• 18 Alliance Lane, Room 229, Monash University, Wellington Road

    3800 Clayton

    Australia

Accepting PhD Students

20152016
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Personal profile

Biography

Leonie obtained her MSc degree in Molecular Life Sciences with a specialization in Physical Chemistry from Wageningen University & Research (the Netherlands) in 2012. After an industrial traineeship at CSIRO (Clayton, Australia) she continued with her PhD in the Department of Chemical Engineering at The University of Melbourne. She received the 2017 ANSTO, Australian Synchrotron Stephen Wilkins Medal for her PhD thesis entitled “Improving success rates for in meso crystallization using integral membrane proteins and membrane protein mimetics in the bicontinuous cubic phase”. Leonie was a Postdoctoral Research Fellow at ETH Zurich (Switzerland) for several years where she worked on a World food system center research project regarding the preservation of African leafy vegetables and a commercial project on the self-assembly of organic/inorganic colloidal hybrids. She started as a Lecturer and set up the Hybrid Assembly Group at Monash University in October 2019.

Research interests

Leonie uses a unique combination of physical chemistry, chemical engineering, biochemistry and cell biology approaches in her research, and applies it to pharmaceutical and food sciences. The Hybrid Assembly Group focusses on understanding soft material (nano-) structure-property relationships using advanced scattering and microscopy techniques to improve production/processing.

Supervision interests

Research projects, including honours and PhD projects, on self-assembly materials for pharmaceutical applications and structure - property relationships of food materials are available. 

Education/Academic qualification

Chemical Engineering, PhD, University of Melbourne

3 Jun 20133 Dec 2016

Research area keywords

  • Self-assembly
  • Bicontinuous cubic phases
  • Vesicles
  • Proteins, peptides and amino acids
  • Lipid bilayers
  • Food Structure
  • Nanostructured materials
  • Pharmaceuticals
  • In meso crystallisation
  • Membrane proteins
  • Small Angle X-Ray Scattering
  • Small Angle Neutron Scattering
  • Protein structure

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Research Output 2015 2016

9 Citations (Scopus)

Effect of lipid-based nanostructure on protein encapsulation within the membrane bilayer mimetic lipidic cubic phase using transmembrane and lipo proteins from the beta-barrel assembly machinery

van 't Hag, L., Shen, H-H., Lin, T-W., Gras, S. L., Drummond, C. J. & Conn, C. E., 29 Nov 2016, In : Langmuir: the ACS journal of surfaces and colloids. 32, 47, p. 12442-12452 11 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Exploring the in meso crystallization mechanism by characterizing the lipid mesophase microenvironment during the growth of single transmembrane α-helical peptide crystals

T'Van Hag, L., Knoblich, K., Seabrook, S. A., Kirby, N. M., Mudie, S. T., Lau, D., Li, X., Gras, S. L., Mulet, X., Call, M. E., Call, M. J., Drummond, C. J. & Conn, C. E., 28 Jul 2016, In : Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences. 374, 2072, 17 p., 20150125.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
17 Citations (Scopus)

Deconvoluting the effect of the hydrophobic and hydrophilic domains of an amphiphilic integral membrane protein in lipid bicontinuous cubic mesophases

van 't Hag, L., Shen, H-H., Lu, J., Hawley, A. M., Gras, S. L., Drummond, C. J. & Conn, C. E., 2015, In : Langmuir: the ACS journal of surfaces and colloids. 31, 44, p. 12025 - 12034 10 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Transmembrane Complexes of DAP12 Crystallized in Lipid Membranes Provide Insights into Control of Oligomerization in Immunoreceptor Assembly

Knoblich, K., Park, S., Lutfi, M., van't Hag, L., Conn, C. E., Seabrook, S. A., Newman, J., Czabotar, P. E., Im, W., Call, M. E. & Call, M. J., 26 May 2015, In : Cell Reports. 11, 8, p. 1184-1192 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File