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Personal profile

Biography

Lee did her PhD at Monash University. Her post-doctoral work at Murdoch Childrens Research Institute marked the beginning of her chromosome biology studies. In 2012, she established her own lab, the Epigenetics and Chromatin (EpiC) Research Laboratory, in the department of Biochemistry and Molecular Biology at Monash.

The main areas focus of Lee's group to identify new epigenetic factors that regulate centromere and telomere function. With this, she aims to uncover mechanisms that control chromosome stability and genetic transmission, of which are pertinent to cell growth, tissue differentiation and embryo development.

Recent studies have identified the frequent mutations of histone variant H3.3 and its chaperone ATRX in human cancers including childhood brain cancers. The current aim of her team is to define the normal function of H3.3 and ATRX in controlling transcription silencing at the telomeres and in the global genome. They also investigate genome-wide epigenetic defects associated with H3.3 and ATRX mutations in cancers. 

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Keywords

  • Chromatin
  • Cancer epigenetics
  • Telomeres
  • Centromeres
  • Histone variants
  • Brain cancers

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Projects 2010 2019

Research Output 1996 2018

Ribosomal DNA copy loss and repeat instability in ATRX-mutated cancers

Udugama, M., Sanij, E., Voon, H. P. J., Son, J., Hii, L., Henson, J. D., Chan, F. L., Chang, F. T. M., Liu, Y., Pearson, R. B., Kalitsis, P., Mann, J. R., Collas, P., Hannan, R. D. & Wong, L. H. 1 May 2018 In : Proceedings of the National Academy of Sciences of the United States of America. 115, 18, p. 4737-4742 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Aurora Kinase B, a novel regulator of TERF1 binding and telomeric integrity

Chan, F. L., Vinod, B., Novy, K., Schittenhelm, R. B., Huang, C., Udugama, M., Nunez-Iglesias, J., Lin, J. I., Hii, L., Chan, J., Pickett, H. A., Daly, R. J. & Wong, L. H. 1 Dec 2017 In : Nucleic Acids Research. 45, 21, p. 12340-12353 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes

Marino, E. , Richards, J. L. , McLeod, K. H. , Stanley, D. , Yap, Y. A. , Knight, J. , McKenzie, C. , Kranich, J. , Oliveira, A. C. , Rossello, F. J. , Krishnamurthy, B. , Nefzger, C. M. , Macia, L. , Thorburn, A. , Baxter, A. G. , Morahan, G. , Wong, L. H. , Polo, J. M. , Moore, R. J. , Lockett, T. J. & 4 others Clarke, J. M., Topping, D. L., Harrison, L. C. & Mackay, C. R. May 2017 In : Nature Immunology. 18, 5, p. 552-562 13 p.

Research output: Contribution to journalArticleResearchpeer-review

PML protein organizes heterochromatin domains where it regulates histone H3.3 deposition by ATRX/DAXX

Delbarre, E., Ivanauskiene, K., Spirkoski, J., Shah, A., Vekterud, K., Moskaug, J., Bøe, S. O., Wong, L. H., Küntziger, T. & Collas, P. 1 Jun 2017 In : Genome Research. 27, 6, p. 913-921 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Compromised telomeric heterochromatin promotes ALTernative lengthening of telomeres

Voon, H. P. J., Collas, P. & Wong, L. H. 1 Mar 2016 In : Trends in Cancer. 2, 3, p. 114-116 3 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Prizes

ARC Future Fellowship

Lee Hwa Wong (Recipient), 2015

Prize: Competitive Fellowships