Projects per year
Personal profile
Biography
Dr Kristen Bubb currently leads the Vascular Pathophysiology and Therapeutics Group in the Department of Physiology, within the Biomedicine Discovery Institute at Monash University. She previously co-led the Oxidative Signalling group at the Kolling Institute of Medical Research, and maintains an honorary Lectureship at the University of Sydney. After completing her PhD at Monash University, Melbourne, in 2010, she moved to London and was awarded a British Pharmacological Society International Fellowship in Clinical Pharmacology at the William Harvey Research Institute. She was then recruited to the Cardiovascular Pharmacology Group in the newly established William Harvey Heart Centre. She has received numerous travel and conference awards during her time as an early career researcher. Her research program centres around identifying novel therapeutic targets for cardiovascular diseases, with a focus on signalling molecules that interact with the vascular endothelium, to regulate vascular tone, integrity and perfusion.
One of Kristen's main focuses is on investigating novel treatments for pulmonary hypertension (PH). PH is a chronic lung disease characterized by progressive remodelling of the pulmonary vasculature, resulting in increased pulmonary vascular resistance which leads to progressive right heart failure. Eight drugs have been FDA-approved for medical management of PH, all of which target the blood vessel wall. Endothelium-derived vasodilators and vasoconstrictors are imbalanced in PH and the majority of approved drugs target these pathways. However, the success of treatments is sub-optimal; they prolong and improve quality of life, but none are a cure. The majority of patients suffer from consequential right heart overload and eventually die of heart failure. We are interested in novel treatments to combat both the excessive pulmonary pressures but also ultimately improve right-sided cardiac function.
Kristen has identified a number of promising candidates. Approaches to investigate their potential range from obtaining clinical samples for investigating the underlying mechanisms, to use of cell and whole animal models to assess the effect of targeted therapy.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Physiology, PhD, MONASH UNIVERSITY
1 Mar 2005 → 19 Jan 2010
Award Date: 19 Jan 2010
Science, Bachelor of Science (Hons), MONASH UNIVERSITY
Award Date: 7 Apr 2005
External positions
Lecturer, University of Sydney
28 Oct 2019 → 27 Oct 2022
Research area keywords
- Vascular Biology
- Cardiovascular Disease
- Pulmonary Hypertension
- angiogenesis
- nitric oxide
- Oxidative stress
- Inflammation
- Vascular Disease
- Atherosclerosis
- cardiac fibrosis
Network
Projects
- 2 Finished
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MediBeacon Transdermal Mini Fluorophore Monitors
Colafella, K., Denton, K., Bubb, K., Cowley, M., Widdop, R., Lyras, D., Samuel, C., Bertram, J. & Parkington, H.
1/10/21 → 31/12/22
Project: Research
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Investigating the protective role of C-type natriuretic peptide in preeclampsia and future cardiovascular risk.
Bubb, K., Nicholls, S., Hobbs, A., Colafella, K. & Ashton, A.
1/04/21 → 31/03/23
Project: Research
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Targeting triglycerides to lower residual cardiovascular risk
Bubb, K. J., Nelson, A. J. & Nicholls, S. J., 2022, In: Expert Review of Cardiovascular Therapy. 20, 3, p. 185-191 7 p.Research output: Contribution to journal › Review Article › Other › peer-review
1 Citation (Scopus) -
An update on emerging drugs for the treatment of hypercholesterolemia
Nelson, A. J., Bubb, K. & Nicholls, S. J., 2021, In: Expert Opinion on Emerging Drugs. 26, 4, p. 363-369 7 p.Research output: Contribution to journal › Review Article › Research › peer-review
4 Citations (Scopus) -
Characterisation of cardiac health in the reduced uterine perfusion pressure model and a 3D cardiac spheroid model, of preeclampsia
Richards, C., Sesperez, K., Chhor, M., Ghorbanpour, S., Rennie, C., Ming, C. L. C., Evenhuis, C., Nikolic, V., Orlic, N. K., Mikovic, Z., Stefanovic, M., Cakic, Z., McGrath, K., Gentile, C., Bubb, K. & McClements, L., 20 Apr 2021, In: Biology of Sex Differences. 12, 1, 14 p., 31.Research output: Contribution to journal › Article › Research › peer-review
Open Access9 Citations (Scopus) -
FXYD1 Is Protective against Vascular Dysfunction
Bubb, K. J., Tang, O., Gentile, C., Moosavi, S. M., Hansen, T., Liu, C-C., Di Bartolo, B. A. & Figtree, G. A., Jun 2021, In: Hypertension. 77, 6, p. 2104-2116 13 p.Research output: Contribution to journal › Article › Research › peer-review
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Patient endothelial colony-forming cells to model coronary artery disease susceptibility and unravel the role of dysregulated mitochondrial redox signalling
Besnier, M., Finemore, M., Yu, C., Kott, K. A., Vernon, S. T., Seebacher, N. A., Genetzakis, E., Furman, A., Tang, O., Davis, R. L., Hansen, T., Psaltis, P. J., Bubb, K. J., Wise, S. G., Grieve, S. M., Di Bartolo, B. A. & Figtree, G. A., Oct 2021, In: Antioxidants. 10, 10, 17 p., 1547.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus)