• Rm 77.139, 23 Innovation Walk, Monash University

    3800 Clayton

    Australia

20052020

Research output per year

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Research Output

2020

Internalized functional DNA aptamers as alternative cancer therapies

Marshall, M. & Wagstaff, K., Jul 2020, In : Frontiers in Pharmacology. 11, 14 p., 1115.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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Open Access
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4 Citations (Scopus)

The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro

Caly, L., Druce, J. D., Catton, M. G., Jans, D. A. & Wagstaff, K. M., Jun 2020, In : Antiviral Research. 178, 4 p., 104787.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
125 Citations (Scopus)
2019

Inhibitors of nuclear transport

Jans, D. A., Martin, A. J. & Wagstaff, K. M., 1 Jun 2019, In : Current Opinion in Cell Biology. 58, p. 50-60 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

12 Citations (Scopus)

Molecular dissection of an inhibitor targeting the HIV integrase dependent preintegration complex nuclear import

Wagstaff, K. M., Headey, S., Telwatte, S., Tyssen, D., Hearps, A. C., Thomas, D. R., Tachedjian, G. & Jans, D. A., Jan 2019, In : Cellular Microbiology. 21, 1, 13 p., e12953.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

Novel Flavivirus Antiviral That Targets the Host Nuclear Transport Importin α/β1 Heterodimer

Yang, S. N. Y., Atkinson, S. C., Fraser, J. E., Wang, C., Maher, B., Roman, N., Forwood, J. K., Wagstaff, K. M., Borg, N. A. & Jans, D. A., 24 Mar 2019, In : Cells. 8, 3, 15 p., 281.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Novel RU486 (mifepristone) analogues with increased activity against Venezuelan Equine Encephalitis Virus but reduced progesterone receptor antagonistic activity

DeBono, A., Thomas, D. R., Lundberg, L., Pinkham, C., Cao, Y., Graham, J. D., Clarke, C. L., Wagstaff, K. M., Shechter, S., Kehn-Hall, K. & Jans, D. A., 22 Feb 2019, In : Scientific Reports. 9, 1, 19 p., 2634.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)
2018

Contribution of the residue at position 4 within classical nuclear localization signals to modulating interaction with importins and nuclear targeting

Smith, K. M., Di Antonio, V., Bellucci, L., Thomas, D. R., Caporuscio, F., Ciccarese, F., Ghassabian, H., Wagstaff, K. M., Forwood, J. K., Jans, D. A., Palù, G. & Alvisi, G., 1 Aug 2018, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1865, 8, p. 1114-1129 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

Erratum to: Novel inhibitors targeting Venezuelan equine encephalitis virus capsid protein identified using In Silico Structure-Based-Drug-Design (Scientific Reports, (2017), 7, 1, (17705), 10.1038/s41598-017-17672-9)

Shechter, S., Thomas, D. R., Lundberg, L., Pinkham, C., Lin, S. C., Wagstaff, K. M., Debono, A., Kehn-Hall, K. & Jans, D. A., 1 Dec 2018, In : Scientific Reports. 8, 1, 13487.

Research output: Contribution to journalComment / DebateOtherpeer-review

Identification of novel antivirals inhibiting recognition of Venezuelan equine encephalitis virus capsid protein by the Importin α/β1 heterodimer through high-throughput screening

Thomas, D. R., Lundberg, L., Pinkham, C., Shechter, S., DeBono, A., Baell, J., Wagstaff, K. M., Hick, C. A., Kehn-Hall, K. & Jans, D. A., 1 Mar 2018, In : Antiviral Research. 151, p. 8-19 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

Nucleocytoplasmic shuttling of the West Nile virus RNA-dependent RNA polymerase NS5 is critical to infection

Lopez-Denman, A. J., Russo, A., Wagstaff, K. M., White, P. A., Jans, D. A. & Mackenzie, J. M., Aug 2018, In : Cellular Microbiology. 20, 8, 13 p., e12848.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
9 Citations (Scopus)

PKA-site phosphorylation of importin13 regulates its subcellular localization and nuclear transport function

Liu, X., Lin, W., Davies, R. G., Wagstaff, K. M., Tao, T. & Jans, D. A., 31 Aug 2018, In : Biochemical Journal. 475, 16, p. 2699-2712 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Recognition by host nuclear transport proteins drives disorder-to-order transition in Hendra virus v

Atkinson, S. C., Audsley, M. D., Lieu, K. G., Marsh, G. A., Thomas, D. R., Heaton, S. M., Paxman, J. J., Wagstaff, K. M., Buckle, A. M., Moseley, G. W., Jans, D. A. & Borg, N. A., 10 Jan 2018, In : Scientific Reports. 8, 1, 17 p., 358.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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8 Citations (Scopus)
2017

Interactome of the inhibitory isoform of the nuclear transporter Importin 13

Fatima, S., Wagstaff, K. M., Lieu, K. G., Davies, R. G., Tanaka, S. S., Yamaguchi, Y. L., Loveland, K. L., Tam, P. P. L. & Jans, D. A., 1 Mar 2017, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1864, 3, p. 546-561 16 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Novel inhibitors targeting Venezuelan equine encephalitis virus capsid protein identified using In Silico Structure-Based-Drug-Design

Shechter, S., Thomas, D. R., Lundberg, L., Pinkham, C., Lin, S. C., Wagstaff, K. M., Debono, A., Kehn-Hall, K. & Jans, D. A., 1 Dec 2017, In : Scientific Reports. 7, 1, 16 p., 17705.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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6 Citations (Scopus)

Nuclear localization and secretion competence are conserved among henipavirus matrix proteins

McLinton, E. C., Wagstaff, K. M., Lee, A., Moseley, G. W., Marsh, G. A., Wang, L-F., Jans, D. A., Lieu, K. G. & Netter, H. J., 1 Apr 2017, In : Journal of General Virology. 98, 4, p. 563-576 14 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)
2016

Nuclear trafficking of the Rabies virus interferon antagonist P-protein is regulated by an importin-binding nuclear localization sequence in the C-terminal domain

Rowe, C. L., Wagstaff, K. M., Oksayan, S., Glover, D. J., Jans, D. A. & Moseley, G. W., 3 Mar 2016, In : PLoS ONE. 11, 3, 18 p., 0150477.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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8 Citations (Scopus)

Selective Inhibitor of Nuclear Export (SINE) Compounds Alter New World Alphavirus Capsid Localization and Reduce Viral Replication in Mammalian Cells

Lundberg, L., Pinkham, C., de la Fuente, C., Brahms, A., Shafagati, N., Wagstaff, K. M., Jans, D. A., Tamir, S. & Kehn-Hall, K., 30 Nov 2016, In : PLoS Neglected Tropical Diseases. 10, 11, 24 p., e0005122.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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13 Citations (Scopus)

Tumor cell-specific photothermal killing by SELEX-derived DNA aptamer-targeted gold nanorods

Chandrasekaran, R., Lee, A. S. W., Yap, L. W., Jans, D. A., Wagstaff, K. M. & Cheng, W., 7 Jan 2016, In : Nanoscale. 8, 1, p. 187-196 10 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)
2015

Enhanced tumour cell nuclear targeting in a tumour progression model

Nastasie, M. S., Thissen, H., Jans, D. A. & Wagstaff, K. M., 2015, In : BMC Cancer. 15, 1, 11 p., 76.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
4 Citations (Scopus)

Fatty acid-binding proteins 1 and 2 differentially modulate the activation of peroxisome proliferator-activated receptor alpha in a ligand-selective manner

Hughes, M. L. R., Liu, B., Halls, M. L., Wagstaff, K. M., Patil, R., Velkov, T., Jans, D. A., Bunnett, N. W., Scanlon, M. & Porter, C. J., 2015, In : The Journal of Biological Chemistry. 290, 22, p. 13895 - 13906 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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22 Citations (Scopus)

Interactome of the negative regulator of nuclear import BRCA1-binding protein 2

Fatima, S., Wagstaff, K. M., Loveland, K. A. L. & Jans, D. A., 2015, In : Scientific Reports. 5, 9 p., 9459.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
9 Citations (Scopus)

Nuclear localization of the dystrophin-associated protein alpha-dystrobrevin through importin alpha2/beta1 is critical for interaction with the nuclear lamina/maintenance of nuclear integrity

Aguilar, A., Wagstaff, K. M., Suarez-Sanchez, R., Zinker, S., Jans, D. A. & Cisneros, B., 2015, In : The FASEB Journal. 29, 5, p. 1842 - 1858 17 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)
2014

A nuclear transport inhibitor that modulates the unfolded protein response and provides in vivo protection against lethal dengue virus infection

Fraser, J. E., Watanabe, S., Wang, C., Chan, W. K. K., Maher, B., Lopez-Denman, A., Hick, C. A., Wagstaff, K. M., Mackenzie, J. M., Sexton, P. M., Vasudevan, S. G. & Jans, D. A., 2014, In : Journal of Infectious Diseases. 210, 11, p. 1780 - 1791 12 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Intracellular mobility and nuclear trafficking of the stress-activated kinase JNK1 are impeded by hyperosmotic stress

Misheva, M., Kaur, G., Ngoei, K. R., Yeap, Y. Y. C., Ng, I. H. W., Wagstaff, K. M., Ng, D. CH., Jans, D. A. & Bogoyevitch, M. A., 2014, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1843, 2, p. 253 - 264 12 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Investigating dengue virus nonstructural protein 5 (NS5) nuclear import

Fraser, J., Rawlinson, S. M., Wang, C., Jans, D. A. & Wagstaff, K. M., 2014, In : Methods in Molecular Biology. 1138, p. 301 - 328 28 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Nuclear import of beta-dystroglycan is facilitated by ezrin-mediated cytoskeleton reorganization

Vasquez-Limeta, A., Wagstaff, K. M., Ortega, A., Crouch, D. H., Jans, D. A. & Cisneros, B., 2014, In : PLoS ONE. 9, 3 (Art. No: e90629), p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
8 Citations (Scopus)

Nuclear Protein Import: Methods

Wagstaff, K. M. & Jans, D. A., 16 Jun 2014, Encyclopedia of Life Sciences. Wiley-Blackwell, 7 p.

Research output: Chapter in Book/Report/Conference proceedingEncyclopaedia / Dictionary EntryOtherpeer-review

Nucleocytoplasmic shuttling of the Duchenne muscular dystrophy gene product dystrophin Dp71d is dependent on the importin a/b and CRM1 nuclear transporters and microtubule motor dynein

Suarz-Sanchez, R., Aguilar, A., Wagstaff, K. M., Velez, G., Azuara-Medina, P. M., Gomez, P., Vasquez-Limeta, A., Hernandez-Hernandez, O., Lieu, K. G., Jans, D. A. & Cisneros, B., 2014, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1843, 5, p. 985 - 1001 17 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Overlapping binding sites for importin b1 and suppressor of fused (SuFu) on glioma-associated oncogene homologue 1 (Gli1) regulate its nuclear localization

Szczepny, A., Wagstaff, K. M., Dias, M., Gajewska, K. A., Wang, C., Davies, R. G., Kaur, G., Ly Huynh, J. D., Loveland, K. A. L. & Jans, D. A., 2014, In : Biochemical Journal. 461, 3, p. 469 - 476 8 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)
2013

Nuclear import and export inhibitors alter capsid protein distribution in mammalian cells and reduce Venezuelan Equine Encephalitis Virus replication

Lundberg, L., Pinkham, C., Baer, A., Amaya, M., Narayanan, A., Wagstaff, K. M., Jans, D. A. & Kehn-Hall, K., 2013, In : Antiviral Research. 100, 3, p. 662 - 672 11 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

The BRCA1-binding protein BRAP2 can act as a cytoplasmic retention factor for nuclear and nuclear envelope-localizing testicular proteins

Davies, R., Wagstaff, K. M., McLaughlin, E. A., Loveland, K. A. L. & Jans, D. A., 2013, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1833, 12, p. 3436 - 3444 9 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)
2012

Global enhancement of nuclear localization-dependent nuclear transport in transformed cells

Kuusisto, H. V., Wagstaff, K. M., Alvisi, G., Martino Roth, D. & Jans, D. A., 2012, In : The FASEB Journal. 26, 3, p. 1181 - 1193 13 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Ivermectin is a specific inhibitor of importin alpha/beta-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus

Wagstaff, K. M., Sivakumaran, H., Heaton, S. M., Harrich, D. & Jans, D. A., 2012, In : Biochemical Journal. 443, 3, p. 851 - 856 6 p.

Research output: Contribution to journalArticleResearchpeer-review

154 Citations (Scopus)

Nuclear trafficking of proteins from RNA viruses: potential target for antivirals?

