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Dr Kristen Bubb holds a PhD in Physiology and leads the Translational Vascular Therapeutics Group, co-located in the Department of Physiology, Monash Biomedicine Discovery Institute and the Victorian Heart Institute research labs in the Victorian Heart Hospital. Dr Bubb completed training at both Monash University and in at the William Harvey Research Institute in London, supported by a British Pharmacological Society International Fellowship in Clinical Pharmacology. Dr Bubb was then recruited to co-lead the Oxidative Signalling group at the Kolling Institute of Medical Research, University of Sydney, before returning to Monash in 2019, to develop her research program to identify novel therapeutic targets for cardiovascular diseases, with a focus on signalling molecules that interact with the vascular endothelium, to regulate vascular tone, integrity, and perfusion.


One of Kristen's main focuses is on investigating novel treatments for pulmonary hypertension (PH). PH is a chronic lung disease characterized by progressive remodelling of the pulmonary vasculature, resulting in increased pulmonary vascular resistance which leads to progressive right heart failure. Eight drugs have been FDA-approved for medical management of PH, all of which target the blood vessel wall. Endothelium-derived vasodilators and vasoconstrictors are imbalanced in PH and the majority of approved drugs target these pathways. However, the success of treatments is sub-optimal; they prolong and improve quality of life, but none are a cure. The majority of patients suffer from consequential right heart overload and eventually die of heart failure. We are interested in novel treatments to combat both the excessive pulmonary pressures but also ultimately improve right-sided cardiac function.

Kristen has identified a number of promising candidates. Approaches to investigate their potential range from obtaining clinical samples for investigating the underlying mechanisms, to use of cell and whole animal models to assess the effect of targeted therapy.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Physiology, PhD, The effect of vitamin D deficiency in early life on the cardiovascularsystem in adulthood, MONASH UNIVERSITY

1 Mar 200519 Jan 2010

Award Date: 19 Jan 2010

Science, Bachelor of Science (Hons), Intrauterine growth restriction results in delayed cardiomyocyte maturation and altered coronary vascular function, MONASH UNIVERSITY

Award Date: 7 Apr 2005

External positions

Lecturer, University of Sydney

28 Oct 201927 Oct 2022

Research area keywords

  • Vascular Biology
  • Cardiovascular Disease
  • Pulmonary Hypertension
  • angiogenesis
  • nitric oxide
  • Oxidative stress
  • Inflammation
  • Vascular Disease
  • Atherosclerosis
  • cardiac fibrosis

Collaborations and top research areas from the last five years

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