• Rm 77.139, 23 Innovation Walk, Monash University

    3800 Clayton

    Australia

20052019
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Personal profile

Biography

Dr. Kylie M, Ph.D, is a National Breast Cancer Foundation Career Development Fellow within the Department of Biochemistry and Mol. Biology, at Monash University (Clayton, Melbourne, Australia) and Head of the Cancer Targeting and Nuclear Therapeutics Laboratory. She got her B.Biomed.Sci.and her Ph.D.in Biochemistry at Monash University (Melbourne). Her research over the last 18 years has focused on the regulation of transport into and out of the eukaryotic cell nucleus, and how this relates to viral disease, cancer and development. She has c. 40 peer-reviewed publications (>1,000 citations; H-factor of 18). Her awards and prizes include National Breast Cancer Foundation, Career Development Fellowship(2017), the International Union of Biochemistry and Molecular Biology (IUBMB) Young Scientist Program Prize (2009) and the Caroline Chisholm award for service (2015).

Research interests

Transport of proteins between the cytoplasm and nucleus and the application of this to diseases including cancer and viral infection.

Keywords

  • Nuclear Transport
  • Drug development
  • anti-viral drugs
  • Cell Biology

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Projects 2011 2019

Research Output 2005 2019

Ivermectin is a specific inhibitor of importin alpha/beta-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus

Wagstaff, K. M., Sivakumaran, H., Heaton, S. M., Harrich, D. & Jans, D. A., 2012, In : Biochemical Journal. 443, 3, p. 851 - 856 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibitors of nuclear transport

Jans, D. A., Martin, A. J. & Wagstaff, K. M., 1 Jun 2019, In : Current Opinion in Cell Biology. 58, p. 50-60 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Novel Flavivirus Antiviral That Targets the Host Nuclear Transport Importin α/β1 Heterodimer

Yang, S. N. Y., Atkinson, S. C., Fraser, J. E., Wang, C., Maher, B., Roman, N., Forwood, J. K., Wagstaff, K. M., Borg, N. A. & Jans, D. A., 24 Mar 2019, In : Cells. 8, 3, 15 p., 281.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Novel RU486 (mifepristone) analogues with increased activity against Venezuelan Equine Encephalitis Virus but reduced progesterone receptor antagonistic activity

DeBono, A., Thomas, D. R., Lundberg, L., Pinkham, C., Cao, Y., Graham, J. D., Clarke, C. L., Wagstaff, K. M., Shechter, S., Kehn-Hall, K. & Jans, D. A., 22 Feb 2019, In : Scientific Reports. 9, 1, 19 p., 2634.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Contribution of the residue at position 4 within classical nuclear localization signals to modulating interaction with importins and nuclear targeting

Smith, K. M., Di Antonio, V., Bellucci, L., Thomas, D. R., Caporuscio, F., Ciccarese, F., Ghassabian, H., Wagstaff, K. M., Forwood, J. K., Jans, D. A., Palù, G. & Alvisi, G., 1 Aug 2018, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1865, 8, p. 1114-1129 16 p.

Research output: Contribution to journalArticleResearchpeer-review