Caly, L., Wagstaff, K. M. & Jans, D. A., 2012, In : Antiviral Research. 95, 3, p. 202 - 206 5 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)
2011

An AlphaScreen-based assay for high-throughput screening for specific inhibitors of nuclear import

Wagstaff, K. M., Rawlinson, S. M., Hearps, A. & Jans, D. A., 2011, In : Journal of Biomolecular Screening. 16, 2, p. 192 - 200 9 p.

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)
2010

Protein Transduction: Cell Penetrating Peptides and their Therapeutic Applications

Wagstaff, K. & Jans, D., 2010, Frontiers in Medicinal Chemistry (5). Atta-ur-Rahman, Reitz, A. B. & Choudhary, M. I. (eds.). 5th ed. The Netherlands: Bentham Science Publishers, p. 98 - 126 29 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Other

The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65

Newton, H. J., Pearson, J. S., Badea, L., Kelly, M., Lucas, M., Holloway, G., Wagstaff, K. M., Dunstone, M. A., Sloan, J., Whisstock, J. C., Kaper, J. B., Robins-Browne, R. M., Jans, D. A., Frankel, G., Phillips, A. D., Coulson, B. S. & Hartland, E. L., 2010, In : PLoS Pathogens. 6, 5 (e1000898), p. 1 - 16 16 p.

Research output: Contribution to journalArticleResearchpeer-review

153 Citations (Scopus)

Use of fluorescence photobleaching techniques to measure the kinetics of intracellular transport

Davies, R., Jans, D. A. & Wagstaff, K. M., 2010, Microscopy: Science, Technology, Applications and Education. Mendez-Vilas, A. & Diaz, J. (eds.). 4th ed. Spain: Formatex, p. 756 - 763 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Other

2009

Importins and beyond: Non-conventional nuclear transport mechanisms

Wagstaff, K. M. & Jans, D. A., 2009, In : Traffic. 10, 9, p. 1188 - 1198 11 p.

Research output: Contribution to journalArticleResearchpeer-review

113 Citations (Scopus)

Nuclear drug delivery to target tumour cells

Wagstaff, K. M. & Jans, D. A., 2009, In : European Journal of Pharmacology. 625, 1-3, p. 174 - 180 7 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)
2008

Efficient gene delivery using reconstituted chromatin enhanced for nuclear targeting

Wagstaff, K. M., Fan, J. Y., De Jesus, M., Tremethick, D. J. & Jans, D. A., 2008, In : The FASEB Journal. 22, 7, p. 2232 - 2242 11 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

The C-terminus of apoptin represents a unique tumor cell-enhanced nuclear targeting module

Kuusisto, H. V., Wagstaff, K. M., Alvisi, G. & Jans, D. A., 2008, In : International Journal of Cancer. 123, 12, p. 2965 - 2969 5 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)
36 Citations (Scopus)
2007

Getting to the heart of a tumour cell

Jans, D. A. & Wagstaff, K. M., 2007, In : Pharma Focus Asia. 0, 5, p. 21 - 24 4 p.

Research output: Contribution to journalArticleOther

Histone-mediated transduction as an efficient means for gene delivery

Wagstaff, K. M., Glover, D., Tremethick, D. J. & Jans, D. A., 2007, In : Molecular Therapy. 15, 4, p. 721 - 731 11 p.

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)

Nucleocytoplasmic transport of DNA: enhancing non-viral gene transfer

Wagstaff, K. M. & Jans, D. A., 2007, In : Biochemical Journal. 406, 2, p. 185 - 202 18 p.

Research output: Contribution to journalArticleResearchpeer-review

64 Citations (Scopus)

Targeted delivery to the nucleus

Pouton, C. W., Wagstaff, K. M., Martino Roth, D., Moseley, G. W. & Jans, D. A., 2007, In : Advanced Drug Delivery Reviews. 59, 8, p. 698 - 717 20 p.

Research output: Contribution to journalArticleResearchpeer-review

176 Citations (Scopus)
2006

Intramolecular masking of nuclear localization signals: analysis of importin binding using a novel AlphaScreen-based method

Wagstaff, K. M. & Jans, D. A., 2006, In : Analytical Biochemistry. 348, 1, p. 49 - 56 8 p.

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

Protein transduction: cell penetrating peptides and their therapeutic applications

Wagstaff, K. M. & Jans, D. A., 2006, In : Current Medicinal Chemistry. 13, 12, p. 1371 - 1387 17 p.

Research output: Contribution to journalArticleResearchpeer-review

144 Citations (Scopus)