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Research Output 2006 2019

2019

CD4 + T help promotes influenza virus-specific CD8 + T cell memory by limiting metabolic dysfunction

Cullen, J. G., McQuilten, H. A., Quinn, K. M., Olshansky, M., Russ, B. E., Morey, A., Wei, S., Prier, J. E., La Gruta, N. L., Doherty, P. C. & Turner, S. J., 5 Mar 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 10, p. 4481-4488 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

Age-Related Decline in Primary CD8+ T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8+ T Cells

Quinn, K. M., Fox, A., Harland, K. L., Russ, B. E., Li, J., Nguyen, T. H. O., Loh, L., Olshanksy, M., Naeem, H., Tsyganov, K., Wiede, F., Webster, R., Blyth, C., Sng, X. Y. X., Tiganis, T., Powell, D., Doherty, P. C., Turner, S. J., Kedzierska, K. & La Gruta, N. L., 19 Jun 2018, In : Cell Reports. 23, 12, p. 3512-3524 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017

Corrigendum to ‘‘Modelling cross-reactivity and memory in the cellular adaptive immune response to influenza infection in the host’’ [J.Theor. Biol. 413 (2017) 34–49] (S0022519316303629)(10.1016/j.jtbi.2016.11.008)

Yan, A. W. C., Cao, P., Heffernan, J. M., McVernon, J., Quinn, K. M., La Gruta, N. L., Laurie, K. L. & McCaw, J. M., 21 Apr 2017, In : Journal of Theoretical Biology. 419, p. 394 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Extrinsically derived TNF is primarily responsible for limiting antiviral CD8+ T cell response magnitude

Quinn, K. M., Kan, W-T., Watson, K. A., Liddicoat, B. J., Swan, N. G., McQuilten, H., Denton, A. E., Li, J., Chen, W., Brown, L. E., Jackson, D. C., Reading, P. C., Doherty, P. C., Kedzierska, K., Kedzierski, L., Turner, S. J. & La Gruta, N. L., 8 Sep 2017, In : PLoS ONE. 12, 9, 13 p., e0184732.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Modelling cross-reactivity and memory in the cellular adaptive immune response to influenza infection in the host

Yan, A. W. C., Cao, P., Heffernan, J. M., McVernon, J., Quinn, K. M., La Gruta, N. L., Laurie, K. L. & McCaw, J. M., 21 Jan 2017, In : Journal of Theoretical Biology. 413, p. 34-49 16 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

BACH2 regulates CD8 + T cell differentiation by controlling access of AP-1 factors to enhancers

Roychoudhuri, R., Clever, D., Li, P., Wakabayashi, Y., Quinn, K. M., Klebanoff, C. A., Ji, Y., Sukumar, M., Eil, R. L., Yu, Z., Spolski, R., Palmer, D. C., Pan, J. H., Patel, S. J., Macallan, D. C., Fabozzi, G., Shih, H. Y., Kanno, Y., Muto, A., Zhu, J. & 6 othersGattinoni, L., O'Shea, J. J., Okkenhaug, K., Igarashi, K., Leonard, W. J. & Restifo, N. P., 21 Jun 2016, In : Nature Immunology. 17, 7, p. 851-860 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Heightened self-reactivity associated with selective survival, but not expansion, of naïve virus-specific CD8+ T cells in aged mice

Quinn, K. M., Zaloumis, S. G., Cukalac, T., Kan, W-T., Sng, X. Y. X., Mirams, M., Watson, K. A., McCaw, J. M., Doherty, P. C., Thomas, P. G., Handel, A. & La Gruta, N. L., 2 Feb 2016, In : Proceedings of the National Academy of Sciences. 113, 5, p. 1333-1338 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Reversed T cell receptor docking on a major histocompatibility class I complex limits involvement in the immune response

Gras, S., Chadderton, J., Del Campo, C. M., Farenc, C., Wiede, F., Josephs, T. M., Sng, X. Y. X., Mirams, M., Watson, K. A., Tiganis, T., Quinn, K. M., Rossjohn, J. & La Gruta, N. L., 18 Oct 2016, In : Immunity. 45, 4, p. 749-760 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

Antigen expression determines adenoviral vaccine potency independent of IFN and STING signaling

Quinn, K. M., Zak, D. E., Costa, A., Yamamoto, A., Kastenmuller, K., Hill, B. J., Lynn, G. M., Darrah, P. A., Lindsay, R. W. B., Wang, L., Cheng, C., Nicosia, A., Folgori, A., Colloca, S., Cortese, R., Gostick, E., Price, D. A., Gall, J. G. D., Roederer, M., Aderem, A. & 1 othersSeder, R. A., 2 Mar 2015, In : Journal of Clinical Investigation. 125, 3, p. 1129-1146 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Human anti-CD40 antibody and poly IC: LC adjuvant combination induces potent T cell responses in the lung of nonhuman primates

Thompson, E. A., Liang, F., Lindgren, G., Sandgren, K. J., Quinn, K. M., Darrah, P. A., Koup, R. A., Seder, R. A., Kedl, R. M. & Loré, K., 1 Aug 2015, In : Journal of Immunology. 195, 3, p. 1015-1024 10 p.

