Research Output per year
Personal profile
Research interests
To understand the mechanisms involved in epilepsy-associated cardiac dysfunction and sudden unexpected death in epilepsy (SUDEP) and target interventions to prevent it them.
Our research centers on basic research investigating the causal mechanisms of cardiac dysfunction and sudden unexpected death in epilepsy (SUDEP) in epilepsy. We study how alternations in function or expression of ion channels and mRNA and protein levels in both brain and heart tissue result in cardiac dysfunction in people with epilepsy. We compare our findings with animal models and clinical information to get a complete picture to inform strategies for prevention and treatment.
External positions
Honorary Senior Research Fellow, The University of Melbourne
5 Oct 2017 → …Keywords
- epilepsy
- sudden unexplained death in epilepsy
- cardiac function
- ion channels
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Research Output 1996 2019
Cav3.2 T-type calcium channel mutation influences kindling-induced thalamic neuronal firing patterns in Genetic Absence Epilepsy Rats From Strasbourg
Çarçak, N., Ali, I., Powell, K., Zheng, T., Onat, F. & O'Brien, T. J., 22 May 2019, (Accepted/In press) In : Epilepsia. 9 p.Research output: Contribution to journal › Article › Research › peer-review
CaV3.2 drives sustained burst-firing, which is critical for absence seizure propagation in reticular thalamic neurons
Cain, S. M., Tyson, J. R., Choi, H. B., Ko, R., Lin, P. J. C., Ledue, J. M., Powell, K. L., Bernier, L. P., Rungta, R. L., Yang, Y., Cullis, P. R., O'Brien, T. J., Macvicar, B. A. & Snutch, T. P., Apr 2018, In : Epilepsia. 59, 4, p. 778-791 14 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
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Delayed myelination and neurodevelopment in male seizure-prone versus seizure-resistant rats
Sharma, P., Powell, K. L., Wlodek, M. E., O'Brien, T. J. & Gilby, K. L., Apr 2018, In : Epilepsia. 59, 4, p. 753-764 12 p.Research output: Contribution to journal › Article › Research › peer-review
Gene therapy mediated seizure suppression in Genetic Generalised Epilepsy: Neuropeptide Y overexpression in a rat model
Powell, K. L., Fitzgerald, X., Shallue, C., Jovanovska, V., Klugmann, M., Von Jonquieres, G., O'Brien, T. J. & Morris, M. J., 1 May 2018, In : Neurobiology of Disease. 113, 2, p. 23-32 10 p.Research output: Contribution to journal › Article › Research › peer-review