• Rm 77.139, 23 Innovation Walk, Monash University

    3800 Clayton

    Australia

20052020

Research output per year

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Personal profile

Biography

Dr. Kylie M, Ph.D, is a National Breast Cancer Foundation Career Development Fellow within the Department of Biochemistry and Mol. Biology, at Monash University (Clayton, Melbourne, Australia) and Head of the Cancer Targeting and Nuclear Therapeutics Laboratory. She got her B.Biomed.Sci.and her Ph.D.in Biochemistry at Monash University (Melbourne). Her research over the last 18 years has focused on the regulation of transport into and out of the eukaryotic cell nucleus, and how this relates to viral disease, cancer and development. She has c. 40 peer-reviewed publications (>1,000 citations; H-factor of 18). Her awards and prizes include National Breast Cancer Foundation, Career Development Fellowship(2017), the International Union of Biochemistry and Molecular Biology (IUBMB) Young Scientist Program Prize (2009) and the Caroline Chisholm award for service (2015).

Research interests

Transport of proteins between the cytoplasm and nucleus and the application of this to diseases including cancer and viral infection.

Research area keywords

  • Nuclear Transport
  • Drug development
  • anti-viral drugs
  • Cell Biology

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Projects

Research Output

Ivermectin is a specific inhibitor of importin alpha/beta-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus

Wagstaff, K. M., Sivakumaran, H., Heaton, S. M., Harrich, D. & Jans, D. A., 2012, In : Biochemical Journal. 443, 3, p. 851 - 856 6 p.

Research output: Contribution to journalArticleResearchpeer-review

147 Citations (Scopus)
Open Access
File
2 Citations (Scopus)

The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro

Caly, L., Druce, J. D., Catton, M. G., Jans, D. A. & Wagstaff, K. M., Jun 2020, In : Antiviral Research. 178, 4 p., 104787.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
76 Citations (Scopus)

Inhibitors of nuclear transport

Jans, D. A., Martin, A. J. & Wagstaff, K. M., 1 Jun 2019, In : Current Opinion in Cell Biology. 58, p. 50-60 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

11 Citations (Scopus)

Molecular dissection of an inhibitor targeting the HIV integrase dependent preintegration complex nuclear import

Wagstaff, K. M., Headey, S., Telwatte, S., Tyssen, D., Hearps, A. C., Thomas, D. R., Tachedjian, G. & Jans, D. A., Jan 2019, In : Cellular Microbiology. 21, 1, 13 p., e12953.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
3 Citations (Scopus)

Press / Media

Cancer Research Sensory Science Exhibition Discovery Day

Erica Tandori & Kylie Wagstaff

28/11/19

3 Media contributions

Press/Media: Article/Feature