Projects per year
Personal profile
Biography
Lee did her PhD at Monash University. Her post-doctoral work at Murdoch Childrens Research Institute marked the beginning of her chromosome biology studies. In 2012, she established her own lab, the Epigenetics and Chromatin (EpiC) Research Laboratory, in the department of Biochemistry and Molecular Biology at Monash.
The main areas focus of Lee's group to identify new epigenetic factors that regulate centromere and telomere function. With this, she aims to uncover mechanisms that control chromosome stability and genetic transmission, of which are pertinent to cell growth, tissue differentiation and embryo development.
Recent studies have identified the frequent mutations of histone variant H3.3 and its chaperone ATRX in human cancers including childhood brain cancers. The current aim of her team is to define the normal function of H3.3 and ATRX in controlling transcription silencing at the telomeres and in the global genome. They also investigate genome-wide epigenetic defects associated with H3.3 and ATRX mutations in cancers.
Related Links:
Research area keywords
- Chromatin
- Cancer epigenetics
- Telomeres
- Centromeres
- Histone variants
- Brain cancers
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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A next generation single-photon microscope for dynamic live cell biology
Hinde, E. (Primary Chief Investigator (PCI)), McMillan, P. J. (Chief Investigator (CI)), Watt, M. J. (Chief Investigator (CI)), Hatters, D. (Chief Investigator (CI)), McDevitt, C. A. (Chief Investigator (CI)), Harvey, K. (Chief Investigator (CI)), Wong, L. (Chief Investigator (CI)), Francois, M. (Chief Investigator (CI)), Ashe, A. (Chief Investigator (CI)), Whelan, D. (Chief Investigator (CI)), Hong, Y. (Chief Investigator (CI)), Russell, S. M. (Chief Investigator (CI)) & Clayton, A. (Chief Investigator (CI))
30/07/26 → 29/07/27
Project: Research
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Advancing Differentiation Therapy and Immunotherapy for Paediatric High-Grade Gliomas Through Targeted Epigenome Regulation
Wong, L. (Primary Chief Investigator (PCI)), Firestein, R. (Chief Investigator (CI)), Faridi, P. (Chief Investigator (CI)), Cain, J. (Chief Investigator (CI)), Khuong-Quang, D.-A. (Chief Investigator (CI)), Geraldine, O. (Chief Investigator (CI)), Dolcetti, R. (Chief Investigator (CI)), Ashley, D. (Chief Investigator (CI)), Jones, C. M. (Chief Investigator (CI)), Collas, P. (Chief Investigator (CI)), Sun, C. (Chief Investigator (CI)), Daniel, P. (Chief Investigator (CI)), Ekert, P. (Associate Investigator (AI)), Eisenstat, D. (Associate Investigator (AI)), Lou, J. (Associate Investigator (AI)), Resnick, A. (Associate Investigator (AI)), Goldstein, R. (Associate Investigator (AI)), Danaher, T. (Associate Investigator (AI)), Deveson, D. (Associate Investigator (AI)), De Rose, R. (Associate Investigator (AI)), Jabado, N. (Associate Investigator (AI)) & Mazzieri, R. (Associate Investigator (AI))
1/04/25 → 31/03/28
Project: Research
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Chromatin defects in histone mutated brain cancers: from basic mechanisms to novel therapeutic strategies
Wong, L. (Primary Chief Investigator (PCI)), Collas, P. (Chief Investigator (CI)), Jabado, N. (Chief Investigator (CI)), Schittenhelm, R. (Associate Investigator (AI)) & Rosenbluh, S. (Associate Investigator (AI))
1/01/22 → 31/12/26
Project: Research
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Uncovering a new therapeutic approach for brain cancer
Wong, L. (Primary Chief Investigator (PCI)), Hannan, R. (Chief Investigator (CI)) & Quinn, L. (Associate Investigator (AI))
30/04/23 → 30/04/25
Project: Research
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Identification of novel treatment targets for histone mutated cancers
Wong, L. (Primary Chief Investigator (PCI)), Schittenhelm, R. (Chief Investigator (CI)), Collas, P. (Chief Investigator (CI)) & Jabado, N. (Chief Investigator (CI))
1/11/21 → 31/10/22
Project: Research
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Telomere length in offspring is determined by mitochondrial-nuclear communication at fertilization
Winstanley, Y. E., Rose, R. D., Sobinoff, A. P., Wu, L. L., Adhikari, D., Zhang, Q.-H., Wells, J. K., Wong, L. H., Szeto, H. H., Piltz, S. G., Thomas, P. Q., Febbraio, M. A., Carroll, J., Pickett, H. A., Russell, D. L. & Robker, R. L., Dec 2025, In: Nature Communications. 16, 1, 20 p., 2527.Research output: Contribution to journal › Article › Research › peer-review
Open Access12 Link opens in a new tab Citations (Scopus) -
Integrative modeling uncovers p21-driven drug resistance and prioritizes therapies for PIK3CA-mutant breast cancer
Yip, H. Y. K., Shin, S.-Y., Chee, A., Ang, C. S., Rossello, F. J., Wong, L. H., Nguyen, L. K. & Papa, A., Dec 2024, In: npj Precision Oncology. 8, 1, 21 p., 20.Research output: Contribution to journal › Article › Research › peer-review
Open Access20 Link opens in a new tab Citations (Scopus) -
Visualizing Epigenetic Modifications and Nuclear Bodies by Immunofluorescence Staining in Naïve, Activated, and Memory B Cell Subsets
Chakma, C. R., Garvie, A., Wong, L. H. & Good-Jacobson, K. L., 2024, Memory B-Cells: Methods and Protocols. Good-Jacobson, K. L. (ed.). 1st ed. New York NY USA: Humana Press, p. 47-54 8 p. (Methods in Molecular Biology; vol. 2826).Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review
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Y chromosome damage underlies testicular abnormalities in ATR-X syndrome
León, N. Y., Le, T. N. U., Garvie, A., Wong, L. H., Bagheri-Fam, S. & Harley, V. R., 17 May 2024, In: iScience. 27, 5, 16 p., 109629.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Chromatin mutations in pediatric high grade gliomas
Voon, H. P. J. & Wong, L. H., 6 Jan 2023, In: Frontiers in Oncology. 12, 9 p., 1104129.Research output: Contribution to journal › Review Article › Other › peer-review
Open Access6 Link opens in a new tab Citations (Scopus)