Projects per year
Personal profile
Biography
Professor Laurence Meagher is interested in how material science and engineering can be applied to and help solve medical problems. As the world population ages, new solutions are required to help shape the future of medicine. The approaches Laurence uses are framed by his extensive experience leading commercially focused research and development with commercial clients. For example, Laurence was a key member of the team that developed the Air OPTIX(TM) soft silicone hydrogel contact lens.
Many devices and materials used in the clinic have been selected for their material properties or function. Often however, the surface properties are not optimal. In a number of cases, sub-optimal surface properties can lead to reduced function and even failure of the device. Laurence uses his background in surface and polymer science to engineer the properties of surface coatings for used in medical applications.
Research interests
There are still strong clinical needs in three main areas: (i) bacterial infections which arise from the implantation of medical devices or use of catheters, (ii) thrombosis or blood clot formation on materials which are placed in the bloodstream and (iii) fibrosis or scar tissue formation on or around devices implanted devices or materials which, as most foreign objects do, invoke an immune response. These are three examples of clinical areas where designed surface coatings can really help to provide solutions to these very challenging problems.
For example, Laurence is applying controlled radical polymerisation approaches to the preparation of antibacterial coatings. He has already developed new polymers that work very well against a range of medically relevant and drug-resistant bacteria and fungi; and which kill biofilms, whilst having low toxicity to human cells. Of great importance is that these polymers do not result in the development of resistance and are very inexpensive to make on a large scale.
Surface coating approaches are also very important in the new area of cell therapies. Where material science and surface engineering can make a difference in this field is in the generation of synthetic coatings and culture systems for cell manufacture that do not use animal products. This reduces the risk of infection and makes the manufacture of these important cells less expensive, which can make the treatments available to more people. These types of concepts (synthetic materials for cell growth) can also be applied in the preparation of synthetic scaffold materials that support the growth of cells for tissue regeneration. This field is often called tissue engineering.
Prof Meagher is the Director of the ARC Training Centre for Cell and Tissue Engineering Technologies which will carry out research in collaboration with industry partners and train a cohort of HDR in all aspects of the translation and commercialisation of cell and tissue-engineered products. He leads one of the four Centre research themes, Advanced Materials and Manufacturing.
Prof Meagher is Director of the Monash SPARK program which provides seed funding and industry mentoring for academic-led research where the team is seeking to translate the medical device, in-vitro diagnostic or therapeutic agent to the clinic for use with patients.
In 2020, Prof Meagher joined the Monash Centre to Impact AMR as Chair of the Industrial Engagement working group to drive translational outcomes from the Centres core research. The Centre will benefit from his extensive expertise in anti-microbial coatings and materials to develop new surfaces to stop the spread of AMR infections
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Medical Engineering
- Materials Science
- Surface modification
- surface characterisation
- biomedical implants
- drug delivery
- cell culture surfaces
- surface initiated polymerisation
- controlled radical polymerisation
- antimicrobial materials
- surface chemistry
- biomedical materials
- electrospinning
- biodegradable polymers
- polymer brush coatings
- atomic force microscopy
- haemopoietic stem cells
- mesenchymal stem cells
- pluripotent stem cells
- cell therapies
- hydrophobic forces
- bioactive small molecules
- bioactive peptides
- stem cell culture surfaces
- surface forces
- interactions between materials
- DLVO Theory
- hydration forces
Network
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Development of a Deep Learning-Based Quantitative Multiplexing Staining Technology for Tissue Cytometry
Batra, J., Ecker, R., Meagher, L. & Ruka, D.
15/02/23 → 30/01/27
Project: Research
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Improving efficacy of CAR T cell therapies for solid tumors
Risbridger, G., Trapani, J. A., Meagher, L. & Ruka, D.
1/09/22 → 12/01/26
Project: Research
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Combating Antimicrobial Resistance with Bismuth, Gallium and Indium
Andrews, P., Dove, A., Ferrero, R. & Meagher, L.
8/06/22 → 7/06/25
Project: Research
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Peripheral Nerve Repair Technologies
Cameron, N., Rhodes, D., Meagher, L. & Ruka, D.
Australian Research Council (ARC)
1/03/22 → 30/09/25
Project: Research
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Reprograming of different cell types into podocytes
Polo, J., Bertram, J., Rackham, O., Meagher, L. & Ruka, D.
3/01/22 → 12/01/26
Project: Research
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Extrusion 3D bioprinting of functional self-supporting neural constructs using a photoclickable gelatin bioink
Yao, Y., Molotnikov, A., Parkington, H. C., Meagher, L. & Forsythe, J. S., 1 Jun 2022, In: Biofabrication. 14, 3, 20 p., 035014.Research output: Contribution to journal › Article › Research › peer-review
3 Citations (Scopus) -
Poly(HPMA-co-NIPAM) copolymer as an alternative to polyethylene glycol-based pharmacokinetic modulation of therapeutic proteins
Subasic, C. N., Ardana, A., Chan, L. J., Huang, F., Scoble, J. A., Butcher, N. J., Meagher, L., Chiefari, J., Kaminskas, L. M. & Williams, C. C., 25 Oct 2021, In: International Journal of Pharmaceutics. 608, 11 p., 121075.Research output: Contribution to journal › Article › Research › peer-review
4 Citations (Scopus) -
Printability and bio-functionality of a shear thinning methacrylated xanthan-gelatin composite bioink
Garcia-Cruz, M. R., Postma, A., Frith, J. E. & Meagher, L., 8 Apr 2021, In: Biofabrication. 13, 3, 19 p., 035023.Research output: Contribution to journal › Article › Research › peer-review
11 Citations (Scopus) -
Review: nanomaterials for reactive oxygen species detection and monitoring in biological environments
Huynh, G. T., Kesarwani, V., Walker, J. A., Frith, J. E., Meagher, L. & Corrie, S. R., 10 Sep 2021, In: Frontiers in Chemistry. 9, 19 p., 728717.Research output: Contribution to journal › Review Article › Research › peer-review
Open AccessFile7 Citations (Scopus) -
Stability and performance study of fluorescent organosilica pH nanosensors
Huynh, G. T., Henderson, E. C., Frith, J. E., Meagher, L. & Corrie, S. R., 19 May 2021, In: Langmuir. 37, 21, p. 6578-6587 10 p.Research output: Contribution to journal › Article › Research › peer-review
2 Citations (Scopus)
Activities
- 1 Patents
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CSIRO - Commonwealth Scientific and Industrial Research Organisation (External organisation)
Katherine Elizabeth Sarah Locock (Inventor), Laurence Meagher (Inventor), Yue Qu (Inventor) & Ana Traven (Inventor)
2016Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent