Projects per year
Personal profile
Biography
Dr Laura Humphrys earned her integrated master's degree in neuroscience from the University of Nottingham, UK (1 year with the University of Melbourne, Australia) in 2015. She was then awarded and AJ Clark Studentship from the British Pharmacological Society in 2015 to perform her postgraduate research on light-activated cell membrane receptors. Her PhD was full of fun research, such as microscopy, primary astrocytes and light-activated biological responses, leading her fully down the academic path. Following her PhD, Laura was recruited to the University of Regensburg, Germany in 2019 as a cell-based postdoctoral scientist in a peptide-based medicinal chemistry lab. Here, she learned the joy of molecular biology and using DNA as Lego bricks. She taught herself the CRISPR gene editing technique and used this to investigate potential peptide-activated orphan receptors as therapeutic targets.
Laura was recruited to the Monash Institute of Pharmaceutical Sciences in 2023 as a Postdoctoral Research Fellow to investigate metabolic receptor pharmacology in the labs of Prof Denise Wootten and Prof Patrick Sexton. Her research interests remain with visualisation and genetic modification of cell receptors in physiologically relevant cells.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Neuropharmacology, PhD, Optogenetic G Protein Coupled Receptors to Investigate Spatiotemporal Signalling, University of Nottingham
31 Oct 2015 → 30 Sept 2019
Award Date: 24 Jul 2020
Neuroscience, MSci, University of Nottingham
20 Sept 2011 → 1 Jun 2015
Award Date: 17 Jul 2015
External positions
Postdoctoral researcher, Universitat Regensburg (University of Regensburg)
1 Oct 2019 → 31 Dec 2022
Research area keywords
- Membrane proteins
- GPCR biology
- Cell signalling
- Microscopy
- Molecular biology
- CRISPR Biology
- Protein Biochemistry
- Drug Discovery
Collaborations and top research areas from the last five years
Projects
- 1 Active
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2025 BPS Pickford Award
Humphrys, L. (Primary Chief Investigator (PCI))
1/08/25 → 31/07/26
Project: Research
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Activation of Multiple G Protein Pathways to Characterize the Five Dopamine Receptor Subtypes Using Bioluminescence Technology
Mönnich, D., Humphrys, L. J., Höring, C., Hoare, B. L., Forster, L. & Pockes, S., 6 Feb 2024, In: ACS Pharmacology & Translational Science. 7, 3, p. 834-854 21 p.Research output: Contribution to journal › Article › Research › peer-review
4 Citations (Scopus) -
The dark sides of the GPCR tree - research progress on understudied GPCRs
Scharf, M. M., Humphrys, L. J., Berndt, S., Di Pizio, A., Lehmann, J., Liebscher, I., Nicoli, A., Niv, M. Y., Peri, L., Schihada, H. & Schulte, G., Jul 2025, In: British Journal of Pharmacology. 182, 14, p. 3109-3134 26 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access11 Citations (Scopus) -
Unique Biased Agonism Profile of βCGRP on CGRP Family Receptors
Mennen, G., Ying, Z., Fletcher, M. M., Abdur Razzak, M., Humphrys, L., Josephs, T. M., Sexton, P. M., Wootten, D. & Zhao, P., 17 Jun 2025, In: Biochemistry. 64, 12, p. 2556–2576 21 p.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus) -
Clonidine stimulates force of contraction via histamine H2 receptors in the human atrium
Neumann, J., Pockes, S., Humphrys, L. J., Mönnich, D., Forster, L., Kirchhefer, U., Hofmann, B. & Gergs, U., Jan 2024, In: Naunyn-Schmiedeberg's Archives of Pharmacology. 397, 1, p. 617-626 10 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Guanidine Derivative ADS1017, a Potent Histamine H3 Receptor Antagonist with Promising Analgesic Activity and Satisfactory Safety Profile
Karcz, T., Szczepańska, K., Mogilski, S., Moroz, A., Olejarz-Maciej, A., Humphrys, L. J., Pockes, S., Siwek, A., Dubiel, K., Staszewski, M., Calmels, T., Waczyński, K. & Kieć-Kononowicz, K., Dec 2024, In: ACS Chemical Neuroscience. 15, 24, p. 4441-4457 17 p.Research output: Contribution to journal › Article › Research › peer-review
2 Citations (Scopus)
Prizes
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British Pharmacological Society Fellow
Humphrys, L. (Recipient), 2023
Prize: Election to learned society
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BJP Editor’s Choice Selection 2025
Humphrys, L. (Recipient), 2025
Prize: Prize (including medals and awards)
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Activities
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British Journal of Pharmacology (Journal)
Humphrys, L. (Peer reviewer)
2025Activity: Publication peer-review and editorial work types › Peer review responsibility
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2024 ASCEPT Drug Discovery Special Interest Group ECR and Student Symposium
Humphrys, L. (Keynote/plenary speaker)
11 Sept 2024Activity: Participating in or organising an event types › Contribution to conference
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4GPCRnet
Humphrys, L. (Speaker)
15 Nov 2023 → 17 Nov 2023Activity: Participating in or organising an event types › Contribution to conference
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Nature Communications (Journal)
Humphrys, L. (Peer reviewer)
2023Activity: Publication peer-review and editorial work types › Peer review responsibility
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ERNEST 6th Conference
Humphrys, L. (Organiser)
28 Mar 2022 → 31 Mar 2022Activity: Participating in or organising an event types › Contribution to conference