19962020

Research output per year

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Article
2018

Inhibition of a K9/K36 demethylase by an H3.3 point mutation found in paediatric glioblastoma

Voon, H. P. J., Udugama, M., Lin, W., Hii, L., Law, R. H. P., Steer, D. L., Das, P. P., Mann, J. R. & Wong, L. H., 1 Dec 2018, In : Nature Communications. 9, 1, 10 p., 3142.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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7 Citations (Scopus)

Ribosomal DNA copy loss and repeat instability in ATRX-mutated cancers

Udugama, M., Sanij, E., Voon, H. P. J., Son, J., Hii, L., Henson, J. D., Chan, F. L., Chang, F. T. M., Liu, Y., Pearson, R. B., Kalitsis, P., Mann, J. R., Collas, P., Hannan, R. D. & Wong, L. H., 1 May 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 18, p. 4737-4742 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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20 Citations (Scopus)
2017

Aurora Kinase B, a novel regulator of TERF1 binding and telomeric integrity

Chan, F. L., Vinod, B., Novy, K., Schittenhelm, R. B., Huang, C., Udugama, M., Nunez-Iglesias, J., Lin, J. I., Hii, L., Chan, J., Pickett, H. A., Daly, R. J. & Wong, L. H., 1 Dec 2017, In : Nucleic Acids Research. 45, 21, p. 12340-12353 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes

Marino, E., Richards, J. L., McLeod, K. H., Stanley, D., Yap, Y. A., Knight, J., McKenzie, C., Kranich, J., Oliveira, A. C., Rossello, F. J., Krishnamurthy, B., Nefzger, C. M., Macia, L., Thorburn, A., Baxter, A. G., Morahan, G., Wong, L. H., Polo, J. M., Moore, R. J., Lockett, T. J. & 4 others, Clarke, J. M., Topping, D. L., Harrison, L. C. & Mackay, C. R., May 2017, In : Nature Immunology. 18, 5, p. 552-562 13 p.

Research output: Contribution to journalArticleResearchpeer-review

178 Citations (Scopus)

PML protein organizes heterochromatin domains where it regulates histone H3.3 deposition by ATRX/DAXX

Delbarre, E., Ivanauskiene, K., Spirkoski, J., Shah, A., Vekterud, K., Moskaug, J., Bøe, S. O., Wong, L. H., Küntziger, T. & Collas, P., 1 Jun 2017, In : Genome Research. 27, 6, p. 913-921 9 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)
2015

A novel role for the Pol I transcription factor UBTF in maintaining genome stability through the regulation of highly transcribed Pol II genes

Sanij, E., Diesch, J., Lesmana, A., Poortinga, G., Hein, N., Lidgerwood, G., Cameron, D. P., Ellul, J., Goodall, G. J., Wong, L. H., Dhillon, A. S., Hamdane, N., Rothblum, L. I., Pearson, R. B., Haviv, I., Moss, T. & Hannan, R. D., 2015, In : Genome Research. 25, 2, p. 201 - 212 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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17 Citations (Scopus)

CHK1-driven histone H3.3 serine 31 phosphorylation is important for chromatin maintenance and cell survival in human ALT cancer cells

Chang, T. M. F., Chan, F. L., McGhie, J. D. R., Udugama, M. I. K., Mayne, L., Collas, P., Mann, J. R. & Wong, L. H., 2015, In : Nucleic Acids Research. 43, 5, p. 2603 - 2614 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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19 Citations (Scopus)

Contribution of the two genes encoding histone variant h3.3 to viability and fertility in mice

Tang, M. C., Jacobs, S. A., Mattiske, D. M., Soh, Y. M., Graham, A. N., Tran, A., Lim, S. L., Hudson, D. F., Kalitsis, P., O'Bryan, M. K., Wong, L. H. & Mann, J. R., 1 Feb 2015, In : PLoS Genetics. 11, 2, 23 p., e1004964.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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43 Citations (Scopus)

Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites

Thorburn, A. N., McKenzie, C., Shen, S. S., Stanley, D., Macia, L., Mason, L. J., Roberts, L. K., Wong, C. H. Y., Shim, R., Robert, R., Chevalier, N., Tan, J. K., Marino, E. M., Moore, R. J., Wong, L. H. H., McConville, M. J., Tull, D. L., Wood, L., Murphy, V., Mattes, J. & 3 others, Gibson, P. G., Wood, L. G. & Mackay, C. R., 2015, In : Nature Communications. 6, 7320, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
282 Citations (Scopus)

HENMT1 and piRNA stability are required for adult male germ cell transposon repression and to define the spermatogenic program in the mouse

Lim, S. L., Qu, Z. P., Kortschak, R. D., Lawrence, D. M., Geoghegan, J., Hempfling, A-L., Bergmann, M., Goodnow, C. C., Ormandy, C. J., Wong, L. H., Mann, J. R., Scott, H. S., Jamsai, D., Adelson, D. L. & O'Bryan, M. K., 2015, In : PLoS Genetics. 11, 10 , 30 p., e1005620.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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43 Citations (Scopus)

Histone variant H3.3 provides the heterochromatic H3 lysine 9 tri-methylation mark at telomeres

Udugama, M. I. K., Chang, T. M. F., Chan, F. L., Tang, M. C., Pickett, H. A., McGhie, J. D. R., Mayne, L., Collas, P., Mann, J. R. & Wong, L. H. H., 2015, In : Nucleic Acids Research. 43, 21, p. 10227 - 10237 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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37 Citations (Scopus)
2014

High histone variant H3.3 content in mouse prospermatogonia suggests a role in epigenetic reformatting

Tang, M. C. W., Binos, S., Ong, E. K., Wong, L. & Mann, J. R., 2014, In : Chromosoma. 123, 6, p. 587 - 595 9 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Telomere epigenetics in stem cells and cancers

Chan, F. L. & Wong, L., 2014, In : Australian Biochemist. 45, 1, p. 7 - 11 5 p.

Research output: Contribution to journalArticleOther

The PML-associated protein DEK regulates the balance of H3.3 loading on chromatin and is important for telomere integrity

Ivanauskiene, K., Delbarre, E., McGhie, J. D. R., Kuntziger, T., Wong, L. & Collas, P., 2014, In : Genome Research. 24, 10, p. 1584 - 1594 11 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)
2013

Conditional allelic replacement applied to genes encoding the histone variant H3.3 in the mouse

Tang, M. C. W., Jacobs, S. A., Wong, L. & Mann, J. R., 2013, In : Genesis. 51, 2, p. 142 - 146 5 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Essential developmental, genomic stability, and tumour suppressor functions of the mouse orthologue of hSSB1/NABP2

Shi, W., Bain, A. L., Schwer, B., Al-Ejeh, F., Smith, C., Wong, L., Chai, H., Miranda, M. S., Ho, U., Kawaguchi, M., Miura, Y., Finnie, J. W., Wall, M., Heierhorst, J., Wicking, C., Spring, K. J., Alt, F. & Khanna, K. K., 2013, In : PLoS Genetics. 9, 2, 19 p., e1003298.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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20 Citations (Scopus)

PML bodies provide an important platform for the maintenance of telomeric chromatin integrity in embryonic stem cells

Chang, T. M. F., McGhie, J. D., Chan, F. L., Tang, M. C., Anderson, M. A., Mann, J. R., Choo, A. & Wong, L., 2013, In : Nucleic Acids Research. 41, 8, p. 4447 - 4458 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
33 Citations (Scopus)
2012

Active transcription and essential role of RNA polymerase II at the centromere during mitosis

Chan, F. L., Marshall, O. J., Saffery, R., Kim, B. W., Earle, E., Choo, A. & Wong, L., 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 6, p. 1979 - 1984 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
135 Citations (Scopus)

Normal DNA methylation dynamics in DICER1-deficient mouse embryonic stem cells

Ip, J., Canham, P., Choo, A., Inaba, Y., Jacobs, S. A., Kalitsis, P., Mattiske, D., Ng, J., Saffery, R., Wong, N. C., Wong, L. & Mann, J. R., 2012, In : PLoS Genetics. 8, 9, 13 p., e1002919.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
12 Citations (Scopus)

Transcription in the maintenance of centromere chromatin identity

Chan, F. L. & Wong, L., 2012, In : Nucleic Acids Research. 40, 22, p. 11178 - 11188 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
50 Citations (Scopus)
2010

ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells

Wong, L., McGhie, J. D. R., Sim, M. L. J., Anderson, M. A., Ahn, S., Hannan, R. D., George, A. J., Morgan, K. A., Mann, J. R. & Choo, A., 2010, In : Genome Research. 20, 3, p. 351 - 360 10 p.

Research output: Contribution to journalArticleResearchpeer-review

237 Citations (Scopus)
2009

Histone H3.3 incorporation provides a unique and functionally essential telomeric chromatin in embryonic stem cells

Wong, L. H., Ren, H., Williams, E. J., McGhie, J. D. R., Ahn, S., Sim, M. L. J., Tam, A., Earle, E., Anderson, M. A., Mann, J. R. & Choo, A., 2009, In : Genome Research. 19, 3, p. 404 - 414 11 p.

