Personal profile
Research interests
The brain uses information from the past and present, as well as prognostications, to better determine effective action or inaction. My research aims to understand how the brain's neurons compute information at the subcellular, neuronal and circuit levels.
I would love it if one day I am able to understand how neuronal processes lead to what defines our experience of life: the phenomenas of perception, cognition, and our conscious sense of agency.
Biography
I grew up in Perth, receiving undergraduate education at The University of Western Australia in Neuroscience and Pharmacology, where I also began research through an honours program under supervision of Profs Shaun Collins and Sarah Dunlop to look at retinal ganglion cell diversity and properties in the lamprey. I then moved to Brisbane at the University of Queensland to conduct PhD research with Prof. Stephen Williams looking at how pyramidal neurons in the primary visual cortex dendritically integrate and process information. Finishing my PhD, I moved to Cambridge, UK in 2019 to begin post-doctoral research in London at the Sainsbury-Wellcome Centre for Neural Circuits and Behaviour at UCL, but through ill health I left this position soon after. Over the next few years I carried out charity work with the Brilliant Club to teach primary and high school students in science, and as Trustee of UK charity The Biodiversity and Environmental Education Society, worked to provide environmental education for adults in the East of England by developing and leading the UK's first nature guide training program alongside my fellow Trustees. I returned to Australia in 2022 as a postdoctoral researcher with Prof Williams at UQ, before receiving a NHMRC Emerging Leadership Investigator grant and taking up my position at Monash University in 2024.
Education/Academic qualification
Neuroscience, PhD, Dendritic integration in principal neurons of the primary visual cortex, University of Queensland
Award Date: 29 Mar 2019
External positions
Co-Director (Australasian Course of Advanced Neuroscience), Australasian Neuroscience Society Inc
1 Jan 2024 → …
Trustee, Biodiversity and Environmental Education Society (BEES)
Jul 2020 → …
Collaborations and top research areas from the last five years
Projects
- 1 Active
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Spatiotemporal patterning of dendritic computations and learning by cholinergic inputs in the neocortex
Fletcher, L. (Primary Chief Investigator (PCI)) & Cowley, M. (Sponsor)
1/01/25 → 31/12/29
Project: Research
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Compartment-specific dendritic information processing in striatal cholinergic interneurons is reconfigured by peptide neuromodulation
Williams, S. R., Zhou, X. & Fletcher, L. N., 21 Jun 2023, In: Neuron. 111, 12, p. 1933-1951.e3 22 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access6 Link opens in a new tab Citations (Scopus) -
Synapse-enriched m6A-modified Malat1 interacts with the novel m6A reader, DPYSL2, and is required for fear-extinction memory
Madugalle, S. U., Liau, W. S., Zhao, Q., Li, X., Gong, H., Marshall, P. R., Periyakaruppiah, A., Zajaczkowski, E. L., Leighton, L. J., Ren, H., Musgrove, M. R. B., Davies, J. W. A., Kim, G., Rauch, S., He, C., Dickinson, B. C., Fulopova, B., Fletcher, L. N., Williams, S. R. & Spitale, R. C. & 1 others, , 25 Oct 2023, In: Journal of Neuroscience. 43, 43, p. 7084-7100 17 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access23 Link opens in a new tab Citations (Scopus) -
High-fidelity dendritic sodium spike generation in human layer 2/3 neocortical pyramidal neurons
Gooch, H. M., Bluett, T., Perumal, M. B., Vo, H. D., Fletcher, L. N., Papacostas, J., Jeffree, R. L., Wood, M., Colditz, M. J., McMillen, J., Tsahtsarlis, T., Amato, D., Campbell, R., Gillinder, L. & Williams, S. R., 18 Oct 2022, In: Cell Reports. 41, 3, 17 p., 111500.Research output: Contribution to journal › Article › Research › peer-review
Open Access15 Link opens in a new tab Citations (Scopus) -
A Dendritic Substrate for the Cholinergic Control of Neocortical Output Neurons
Williams, S. R. & Fletcher, L. N., 6 Feb 2019, In: Neuron. 101, 3, p. 486-499 14 p.Research output: Contribution to journal › Article › Research › peer-review
68 Link opens in a new tab Citations (Scopus) -
Neocortical Topology Governs the Dendritic Integrative Capacity of Layer 5 Pyramidal Neurons
Fletcher, L. N. & Williams, S. R., 2 Jan 2019, In: Neuron. 101, 1, p. 76-90 15 p.Research output: Contribution to journal › Article › Research › peer-review
46 Link opens in a new tab Citations (Scopus)
Prizes
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The Gregory Campbell & Lady Primrose Potter Early Career Excellence Award for Eye Health and Vision Research
Fletcher, L. (Recipient), May 2026
Prize: Prize (including medals and awards)