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Personal profile

Biography

Dr Lan Nguyen studied Applied Mathematics and Computing at Lincoln University (New Zealand) funded by the New Zealand Study Award. He was soon after introduced to the mysteriously wonderful world of cell biology and became deeply interested in interdisciplinary research that integrates cell biology and mathematical modelling. He went on to complete Ph.D in Computational Systems Biology early 2010, funded by the NZ TEC's Top Doctoral Achiever scheme, under Prof. Don Kulasiri at Lincoln. He then joined Systems Biology Ireland (SBI), a leading systems biology institute in Europe, to carry out postdoc under the mentorship of Prof. Boris Kholodenko and Walter Kolch, world experts in modelling and signal transduction. He became a group leader at SBI in 2014. He joined Monash University in September 2015 as a Senior Research Fellow and Head of the Computational Network Modelling Lab in the Dept. of Biochemistry and Molecular Biology.

Research Interest

Cells in our bodies respond to extracellular cues utilizing not just isolated proteins, but their highly ordered responses result from coordinated actions of networks of proteins. Just like an orchestra symphony is a product of multiple instruments rather than any single one, producing beautiful blended music. This understanding together with the availability of a huge amount of large-scale data brought about by advances in 21st century's measurement technologies, has instigated a new paradigm of biological research termed 'systems biology'. In a nutshell, 'systems biology' aims to obtain a holistic, systems view of biological processes, where the system is more than the sum of its parts. The Nguyen Lab deploys systems biology approaches to tackle key issues in cancer research. As cancer is by nature a systems disease and resistance to anti-cancer drugs is inherently a systems problem, quantitative systems approaches have been and will be instrumental in our quest to understand cancer and conquer drug resistance.

The unifying research theme of the Nguyen Lab focuses on the development an employment of predictive mathematical network models to analyse the network structure and regulation of cell signalling, in normal and cancer-related contexts. The main objectives are to develop accurate and predictive models using multi-disciplinary tools from experimental biology and mathematical, computational sciences to:

(i) analyse the specificity of signalling and adaptation processes, thereby understanding cell-fate decision making mechanisms,
(ii) predict network responses to perturbations (such as drugs) and
(iii) define the most sensitive points for therapeutic interference (targets identification).

The ultimate goal of these lines of research is to obtain better network-level understanding of signalling networks in normal and disease states, based on which novel therapeutic strategies can be derived.

Lab members

Sungyoung Shin (Senior postdoc fellow)
Shabnam Khatibi (Postdoc fellow)
Mandy Magias (Research Assistant)
 
Gaya Constance Cremers (PhD student)
Karina Islas Rios (PhD student)
Milad Ghomlaghi (PhD student)
Simon Judah Rosin (PhD student - joint supervision with Tianhai Tian)
 
Anthony Hart (Honours student)
Mikhail Dias (Honours student)
Jamin Wu (undergraduate scholarship student)
 
Past Members
 
Brennan Chong (Honours student - 1st class)
Annette Phoa (Cancer Council VIC Vacation scholarship student)
Mehul Gajwani (summer scholarship student)
Alice Kim (summer scholarship student)
 
Other lab webpages
 
www.nguyenlab.org (under development)

http://www.med.monash.edu.au/biochem/staff/lan-nguyen.html

Projects on offer

https://supervisorconnect.med.monash.edu/research-projects?combine=Dr%20Lan%20Nguyen

Keywords

  • Systems Biology
  • Network biology
  • Cancer Research

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2017 2023

Research Output 2007 2019

LC3/GABARAPs drive ubiquitin-independent recruitment of Optineurin and NDP52 to amplify mitophagy

Padman, B. S., Nguyen, T. N., Uoselis, L., Skulsuppaisarn, M., Nguyen, L. K. & Lazarou, M., 24 Jan 2019, In : Nature Communications. 10, 1, 13 p., 408.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Computational modeling of the dynamics of spatiotemporal rho gtpase signaling: A systematic review

Khatibi, S., Rios, K. I. & Nguyen, L. K., 2018, Rho GTPases. Rivero, F. (ed.). New York, NY: Humana Press, p. 3-20 18 p. (Methods in Molecular Biology; vol. 1821).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Dynamic modelling of the mTOR signalling network reveals complex emergent behaviours conferred by DEPTOR

Varusai, T. M. & Nguyen, L. K., 12 Jan 2018, In : Scientific Reports. 8, 1, 14 p., 643.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Rac1 and RhoA: Networks, loops and bistability

Nguyen, L. K., Kholodenko, B. N. & Kriegsheim, A. V., 2018, In : Small GTPases. 9, 4, p. 316-321 6 p.

Research output: Contribution to journalArticleOtherpeer-review

Systems modelling of the EGFR-PYK2-c-Met interaction network predicts and prioritizes synergistic drug combinations for triple-negative breast cancer

Shin, S-Y., Müller, A. K., Verma, N., Lev, S. & Nguyen, L., 19 Jun 2018, In : PLoS Computational Biology. 14, 6, 30 p., e1006192.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Prizes

Prizes and awards

Lan Nguyen (Recipient), 2016

Prize: Prize (including medals and awards)

Press / Media

Research Highlights

Lan Nguyen & Sungyoung Shin

2/07/18

1 item of media coverage

Press/Media: Research