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Personal profile

Research interests

To understand the mechanisms involved in epilepsy-associated cardiac dysfunction and sudden unexpected death in epilepsy (SUDEP) and target interventions to prevent it them.

Our research centers on basic research investigating the causal mechanisms of cardiac dysfunction and sudden unexpected death in epilepsy (SUDEP) in epilepsy. We study how alternations in function or expression of ion channels and mRNA and protein levels in both brain and heart tissue result in cardiac dysfunction in people with epilepsy. We compare our findings with animal models and clinical information to get a complete picture to inform strategies for prevention and treatment.

External positions

Honorary Senior Research Fellow, The University of Melbourne

5 Oct 2017 → …

Keywords

  • epilepsy
  • sudden unexplained death in epilepsy
  • cardiac function
  • ion channels

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Research Output 1996 2019

Cav3.2 T-type calcium channel mutation influences kindling-induced thalamic neuronal firing patterns in Genetic Absence Epilepsy Rats From Strasbourg

Çarçak, N., Ali, I., Powell, K., Zheng, T., Onat, F. & O'Brien, T. J., 22 May 2019, (Accepted/In press) In : Epilepsia. 9 p.

Research output: Contribution to journalArticleResearchpeer-review

CaV3.2 drives sustained burst-firing, which is critical for absence seizure propagation in reticular thalamic neurons

Cain, S. M., Tyson, J. R., Choi, H. B., Ko, R., Lin, P. J. C., Ledue, J. M., Powell, K. L., Bernier, L. P., Rungta, R. L., Yang, Y., Cullis, P. R., O'Brien, T. J., Macvicar, B. A. & Snutch, T. P., Apr 2018, In : Epilepsia. 59, 4, p. 778-791 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Delayed myelination and neurodevelopment in male seizure-prone versus seizure-resistant rats

Sharma, P., Powell, K. L., Wlodek, M. E., O'Brien, T. J. & Gilby, K. L., Apr 2018, In : Epilepsia. 59, 4, p. 753-764 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Gene therapy mediated seizure suppression in Genetic Generalised Epilepsy: Neuropeptide Y overexpression in a rat model

Powell, K. L., Fitzgerald, X., Shallue, C., Jovanovska, V., Klugmann, M., Von Jonquieres, G., O'Brien, T. J. & Morris, M. J., 1 May 2018, In : Neurobiology of Disease. 113, 2, p. 23-32 10 p.

Research output: Contribution to journalArticleResearchpeer-review