Research output: Contribution to journalArticleResearchpeer-review

106 Citations (Scopus)

LINE retrotransposon RNA is an essential structural and functional epigenetic component of a core neocentromeric chromatin

Chueh, A. C., Northrop, E. L., Brettingham-Moore, K. H., Choo, K. H. A. & Wong, L. H., Jan 2009, In : PLoS Genetics. 5, 1, e1000354.

Research output: Contribution to journalArticleResearchpeer-review

105 Citations (Scopus)
2008

UBF levels determine the number of active ribosomal RNA genes in mammals

Sanij, E., Poortinga, G., Sharkey, K., Hung, S., Holloway, T. P., Quin, J., Robb, E., Wong, L. H., Thomas, W. G., Stefanovsky, V., Moss, T., Rothblum, L., Hannan, K. M., McArthur, G. A., Pearson, R. B. & Hannan, R. D., 29 Dec 2008, In : Journal of Cell Biology. 183, 7, p. 1259-1274 16 p.

Research output: Contribution to journalArticleResearchpeer-review

121 Citations (Scopus)
2007

Centromere RNA is a key component for the assembly of nucleoproteins at the nucleolus and centromere

Wong, L. H., Brettingham-Moore, K. H., Chan, L., Quach, J. M., Anderson, M. A., Northrop, E. L., Hannan, R., Saffery, R., Shaw, M. L., Williams, E. & Choo, K. H. A., 2007, In : Genome Research. 17, 8, p. 1146-1160 15 p.

Research output: Contribution to journalArticleResearchpeer-review

177 Citations (Scopus)
2006

Permissive transcriptional activity at the centromere through pockets of DNA hypomethylation

Wong, N. C., Wong, L. H., Quach, J. M., Canham, P., Craig, J. M., Song, J. Z., Clark, S. J. & Choo, K. H. A., Feb 2006, In : PLoS Genetics. 2, 2, p. 172-186 15 p.

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)
2005

Analysis of mitotic and expression properties of human neocentromere-based transchromosomes in mice

Wong, L. H., Saffery, R., Anderson, M. A., Earle, E., Quach, J. M., Stafford, A. J., Fowler, K. J. & Choo, K. H. A., 4 Feb 2005, In : Journal of Biological Chemistry. 280, 5, p. 3954-3962 9 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

BAC-based PCR fragment microarray: High-resolution detection of chromosomal deletion and duplication breakpoints

Ren, H., Francis, W., Boys, A., Chueh, A. C., Wong, N., La, P., Wong, L. H., Ryan, J., Slater, H. R. & Choo, K. H. A., May 2005, In : Human Mutation. 25, 5, p. 476-482 7 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Variable and hierarchical size distribution of L1-retroelement-enriched CENP-A clusters within a functional human neocentromere

Chueh, A. C., Wong, L. H., Wong, N. & Choo, K. H. A., 1 Jan 2005, In : Human Molecular Genetics. 14, 1, p. 85-93 9 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)
2004

Centromere protein b-null mice display decreasing reproductive performance through successive generations of breeding due to diminishing endometrial glands

Fowler, K. J., Wong, L. H., Griffiths, B. K., Sibson, M. C., Reed, S. & Choo, K. H. A., Mar 2004, In : Reproduction. 127, 3, p. 367-377 11 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Human centromere repositioning "in progress"

Amor, D. J., Bentley, K., Ryan, J., Perry, J., Wong, L., Slater, H. & Choo, K. H. A., 27 Apr 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 17, p. 6542-6547 6 p.

Research output: Contribution to journalArticleResearchpeer-review

143 Citations (Scopus)
2003

Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns

Craig, J. M., Earle, E., Canham, P., Wong, L. H., Anderson, M. & Choo, K. H. A., 1 Dec 2003, In : Human Molecular Genetics. 12, 23, p. 3109-3121 13 p.

Research output: Contribution to journalArticleResearchpeer-review

63 Citations (Scopus)

Centromeric chromatin pliability and memory at a human neocentromere

Craig, J. M., Wong, L. H., Lo, A. W. I., Earle, E. & Choo, K. H. A., 15 May 2003, In : The EMBO Journal. 22, 10, p. 2495-2504 10 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Transcription within a functional human centromere

Saffery, R., Sumer, H., Hassan, S., Wong, L. H., Craig, J. M., Todokoro, K., Anderson, M., Stafford, A. & Choo, K. H. A., 2003, In : Molecular Cell. 12, 2, p. 509 - 516 8 p.

Research output: Contribution to journalArticleResearchpeer-review

116 Citations (Scopus)
2002

Centromere proteins Cenpa, Cenpb, and Bub3 interact with poly(ADP-ribose) polymerase-1 protein and are poly(ADP-ribosyl)ated

Saxena, A., Saffery, R., Wong, L. H., Kalitsis, P. & Choo, K. H. A., 26 Jul 2002, In : Journal of Biological Chemistry. 277, 30, p. 26921-26926 6 p.

