Projects per year
Personal profile
Biography
Dr. Kim Jacobson (publishing as Kim Good-Jacobson) studies the formation of immunity. Human health and longevity is dependent on the ability of the immune system to clear the multitude of different foreign pathogens encountered over the life of the host. Her research studies the ability of the immune system to clear pathogens and form immunity through production of B cell memory.
Dr. Kim Good-Jacobson investigates chromatin and transcriptional modifications underlying diversification and selection of B cell fates during the formation of immunity. Dr. Jacobson completed her PhD at the Centenary and Garvan Institutes in 2007. She was awarded an Arthritis Australia AFA-ARA Heald Fellowship, followed by a CJ Martin Fellowship from the NHMRC to undertake postdoctoral training at Yale University, where she revealed a novel role for the inhibitory receptor PD-1 in humoral responses. She returned to Australia in 2010 and has since made key insights into how histone modifications regulate B cell memory, and the essential requirement for the oncogene c-Myb in the establishment of long-lived humoral immunity. Dr. Jacobson has recently relocated to Monash University to establish her own laboratory, focusing on immune memory regulation in health and chronic disease. She currently serves as Deputy Treasurer for ASI and has written for The Conversation. Dr. Jacobson has also been the recipient of funding from the Cancer Institute NSW and Leukaemia Foundation of Australia.
Related Links:
- B Cells and Antibody Memory Laboratory http://www.med.monash.edu.au/biochem/labs/jacobson/index.html
- The Conversation: Explainer: How viruses can fool the immune system https://theconversation.com/explainer-how-viruses-can-fool-the-immune-system-43707
- The Conversation: Six Steps to Fairer Funding for Female Scientists https://theconversation.com/six-steps-to-fairer-funding-for-female-scientists-16895
Research interests
Previous grants awarded:
2012-2014: NHMRC Project Grant (CIA)
"Epigenetic mechanisms that regulate B cell differentiation and memory B cell persistence to provide long-term protection".
2013: Leukaemia Foundation grant-in-aid (CIA).
"Regulation of B cell survival and migration by the oncogene c-Myb."
Supervision interests
Current graduate student:
Lucy Cooper - Master of Biomedical Science Preliminary - Role of transcription factors in regulating antibody responses to infection
Current honours student:
Rohia Farighi - Bachelor of Science (Honours) - Epigenetic regulation of B cell responses
Previous honours student:
Callisthenis Yiannis - Bachelor of Biomedical Science (Honours) - Epigenetic regulation of antibody responses
Keywords
- Immunology
- Infection
- B cells
- Immunity
- Immune memory
- Antibody
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2014 2024
Multiple paths of TFH differentiation and their impact on B cell protection against infection
Groom, J. R., Jacobson, K. & Shi, W.
1/01/18 → 31/12/21
Project: Research
How do cross-reactive memory B cells affect influenza vaccine titers?
Fox, A., Barr, I., Jacobson, K., Wertheim, H., Smith, D. J., Boyd, S. & Mai, L.
1/01/16 → 31/12/16
Project: Research
How the immune system responds to different types of infection and establishes immunity
Jacobson, K. & Groom, J.
National Health & Medical Research Council (NHMRC)
1/01/14 → 31/01/18
Project: Research
Research Output 2006 2019
B Cells Hit a Class Ceiling in the Germinal Center
Cooper, L. & Good-Jacobson, K. L., 20 Aug 2019, In : Immunity. 51, 2, p. 206-208 3 p.Research output: Contribution to journal › Short Survey › Other › peer-review
B cells turn on, tune in with LSD1
Good-Jacobson, K., 1 Jan 2019, In : Nature Immunology. 20, 1, p. 3-5 3 p.Research output: Contribution to journal › Article › Other › peer-review
Context-Dependent Role for T-bet in T Follicular Helper Differentiation and Germinal Center Function following Viral Infection
Sheikh, A. A., Cooper, L., Feng, M., Souza-Fonseca-Guimaraes, F., Lafouresse, F., Duckworth, B. C., Huntington, N. D., Moon, J. J., Pellegrini, M., Nutt, S. L., Belz, G. T., Good-Jacobson, K. L. & Groom, J. R., 13 Aug 2019, In : Cell Reports. 28, 7, p. 1758-1772 15 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Epigenetic regulation of B cell fate and function during an immune response
Zhang, Y. & Good-Jacobson, K. L., 1 Mar 2019, In : Immunological Reviews. 288, 1, p. 75-84 10 p.Research output: Contribution to journal › Review Article › Research › peer-review
Type I interferon induces CXCL13 to support ectopic germinal center formation
Denton, A. E., Innocentin, S., Carr, E. J., Bradford, B. M., Lafouresse, F., Mabbott, N. A., Mörbe, U., Ludewig, B., Groom, J. R., Good-Jacobson, K. L. & Linterman, M. A., 4 Mar 2019, In : The Journal of experimental medicine. 216, 3, p. 621-637 17 p.Research output: Contribution to journal › Article › Research › peer-review
Prizes
Victorian Young Tall Poppy Science Award
Kim Jacobson (Recipient), 2016
Prize: Prize (including medals and awards)
Activities 2016 2016
- 2 Editorial responsibility
Frontiers in Immunology (Journal)
Kim Jacobson (Editorial board member)2016 → …
Activity: Publication peer-review and editorial work types › Editorial responsibility
Journal of Immunology (Journal)
Kim Jacobson (Associate editor)2016 → 2018
Activity: Publication peer-review and editorial work types › Editorial responsibility
Press / Media
Scientists find tiny part in body that may be key to how vaccines work
22/08/18
1 media contribution
Press/Media: Expert Comment
Scientists unlock new secrets of disease-battling immune cells
27/09/16
1 media contribution
Press/Media: Expert Comment
Comment: Six steps to fairer funding for female scientists
25/10/13
1 media contribution
Press/Media: Expert Comment