Research output: Contribution to journalArticleResearchpeer-review

In vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity

Lynn, G. M., Laga, R., Darrah, P. A., Ishizuka, A. S., Balaci, A. J., Dulcey, A. E., Pechar, M., Pola, R., Gerner, M. Y., Yamamoto, A., Buechler, C. R., Quinn, K. M., Smelkinson, M. G., Vanek, O., Cawood, R., Hills, T., Vasalatiy, O., Kastenmüller, K., Francica, J. R., Stutts, L. & 7 othersTom, J. K., Ryu, K. A., Esser-Kahn, A. P., Etrych, T., Fisher, K. D., Seymour, L. W. & Seder, R. A., 1 Nov 2015, In : Nature Biotechnology. 33, 11, p. 1201-1210 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Paired TCRαβ analysis of virus-specific CD8+ T cells exposes diversity in a previously defined 'narrow' repertoire

Cukalac, T., Kan, W-T., Dash, P. K., Guan, J., Quinn, K. M., Gras, S., Thomas, P. G. & La Gruta, N. L., 2015, In : Immunology and Cell Biology. 93, 9, p. 804-814 11 p.

Research output: Contribution to journalArticleResearchpeer-review

T cells recognizing a 11mer influenza peptide complexed to H-2D b show promiscuity for peptide length

Zanker, D., Quinn, K., Waithman, J., Lata, R., Murphy, R., La Gruta, N. L. & Chen, W., 28 May 2015, In : Immunology and Cell Biology. 93, 5, p. 500-507 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Epitope specificity delimits the functional capabilities of vaccine-induced CD8 T cell populations

Hill, B. J., Darrah, P. A., Ende, Z., Ambrozak, D. R., Quinn, K. M., Darko, S., Gostick, E., Wooldridge, L., Van Den Berg, H. A., Venturi, V., Larsen, M., Davenport, M. P., Seder, R. A., Price, D. A. & Douek, D. C., 1 Dec 2014, In : Journal of Immunology. 193, 11, p. 5626-5636 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

Coadministration of polyinosinic: Polycytidylic acid and immunostimulatory complexes modifies antigen processing in dendritic cell subsets and enhances HIV gag-specific T cell immunity

Quinn, K. M., Yamamoto, A., Costa, A., Darrah, P. A., Lindsay, R. W. B., Hegde, S. T., Johnson, T. R., Flynn, B. J., Loré, K. & Seder, R. A., 15 Nov 2013, In : Journal of Immunology. 191, 10, p. 5085-5096 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Comparative analysis of the magnitude, quality, phenotype, and protective capacity of simian immunodeficiency virus gag-specific CD8+ T Cells following human-,simian-,and chimpanzee-derived recombinant adenoviral vector immunization

Quinn, K. M., Da Costa, A., Yamamoto, A., Berry, D., Lindsay, R. W. B., Darrah, P. A., Wang, L., Cheng, C., Kong, W. P., Gall, J. G. D., Nicosia, A., Folgori, A., Colloca, S., Cortese, R., Gostick, E., Price, D. A., Gomez, C. E., Esteban, M., Wyatt, L. S., Moss, B. & 6 othersMorgan, C., Roederer, M., Bailer, R. T., Nabel, G. J., Koup, R. A. & Seder, R. A., 15 Mar 2013, In : Journal of Immunology. 190, 6, p. 2720-2735 16 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

A key role for lung-resident memory lymphocytes in protective immune responses after BCG vaccination

Connor, L. M., Harvie, M. C., Rich, F. J., Quinn, K. M., Brinkmann, V., Le Gros, G. & Kirman, J. R., 2010, In : European Journal of Immunology. 40, 9, p. 2482-2492 11 p.

Research output: Contribution to journalArticleResearchpeer-review

CD8+ T cell responses following replication-defective adenovirus serotype 5 immunization are dependent on CD11c+ dendritic cells but show redundancy in their requirement of TLR and nucleotide-binding oligomerization domain-like receptor signaling

Lindsay, R. W. B., Darrah, P. A., Quinn, K. M., Wille-Reece, U., Mattei, L. M., Iwasaki, A., Kasturi, S. P., Pulendran, B., Gall, J. G. D., Spies, A. G. & Seder, R. A., 1 Aug 2010, In : Journal of Immunology. 185, 3, p. 1513-1521 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Convergent recombination shapes the clonotypic landscape of the naïve T-cell repertoire

Quigley, M. F., Greenaway, H. Y., Venturi, V., Lindsay, R., Quinn, K. M., Seder, R. A., Douek, D. C., Davenport, M. P. & Price, D. A., 9 Nov 2010, In : Proceedings of the National Academy of Sciences. 107, 45, p. 19414-19419 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

Accelerating the secondary immune response by inactivating CD4+CD25+ T regulatory cells prior to BCG vaccination does not enhance protection against tuberculosis

Quinn, K. M., Rich, F. J., Goldsack, L. M., de Lisle, G. W., Buddle, B. M., Delahunt, B. & Kirman, J. R., Mar 2008, In : European Journal of Immunology. 38, 3, p. 695-705 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2006

Inactivation of CD4+CD25+ regulatory T cells during early mycobacterial infection increases cytokine production but does not affect pathogen load

Quinn, K. M., McHugh, R. S., Rich, F. J., Goldsack, L. M., De Lisle, G. W., Buddle, B. M., Delahunt, B. & Kirman, J. R., Oct 2006, In : Immunology and Cell Biology. 84, 5, p. 467-474 8 p.

Research output: Contribution to journalArticleResearchpeer-review