Research output: Contribution to journalArticleResearchpeer-review

90 Citations (Scopus)

Construction of neocentromere-based human minichromosomes for gene delivery and centromere studies

Wong, L. H., Saffery, R. & Choo, K. H. A., 2002, In : Gene Therapy. 9, 11, p. 724-726 3 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Isolation and characterization of a human STAT1 gene regulatory element. Inducibility by interferon (IFN) types I and II and role of IFN regulatory factor-1

Wong, L. H., Sim, H., Chatterjee-Kishore, M., Hatzinisiriou, I., Devenish, R. J., Stark, G. & Ralph, S. J., 31 May 2002, In : Journal of Biological Chemistry. 277, 22, p. 19408-19417 10 p.

Research output: Contribution to journalArticleResearchpeer-review

80 Citations (Scopus)

Isolation and Characterization of a Human STATI Gene Regulatory Element

Wong, L. H., Sim, H., Chatterjee-Kishore, M., Hatzinisiriou, I., Devenish, R. J., Stark, G. & Ralph, S. J., 2002, In : Journal of Biological Chemistry. 277, 22, p. 19408 - 19417 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Poly(ADP-ribose) polymerase 2 localizes to mammalian active centromeres and interacts with PARP-1, Cenpa, Cenpb and Bub3, but not Cenpc

Saxena, A., Wong, L. H., Kalitsis, P., Earle, E., Shaffer, L. G. & Choo, K. H. A., 15 Sep 2002, In : Human Molecular Genetics. 11, 19, p. 2319-2329 11 p.

Research output: Contribution to journalArticleResearchpeer-review

70 Citations (Scopus)
2001

Centromere on the move

Wong, L. H. & Choo, K. H. A., 2001, In : Genome Research. 11, 4, p. 513-516 4 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Construction of neocentromere-based human minichromosomes by telomere-associated chromosomal truncation

Saffery, R., Wong, L. H., Irvine, D. V., Bateman, M. A., Griffiths, B., Cutts, S. M., Cancilla, M. R., Cendron, A. C., Stafford, A. J. & Choo, K. H. A., 8 May 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 10, p. 5705-5710 6 p.

Research output: Contribution to journalArticleResearchpeer-review

59 Citations (Scopus)
2000

Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype

Uren, A. G., Wong, L., Pakusch, M., Fowler, K. J., Burrows, F. J., Vaux, D. L. & Choo, K. H. A., 2 Nov 2000, In : Current Biology. 10, 21, p. 1319-1328 10 p.

Research output: Contribution to journalArticleResearchpeer-review

453 Citations (Scopus)
1998

IFN - g priming up - regulates IFN - stimulated gener factor 3 (ISGF3) components, augmenting responsiveness of IFN-resistant melanoma cells to type IIFNs

Wong, L. H., Hatzinisiriou, I., Devenish, R. J. & Ralph, S. J., 1998, In : Journal of Immunology. p. 5475 - 5484 10 p.

Research output: Contribution to journalArticleResearchpeer-review

IFN-γ priming up-regulates IFN-stimulated gene factor 3 (ISGF3) components, augmenting responsiveness of IFN-resistant melanoma cells to type I IFNs

Wong, L. H., Hatzinisiriou, I., Devenish, R. J. & Ralph, S. J., 1 Jun 1998, In : Journal of Immunology. 160, 11, p. 5475-5484 10 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Revising interferons - prodigies among the cytokines

Ralph, S. J., Wong, L. H., Hatzinisiriou, I., Estcourt, M., Hersey, P. & Devenish, R. J., 1998, In : Today's Life Science. 10, 10, p. 37 - 43 7 p.

Research output: Contribution to journalArticleOther

1997

Interferon - resistant human melanoma cells are deficient in ISGF3 components, STAT1, STAT2, and p48 - ISGF3g

Wong, L. H., Krauer, K., Hatzinisiriou, I., Estcourt, M., Hersey, P., Tam, N., Edmondson, S., Devenish, R. J. & Ralph, S. J., 1997, In : Journal of Biological Chemistry. p. 28779-28785 7 p.

Research output: Contribution to journalArticleResearchpeer-review

1996

The SH2 domains of Stat1 and Stat2 mediate multiple interactions in the transduction of IFN-α signals

Gupta, S., Yan, H., Wong, L. H., Ralph, S., Krolewski, J. & Schindler, C., 1 Mar 1996, In : The EMBO Journal. 15, 5, p. 1075-1084 10 p.

Research output: Contribution to journalArticleResearchpeer-review

125 Citations (Scopus)