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Personal profile

Research interests

To understand the mechanisms involved in epilepsy-associated cardiac dysfunction and sudden unexpected death in epilepsy (SUDEP) and target interventions to prevent it them.

Our research centers on basic research investigating the causal mechanisms of cardiac dysfunction and sudden unexpected death in epilepsy (SUDEP) in epilepsy. We study how alternations in function or expression of ion channels and mRNA and protein levels in both brain and heart tissue result in cardiac dysfunction in people with epilepsy. We compare our findings with animal models and clinical information to get a complete picture to inform strategies for prevention and treatment.

External positions

Honorary Senior Research Fellow, The University of Melbourne

5 Oct 2017 → …

Research area keywords

  • epilepsy
  • sudden unexplained death in epilepsy
  • cardiac function
  • ion channels

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Research Output 1996 2019

Acquired cardiac channelopathies in epilepsy: Evidence, mechanisms, and clinical significance

Li, M. C. H., O'Brien, T. J., Todaro, M. & Powell, K. L., 1 Sep 2019, In : Epilepsia. 60, 9, p. 1753-1767 15 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

An animal model of genetic predisposition to develop acquired epileptogenesis: The FAST and SLOW rats

Leung, W. L., Casillas-Espinosa, P., Sharma, P., Perucca, P., Powell, K., O'Brien, T. J. & Semple, B. D., Oct 2019, In : Epilepsia. 60, 10, p. 2023-2036 14 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Cav3.2 T-type calcium channel mutation influences kindling-induced thalamic neuronal firing patterns in Genetic Absence Epilepsy Rats From Strasbourg

Çarçak, N., Ali, I., Powell, K., Zheng, T., Onat, F. & O'Brien, T. J., Jul 2019, In : Epilepsia. 60, 7, p. 1378-1386 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Disease-modifying effects of a novel T-type calcium channel antagonist, Z944, in a model of temporal lobe epilepsy

Casillas-Espinosa, P. M., Shultz, S. R., Braine, E. L., Jones, N. C., Snutch, T. P., Powell, K. L. & O'Brien, T. J., 13 Aug 2019, (Accepted/In press) In : Progress in Neurobiology. 11 p.

Research output: Contribution to journalArticleResearchpeer-review

CaV3.2 drives sustained burst-firing, which is critical for absence seizure propagation in reticular thalamic neurons

Cain, S. M., Tyson, J. R., Choi, H. B., Ko, R., Lin, P. J. C., Ledue, J. M., Powell, K. L., Bernier, L. P., Rungta, R. L., Yang, Y., Cullis, P. R., O'Brien, T. J., Macvicar, B. A. & Snutch, T. P., Apr 2018, In : Epilepsia. 59, 4, p. 778-791 14 p.

Research output: Contribution to journalArticleResearchpeer-review

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