Projects per year
Personal profile
Biography
Dr. Kylie M, Ph.D, is a National Breast Cancer Foundation Career Development Fellow within the Department of Biochemistry and Mol. Biology, at Monash University (Clayton, Melbourne, Australia) and Head of the Cancer Targeting and Nuclear Therapeutics Laboratory. She got her B.Biomed.Sci.and her Ph.D.in Biochemistry at Monash University (Melbourne). Her research over the last 18 years has focused on the regulation of transport into and out of the eukaryotic cell nucleus, and how this relates to viral disease, cancer and development. She has c. 40 peer-reviewed publications (>1,000 citations; H-factor of 18). Her awards and prizes include National Breast Cancer Foundation, Career Development Fellowship(2017), the International Union of Biochemistry and Molecular Biology (IUBMB) Young Scientist Program Prize (2009) and the Caroline Chisholm award for service (2015).
Research interests
Transport of proteins between the cytoplasm and nucleus and the application of this to diseases including cancer and viral infection.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Nuclear Transport
- Drug development
- anti-viral drugs
- Cell Biology
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 9 Finished
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Ivermectin as an anti-viral against SARS-CoV-2
Wagstaff, K., Jans, D., Druce, J. D., Caly, L. & Denholm, J. T.
1/06/20 → 28/02/21
Project: Research
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Targeting aggressive breast cancers using DNA aptamers
Wagstaff, K. & Marshall, M. L.
CSIRO - Health and Biosecurity (New South Wales)
1/01/20 → 5/05/22
Project: Research
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Advanced theranostic technology for the early detection and specific targeting of advanced stage triple negative breast cancer.
1/01/17 → 30/04/21
Project: Research
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A Safe, Orally Administered Agent for Dengue
Jans, D., Charman, S., Dow, G., Low, J., Porter, C., Vasudevan, S. & Wagstaff, K.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/17 → 31/12/19
Project: Research
Research output
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Ivermectin is a specific inhibitor of importin alpha/beta-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus
Wagstaff, K. M., Sivakumaran, H., Heaton, S. M., Harrich, D. & Jans, D. A., 2012, In: Biochemical Journal. 443, 3, p. 851 - 856 6 p.Research output: Contribution to journal › Article › Research › peer-review
458 Citations (Scopus) -
Harnessing sortase A transpeptidation for advanced targeted therapeutics and vaccine engineering
Obeng, E. M., Fulcher, A. J. & Wagstaff, K. M., 1 May 2023, In: Biotechnology Advances. 64, 18 p., 108108.Research output: Contribution to journal › Review Article › Research › peer-review
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The Nuclear Transporter Importin 13 Can Regulate Stress-Induced Cell Death through the Clusterin/KU70 Axis
Gajewska, K. A., Jans, D. A. & Wagstaff, K. M., Jan 2023, In: Cells. 12, 2, 30 p., 279.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Conservation of Importin α Function in Apicomplexans: Ivermectin and GW5074 Target Plasmodium falciparum Importin α and Inhibit Parasite Growth in Culture
Walunj, S. B., Wang, C., Wagstaff, K. M., Patankar, S. & Jans, D. A., Nov 2022, In: International Journal of Molecular Sciences. 23, 22, 12 p., 13899.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
High Throughput Screening Targeting the Dengue NS3-NS5 Interface Identifies Antivirals against Dengue, Zika and West Nile Viruses
Yang, S. N. Y., Maher, B., Wang, C., Wagstaff, K. M., Fraser, J. E. & Jans, D. A., 2 Feb 2022, In: Cells. 11, 4, 11 p., 730.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus)
Activities
- 2 Patents
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MONASH UNIVERSITY (Organisational unit)
Leon Caly (Inventor), David Jans (Inventor) & Kylie Wagstaff (Inventor)
2020Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
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MONASH UNIVERSITY (Organisational unit)
Johanna Fraser (Inventor), David Jans (Inventor) & Kylie Wagstaff (Inventor)
31 Oct 2014Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
Press/Media
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Cancer Research Sensory Science Exhibition Discovery Day
Erica Tandori & Kylie Wagstaff
28/11/19
3 Media contributions
Press/Media: Article/Feature