Research Output per year
Personal profile
Research interests
To understand the mechanisms involved in epilepsy-associated cardiac dysfunction and sudden unexpected death in epilepsy (SUDEP) and target interventions to prevent it them.
Our research centers on basic research investigating the causal mechanisms of cardiac dysfunction and sudden unexpected death in epilepsy (SUDEP) in epilepsy. We study how alternations in function or expression of ion channels and mRNA and protein levels in both brain and heart tissue result in cardiac dysfunction in people with epilepsy. We compare our findings with animal models and clinical information to get a complete picture to inform strategies for prevention and treatment.
External positions
Honorary Senior Research Fellow, University of Melbourne
5 Oct 2017 → …Research area keywords
- epilepsy
- sudden unexplained death in epilepsy
- cardiac function
- ion channels
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Research Output
A rat model of valproate teratogenicity from chronic oral treatment during pregnancy
Jazayeri, D., Braine, E., McDonald, S., Dworkin, S., Powell, K. L., Griggs, K., Vajda, F. J. E., O’Brien, T. J. & Jones, N. C., 1 Jun 2020, In : Epilepsia. 61, 6, p. 1291-1300 10 p.Research output: Contribution to journal › Article › Research › peer-review
Validation of reference genes for gene expression analysis following experimental traumatic brain injury in a pediatric mouse model
Zamani, A., Powell, K. L., May, A. & Semple, B. D., 1 Mar 2020, In : Brain Research Bulletin. 156, p. 43-49 7 p.Research output: Contribution to journal › Article › Research › peer-review
Acquired cardiac channelopathies in epilepsy: Evidence, mechanisms, and clinical significance
Li, M. C. H., O'Brien, T. J., Todaro, M. & Powell, K. L., 1 Sep 2019, In : Epilepsia. 60, 9, p. 1753-1767 15 p.Research output: Contribution to journal › Review Article › Research › peer-review
3
Citations
(Scopus)
An animal model of genetic predisposition to develop acquired epileptogenesis: The FAST and SLOW rats
Leung, W. L., Casillas-Espinosa, P., Sharma, P., Perucca, P., Powell, K., O'Brien, T. J. & Semple, B. D., Oct 2019, In : Epilepsia. 60, 10, p. 2023-2036 14 p.Research output: Contribution to journal › Review Article › Research › peer-review
1
Citation
(Scopus)
Cav3.2 T-type calcium channel mutation influences kindling-induced thalamic neuronal firing patterns in Genetic Absence Epilepsy Rats From Strasbourg
Çarçak, N., Ali, I., Powell, K., Zheng, T., Onat, F. & O'Brien, T. J., Jul 2019, In : Epilepsia. 60, 7, p. 1378-1386 9 p.Research output: Contribution to journal › Article › Research › peer-review