and awards)
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Dux award (B.S. Hons) - Pharmacology, the University of Melbourne
Koehn, L. (Recipient), 2015
Prize: Prize (including medals and awards)
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Frances Elizabeth Thomson Trust Scholarship
Koehn, L. (Recipient), 2015
Prize: Prize (including medals and awards)